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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4556

FusionGeneSummary for BTF3_GGA1

check button Fusion gene summary
Fusion gene informationFusion gene name: BTF3_GGA1
Fusion gene ID: 4556
HgeneTgene
Gene symbol

BTF3

GGA1

Gene ID

10384

26088

Gene namebutyrophilin subfamily 3 member A3golgi associated, gamma adaptin ear containing, ARF binding protein 1
SynonymsBTF3|BTN3.3-
Cytomap

6p22.2

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionbutyrophilin subfamily 3 member A3butyrophilin 3butyrophilin subfamily 3 member A3 secreted isoformADP-ribosylation factor-binding protein GGA1ADP-ribosylation factor binding protein 1gamma-adaptin related protein 1golgi-localized, gamma ear-containing, ARF-binding protein 1
Modification date2018052320180522
UniProtAcc

P20290

Q9UJY5

Ensembl transtripts involved in fusion geneENST00000335895, ENST00000514505, 
ENST00000380591, 
ENST00000414350, 
ENST00000343632, ENST00000381756, 
ENST00000405147, ENST00000325180, 
ENST00000337437, ENST00000406772, 
ENST00000488672, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 5 X 3=75
# samples 48
** MAII scorelog2(4/4*10)=3.32192809488736log2(8/75*10)=0.0931094043914815
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BTF3 [Title/Abstract] AND GGA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB454451BTF3chr5

72794748

+GGA1chr22

38026981

+
ChiTaRS3.1BI562608BTF3chr5

72794748

+GGA1chr22

38026981

+
ChiTaRS3.1BI562704BTF3chr5

72794748

+GGA1chr22

38026981

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000335895ENST00000414350BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000335895ENST00000343632BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000335895ENST00000381756BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000335895ENST00000405147BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000335895ENST00000325180BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000335895ENST00000337437BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000335895ENST00000406772BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000335895ENST00000488672BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000514505ENST00000414350BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000514505ENST00000343632BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000514505ENST00000381756BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000514505ENST00000405147BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000514505ENST00000325180BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000514505ENST00000337437BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000514505ENST00000406772BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000514505ENST00000488672BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000380591ENST00000414350BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000380591ENST00000343632BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000380591ENST00000381756BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000380591ENST00000405147BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000380591ENST00000325180BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000380591ENST00000337437BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000380591ENST00000406772BTF3chr5

72794748

+GGA1chr22

38026981

+
intron-intronENST00000380591ENST00000488672BTF3chr5

72794748

+GGA1chr22

38026981

+

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FusionProtFeatures for BTF3_GGA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BTF3

P20290

GGA1

Q9UJY5

When associated with NACA, prevents inappropriatetargeting of non-secretory polypeptides to the endoplasmicreticulum (ER). Binds to nascent polypeptide chains as they emergefrom the ribosome and blocks their interaction with the signalrecognition particle (SRP), which normally targets nascentsecretory peptides to the ER. BTF3 is also a general transcriptionfactor that can form a stable complex with RNA polymerase II.Required for the initiation of transcription.{ECO:0000269|PubMed:10982809}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BTF3_GGA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BTF3_GGA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BTF3_GGA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BTF3_GGA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource