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Fusion gene ID: 464 |
FusionGeneSummary for ACPP_RDH11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACPP_RDH11 | Fusion gene ID: 464 | Hgene | Tgene | Gene symbol | ACPP | RDH11 | Gene ID | 55 | 51109 |
| Gene name | acid phosphatase, prostate | retinol dehydrogenase 11 | |
| Synonyms | 5'-NT|ACP-3|ACP3 | ARSDR1|CGI82|HCBP12|MDT1|PSDR1|RALR1|RDJCSS|SCALD|SDR7C1 | |
| Cytomap | 3q22.1 | 14q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | prostatic acid phosphataseTMPaseecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphatase | retinol dehydrogenase 11HCV core-binding protein HCBP12androgen-regulated short-chain dehydrogenase/reductase 1prostate short-chain dehydrogenase reductase 1retinal reductase 1retinol dehydrogenase 11 (all-trans/9-cis/11-cis)short chain dehydrogenas | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P15309 | Q8TC12 | |
| Ensembl transtripts involved in fusion gene | ENST00000336375, ENST00000475741, ENST00000351273, ENST00000489084, | ENST00000381346, ENST00000553384, ENST00000428130, | |
| Fusion gene scores | * DoF score | 13 X 6 X 2=156 | 10 X 9 X 4=360 |
| # samples | 15 | 10 | |
| ** MAII score | log2(15/156*10)=-0.0565835283663674 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ACPP [Title/Abstract] AND RDH11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACPP | GO:0046085 | adenosine metabolic process | 18940592 |
| Hgene | ACPP | GO:0051289 | protein homotetramerization | 10639192 |
| Tgene | RDH11 | GO:0042574 | retinal metabolic process | 12807874 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-CH-5789-01A | ACPP | chr3 | 132075699 | + | RDH11 | chr14 | 68157138 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000336375 | ENST00000381346 | ACPP | chr3 | 132075699 | + | RDH11 | chr14 | 68157138 | - |
| Frame-shift | ENST00000336375 | ENST00000553384 | ACPP | chr3 | 132075699 | + | RDH11 | chr14 | 68157138 | - |
| 5CDS-intron | ENST00000336375 | ENST00000428130 | ACPP | chr3 | 132075699 | + | RDH11 | chr14 | 68157138 | - |
| Frame-shift | ENST00000475741 | ENST00000381346 | ACPP | chr3 | 132075699 | + | RDH11 | chr14 | 68157138 | - |
| Frame-shift | ENST00000475741 | ENST00000553384 | ACPP | chr3 | 132075699 | + | RDH11 | chr14 | 68157138 | - |
| 5CDS-intron | ENST00000475741 | ENST00000428130 | ACPP | chr3 | 132075699 | + | RDH11 | chr14 | 68157138 | - |
| In-frame | ENST00000351273 | ENST00000381346 | ACPP | chr3 | 132075699 | + | RDH11 | chr14 | 68157138 | - |
| In-frame | ENST00000351273 | ENST00000553384 | ACPP | chr3 | 132075699 | + | RDH11 | chr14 | 68157138 | - |
| 5CDS-intron | ENST00000351273 | ENST00000428130 | ACPP | chr3 | 132075699 | + | RDH11 | chr14 | 68157138 | - |
| intron-3CDS | ENST00000489084 | ENST00000381346 | ACPP | chr3 | 132075699 | + | RDH11 | chr14 | 68157138 | - |
| intron-3CDS | ENST00000489084 | ENST00000553384 | ACPP | chr3 | 132075699 | + | RDH11 | chr14 | 68157138 | - |
