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Fusion gene ID: 455 |
FusionGeneSummary for ACPP_ARFIP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACPP_ARFIP1 | Fusion gene ID: 455 | Hgene | Tgene | Gene symbol | ACPP | ARFIP1 | Gene ID | 55 | 27236 |
| Gene name | acid phosphatase, prostate | ADP ribosylation factor interacting protein 1 | |
| Synonyms | 5'-NT|ACP-3|ACP3 | HSU52521 | |
| Cytomap | 3q22.1 | 4q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | prostatic acid phosphataseTMPaseecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphatase | arfaptin-1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P15309 | P53367 | |
| Ensembl transtripts involved in fusion gene | ENST00000336375, ENST00000475741, ENST00000351273, ENST00000489084, | ENST00000451320, ENST00000429148, ENST00000353617, ENST00000405727, ENST00000356064, ENST00000511289, | |
| Fusion gene scores | * DoF score | 13 X 6 X 2=156 | 7 X 6 X 7=294 |
| # samples | 15 | 10 | |
| ** MAII score | log2(15/156*10)=-0.0565835283663674 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/294*10)=-1.55581615506164 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ACPP [Title/Abstract] AND ARFIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACPP | GO:0046085 | adenosine metabolic process | 18940592 |
| Hgene | ACPP | GO:0051289 | protein homotetramerization | 10639192 |
| Tgene | ARFIP1 | GO:0006886 | intracellular protein transport | 12606037 |
| Tgene | ARFIP1 | GO:0050708 | regulation of protein secretion | 12606037 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-EJ-A46D-01A | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000336375 | ENST00000451320 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000336375 | ENST00000429148 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000336375 | ENST00000353617 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000336375 | ENST00000405727 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000336375 | ENST00000356064 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-3UTR | ENST00000336375 | ENST00000511289 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| In-frame | ENST00000475741 | ENST00000451320 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000475741 | ENST00000429148 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000475741 | ENST00000353617 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000475741 | ENST00000405727 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000475741 | ENST00000356064 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-3UTR | ENST00000475741 | ENST00000511289 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| In-frame | ENST00000351273 | ENST00000451320 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000351273 | ENST00000429148 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000351273 | ENST00000353617 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000351273 | ENST00000405727 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-intron | ENST00000351273 | ENST00000356064 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 5CDS-3UTR | ENST00000351273 | ENST00000511289 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 3UTR-3CDS | ENST00000489084 | ENST00000451320 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 3UTR-intron | ENST00000489084 | ENST00000429148 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 3UTR-intron | ENST00000489084 | ENST00000353617 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 3UTR-intron | ENST00000489084 | ENST00000405727 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 3UTR-intron | ENST00000489084 | ENST00000356064 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
| 3UTR-3UTR | ENST00000489084 | ENST00000511289 | ACPP | chr3 | 132036420 | + | ARFIP1 | chr4 | 153784758 | + |
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FusionProtFeatures for ACPP_ARFIP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACPP | ARFIP1 |
| A non-specific tyrosine phosphatase thatdephosphorylates a diverse number of substrates under acidicconditions (pH 4-6) including alkyl, aryl, and acyl orthophosphatemonoesters and phosphorylated proteins. Has lipid phosphataseactivity and inactivates lysophosphatidic acid in seminal plasma. Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons.Generates adenosine from AMP which acts as a pain suppressor. Actsas a tumor suppressor of prostate cancer through dephosphorylationof ERBB2 and deactivation of MAPK-mediated signaling. | Putative target protein of ADP-ribosylation factor. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ARFIP1 | chr3:132036420 | chr4:153784758 | ENST00000353617 | + | 1 | 9 | 153_353 | 31 | 374 | Domain | AH |
