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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4604

FusionGeneSummary for C10orf11_RTKN2

check button Fusion gene summary
Fusion gene informationFusion gene name: C10orf11_RTKN2
Fusion gene ID: 4604
HgeneTgene
Gene symbol

C10orf11

RTKN2

Gene ID

219790

Gene namerhotekin 2
SynonymsPLEKHK1|bA531F24.1
Cytomap

10q21.2

Type of geneprotein-coding
Descriptionrhotekin-2PH domain-containing family K member 1pleckstrin homology domain-containing family K member 1
Modification date20180523
UniProtAcc

Q8IZC4

Ensembl transtripts involved in fusion geneENST00000593699, ENST00000372499, 
ENST00000496424, 
ENST00000315289, 
ENST00000395265, ENST00000373789, 
ENST00000395260, 
Fusion gene scores* DoF score11 X 4 X 8=3526 X 4 X 5=120
# samples 145
** MAII scorelog2(14/352*10)=-1.33014860169233
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C10orf11 [Title/Abstract] AND RTKN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCOADTCGA-AD-6899-01AC10orf11chr10

77198252

+RTKN2chr10

64005816

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000593699ENST00000315289C10orf11chr10

77198252

+RTKN2chr10

64005816

-
intron-intronENST00000593699ENST00000395265C10orf11chr10

77198252

+RTKN2chr10

64005816

-
intron-intronENST00000593699ENST00000373789C10orf11chr10

77198252

+RTKN2chr10

64005816

-
intron-intronENST00000593699ENST00000395260C10orf11chr10

77198252

+RTKN2chr10

64005816

-
intron-intronENST00000372499ENST00000315289C10orf11chr10

77198252

+RTKN2chr10

64005816

-
intron-intronENST00000372499ENST00000395265C10orf11chr10

77198252

+RTKN2chr10

64005816

-
intron-intronENST00000372499ENST00000373789C10orf11chr10

77198252

+RTKN2chr10

64005816

-
intron-intronENST00000372499ENST00000395260C10orf11chr10

77198252

+RTKN2chr10

64005816

-
intron-intronENST00000496424ENST00000315289C10orf11chr10

77198252

+RTKN2chr10

64005816

-
intron-intronENST00000496424ENST00000395265C10orf11chr10

77198252

+RTKN2chr10

64005816

-
intron-intronENST00000496424ENST00000373789C10orf11chr10

77198252

+RTKN2chr10

64005816

-
intron-intronENST00000496424ENST00000395260C10orf11chr10

77198252

+RTKN2chr10

64005816

-

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FusionProtFeatures for C10orf11_RTKN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C10orf11

RTKN2

Q8IZC4

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. May play an important role in lymphopoiesis.{ECO:0000269|PubMed:15504364}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C10orf11_RTKN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C10orf11_RTKN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C10orf11RTKN2PACSIN1, BRCA1, SH3KBP1, RHOC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C10orf11_RTKN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C10orf11_RTKN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRTKN2C0036341Schizophrenia1PSYGENET