| intron-intron | ENST00000489084 | ENST00000428130 | ACPP | chr3 | 132075699 | + | RDH11 | chr14 | 68157138 | - |
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FusionProtFeatures for ACPP_RDH11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACPP | RDH11 |
| A non-specific tyrosine phosphatase thatdephosphorylates a diverse number of substrates under acidicconditions (pH 4-6) including alkyl, aryl, and acyl orthophosphatemonoesters and phosphorylated proteins. Has lipid phosphataseactivity and inactivates lysophosphatidic acid in seminal plasma. Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons.Generates adenosine from AMP which acts as a pain suppressor. Actsas a tumor suppressor of prostate cancer through dephosphorylationof ERBB2 and deactivation of MAPK-mediated signaling. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACPP_RDH11 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ACPP_ENST00000351273_chr3_132075699_+_RDH11_ENST00000381346_chr14_68157138_-_547aa MRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELGEYIRKRYR KFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETLKSEEFQKR LHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGVLVNEILNH MKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCPLERFAELV GPVIPQDWSTECMTTNSHQGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKG SGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVSCDL >In-frame_ACPP_ENST00000351273_chr3_132075699_+_RDH11_ENST00000553384_chr14_68157138_-_547aa MRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLVFRHGDRSPIDTFPTDPIKESSWPQGFGQLTQLGMEQHYELGEYIRKRYR KFLNESYKHEQVYIRSTDVDRTLMSAMTNLAALFPPEGVSIWNPILLWQPIPVHTVPLSEDQLLYLPFRNCPRFQELESETLKSEEFQKR LHPYKDFIATLGKLSGLHGQDLFGIWSKVYDPLYCESVHNFTLPSWATEDTMTKLRELSELSLLSLYGIHKQKEKSRLQGGVLVNEILNH MKRATQIPSYKKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHLTELYFEKGEYFVEMYYRNETQHEPYPLMLPGCSPSCPLERFAELV GPVIPQDWSTECMTTNSHQGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKG SGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVSCDL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ACPP_ENST00000351273_chr3_132075699_+_RDH11_ENST00000381346_chr14_68157138_-_1641nt ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGCATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAA TCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGGGCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGA AAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATATTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTG GCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATCCTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAA GATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTTTTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGG CTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAACTTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTAC GACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTACCCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAA TTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAGAGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCAC ATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCATCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTA GATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCCACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTAC TATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGCTACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTT GGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGACCACAAACAGCCATCAAGGTCACTTCCTCCTAACCCATCTGCTGCTAGAG AAACTAAAGGAATCAGCCCCATCAAGGATAGTAAATGTGTCTTCCCTCGCACATCACCTGGGAAGGATCCACTTCCATAACCTGCAGGGC GAGAAATTCTACAATGCAGGCCTGGCCTACTGTCACAGCAAGCTAGCCAACATCCTCTTCACCCAGGAACTGGCCCGGAGACTAAAAGGC TCTGGCGTTACGACGTATTCTGTACACCCTGGCACAGTCCAATCTGAACTGGTTCGGCACTCATCTTTCATGAGATGGATGTGGTGGCTT TTCTCCTTTTTCATCAAGACTCCTCAGCAGGGAGCCCAGACCAGCCTGCACTGTGCCTTAACAGAAGGTCTTGAGATTCTAAGTGGGAAT CATTTCAGTGACTGTCATGTGGCATGGGTCTCTGCCCAAGCTCGTAATGAGACTATAGCAAGGCGGCTGTGGGACGTCAGTTGTGACCTG >In-frame_ACPP_ENST00000351273_chr3_132075699_+_RDH11_ENST00000553384_chr14_68157138_-_1641nt ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGCATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAA TCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGGGCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGA AAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATATTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTG GCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATCCTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAA GATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTTTTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGG CTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAACTTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTAC GACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTACCCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAA TTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAGAGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCAC ATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCATCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTA GATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCCACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTAC TATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGCTACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTT GGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGACCACAAACAGCCATCAAGGTCACTTCCTCCTAACCCATCTGCTGCTAGAG AAACTAAAGGAATCAGCCCCATCAAGGATAGTAAATGTGTCTTCCCTCGCACATCACCTGGGAAGGATCCACTTCCATAACCTGCAGGGC GAGAAATTCTACAATGCAGGCCTGGCCTACTGTCACAGCAAGCTAGCCAACATCCTCTTCACCCAGGAACTGGCCCGGAGACTAAAAGGC TCTGGCGTTACGACGTATTCTGTACACCCTGGCACAGTCCAATCTGAACTGGTTCGGCACTCATCTTTCATGAGATGGATGTGGTGGCTT TTCTCCTTTTTCATCAAGACTCCTCAGCAGGGAGCCCAGACCAGCCTGCACTGTGCCTTAACAGAAGGTCTTGAGATTCTAAGTGGGAAT CATTTCAGTGACTGTCATGTGGCATGGGTCTCTGCCCAAGCTCGTAATGAGACTATAGCAAGGCGGCTGTGGGACGTCAGTTGTGACCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ACPP_ENST00000351273_chr3_132075699_+_RDH11_ENST00000381346_chr14_68157138_-_3211nt GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA CCACAAACAGCCATCAAGGTCACTTCCTCCTAACCCATCTGCTGCTAGAGAAACTAAAGGAATCAGCCCCATCAAGGATAGTAAATGTGT CTTCCCTCGCACATCACCTGGGAAGGATCCACTTCCATAACCTGCAGGGCGAGAAATTCTACAATGCAGGCCTGGCCTACTGTCACAGCA AGCTAGCCAACATCCTCTTCACCCAGGAACTGGCCCGGAGACTAAAAGGCTCTGGCGTTACGACGTATTCTGTACACCCTGGCACAGTCC AATCTGAACTGGTTCGGCACTCATCTTTCATGAGATGGATGTGGTGGCTTTTCTCCTTTTTCATCAAGACTCCTCAGCAGGGAGCCCAGA CCAGCCTGCACTGTGCCTTAACAGAAGGTCTTGAGATTCTAAGTGGGAATCATTTCAGTGACTGTCATGTGGCATGGGTCTCTGCCCAAG CTCGTAATGAGACTATAGCAAGGCGGCTGTGGGACGTCAGTTGTGACCTGCTGGGCCTCCCAATAGACTAACAGGCAGTGCCAGTTGGAC CCAAGAGAAGACTGCAGCAGACTACACAGTACTTCTTGTCAAAATGATTCTCCTTCAAGGTTTTCAAAACCTTTAGCACAAAGAGAGCAA AACCTTCCAGCCTTGCCTGCTTGGTGTCCAGTTAAAACTCAGTGTACTGCCAGATTCGTCTAAATGTCTGTCATGTCCAGATTTACTTTG CTTCTGTTACTGCCAGAGTTACTAGAGATATCATAATAGGATAAGAAGACCCTCATATGACCTGCACAGCTCATTTTCCTTCTGAAAGAA ACTACTACCTAGGAGAATCTAAGCTATAGCAGGGATGATTTATGCAAATTTGAACTAGCTTCTTTGTTCACAATTCAGTTCCTCCCAACC AACCAGTCTTCACTTCAAGAGGGCCACACTGCAACCTCAGCTTAACATGAATAACAAAGACTGGCTCAGGAGCAGGGCTTGCCCAGGCAT GGTGGATCACCGGAGGTCAGTAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCACCTCTACTAAAAATTGTGTATATCTTTGTGTG TCTTCCTGTTTATGTGTGCCAAGGGAGTATTTTCACAAAGTTCAAAACAGCCACAATAATCAGAGATGGAGCAAACCAGTGCCATCCAGT CTTTATGCAAATGAAATGCTGCAAAGGGAAGCAGATTCTGTATATGTTGGTAACTACCCACCAAGAGCACATGGGTAGCAGGGAAGAAGT AAAAAAAGAGAAGGAGAATACTGGAAGATAATGCACAAAATGAAGGGACTAGTTAAGGATTAACTAGCCCTTTAAGGATTAACTAGTTAA GGATTAATAGCAAAAGATATTAAATATGCTAACATAGCTATGGAGGAATTGAGGGCAAGCACCCAGGACTGATGAGGTCTTAACAAAAAC CAGTGTGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAATCCTAAAAACAAACAAACAAAAAAAACAATTCTTCATTCAGAAAAATTATCT TAGGGACTGATATTGGTAATTATGGTCAATTTAATAATATTTTGGGGCATTTCCTTACATTGTCTTGACAAGATTAAAATGTCTGTGCCA AAATTTTGTATTTTATTTGGAGACTTCTTATCAAAAGTAATGCTGCCAAAGGAAGTCTAAGGAATTAGTAGTGTTCCCATCACTTGTTTG GAGTGTGCTATTCTAAAAGATTTTGATTTCCTGGAATGACAATTATATTTTAACTTTGGTGGGGGAAAGAGTTATAGGACCACAGTCTTC ACTTCTGATACTTGTAAATTAATCTTTTATTGCACTTGTTTTGACCATTAAGCTATATGTTTAGAAATGGTCATTTTACGGAAAAATTAG AAAAATTCTGATAATAGTGCAGAATAAATGAATTAATGTTTTACTTAATTTATATTGAACTGTCAATGACAAATAAAAATTCTTTTTGAT >In-frame_ACPP_ENST00000351273_chr3_132075699_+_RDH11_ENST00000553384_chr14_68157138_-_2648nt GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGTGTTTCGGC ATGGAGACCGAAGTCCCATTGACACCTTTCCCACTGACCCCATAAAGGAATCCTCATGGCCACAAGGATTTGGCCAACTCACCCAGCTGG GCATGGAGCAGCATTATGAACTTGGAGAGTATATAAGAAAGAGATATAGAAAATTCTTGAATGAGTCCTATAAACATGAACAGGTTTATA TTCGAAGCACAGACGTTGACCGGACTTTGATGAGTGCTATGACAAACCTGGCAGCCCTGTTTCCCCCAGAAGGTGTCAGCATCTGGAATC CTATCCTACTCTGGCAGCCCATCCCGGTGCACACAGTTCCTCTTTCTGAAGATCAGTTGCTATACCTGCCTTTCAGGAACTGCCCTCGTT TTCAAGAACTTGAGAGTGAGACTTTGAAATCAGAGGAATTCCAGAAGAGGCTGCACCCTTATAAGGATTTTATAGCTACCTTGGGAAAAC TTTCAGGATTACATGGCCAGGACCTTTTTGGAATTTGGAGTAAAGTCTACGACCCTTTATATTGTGAGAGTGTTCACAATTTCACTTTAC