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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4715

FusionGeneSummary for C15orf41_MEIS2

check button Fusion gene summary
Fusion gene informationFusion gene name: C15orf41_MEIS2
Fusion gene ID: 4715
HgeneTgene
Gene symbol

C15orf41

MEIS2

Gene ID

84529

4212

Gene namechromosome 15 open reading frame 41Meis homeobox 2
SynonymsHH114CPCMR|HsT18361|MRG1
Cytomap

15q14

15q14

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C15orf41homeobox protein Meis2Meis homolog 2Meis1, myeloid ecotropic viral integration site 1 homolog 2Meis1-related gene 1TALE homeobox protein Meis2meis1-related protein 1
Modification date2018051920180523
UniProtAcc

Q9Y2V0

O14770

Ensembl transtripts involved in fusion geneENST00000566621, ENST00000437989, 
ENST00000569302, ENST00000567389, 
ENST00000562877, ENST00000338183, 
ENST00000565792, ENST00000562489, 
ENST00000563167, 
ENST00000338564, 
ENST00000561208, ENST00000397624, 
ENST00000382766, ENST00000444725, 
ENST00000340545, ENST00000559085, 
ENST00000219869, ENST00000557796, 
ENST00000397620, ENST00000424352, 
ENST00000559561, ENST00000559408, 
Fusion gene scores* DoF score8 X 3 X 6=1443 X 3 X 2=18
# samples 83
** MAII scorelog2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: C15orf41 [Title/Abstract] AND MEIS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMEIS2

GO:0045931

positive regulation of mitotic cell cycle

26512644

TgeneMEIS2

GO:0045944

positive regulation of transcription by RNA polymerase II

10764806

TgeneMEIS2

GO:0110024

positive regulation of cardiac muscle myoblast proliferation

26512644


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-06-0174-01AC15orf41chr15

36872162

+MEIS2chr15

37242601

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000566621ENST00000338564C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000566621ENST00000561208C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000566621ENST00000397624C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000566621ENST00000382766C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000566621ENST00000444725C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000566621ENST00000340545C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000566621ENST00000559085C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000566621ENST00000219869C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000566621ENST00000557796C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000566621ENST00000397620C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000566621ENST00000424352C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000566621ENST00000559561C15orf41chr15

36872162

+MEIS2chr15

37242601

-
5CDS-intronENST00000566621ENST00000559408C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000437989ENST00000338564C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000437989ENST00000561208C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000437989ENST00000397624C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000437989ENST00000382766C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000437989ENST00000444725C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000437989ENST00000340545C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000437989ENST00000559085C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000437989ENST00000219869C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000437989ENST00000557796C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000437989ENST00000397620C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000437989ENST00000424352C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000437989ENST00000559561C15orf41chr15

36872162

+MEIS2chr15

37242601

-
5CDS-intronENST00000437989ENST00000559408C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000569302ENST00000338564C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000569302ENST00000561208C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000569302ENST00000397624C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000569302ENST00000382766C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000569302ENST00000444725C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000569302ENST00000340545C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000569302ENST00000559085C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000569302ENST00000219869C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000569302ENST00000557796C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000569302ENST00000397620C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000569302ENST00000424352C15orf41chr15

36872162

+MEIS2chr15

37242601

-
Frame-shiftENST00000569302ENST00000559561C15orf41chr15

36872162

+MEIS2chr15

37242601

-
5CDS-intronENST00000569302ENST00000559408C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000567389ENST00000338564C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000567389ENST00000561208C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000567389ENST00000397624C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000567389ENST00000382766C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000567389ENST00000444725C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000567389ENST00000340545C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000567389ENST00000559085C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000567389ENST00000219869C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000567389ENST00000557796C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000567389ENST00000397620C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000567389ENST00000424352C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000567389ENST00000559561C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-intronENST00000567389ENST00000559408C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562877ENST00000338564C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562877ENST00000561208C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562877ENST00000397624C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562877ENST00000382766C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562877ENST00000444725C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562877ENST00000340545C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562877ENST00000559085C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562877ENST00000219869C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562877ENST00000557796C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562877ENST00000397620C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562877ENST00000424352C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562877ENST00000559561C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-intronENST00000562877ENST00000559408C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000338183ENST00000338564C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000338183ENST00000561208C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000338183ENST00000397624C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000338183ENST00000382766C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000338183ENST00000444725C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000338183ENST00000340545C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000338183ENST00000559085C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000338183ENST00000219869C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000338183ENST00000557796C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000338183ENST00000397620C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000338183ENST00000424352C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000338183ENST00000559561C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-intronENST00000338183ENST00000559408C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000565792ENST00000338564C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000565792ENST00000561208C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000565792ENST00000397624C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000565792ENST00000382766C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000565792ENST00000444725C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000565792ENST00000340545C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000565792ENST00000559085C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000565792ENST00000219869C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000565792ENST00000557796C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000565792ENST00000397620C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000565792ENST00000424352C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000565792ENST00000559561C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-intronENST00000565792ENST00000559408C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562489ENST00000338564C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562489ENST00000561208C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562489ENST00000397624C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562489ENST00000382766C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562489ENST00000444725C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562489ENST00000340545C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562489ENST00000559085C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562489ENST00000219869C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562489ENST00000557796C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562489ENST00000397620C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562489ENST00000424352C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000562489ENST00000559561C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-intronENST00000562489ENST00000559408C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000563167ENST00000338564C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000563167ENST00000561208C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000563167ENST00000397624C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000563167ENST00000382766C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000563167ENST00000444725C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000563167ENST00000340545C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000563167ENST00000559085C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000563167ENST00000219869C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000563167ENST00000557796C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000563167ENST00000397620C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000563167ENST00000424352C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-3CDSENST00000563167ENST00000559561C15orf41chr15

36872162

+MEIS2chr15

37242601

-
intron-intronENST00000563167ENST00000559408C15orf41chr15

36872162

+MEIS2chr15

37242601

-

Top

FusionProtFeatures for C15orf41_MEIS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C15orf41

Q9Y2V0

MEIS2

O14770


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C15orf41_MEIS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for C15orf41_MEIS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C15orf41ASF1B, HIST1H3A, ASF1A, TRIM25MEIS2PBX1, TRIM25, ZNHIT3, SP1, APP, SOX2, SQSTM1, ARNT2, DGCR6, CRBN, ANXA1, MEIS2, OSGIN1, C1orf94, LINC00238, LMX1B, MAB21L1, MEIS3, MEIS1, PBX2, PBX4, PBX3, GNB4, PIGL, MAB21L2, FAM222A, CCDC120, C16orf71, TMOD3, ACTB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for C15orf41_MEIS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for C15orf41_MEIS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneC15orf41C3810185ANEMIA, CONGENITAL DYSERYTHROPOIETIC, TYPE Ib1UNIPROT