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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4739

FusionGeneSummary for C16orf70_CMTM4

check button Fusion gene summary
Fusion gene informationFusion gene name: C16orf70_CMTM4
Fusion gene ID: 4739
HgeneTgene
Gene symbol

C16orf70

CMTM4

Gene ID

80262

146223

Gene namechromosome 16 open reading frame 70CKLF like MARVEL transmembrane domain containing 4
SynonymsC16orf6|LIN10|lin-10CKLFSF4
Cytomap

16q22.1

16q21-q22.1

Type of geneprotein-codingprotein-coding
DescriptionUPF0183 protein C16orf70lin-10 homologCKLF-like MARVEL transmembrane domain-containing protein 4chemokine-like factor super family 4chemokine-like factor superfamily member 4
Modification date2018052320180523
UniProtAcc

Q9BSU1

Q8IZR5

Ensembl transtripts involved in fusion geneENST00000569600, ENST00000219139, 
ENST00000569683, 
ENST00000330687, 
ENST00000394106, ENST00000563952, 
Fusion gene scores* DoF score7 X 6 X 7=2942 X 1 X 2=4
# samples 72
** MAII scorelog2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: C16orf70 [Title/Abstract] AND CMTM4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0AS-01AC16orf70chr16

67144142

+CMTM4chr16

66670484

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000569600ENST00000330687C16orf70chr16

67144142

+CMTM4chr16

66670484

-
Frame-shiftENST00000569600ENST00000394106C16orf70chr16

67144142

+CMTM4chr16

66670484

-
Frame-shiftENST00000569600ENST00000563952C16orf70chr16

67144142

+CMTM4chr16

66670484

-
Frame-shiftENST00000219139ENST00000330687C16orf70chr16

67144142

+CMTM4chr16

66670484

-
Frame-shiftENST00000219139ENST00000394106C16orf70chr16

67144142

+CMTM4chr16

66670484

-
Frame-shiftENST00000219139ENST00000563952C16orf70chr16

67144142

+CMTM4chr16

66670484

-
3UTR-3CDSENST00000569683ENST00000330687C16orf70chr16

67144142

+CMTM4chr16

66670484

-
3UTR-3CDSENST00000569683ENST00000394106C16orf70chr16

67144142

+CMTM4chr16

66670484

-
3UTR-3CDSENST00000569683ENST00000563952C16orf70chr16

67144142

+CMTM4chr16

66670484

-

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FusionProtFeatures for C16orf70_CMTM4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C16orf70

Q9BSU1

CMTM4

Q8IZR5

Acts as a backup for CMTM6 to regulate plasma membraneexpression of PD-L1/CD274, an immune inhibitory ligand criticalfor immune tolerance to self and antitumor immunity. May protectPD-L1/CD274 from being polyubiquitinated and targeted fordegradation. {ECO:0000269|PubMed:28813410}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C16orf70_CMTM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C16orf70_CMTM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C16orf70ATXN3, APP, SERPINB6, BCAS3, CELA2B, SERPINA3, NEFH, NEFL, CALML5, OCRL, APPL1, SBSN, CST6, NUP35, ANK3, MASTL, SERPINB4, SERPINB3, TGM3, POMP, POF1B, CALML3, PSMG2, GM2A, FBXO30, PPFIA1, S100A7, ZBTB16, WIPI2, MAGEE1, AZGP1CMTM4MRPL2, APPL1, TMEM171, PTGER3, MANSC1, LPAR1, VIPR2, SLC7A1, SPPL2B, MPPE1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C16orf70_CMTM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C16orf70_CMTM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource