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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4783

FusionGeneSummary for C19orf10_FAM187B

check button Fusion gene summary
Fusion gene informationFusion gene name: C19orf10_FAM187B
Fusion gene ID: 4783
HgeneTgene
Gene symbol

C19orf10

FAM187B

Gene ID

56005

148109

Gene namemyeloid derived growth factorfamily with sequence similarity 187 member B
SynonymsC19orf10|EUROIMAGE1875335|IL25|IL27|IL27w|R33729_1|SF20TMEM162
Cytomap

19p13.3

19q13.12

Type of geneprotein-codingprotein-coding
Descriptionmyeloid-derived growth factorUPF0556 protein C19orf10interleukin 27 working designationinterleukin-25stromal cell-derived growth factor SF20protein FAM187Btransmembrane protein 162
Modification date2018051920180519
UniProtAcc

Q17R55

Ensembl transtripts involved in fusion geneENST00000262947, ENST00000599630, 
ENST00000324675, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 1 X 3=9
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: C19orf10 [Title/Abstract] AND FAM187B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneC19orf10

GO:0001938

positive regulation of endothelial cell proliferation

25581518

HgeneC19orf10

GO:0045766

positive regulation of angiogenesis

25581518


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-TM-A7CF-01AC19orf10chr19

4659943

-FAM187Bchr19

35716115

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262947ENST00000324675C19orf10chr19

4659943

-FAM187Bchr19

35716115

-
intron-3CDSENST00000599630ENST00000324675C19orf10chr19

4659943

-FAM187Bchr19

35716115

-

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FusionProtFeatures for C19orf10_FAM187B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C19orf10

FAM187B

Q17R55

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAM187Bchr19:4659943chr19:35716115ENST00000324675-02357_369240370Topological domainCytoplasmic
TgeneFAM187Bchr19:4659943chr19:35716115ENST00000324675-02336_356240370TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAM187Bchr19:4659943chr19:35716115ENST00000324675-0218_335240370Topological domainExtracellular


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FusionGeneSequence for C19orf10_FAM187B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_C19orf10_ENST00000262947_chr19_4659943_-_FAM187B_ENST00000324675_chr19_35716115_-_276aa
MAAPSGGWNGVGASLWAALLLGAVALRPAEAVSEPTTVAFDVRPGGVVHSFSHNVGPGDKYTCMFTYASQGGTNEQWQMSLGTSEDHQHF
TCTIWRPQGKSYLYFTQFKAEVRGAEIEYAMAYSKAAFERESDVPLKTEEFEVTKTAGPSTGVPTTPPXRGRASSPARTSPPFWTPPPAA
GSCRFSSRPSTSASCSRSSWPSSNPPPVWRRWRLSGERTMPSGGRQGRPCGAGRTPCSRGXSWCCSWSPSWPCWGRCSSASTLPRAGEAH


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_C19orf10_ENST00000262947_chr19_4659943_-_FAM187B_ENST00000324675_chr19_35716115_-_830nt
ATGGCGGCGCCCAGCGGAGGGTGGAACGGCGTCGGCGCGAGCTTGTGGGCCGCGCTGCTCCTAGGGGCCGTGGCGCTGAGGCCGGCGGAG
GCGGTGTCCGAGCCCACGACGGTGGCGTTTGACGTGCGGCCCGGCGGCGTCGTGCATTCCTTCTCCCATAACGTGGGCCCGGGGGACAAA
TATACGTGTATGTTCACTTACGCCTCTCAAGGAGGGACCAATGAGCAATGGCAGATGAGTCTGGGGACCAGCGAAGACCACCAGCACTTC
ACCTGCACCATCTGGAGGCCCCAGGGGAAGTCCTATCTGTACTTCACACAGTTCAAGGCAGAGGTGCGGGGCGCTGAGATTGAGTACGCC
ATGGCCTACTCTAAAGCCGCATTTGAAAGGGAAAGTGATGTCCCTCTGAAAACTGAGGAATTTGAAGTGACCAAAACAGCAGGCCCGTCA
ACTGGCGTGCCAACGACACCCCCCTGACGTGGGAGAGCCAGCTCTCCGGCCAGGACTTCACCACCTTTCTGGACCCCTCCACCGGCGGCA
GGCAGCTGCAGGTTTTCCAGCCGGCCGTCTACAAGTGCTTCGTGCAGCAGGAGCTCGTGGCCCAGTTCAAACCCGCCGCCAGTCTGGAGA
CGCTGGAGGCTCAGTGGAGAGAGAACGATGCCCAGTGGCGGGAGGCAAGGAAGGCCCTGCGGGGCAGGGCGGACTCCGTGCTCAAGGGGC
TGAAGCTGGTGCTGCTCGTGGTCACCGTCCTGGCCCTGCTGGGGGCGCTGCTCAAGTGCATCCACCCTTCCCCGGGCAGGAGAAGCACAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_C19orf10_ENST00000262947_chr19_4659943_-_FAM187B_ENST00000324675_chr19_35716115_-_891nt
GTCTACCCGCCCCTGCCCTGAGGACCCTAGTCCAACATGGCGGCGCCCAGCGGAGGGTGGAACGGCGTCGGCGCGAGCTTGTGGGCCGCG
CTGCTCCTAGGGGCCGTGGCGCTGAGGCCGGCGGAGGCGGTGTCCGAGCCCACGACGGTGGCGTTTGACGTGCGGCCCGGCGGCGTCGTG
CATTCCTTCTCCCATAACGTGGGCCCGGGGGACAAATATACGTGTATGTTCACTTACGCCTCTCAAGGAGGGACCAATGAGCAATGGCAG
ATGAGTCTGGGGACCAGCGAAGACCACCAGCACTTCACCTGCACCATCTGGAGGCCCCAGGGGAAGTCCTATCTGTACTTCACACAGTTC
AAGGCAGAGGTGCGGGGCGCTGAGATTGAGTACGCCATGGCCTACTCTAAAGCCGCATTTGAAAGGGAAAGTGATGTCCCTCTGAAAACT
GAGGAATTTGAAGTGACCAAAACAGCAGGCCCGTCAACTGGCGTGCCAACGACACCCCCCTGACGTGGGAGAGCCAGCTCTCCGGCCAGG
ACTTCACCACCTTTCTGGACCCCTCCACCGGCGGCAGGCAGCTGCAGGTTTTCCAGCCGGCCGTCTACAAGTGCTTCGTGCAGCAGGAGC
TCGTGGCCCAGTTCAAACCCGCCGCCAGTCTGGAGACGCTGGAGGCTCAGTGGAGAGAGAACGATGCCCAGTGGCGGGAGGCAAGGAAGG
CCCTGCGGGGCAGGGCGGACTCCGTGCTCAAGGGGCTGAAGCTGGTGCTGCTCGTGGTCACCGTCCTGGCCCTGCTGGGGGCGCTGCTCA


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FusionGenePPI for C19orf10_FAM187B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C19orf10BAG6, UBQLN4, ATF2, SGTA, MOV10, NXF1, MDM2FAM187BCLGN, VRK2, ATP1A3, CANX, HSPA5, SPPL2B, SLC25A6, RPL23, OSBPL8, TUBA1A, SOAT1, MOSPD2, HSPA8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C19orf10_FAM187B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C19orf10_FAM187B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource