FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 4597

FusionGeneSummary for C10orf11_ADK

check button Fusion gene summary
Fusion gene informationFusion gene name: C10orf11_ADK
Fusion gene ID: 4597
HgeneTgene
Gene symbol

C10orf11

ADK

Gene ID

132

Gene nameadenosine kinase
SynonymsAK
Cytomap

10q22.2|10q11-q24

Type of geneprotein-coding
Descriptionadenosine kinaseadenosine 5'-phosphotransferasetesticular tissue protein Li 14
Modification date20180523
UniProtAcc

P55263

Ensembl transtripts involved in fusion geneENST00000593699, ENST00000372499, 
ENST00000496424, 		ENST00000539909, 
ENST00000286621, ENST00000372734, 
ENST00000541550, ENST00000467840, 
Fusion gene scores* DoF score11 X 4 X 8=35218 X 8 X 11=1584
# samples 1421
** MAII scorelog2(14/352*10)=-1.33014860169233
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1584*10)=-2.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C10orf11 [Title/Abstract] AND ADK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A09N-01AC10orf11chr10

77198252

+ADKchr10

76285014

+
TCGARVLUSCTCGA-22-5472-01AC10orf11chr10

77198252

+ADKchr10

76468079

+
TCGARVUCECTCGA-D1-A3DH-01AC10orf11chr10

77198252

+ADKchr10

76153899

+
TCGARVUCECTCGA-5B-A90C-01AC10orf11chr10

77198252

+ADKchr10

76285014

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000593699ENST00000539909C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000593699ENST00000286621C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000593699ENST00000372734C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000593699ENST00000541550C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000593699ENST00000467840C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000372499ENST00000539909C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000372499ENST00000286621C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000372499ENST00000372734C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000372499ENST00000541550C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000372499ENST00000467840C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000496424ENST00000539909C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000496424ENST00000286621C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000496424ENST00000372734C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000496424ENST00000541550C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-intronENST00000496424ENST00000467840C10orf11chr10

77198252

+ADKchr10

76285014

+
intron-3CDSENST00000593699ENST00000539909C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-3CDSENST00000593699ENST00000286621C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-3CDSENST00000593699ENST00000372734C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-3CDSENST00000593699ENST00000541550C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-intronENST00000593699ENST00000467840C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-3CDSENST00000372499ENST00000539909C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-3CDSENST00000372499ENST00000286621C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-3CDSENST00000372499ENST00000372734C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-3CDSENST00000372499ENST00000541550C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-intronENST00000372499ENST00000467840C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-3CDSENST00000496424ENST00000539909C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-3CDSENST00000496424ENST00000286621C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-3CDSENST00000496424ENST00000372734C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-3CDSENST00000496424ENST00000541550C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-intronENST00000496424ENST00000467840C10orf11chr10

77198252

+ADKchr10

76468079

+
intron-3CDSENST00000593699ENST00000539909C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-3CDSENST00000593699ENST00000286621C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-3CDSENST00000593699ENST00000372734C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-3CDSENST00000593699ENST00000541550C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-intronENST00000593699ENST00000467840C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-3CDSENST00000372499ENST00000539909C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-3CDSENST00000372499ENST00000286621C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-3CDSENST00000372499ENST00000372734C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-3CDSENST00000372499ENST00000541550C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-intronENST00000372499ENST00000467840C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-3CDSENST00000496424ENST00000539909C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-3CDSENST00000496424ENST00000286621C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-3CDSENST00000496424ENST00000372734C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-3CDSENST00000496424ENST00000541550C10orf11chr10

77198252

+ADKchr10

76153899

+
intron-intronENST00000496424ENST00000467840C10orf11chr10

77198252

+ADKchr10

76153899

+

Top

FusionProtFeatures for C10orf11_ADK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C10orf11

ADK

P55263

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for C10orf11_ADK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for C10orf11_ADK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C10orf11ADKFICD, SRD5A3, ASS1, CAPG, DAZAP1, KYNU, LDHA, PIR, PTGR1, SOD1, NNMT, NQO1, PCBP1, PITPNB, RBM12, NPLOC4, FGB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for C10orf11_ADK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneADKP55263DB00811RibavirinAdenosine kinasesmall moleculeapproved

Top

RelatedDiseases for C10orf11_ADK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneADKC0036341Schizophrenia1PSYGENET
TgeneADKC0242184Hypoxia1CTD_human
TgeneADKC3280381HYPERMETHIONINEMIA DUE TO ADENOSINE KINASE DEFICIENCY1CTD_human;ORPHANET;UNIPROT
TgeneADKC3714756Intellectual Disability1CTD_human