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Fusion gene ID: 4643 |
FusionGeneSummary for C11orf68_EDC4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C11orf68_EDC4 | Fusion gene ID: 4643 | Hgene | Tgene | Gene symbol | C11orf68 | EDC4 | Gene ID | 83638 | 23644 |
| Gene name | chromosome 11 open reading frame 68 | enhancer of mRNA decapping 4 | |
| Synonyms | BLES03|P5326 | GE1|Ge-1|HEDL5|HEDLS|RCD-8|RCD8 | |
| Cytomap | 11q13.1 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | UPF0696 protein C11orf68basophilic leukemia expressed protein BLES03basophilic leukemia-expressed protein Bles03protein p5326 | enhancer of mRNA-decapping protein 4autoantigen Ge-1autoantigen RCD-8human enhancer of decapping large subunit | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9H3H3 | Q6P2E9 | |
| Ensembl transtripts involved in fusion gene | ENST00000438576, ENST00000449692, ENST00000530188, | ENST00000358933, ENST00000574770, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: C11orf68 [Title/Abstract] AND EDC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF961366 | C11orf68 | chr11 | 65684545 | + | EDC4 | chr16 | 67916607 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000438576 | ENST00000358933 | C11orf68 | chr11 | 65684545 | + | EDC4 | chr16 | 67916607 | + |
| intron-intron | ENST00000438576 | ENST00000574770 | C11orf68 | chr11 | 65684545 | + | EDC4 | chr16 | 67916607 | + |
| intron-3CDS | ENST00000449692 | ENST00000358933 | C11orf68 | chr11 | 65684545 | + | EDC4 | chr16 | 67916607 | + |
| intron-intron | ENST00000449692 | ENST00000574770 | C11orf68 | chr11 | 65684545 | + | EDC4 | chr16 | 67916607 | + |
| intron-3CDS | ENST00000530188 | ENST00000358933 | C11orf68 | chr11 | 65684545 | + | EDC4 | chr16 | 67916607 | + |
| intron-intron | ENST00000530188 | ENST00000574770 | C11orf68 | chr11 | 65684545 | + | EDC4 | chr16 | 67916607 | + |
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FusionProtFeatures for C11orf68_EDC4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C11orf68 | EDC4 |
| In the process of mRNA degradation, seems to play a rolein mRNA decapping. Component of a complex containing DCP2 andDCP1A which functions in decapping of ARE-containing mRNAs.Promotes complex formation between DCP1A and DCP2. Enhances thecatalytic activity of DCP2 (in vitro).{ECO:0000269|PubMed:16364915}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for C11orf68_EDC4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for C11orf68_EDC4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C11orf68_EDC4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C11orf68_EDC4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | C11orf68 | C0025202 | melanoma | 1 | CTD_human |
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