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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 458

FusionGeneSummary for ACPP_BCR

check button Fusion gene summary
Fusion gene informationFusion gene name: ACPP_BCR
Fusion gene ID: 458
HgeneTgene
Gene symbol

ACPP

BCR

Gene ID

55

613

Gene nameacid phosphatase, prostateBCR, RhoGEF and GTPase activating protein
Synonyms5'-NT|ACP-3|ACP3ALL|BCR1|CML|D22S11|D22S662|PHL
Cytomap

3q22.1

22q11.23

Type of geneprotein-codingprotein-coding
Descriptionprostatic acid phosphataseTMPaseecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphatasebreakpoint cluster region proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26
Modification date2018051920180527
UniProtAcc

P15309

P11274

Ensembl transtripts involved in fusion geneENST00000336375, ENST00000475741, 
ENST00000351273, ENST00000489084, 
ENST00000305877, ENST00000359540, 
ENST00000398512, ENST00000436990, 
Fusion gene scores* DoF score13 X 6 X 2=1566 X 12 X 4=288
# samples 1515
** MAII scorelog2(15/156*10)=-0.0565835283663674
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/288*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACPP [Title/Abstract] AND BCR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACPP

GO:0046085

adenosine metabolic process

18940592

HgeneACPP

GO:0051289

protein homotetramerization

10639192


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-4L-AA1F-01AACPPchr3

132056398

+BCRchr22

23653884

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000336375ENST00000305877ACPPchr3

132056398

+BCRchr22

23653884

+
Frame-shitENST00000336375ENST00000359540ACPPchr3

132056398

+BCRchr22

23653884

+
5CDS-intronENST00000336375ENST00000398512ACPPchr3

132056398

+BCRchr22

23653884

+
5CDS-3UTRENST00000336375ENST00000436990ACPPchr3

132056398

+BCRchr22

23653884

+
intron-3CDSENST00000475741ENST00000305877ACPPchr3

132056398

+BCRchr22

23653884

+
intron-3CDSENST00000475741ENST00000359540ACPPchr3

132056398

+BCRchr22

23653884

+
intron-intronENST00000475741ENST00000398512ACPPchr3

132056398

+BCRchr22

23653884

+
intron-3UTRENST00000475741ENST00000436990ACPPchr3

132056398

+BCRchr22

23653884

+
Frame-shitENST00000351273ENST00000305877ACPPchr3

132056398

+BCRchr22

23653884

+
Frame-shitENST00000351273ENST00000359540ACPPchr3

132056398

+BCRchr22

23653884

+
5CDS-intronENST00000351273ENST00000398512ACPPchr3

132056398

+BCRchr22

23653884

+
5CDS-3UTRENST00000351273ENST00000436990ACPPchr3

132056398

+BCRchr22

23653884

+
intron-3CDSENST00000489084ENST00000305877ACPPchr3

132056398

+BCRchr22

23653884

+
intron-3CDSENST00000489084ENST00000359540ACPPchr3

132056398

+BCRchr22

23653884

+
intron-intronENST00000489084ENST00000398512ACPPchr3

132056398

+BCRchr22

23653884

+
intron-3UTRENST00000489084ENST00000436990ACPPchr3

132056398

+BCRchr22

23653884

+

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FusionProtFeatures for ACPP_BCR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACPP

P15309

BCR

P11274

A non-specific tyrosine phosphatase thatdephosphorylates a diverse number of substrates under acidicconditions (pH 4-6) including alkyl, aryl, and acyl orthophosphatemonoesters and phosphorylated proteins. Has lipid phosphataseactivity and inactivates lysophosphatidic acid in seminal plasma. Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons.Generates adenosine from AMP which acts as a pain suppressor. Actsas a tumor suppressor of prostate cancer through dephosphorylationof ERBB2 and deactivation of MAPK-mediated signaling. GTPase-activating protein for RAC1 and CDC42. Promotesthe exchange of RAC or CDC42-bound GDP by GTP, thereby activatingthem. Displays serine/threonine kinase activity.{ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:1903516}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACPP_BCR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACPP_BCR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACPPACPP, UBC, SHBG, MMRN1, DDX19B, RPS6KB2, TBC1D22B, FTH1, CDK15, CCDC103, CPLX3, FBXL4, AIRE, ZIC1, DUSP21, IL31RA, FCRL5, KIF3A, NPPA, HSF2, FCF1, LACC1, L2HGDHBCRMLLT4, HCK, PTPN6, FES, RB1, ERCC3, GRB2, ABL1, GAB2, HOXA9, CRKL, KIT, PIK3CG, IGSF21, TP53, UNC119, SOS1, PXN, RAC1, CDC42, RHOA, IL3, WDR48, TSG101, VPS28, INPP5D, MYC, HSP90AA1, HSPA8, HIF1A, CRK, GABRR1, CBL, LNX1, LRRK1, GRK5, UBASH3B, PIK3R2, SHC1, AP2M1, CFTR, ERBB2IP, DOK1, PTGES3, HSPA4, HSPD1, UBC, CSNK2A2, STUB1, CCDC183, RSPH9, SEC13, NTRK1, CEP128, NINL, XPO1, PIK3R1, PDZK1, COMMD1, TULP3, JPH4, NAGK, USP15, SPAG9, MCM2, MCM4, WEE1, CSNK1A1, MCM6, TRIM25, RAD51


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACPP_BCR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneACPPP15309DB06688Sipuleucel-TProstatic acid phosphatasebiotechapproved|investigational
TgeneBCRP11274DB06616BosutinibBreakpoint cluster region proteinsmall moleculeapproved
TgeneBCRP11274DB01254DasatinibBreakpoint cluster region proteinsmall moleculeapproved|investigational
TgeneBCRP11274DB08901PonatinibBreakpoint cluster region proteinsmall moleculeapproved|investigational

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RelatedDiseases for ACPP_BCR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACPPC3495559Juvenile arthritis1CTD_human
TgeneBCRC0005586Bipolar Disorder4PSYGENET
TgeneBCRC0023473Myeloid Leukemia, Chronic3CTD_human;HPO;ORPHANET
TgeneBCRC0005699Blast Phase1CTD_human
TgeneBCRC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneBCRC0027022Myeloproliferative disease1CTD_human;HPO
TgeneBCRC0027540Necrosis1CTD_human
TgeneBCRC0027659Neoplasms, Experimental1CTD_human
TgeneBCRC0041696Unipolar Depression1PSYGENET
TgeneBCRC1269683Major Depressive Disorder1PSYGENET