FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 4590

FusionGeneSummary for BZW2_GAP43

check button Fusion gene summary
Fusion gene informationFusion gene name: BZW2_GAP43
Fusion gene ID: 4590
HgeneTgene
Gene symbol

BZW2

GAP43

Gene ID

28969

2596

Gene namebasic leucine zipper and W2 domains 2growth associated protein 43
SynonymsHSPC028|MST017|MSTP017B-50|PP46
Cytomap

7p21.1

3q13.31

Type of geneprotein-codingprotein-coding
Descriptionbasic leucine zipper and W2 domain-containing protein 2neuromodulinaxonal membrane protein GAP-43calmodulin-binding protein P-57nerve growth-related peptide GAP43neural phosphoprotein B-50neuron growth-associated protein 43protein F1
Modification date2018052320180523
UniProtAcc

Q9Y6E2

P17677

Ensembl transtripts involved in fusion geneENST00000258761, ENST00000433922, 
ENST00000432311, ENST00000452975, 
ENST00000405202, ENST00000407633, 
ENST00000305124, ENST00000393780, 
Fusion gene scores* DoF score8 X 6 X 5=2404 X 4 X 3=48
# samples 84
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BZW2 [Title/Abstract] AND GAP43 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGAP43

GO:0051489

regulation of filopodium assembly

14978216


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-RD-A7C1-01ABZW2chr7

16685913

+GAP43chr3

115439641

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000258761ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000258761ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000433922ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000433922ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439641

+
3UTR-3CDSENST00000432311ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439641

+
3UTR-3CDSENST00000432311ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000452975ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000452975ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000405202ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439641

+
5UTR-3CDSENST00000405202ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439641

+
intron-3CDSENST00000407633ENST00000305124BZW2chr7

16685913

+GAP43chr3

115439641

+
intron-3CDSENST00000407633ENST00000393780BZW2chr7

16685913

+GAP43chr3

115439641

+

Top

FusionProtFeatures for BZW2_GAP43


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BZW2

Q9Y6E2

GAP43

P17677

May be involved in neuronal differentiation.{ECO:0000250}. This protein is associated with nerve growth. It is amajor component of the motile "growth cones" that form the tips ofelongating axons. Plays a role in axonal and dendritic filopodiainduction. {ECO:0000269|PubMed:14978216,ECO:0000269|PubMed:21152083}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BZW2_GAP43


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BZW2_GAP43


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BZW2BZW1, PSTPIP1, GSK3B, ELAVL1, VCP, FN1, EGFR, ABHD14A, CAPN1, CNBP, DFFA, EIF6, HSPA9, PFAS, CTSA, PPP5C, C11orf58, GINS3, PAFAH1B2, PHKG2, PTPLAD1, EIF2A, EIF2B1, EIF3A, STX12, RAB1B, CD68, GPR183, LYPD3, SCN2B, CYFIP1, EIF5, HSD17B10, STAG2, NTRK1, CDH1, PTPRE, MUL1, EXOG, NT5C3A, CANT1, ENDOD1, TMEM43, TMEM206, ZFPL1, SCCPDH, GYPB, MRS2, MAVS, OMA1, TVP23C, NXT1, RRAS, NRAS, VIPR2, SLC27A2, PTPRN, TPTE, SMDT1, EIF2B2, EIF2B4GAP43PLCD1, RABEP1, CALM1, SLC25A41, CCR1, TMEM185A, CCNL2, MED21, PCDHGC3, KIFAP3, GJB7, TIGD5, BIRC2, S1PR2, MARVELD2, GDE1, CYP2S1, PCK2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BZW2_GAP43


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for BZW2_GAP43


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGAP43C0036341Schizophrenia4PSYGENET
TgeneGAP43C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneGAP43C0005586Bipolar Disorder1PSYGENET
TgeneGAP43C0009375Colonic Neoplasms1CTD_human
TgeneGAP43C0011570Mental Depression1PSYGENET
TgeneGAP43C0011581Depressive disorder1PSYGENET
TgeneGAP43C0013415Dysthymic Disorder1PSYGENET
TgeneGAP43C0038220Status Epilepticus1CTD_human
TgeneGAP43C0525045Mood Disorders1PSYGENET