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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4655

FusionGeneSummary for C11orf84_BUB1B

check button Fusion gene summary
Fusion gene informationFusion gene name: C11orf84_BUB1B
Fusion gene ID: 4655
HgeneTgene
Gene symbol

C11orf84

BUB1B

Gene ID

701

Gene nameBUB1 mitotic checkpoint serine/threonine kinase B
SynonymsBUB1beta|BUBR1|Bub1A|MAD3L|MVA1|SSK1|hBUBR1
Cytomap

15q15.1

Type of geneprotein-coding
Descriptionmitotic checkpoint serine/threonine-protein kinase BUB1 betaBUB1B, mitotic checkpoint serine/threonine kinaseMAD3/BUB1-related protein kinasebudding uninhibited by benzimidazoles 1 homolog betamitotic checkpoint kinase MAD3L
Modification date20180523
UniProtAcc

Q9BUA3

O60566

Ensembl transtripts involved in fusion geneENST00000294244, ENST00000287598, 
ENST00000412359, ENST00000560120, 
Fusion gene scores* DoF score5 X 3 X 5=755 X 4 X 4=80
# samples 74
** MAII scorelog2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C11orf84 [Title/Abstract] AND BUB1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-94-7557-01AC11orf84chr11

63581285

+BUB1Bchr15

40468678

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000294244ENST00000287598C11orf84chr11

63581285

+BUB1Bchr15

40468678

+
Frame-shitENST00000294244ENST00000412359C11orf84chr11

63581285

+BUB1Bchr15

40468678

+
5CDS-3UTRENST00000294244ENST00000560120C11orf84chr11

63581285

+BUB1Bchr15

40468678

+

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FusionProtFeatures for C11orf84_BUB1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C11orf84

Q9BUA3

BUB1B

O60566

Negatively regulates the transcriptional activatoractivity of SPIN1 via inhibition of its histone methyl-bindingability. Represses the expression of a number of SPIN1-regulatedgenes and the SPIN1-mediated activation of the Wnt signalingpathway. Can also inhibit the histone methyl-binding abilities ofSPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846).{ECO:0000269|PubMed:29061846}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C11orf84_BUB1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C11orf84_BUB1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C11orf84EGFR, YWHAE, UBL4A, HECW2, ASB2, FBXW11, SPIN2B, SPIN1, SPIN3, HIST1H3E, GAN, RC3H1, CRBN, CFAP20, POLR2E, C17orf89, CYLD, PARK7, TRIM25, YAP1BUB1BHDAC1, BRCA2, SNCG, CDC20, BUB3, MAD2L1, CENPE, AP2B1, APC, CDC27, CDC16, ANAPC7, UBE2C, PARP1, KAT2B, ANAPC4, BUB1, MIS12, ZWINT, BUB1B, NSL1, DNMBP, MXI1, MDM2, MAD2L1BP, PLK1, TUBB, CASC5, TP73, AJUBA, AURKB, PLK3, PTTG1, SGOL1, DAXX, FZR1, TRIM33, COMMD4, GANAB, PRKCSH, PNMA2, UGP2, TRIP13, SUMO1, ANAPC1, ANAPC2, BAG2, DSN1, ZFC3H1, CCT2, EEF2, HSPB1, HSPH1, NDC80, NUF2, PMF1, PSMA3, PSMA4, PSMA6, PSMB5, PSMD6, RPL39, SKIV2L2, RAE1, UBR5, CCNA2, FBXW7, BTRC, MED4, XPO1, CD14, CDC23, SMEK1, CERK, ANAPC10, NEK2, SNW1, CDC5L, PPP2R5A, TYW3, HDAC2, HDAC3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C11orf84_BUB1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C11orf84_BUB1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBUB1BC0018273Growth Disorders1CTD_human
TgeneBUB1BC0025958Microcephaly1CTD_human
TgeneBUB1BC0206656Rhabdomyosarcoma, Embryonal1CTD_human
TgeneBUB1BC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneBUB1BC1850343MOSAIC VARIEGATED ANEUPLOIDY SYNDROME1CTD_human;ORPHANET;UNIPROT
TgeneBUB1BC1864389PREMATURE CHROMATID SEPARATION TRAIT1CTD_human;UNIPROT