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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4720

FusionGeneSummary for C15orf57_SFTPC

check button Fusion gene summary
Fusion gene informationFusion gene name: C15orf57_SFTPC
Fusion gene ID: 4720
HgeneTgene
Gene symbol

C15orf57

SFTPC

Gene ID

6440

Gene namesurfactant protein C
SynonymsBRICD6|PSP-C|SFTP2|SMDP2|SP-C
Cytomap

8p21.3

Type of geneprotein-coding
Descriptionpulmonary surfactant-associated protein CBRICHOS domain containing 6SP5pulmonary surfactant apoprotein-2 SP-Cpulmonary surfactant-associated proteolipid SPL(Val)
Modification date20180520
UniProtAcc

P11686

Ensembl transtripts involved in fusion geneENST00000560305, ENST00000561011, 
ENST00000559911, ENST00000558113, 
ENST00000358005, ENST00000416810, 
ENST00000558750, ENST00000558871, 
ENST00000560109, 
ENST00000318561, 
ENST00000521315, ENST00000437090, 
ENST00000520605, ENST00000522109, 
ENST00000524255, ENST00000522880, 
Fusion gene scores* DoF score2 X 2 X 1=46 X 6 X 4=144
# samples 37
** MAII scorelog2(3/4*10)=2.90689059560852log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C15orf57 [Title/Abstract] AND SFTPC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG529836C15orf57chr15

40824319

-SFTPCchr8

22021513

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000560305ENST00000318561C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000560305ENST00000521315C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000560305ENST00000437090C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000560305ENST00000520605C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000560305ENST00000522109C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000560305ENST00000524255C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000560305ENST00000522880C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000561011ENST00000318561C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000561011ENST00000521315C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000561011ENST00000437090C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000561011ENST00000520605C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000561011ENST00000522109C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000561011ENST00000524255C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000561011ENST00000522880C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000559911ENST00000318561C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000559911ENST00000521315C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000559911ENST00000437090C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000559911ENST00000520605C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000559911ENST00000522109C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000559911ENST00000524255C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000559911ENST00000522880C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000558113ENST00000318561C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000558113ENST00000521315C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000558113ENST00000437090C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000558113ENST00000520605C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000558113ENST00000522109C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000558113ENST00000524255C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000558113ENST00000522880C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000358005ENST00000318561C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000358005ENST00000521315C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000358005ENST00000437090C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000358005ENST00000520605C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000358005ENST00000522109C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000358005ENST00000524255C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000358005ENST00000522880C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000416810ENST00000318561C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000416810ENST00000521315C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000416810ENST00000437090C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000416810ENST00000520605C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000416810ENST00000522109C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000416810ENST00000524255C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000416810ENST00000522880C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000558750ENST00000318561C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000558750ENST00000521315C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000558750ENST00000437090C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000558750ENST00000520605C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000558750ENST00000522109C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000558750ENST00000524255C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000558750ENST00000522880C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000558871ENST00000318561C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000558871ENST00000521315C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000558871ENST00000437090C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000558871ENST00000520605C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000558871ENST00000522109C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000558871ENST00000524255C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000558871ENST00000522880C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000560109ENST00000318561C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3CDSENST00000560109ENST00000521315C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000560109ENST00000437090C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000560109ENST00000520605C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000560109ENST00000522109C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-3UTRENST00000560109ENST00000524255C15orf57chr15

40824319

-SFTPCchr8

22021513

+
intron-intronENST00000560109ENST00000522880C15orf57chr15

40824319

-SFTPCchr8

22021513

+

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FusionProtFeatures for C15orf57_SFTPC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C15orf57

SFTPC

P11686

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Pulmonary surfactant associated proteins promotealveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C15orf57_SFTPC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C15orf57_SFTPC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C15orf57_SFTPC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C15orf57_SFTPC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSFTPCC1970470SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 2 (disorder)5CTD_human;ORPHANET;UNIPROT
TgeneSFTPCC0019284Diaphragmatic Hernia1CTD_human
TgeneSFTPCC0032460Polycystic Ovary Syndrome1CTD_human
TgeneSFTPCC0152013Adenocarcinoma of lung (disorder)1CTD_human