CCTCCTGGGCCACTGAGGACACCATGACTAAGTTGAGAGAATTGTCAGAATTGTCCCTCCTGTCCCTCTATGGAATTCACAAGCAGAAAG AGAAATCTAGGCTCCAAGGGGGTGTCCTGGTCAATGAAATCCTCAATCACATGAAGAGAGCAACTCAGATACCAAGCTACAAAAAACTCA TCATGTATTCTGCGCATGACACTACTGTGAGTGGCCTACAGATGGCGCTAGATGTTTACAACGGACTCCTTCCTCCCTATGCTTCTTGCC ACTTGACGGAATTGTACTTTGAGAAGGGGGAGTACTTTGTGGAGATGTACTATCGGAATGAGACGCAGCACGAGCCGTATCCCCTCATGC TACCTGGCTGCAGCCCCAGCTGTCCTCTGGAGAGGTTTGCTGAGCTGGTTGGCCCTGTGATCCCTCAAGACTGGTCCACGGAGTGTATGA CCACAAACAGCCATCAAGGTCACTTCCTCCTAACCCATCTGCTGCTAGAGAAACTAAAGGAATCAGCCCCATCAAGGATAGTAAATGTGT CTTCCCTCGCACATCACCTGGGAAGGATCCACTTCCATAACCTGCAGGGCGAGAAATTCTACAATGCAGGCCTGGCCTACTGTCACAGCA AGCTAGCCAACATCCTCTTCACCCAGGAACTGGCCCGGAGACTAAAAGGCTCTGGCGTTACGACGTATTCTGTACACCCTGGCACAGTCC AATCTGAACTGGTTCGGCACTCATCTTTCATGAGATGGATGTGGTGGCTTTTCTCCTTTTTCATCAAGACTCCTCAGCAGGGAGCCCAGA CCAGCCTGCACTGTGCCTTAACAGAAGGTCTTGAGATTCTAAGTGGGAATCATTTCAGTGACTGTCATGTGGCATGGGTCTCTGCCCAAG CTCGTAATGAGACTATAGCAAGGCGGCTGTGGGACGTCAGTTGTGACCTGCTGGGCCTCCCAATAGACTAACAGGCAGTGCCAGTTGGAC CCAAGAGAAGACTGCAGCAGACTACACAGTACTTCTTGTCAAAATGATTCTCCTTCAAGGTTTTCAAAACCTTTAGCACAAAGAGAGCAA AACCTTCCAGCCTTGCCTGCTTGGTGTCCAGTTAAAACTCAGTGTACTGCCAGATTCGTCTAAATGTCTGTCATGTCCAGATTTACTTTG CTTCTGTTACTGCCAGAGTTACTAGAGATATCATAATAGGATAAGAAGACCCTCATATGACCTGCACAGCTCATTTTCCTTCTGAAAGAA ACTACTACCTAGGAGAATCTAAGCTATAGCAGGGATGATTTATGCAAATTTGAACTAGCTTCTTTGTTCACAATTCAGTTCCTCCCAACC AACCAGTCTTCACTTCAAGAGGGCCACACTGCAACCTCAGCTTAACATGAATAACAAAGACTGGCTCAGGAGCAGGGCTTGCCCAGGCAT GGTGGATCACCGGAGGTCAGTAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCACCTCTACTAAAAATTGTGTATATCTTTGTGTG TCTTCCTGTTTATGTGTGCCAAGGGAGTATTTTCACAAAGTTCAAAACAGCCACAATAATCAGAGATGGAGCAAACCAGTGCCATCCAGT CTTTATGCAAATGAAATGCTGCAAAGGGAAGCAGATTCTGTATATGTTGGTAACTACCCACCAAGAGCACATGGGTAGCAGGGAAGAAGT AAAAAAAGAGAAGGAGAATACTGGAAGATAATGCACAAAATGAAGGGACTAGTTAAGGATTAACTAGCCCTTTAAGGATTAACTAGTTAA GGATTAATAGCAAAAGATATTAAATATGCTAACATAGCTATGGAGGAATTGAGGGCAAGCACCCAGGACTGATGAGGTCTTAACAAAAAC |
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FusionGenePPI for ACPP_RDH11 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ACPP | ACPP, UBC, SHBG, MMRN1, DDX19B, RPS6KB2, TBC1D22B, FTH1, CDK15, CCDC103, CPLX3, FBXL4, AIRE, ZIC1, DUSP21, IL31RA, FCRL5, KIF3A, NPPA, HSF2, FCF1, LACC1, L2HGDH | RDH11 | ROBO2, CA12, BLOC1S2, RDH11, ISG15, SRPRB, TSPAN5, NRG1, MCOLN3, GINM1, UBAC1, POMK, ZACN, PLTP, HEPACAM2, HTR3C, PON2, NTRK1, COQ9, C15orf48, DPEP1, PMEL, HCCS, COMT, ESYT1, DCAKD, TMX1, GBA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACPP_RDH11 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ACPP | P15309 | DB06688 | Sipuleucel-T | Prostatic acid phosphatase | biotech | approved|investigational |
| Tgene | RDH11 | Q8TC12 | DB00162 | Vitamin A | Retinol dehydrogenase 11 | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for ACPP_RDH11 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ACPP | C3495559 | Juvenile arthritis | 1 | CTD_human |
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