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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4722

FusionGeneSummary for C16orf45_PNCK

check button Fusion gene summary
Fusion gene informationFusion gene name: C16orf45_PNCK
Fusion gene ID: 4722
HgeneTgene
Gene symbol

C16orf45

PNCK

Gene ID

89927

139728

Gene namechromosome 16 open reading frame 45pregnancy up-regulated nonubiquitous CaM kinase
SynonymsMINPBSTK3|CaMK1b
Cytomap

16p13.11

Xq28

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C16orf45migration inhibitory proteincalcium/calmodulin-dependent protein kinase type 1BcaM kinase I betacaM kinase IBcaM-KI betacaMKI-betapregnancy up-regulated non-ubiquitously-expressed CaM kinasepregnancy upregulated non-ubiquitously expressed CaM kinase
Modification date2018051920180523
UniProtAcc

Q96MC5

Q6P2M8

Ensembl transtripts involved in fusion geneENST00000300006, ENST00000566490, 
ENST00000452191, ENST00000561692, 
ENST00000565913, 
ENST00000340888, 
ENST00000370150, ENST00000393831, 
ENST00000370142, ENST00000370145, 
ENST00000447676, ENST00000475172, 
Fusion gene scores* DoF score5 X 3 X 3=451 X 1 X 1=1
# samples 51
** MAII scorelog2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: C16orf45 [Title/Abstract] AND PNCK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI141657C16orf45chr16

15681452

-PNCKchrX

152935905

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000300006ENST00000340888C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000300006ENST00000370150C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000300006ENST00000393831C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000300006ENST00000370142C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000300006ENST00000370145C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000300006ENST00000447676C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000300006ENST00000475172C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000566490ENST00000340888C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000566490ENST00000370150C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000566490ENST00000393831C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000566490ENST00000370142C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000566490ENST00000370145C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000566490ENST00000447676C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000566490ENST00000475172C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000452191ENST00000340888C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000452191ENST00000370150C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000452191ENST00000393831C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000452191ENST00000370142C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000452191ENST00000370145C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000452191ENST00000447676C16orf45chr16

15681452

-PNCKchrX

152935905

+
3UTR-intronENST00000452191ENST00000475172C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000561692ENST00000340888C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000561692ENST00000370150C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000561692ENST00000393831C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000561692ENST00000370142C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000561692ENST00000370145C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000561692ENST00000447676C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000561692ENST00000475172C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000565913ENST00000340888C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000565913ENST00000370150C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000565913ENST00000393831C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000565913ENST00000370142C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000565913ENST00000370145C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000565913ENST00000447676C16orf45chr16

15681452

-PNCKchrX

152935905

+
intron-intronENST00000565913ENST00000475172C16orf45chr16

15681452

-PNCKchrX

152935905

+

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FusionProtFeatures for C16orf45_PNCK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C16orf45

Q96MC5

PNCK

Q6P2M8

Calcium/calmodulin-dependent protein kinase belonging toa proposed calcium-triggered signaling cascade. In vitrophosphorylates CREB1 and SYN1/synapsin I. Phosphorylates andactivates CAMK1 (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C16orf45_PNCK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C16orf45_PNCK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C16orf45_PNCK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C16orf45_PNCK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource