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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4733

FusionGeneSummary for C16orf62_ABCC6P1

check button Fusion gene summary
Fusion gene informationFusion gene name: C16orf62_ABCC6P1
Fusion gene ID: 4733
HgeneTgene
Gene symbol

C16orf62

ABCC6P1

Gene ID

653190

Gene nameATP binding cassette subfamily C member 6 pseudogene 1
Synonyms-
Cytomap

16p12.3

Type of genepseudo
DescriptionATP binding cassette subfamily C member 6 pseudogene 1 (functional)ATP-binding cassette, sub-family C, member 6 pseudogene 1 (functional)
Modification date20180329
UniProtAcc

Q7Z3J2

Ensembl transtripts involved in fusion geneENST00000438132, ENST00000542263, 
ENST00000417362, ENST00000251143, 
ENST00000543152, ENST00000448695, 
ENST00000544275, ENST00000538853, 
ENST00000546162, 
Fusion gene scores* DoF score5 X 5 X 4=1001 X 1 X 1=1
# samples 51
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: C16orf62 [Title/Abstract] AND ABCC6P1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A0TX-01AC16orf62chr16

19644494

+ABCC6P1chr16

18593728

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000438132ENST00000546162C16orf62chr16

19644494

+ABCC6P1chr16

18593728

+
5CDS-3UTRENST00000542263ENST00000546162C16orf62chr16

19644494

+ABCC6P1chr16

18593728

+
5CDS-3UTRENST00000417362ENST00000546162C16orf62chr16

19644494

+ABCC6P1chr16

18593728

+
5CDS-3UTRENST00000251143ENST00000546162C16orf62chr16

19644494

+ABCC6P1chr16

18593728

+
5CDS-3UTRENST00000543152ENST00000546162C16orf62chr16

19644494

+ABCC6P1chr16

18593728

+
5CDS-3UTRENST00000448695ENST00000546162C16orf62chr16

19644494

+ABCC6P1chr16

18593728

+
intron-3UTRENST00000544275ENST00000546162C16orf62chr16

19644494

+ABCC6P1chr16

18593728

+
intron-3UTRENST00000538853ENST00000546162C16orf62chr16

19644494

+ABCC6P1chr16

18593728

+

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FusionProtFeatures for C16orf62_ABCC6P1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C16orf62

Q7Z3J2

ABCC6P1

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C16orf62_ABCC6P1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C16orf62_ABCC6P1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C16orf62CCDC22, CCDC93, COMMD1, BSG, COMMD3, COMMD4, DCUN1D1, TRIM25, NTRK1, COMMD6, VPS29, COMMD2, COMMD10, COMMD8, FAM45A, HDAC11ABCC6P1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C16orf62_ABCC6P1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C16orf62_ABCC6P1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource