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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4796

FusionGeneSummary for C19orf43_THNSL2

check button Fusion gene summary
Fusion gene informationFusion gene name: C19orf43_THNSL2
Fusion gene ID: 4796
HgeneTgene
Gene symbol

C19orf43

THNSL2

Gene ID

55258

Gene namethreonine synthase like 2
SynonymsSOFAT|THS2|TSH2
Cytomap

2p11.2

Type of geneprotein-coding
Descriptionthreonine synthase-like 2secreted osteoclastogenic factor of activated T cells
Modification date20180523
UniProtAcc

Q86YJ6

Ensembl transtripts involved in fusion geneENST00000592273, ENST00000242784, 
ENST00000588213, 		ENST00000402102, 
ENST00000377254, ENST00000358591, 
ENST00000449349, ENST00000343544, 
ENST00000324166, ENST00000496844, 
Fusion gene scores* DoF score4 X 4 X 2=321 X 1 X 1=1
# samples 41
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: C19orf43 [Title/Abstract] AND THNSL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE172782C19orf43chr19

12844801

-THNSL2chr2

88472569

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000592273ENST00000402102C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000592273ENST00000377254C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000592273ENST00000358591C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000592273ENST00000449349C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000592273ENST00000343544C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-5UTRENST00000592273ENST00000324166C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000592273ENST00000496844C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000242784ENST00000402102C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000242784ENST00000377254C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000242784ENST00000358591C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000242784ENST00000449349C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000242784ENST00000343544C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-5UTRENST00000242784ENST00000324166C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000242784ENST00000496844C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000588213ENST00000402102C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000588213ENST00000377254C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000588213ENST00000358591C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000588213ENST00000449349C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000588213ENST00000343544C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-5UTRENST00000588213ENST00000324166C19orf43chr19

12844801

-THNSL2chr2

88472569

+
intron-intronENST00000588213ENST00000496844C19orf43chr19

12844801

-THNSL2chr2

88472569

+

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FusionProtFeatures for C19orf43_THNSL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C19orf43

THNSL2

Q86YJ6

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Isoform 1: Acts as a catabolic phospho-lyase on bothgamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (Bysimilarity). {ECO:0000250}. Isoform SOFAT: Potent inducer of osteoblastic productionof IL6. May act to exacerbate inflammation and/or bone turnoverunder inflammatory conditions. {ECO:0000269|PubMed:19877052}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C19orf43_THNSL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C19orf43_THNSL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C19orf43_THNSL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C19orf43_THNSL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource