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Fusion gene ID: 4789 |
FusionGeneSummary for C19orf25_KLF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C19orf25_KLF2 | Fusion gene ID: 4789 | Hgene | Tgene | Gene symbol | C19orf25 | KLF2 | Gene ID | 148223 | 10365 |
| Gene name | chromosome 19 open reading frame 25 | Kruppel like factor 2 | |
| Synonyms | - | LKLF | |
| Cytomap | 19p13.3 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | UPF0449 protein C19orf25 | Krueppel-like factor 2Kruppel-like factor 2 (lung)Kruppel-like factor LKLFlung Kruppel-like factorlung Kruppel-like zinc finger transcription factorlung krueppel-like factor | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9UFG5 | Q9Y5W3 | |
| Ensembl transtripts involved in fusion gene | ENST00000588427, ENST00000436106, ENST00000588871, ENST00000427685, ENST00000588849, ENST00000586564, ENST00000592872, ENST00000585675, ENST00000591027, | ENST00000248071, ENST00000592003, | |
| Fusion gene scores | * DoF score | 5 X 2 X 5=50 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/50*10)=0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: C19orf25 [Title/Abstract] AND KLF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KLF2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 26299712 |
| Tgene | KLF2 | GO:0045429 | positive regulation of nitric oxide biosynthetic process | 21768538 |
| Tgene | KLF2 | GO:0045893 | positive regulation of transcription, DNA-templated | 21063504 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AJ713185 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000588427 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000588427 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000436106 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000436106 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000588871 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000588871 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| intron-3CDS | ENST00000427685 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| intron-3CDS | ENST00000427685 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| In-frame | ENST00000588849 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| In-frame | ENST00000588849 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| In-frame | ENST00000586564 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| In-frame | ENST00000586564 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| In-frame | ENST00000592872 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| In-frame | ENST00000592872 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000585675 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000585675 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| 5UTR-3CDS | ENST00000591027 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| 5UTR-3CDS | ENST00000591027 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
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FusionProtFeatures for C19orf25_KLF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C19orf25 | KLF2 |
| Transcription factor that binds to the CACCC box in thepromoter of target genes such as HBB/beta globin or NOV andactivates their transcription. {ECO:0000269|PubMed:21063504}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for C19orf25_KLF2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_C19orf25_ENST00000588849_chr19_1478771_-_KLF2_ENST00000248071_chr19_16437665_+_45aa >In-frame_C19orf25_ENST00000586564_chr19_1478771_-_KLF2_ENST00000248071_chr19_16437665_+_45aa >In-frame_C19orf25_ENST00000592872_chr19_1478771_-_KLF2_ENST00000248071_chr19_16437665_+_45aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_C19orf25_ENST00000588849_chr19_1478771_-_KLF2_ENST00000248071_chr19_16437665_+_135nt ATGGGCTCCAAGGCAAAGAAGCGCGTGCTGCTGCCCACCCGCCCAGCGCCCCCCACGGTGGAGCAGATCCTGGAGGATGTGCGGGGTGCG >In-frame_C19orf25_ENST00000586564_chr19_1478771_-_KLF2_ENST00000248071_chr19_16437665_+_135nt ATGGGCTCCAAGGCAAAGAAGCGCGTGCTGCTGCCCACCCGCCCAGCGCCCCCCACGGTGGAGCAGATCCTGGAGGATGTGCGGGGTGCG >In-frame_C19orf25_ENST00000592872_chr19_1478771_-_KLF2_ENST00000248071_chr19_16437665_+_135nt ATGGGCTCCAAGGCAAAGAAGCGCGTGCTGCTGCCCACCCGCCCAGCGCCCCCCACGGTGGAGCAGATCCTGGAGGATGTGCGGGGTGCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_C19orf25_ENST00000588849_chr19_1478771_-_KLF2_ENST00000248071_chr19_16437665_+_1162nt CCCGCCTTCAGAGATGGGCTCCAAGGCAAAGAAGCGCGTGCTGCTGCCCACCCGCCCAGCGCCCCCCACGGTGGAGCAGATCCTGGAGGA TGTGCGGGGTGCGCCGGCAGAGGATCCAGTGTTCACCATCCTGGCCCCGGAAGGTGAGAAGCCCTACCACTGCAACTGGGACGGCTGCGG CTGGAAGTTTGCGCGCTCAGACGAGCTCACGCGCCACTACCGAAAGCACACGGGCCACCGGCCATTCCAGTGCCATCTGTGCGATCGTGC CTTCTCGCGCTCCGATCACCTGGCGCTGCACATGAAACGGCACATGTAGCCGGGACGCCCCCGCCCACCTGCGCGCGGCCGTGGCGGGTC CCACGCGCCGGGCGCGGCCCCCTCCCAAACTGTGACTGGTATTTATTGGACCCAGAGAACCGGGCCGGGCACAGCGTGGCTACAGAGGGT CTCCCTCGATGACGACGACGACGACGCCACCACCCCAGCCCCCGTCTGTGACTGAAGGCCCGGTGGGAAAAGACCACGATCCTCCTTGAC GAGTTTTGTTTTTCAAAATGGTGCAATAATTTAAGTGGCATCTTCTCTCCCACCGGGTCTACACTAGAGGATCGAGGCTTGTGATGCCTT GTGAGAAATAAGGGCCTTAATTTGTACTGTCTGCGGCATTTTTTATAATATTGTATATAGTGACTGACAAATATTGTATTACTGTACATA GAGAGACAGGTGGGCATTTTTGGGCTACCTGGTTCGTTTTTATAAGATTTTGCTGGGTTGGTTTTTTTTTTAATTAAAAAGTTTTGCATC TTTTAAAAAAAATCACAGCACTGGTCTGGTTGCTTGGAACTGGGGCCTTGGGGCACTTGGGAGGAGGGGGGAGCGGAGAGTTTGATGGAG GGCAGCCCCACTAAAGCATCGTGTGCAGTGGGTCCTGCGTCTGCCAGCACCGGGACTGCCAGCTGCTGTGCCTGCCTGCCAGGAACCTGT GGGTTTTTCTGTAAATTTAGACACTGCATTTTAGGACTGAGGGAGGGTTATTTTAAGGTTGTTCTTTGAGCCATAAATTGCCTCTTTGCC >In-frame_C19orf25_ENST00000588849_chr19_1478771_-_KLF2_ENST00000592003_chr19_16437665_+_548nt CCCGCCTTCAGAGATGGGCTCCAAGGCAAAGAAGCGCGTGCTGCTGCCCACCCGCCCAGCGCCCCCCACGGTGGAGCAGATCCTGGAGGA TGTGCGGGGTGCGCCGGCAGAGGATCCAGTGTTCACCATCCTGGCCCCGGAAGGTGAGAAGCCCTACCACTGCAACTGGGACGGCTGCGG CTGGAAGTTTGCGCGCTCAGACGAGCTCACGCGCCACTACCGAAAGCACACGGGCCACCGGCCATTCCAGTGCCATCTGTGCGATCGTGC CTTCTCGCGCTCCGATCACCTGGCGCTGCACATGAAACGGCACATGTAGCCGGGACGCCCCCGCCCACCTGCGCGCGGCCGTGGCGGGTC CCACGCGCCGGGCGCGGCCCCCTCCCAAACTGTGACTGGTATTTATTGGACCCAGAGAACCGGGCCGGGCACAGCGTGGCTACAGAGGGT CTCCCTCGATGACGACGACGACGACGCCACCACCCCAGCCCCCGTCTGTGACTGAAGGCCCGGTGGGAAAAGACCACGATCCTCCTTGAC >In-frame_C19orf25_ENST00000586564_chr19_1478771_-_KLF2_ENST00000248071_chr19_16437665_+_1364nt CAGAGGTTGAGCCAGACCCTGAAGCCTTGGCCACCGTGTTTTTGGGCGGAGGGAGGGTCAGGGCCTGGGGCGAGCTCAGAGGGGCGGGAC AGGGCGGGCTTCCCCGGGAGCGGGACCGCGACGGGTGCGTACGAGTTCGCTGGGCGGGAGGAGCAGCCCGGGCAAGGGCGGAGAGGTGGA CGCCCCGGTCAGCGCCCCCTTCCCCGCCTTCAGAGATGGGCTCCAAGGCAAAGAAGCGCGTGCTGCTGCCCACCCGCCCAGCGCCCCCCA CGGTGGAGCAGATCCTGGAGGATGTGCGGGGTGCGCCGGCAGAGGATCCAGTGTTCACCATCCTGGCCCCGGAAGGTGAGAAGCCCTACC ACTGCAACTGGGACGGCTGCGGCTGGAAGTTTGCGCGCTCAGACGAGCTCACGCGCCACTACCGAAAGCACACGGGCCACCGGCCATTCC AGTGCCATCTGTGCGATCGTGCCTTCTCGCGCTCCGATCACCTGGCGCTGCACATGAAACGGCACATGTAGCCGGGACGCCCCCGCCCAC CTGCGCGCGGCCGTGGCGGGTCCCACGCGCCGGGCGCGGCCCCCTCCCAAACTGTGACTGGTATTTATTGGACCCAGAGAACCGGGCCGG GCACAGCGTGGCTACAGAGGGTCTCCCTCGATGACGACGACGACGACGCCACCACCCCAGCCCCCGTCTGTGACTGAAGGCCCGGTGGGA AAAGACCACGATCCTCCTTGACGAGTTTTGTTTTTCAAAATGGTGCAATAATTTAAGTGGCATCTTCTCTCCCACCGGGTCTACACTAGA GGATCGAGGCTTGTGATGCCTTGTGAGAAATAAGGGCCTTAATTTGTACTGTCTGCGGCATTTTTTATAATATTGTATATAGTGACTGAC AAATATTGTATTACTGTACATAGAGAGACAGGTGGGCATTTTTGGGCTACCTGGTTCGTTTTTATAAGATTTTGCTGGGTTGGTTTTTTT TTTAATTAAAAAGTTTTGCATCTTTTAAAAAAAATCACAGCACTGGTCTGGTTGCTTGGAACTGGGGCCTTGGGGCACTTGGGAGGAGGG GGGAGCGGAGAGTTTGATGGAGGGCAGCCCCACTAAAGCATCGTGTGCAGTGGGTCCTGCGTCTGCCAGCACCGGGACTGCCAGCTGCTG TGCCTGCCTGCCAGGAACCTGTGGGTTTTTCTGTAAATTTAGACACTGCATTTTAGGACTGAGGGAGGGTTATTTTAAGGTTGTTCTTTG AGCCATAAATTGCCTCTTTGCCCCACAGCTGGGGAAAGTGCTGGTCCCACTGACGTGGCCTCCTCTACGTTGAAAAAAATAAAACTACTT >In-frame_C19orf25_ENST00000586564_chr19_1478771_-_KLF2_ENST00000592003_chr19_16437665_+_750nt CAGAGGTTGAGCCAGACCCTGAAGCCTTGGCCACCGTGTTTTTGGGCGGAGGGAGGGTCAGGGCCTGGGGCGAGCTCAGAGGGGCGGGAC AGGGCGGGCTTCCCCGGGAGCGGGACCGCGACGGGTGCGTACGAGTTCGCTGGGCGGGAGGAGCAGCCCGGGCAAGGGCGGAGAGGTGGA CGCCCCGGTCAGCGCCCCCTTCCCCGCCTTCAGAGATGGGCTCCAAGGCAAAGAAGCGCGTGCTGCTGCCCACCCGCCCAGCGCCCCCCA CGGTGGAGCAGATCCTGGAGGATGTGCGGGGTGCGCCGGCAGAGGATCCAGTGTTCACCATCCTGGCCCCGGAAGGTGAGAAGCCCTACC ACTGCAACTGGGACGGCTGCGGCTGGAAGTTTGCGCGCTCAGACGAGCTCACGCGCCACTACCGAAAGCACACGGGCCACCGGCCATTCC AGTGCCATCTGTGCGATCGTGCCTTCTCGCGCTCCGATCACCTGGCGCTGCACATGAAACGGCACATGTAGCCGGGACGCCCCCGCCCAC CTGCGCGCGGCCGTGGCGGGTCCCACGCGCCGGGCGCGGCCCCCTCCCAAACTGTGACTGGTATTTATTGGACCCAGAGAACCGGGCCGG