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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4766

FusionGeneSummary for C17orf67_ITFG1

check button Fusion gene summary
Fusion gene informationFusion gene name: C17orf67_ITFG1
Fusion gene ID: 4766
HgeneTgene
Gene symbol

C17orf67

ITFG1

Gene ID

339210

81533

Gene namechromosome 17 open reading frame 67integrin alpha FG-GAP repeat containing 1
Synonyms-2310047C21Rik|CDA08|LNKN-1|TIP
Cytomap

17q22

16q12.1

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C17orf67T-cell immunomodulatory proteinLINKINintegrin-alpha FG-GAP repeat-containing protein 1
Modification date2018051920180519
UniProtAcc

Q0P5P2

Q8TB96

Ensembl transtripts involved in fusion geneENST00000397861, ENST00000397862, 
ENST00000575658, ENST00000487705, 
ENST00000568047, ENST00000320640, 
ENST00000544001, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 3 X 5=90
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C17orf67 [Title/Abstract] AND ITFG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF855391C17orf67chr17

54909009

+ITFG1chr16

47294519

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000397861ENST00000568047C17orf67chr17

54909009

+ITFG1chr16

47294519

+
intron-5UTRENST00000397861ENST00000320640C17orf67chr17

54909009

+ITFG1chr16

47294519

+
intron-5UTRENST00000397861ENST00000544001C17orf67chr17

54909009

+ITFG1chr16

47294519

+
intron-5UTRENST00000397862ENST00000568047C17orf67chr17

54909009

+ITFG1chr16

47294519

+
intron-5UTRENST00000397862ENST00000320640C17orf67chr17

54909009

+ITFG1chr16

47294519

+
intron-5UTRENST00000397862ENST00000544001C17orf67chr17

54909009

+ITFG1chr16

47294519

+
intron-5UTRENST00000575658ENST00000568047C17orf67chr17

54909009

+ITFG1chr16

47294519

+
intron-5UTRENST00000575658ENST00000320640C17orf67chr17

54909009

+ITFG1chr16

47294519

+
intron-5UTRENST00000575658ENST00000544001C17orf67chr17

54909009

+ITFG1chr16

47294519

+
intron-5UTRENST00000487705ENST00000568047C17orf67chr17

54909009

+ITFG1chr16

47294519

+
intron-5UTRENST00000487705ENST00000320640C17orf67chr17

54909009

+ITFG1chr16

47294519

+
intron-5UTRENST00000487705ENST00000544001C17orf67chr17

54909009

+ITFG1chr16

47294519

+

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FusionProtFeatures for C17orf67_ITFG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C17orf67

Q0P5P2

ITFG1

Q8TB96

Modulator of T-cell function. Has a protective effect ingraft versus host disease model (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C17orf67_ITFG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C17orf67_ITFG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C17orf67_ITFG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C17orf67_ITFG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource