	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 4762

FusionGeneSummary for C17orf62_ENTPD4

Fusion gene summary

Fusion gene information	Fusion gene name: C17orf62_ENTPD4
	Fusion gene ID: 4762
		Hgene	Tgene
	Gene symbol	C17orf62	ENTPD4
	Gene ID		9583
	Gene name		ectonucleoside triphosphate diphosphohydrolase 4
	Synonyms		LALP70\|LAP70\|LYSAL1\|NTPDase-4\|UDPase
	Cytomap		8p21.3
	Type of gene		protein-coding
	Description		ectonucleoside triphosphate diphosphohydrolase 4golgi luminal UDPaseguanosine-diphosphatase like proteinlysosomal apyrase-like 1lysosomal apyrase-like protein of 70 kDauridine-diphosphatase
	Modification date		20180519
	UniProtAcc		Q9Y227
	Ensembl transtripts involved in fusion gene	ENST00000342572, ENST00000306645, ENST00000437807, ENST00000336995, ENST00000434650, ENST00000583617, ENST00000577436, ENST00000585064, ENST00000577732, ENST00000578919, ENST00000585080, ENST00000578913, ENST00000583359,	ENST00000356206, ENST00000521321, ENST00000358689, ENST00000417069,
Fusion gene scores	* DoF score	3 X 3 X 3=27	5 X 6 X 2=60
	# samples	3	6
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/60*10)=0
Context	PubMed: C17orf62 [Title/Abstract] AND ENTPD4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ENTPD4	GO:0006256	UDP catabolic process	9556635

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA465661	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000342572	ENST00000356206	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000342572	ENST00000521321	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-3UTR	ENST00000342572	ENST00000358689	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000342572	ENST00000417069	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000306645	ENST00000356206	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000306645	ENST00000521321	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-3UTR	ENST00000306645	ENST00000358689	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000306645	ENST00000417069	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000437807	ENST00000356206	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000437807	ENST00000521321	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-3UTR	ENST00000437807	ENST00000358689	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000437807	ENST00000417069	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000336995	ENST00000356206	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000336995	ENST00000521321	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-3UTR	ENST00000336995	ENST00000358689	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000336995	ENST00000417069	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000434650	ENST00000356206	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000434650	ENST00000521321	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-3UTR	ENST00000434650	ENST00000358689	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000434650	ENST00000417069	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000583617	ENST00000356206	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000583617	ENST00000521321	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-3UTR	ENST00000583617	ENST00000358689	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000583617	ENST00000417069	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000577436	ENST00000356206	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000577436	ENST00000521321	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-3UTR	ENST00000577436	ENST00000358689	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000577436	ENST00000417069	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000585064	ENST00000356206	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000585064	ENST00000521321	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-3UTR	ENST00000585064	ENST00000358689	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000585064	ENST00000417069	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000577732	ENST00000356206	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000577732	ENST00000521321	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-3UTR	ENST00000577732	ENST00000358689	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000577732	ENST00000417069	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000578919	ENST00000356206	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000578919	ENST00000521321	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-3UTR	ENST00000578919	ENST00000358689	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000578919	ENST00000417069	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000585080	ENST00000356206	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000585080	ENST00000521321	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-3UTR	ENST00000585080	ENST00000358689	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000585080	ENST00000417069	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000578913	ENST00000356206	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000578913	ENST00000521321	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-3UTR	ENST00000578913	ENST00000358689	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000578913	ENST00000417069	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000583359	ENST00000356206	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000583359	ENST00000521321	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-3UTR	ENST00000583359	ENST00000358689	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+
intron-intron	ENST00000583359	ENST00000417069	C17orf62	chr17	80400578	+	ENTPD4	chr8	23289140	+

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FusionProtFeatures for C17orf62_ENTPD4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
C17orf62	ENTPD4 Q9Y227
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269\|PubMed:10224141, ECO:0000269\|PubMed:28301481}.	Hydrolyzes preferentially nucleoside 5'-diphosphates,nucleoside 5'-triphosphates are hydrolyzed only to a minor extent.The order of activity with different substrates is UDP >> GDP =CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferredsubstrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, whileisoform 1 utilizes UTP and TTP.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for C17orf62_ENTPD4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C17orf62_ENTPD4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for C17orf62_ENTPD4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for C17orf62_ENTPD4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	ENTPD4	C0036341	Schizophrenia	1	PSYGENET

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Fusion gene ID: 4762

FusionGeneSummary for C17orf62_ENTPD4

FusionProtFeatures for C17orf62_ENTPD4

FusionGeneSequence for C17orf62_ENTPD4

FusionGenePPI for C17orf62_ENTPD4

RelatedDrugs for C17orf62_ENTPD4

RelatedDiseases for C17orf62_ENTPD4