GCACAGCGTGGCTACAGAGGGTCTCCCTCGATGACGACGACGACGACGCCACCACCCCAGCCCCCGTCTGTGACTGAAGGCCCGGTGGGA >In-frame_C19orf25_ENST00000592872_chr19_1478771_-_KLF2_ENST00000248071_chr19_16437665_+_1221nt GCTTTCGGGTCCCGCGCCCAGGTGGGAAGAGGCCGGCGACTGGGGTGACCGCGGGGAAACTGAGGCAGAGAGATGGGCTCCAAGGCAAAG AAGCGCGTGCTGCTGCCCACCCGCCCAGCGCCCCCCACGGTGGAGCAGATCCTGGAGGATGTGCGGGGTGCGCCGGCAGAGGATCCAGTG TTCACCATCCTGGCCCCGGAAGGTGAGAAGCCCTACCACTGCAACTGGGACGGCTGCGGCTGGAAGTTTGCGCGCTCAGACGAGCTCACG CGCCACTACCGAAAGCACACGGGCCACCGGCCATTCCAGTGCCATCTGTGCGATCGTGCCTTCTCGCGCTCCGATCACCTGGCGCTGCAC ATGAAACGGCACATGTAGCCGGGACGCCCCCGCCCACCTGCGCGCGGCCGTGGCGGGTCCCACGCGCCGGGCGCGGCCCCCTCCCAAACT GTGACTGGTATTTATTGGACCCAGAGAACCGGGCCGGGCACAGCGTGGCTACAGAGGGTCTCCCTCGATGACGACGACGACGACGCCACC ACCCCAGCCCCCGTCTGTGACTGAAGGCCCGGTGGGAAAAGACCACGATCCTCCTTGACGAGTTTTGTTTTTCAAAATGGTGCAATAATT TAAGTGGCATCTTCTCTCCCACCGGGTCTACACTAGAGGATCGAGGCTTGTGATGCCTTGTGAGAAATAAGGGCCTTAATTTGTACTGTC TGCGGCATTTTTTATAATATTGTATATAGTGACTGACAAATATTGTATTACTGTACATAGAGAGACAGGTGGGCATTTTTGGGCTACCTG GTTCGTTTTTATAAGATTTTGCTGGGTTGGTTTTTTTTTTAATTAAAAAGTTTTGCATCTTTTAAAAAAAATCACAGCACTGGTCTGGTT GCTTGGAACTGGGGCCTTGGGGCACTTGGGAGGAGGGGGGAGCGGAGAGTTTGATGGAGGGCAGCCCCACTAAAGCATCGTGTGCAGTGG GTCCTGCGTCTGCCAGCACCGGGACTGCCAGCTGCTGTGCCTGCCTGCCAGGAACCTGTGGGTTTTTCTGTAAATTTAGACACTGCATTT TAGGACTGAGGGAGGGTTATTTTAAGGTTGTTCTTTGAGCCATAAATTGCCTCTTTGCCCCACAGCTGGGGAAAGTGCTGGTCCCACTGA >In-frame_C19orf25_ENST00000592872_chr19_1478771_-_KLF2_ENST00000592003_chr19_16437665_+_607nt GCTTTCGGGTCCCGCGCCCAGGTGGGAAGAGGCCGGCGACTGGGGTGACCGCGGGGAAACTGAGGCAGAGAGATGGGCTCCAAGGCAAAG AAGCGCGTGCTGCTGCCCACCCGCCCAGCGCCCCCCACGGTGGAGCAGATCCTGGAGGATGTGCGGGGTGCGCCGGCAGAGGATCCAGTG TTCACCATCCTGGCCCCGGAAGGTGAGAAGCCCTACCACTGCAACTGGGACGGCTGCGGCTGGAAGTTTGCGCGCTCAGACGAGCTCACG CGCCACTACCGAAAGCACACGGGCCACCGGCCATTCCAGTGCCATCTGTGCGATCGTGCCTTCTCGCGCTCCGATCACCTGGCGCTGCAC ATGAAACGGCACATGTAGCCGGGACGCCCCCGCCCACCTGCGCGCGGCCGTGGCGGGTCCCACGCGCCGGGCGCGGCCCCCTCCCAAACT GTGACTGGTATTTATTGGACCCAGAGAACCGGGCCGGGCACAGCGTGGCTACAGAGGGTCTCCCTCGATGACGACGACGACGACGCCACC |
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FusionGenePPI for C19orf25_KLF2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| C19orf25 | C19orf57, CCDC85B, CEP170P1, MYEOV2, DUT, HNRNPH2, ZW10, EPS8, SAT1, BAIAP2, VTI1B, USE1, BSG, P2RY12, P2RY8, SLC30A4, SCARA3, SCLT1, SSX2IP, PTPRJ, RINT1, SCFD2, SEC22B, APLNR, TMEM206, SLC15A1, HTR2C, F2RL1, PTPRN | KLF2 | GATA5, GATA6, WWP1, SMURF1, ELAVL1, FBXW7, GSK3B, CREBBP, EP300, KAT2B, PSME3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C19orf25_KLF2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C19orf25_KLF2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | KLF2 | C0024115 | Lung diseases | 1 | CTD_human |
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