| Tgene | >ARFIP1 | chr3:132036420 | chr4:153784758 | ENST00000356064 | + | 1 | 8 | 153_353 | 31 | 342 | Domain | AH |
| Tgene | >ARFIP1 | chr3:132036420 | chr4:153784758 | ENST00000405727 | + | 1 | 8 | 153_353 | 31 | 342 | Domain | AH |
| Tgene | >ARFIP1 | chr3:132036420 | chr4:153784758 | ENST00000451320 | + | 1 | 9 | 153_353 | 31 | 374 | Domain | AH |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACPP_ARFIP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ACPP_ENST00000336375_chr3_132036420_+_ARFIP1_ENST00000451320_chr4_153784758_+_383aa MRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLDLKHSLPSGLGLSETQITSHGFDNTKEGVIEAGAFQGSPAPPLPSVMSPS RVAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKK YENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYE SARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQT >In-frame_ACPP_ENST00000475741_chr3_132036420_+_ARFIP1_ENST00000451320_chr4_153784758_+_383aa MRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLDLKHSLPSGLGLSETQITSHGFDNTKEGVIEAGAFQGSPAPPLPSVMSPS RVAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKK YENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYE SARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQT >In-frame_ACPP_ENST00000351273_chr3_132036420_+_ARFIP1_ENST00000451320_chr4_153784758_+_383aa MRAAPLLLARAASLSLGFLFLLFFWLDRSVLAKELKFVTLDLKHSLPSGLGLSETQITSHGFDNTKEGVIEAGAFQGSPAPPLPSVMSPS RVAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKK YENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYE SARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ACPP_ENST00000336375_chr3_132036420_+_ARFIP1_ENST00000451320_chr4_153784758_+_1149nt ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAATTACATCTCAT GGCTTTGACAATACCAAAGAGGGTGTTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTATGTCTCCTAGC AGGGTTGCAGCTAGTCGACTGGCTCAGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAAGTGGACCAGTT ATTCTAGCAGATGAAATTAAAAATCCTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGTGTACTCGACAG ATTATCTCTGAGAAGCTAGGCCGTGGCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATAACAAGAAAAAA TATGAAAATATTTTAAAACTGGCTCAAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAGATGCATTTGCT GACCTGAGTTTGAAGTCACTAGAACTTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATGGAGAGACTCTT CTTGGGGCCATTAATTTTTTCATTGCTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGAAACAGTATGAA AGTGCCAGGATTGAATATGATGCATATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGCCAAAGATTGAG CAGTCACAGCATCTCTTCCAAGCACATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTCTAGAAGAAAAT AAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACA >In-frame_ACPP_ENST00000475741_chr3_132036420_+_ARFIP1_ENST00000451320_chr4_153784758_+_1149nt ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAATTACATCTCAT GGCTTTGACAATACCAAAGAGGGTGTTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTATGTCTCCTAGC AGGGTTGCAGCTAGTCGACTGGCTCAGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAAGTGGACCAGTT ATTCTAGCAGATGAAATTAAAAATCCTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGTGTACTCGACAG ATTATCTCTGAGAAGCTAGGCCGTGGCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATAACAAGAAAAAA TATGAAAATATTTTAAAACTGGCTCAAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAGATGCATTTGCT GACCTGAGTTTGAAGTCACTAGAACTTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATGGAGAGACTCTT CTTGGGGCCATTAATTTTTTCATTGCTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGAAACAGTATGAA AGTGCCAGGATTGAATATGATGCATATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGCCAAAGATTGAG CAGTCACAGCATCTCTTCCAAGCACATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTCTAGAAGAAAAT AAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACA >In-frame_ACPP_ENST00000351273_chr3_132036420_+_ARFIP1_ENST00000451320_chr4_153784758_+_1149nt ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAATTACATCTCAT GGCTTTGACAATACCAAAGAGGGTGTTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTATGTCTCCTAGC AGGGTTGCAGCTAGTCGACTGGCTCAGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAAGTGGACCAGTT ATTCTAGCAGATGAAATTAAAAATCCTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGTGTACTCGACAG ATTATCTCTGAGAAGCTAGGCCGTGGCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATAACAAGAAAAAA TATGAAAATATTTTAAAACTGGCTCAAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAGATGCATTTGCT GACCTGAGTTTGAAGTCACTAGAACTTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATGGAGAGACTCTT CTTGGGGCCATTAATTTTTTCATTGCTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGAAACAGTATGAA AGTGCCAGGATTGAATATGATGCATATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGCCAAAGATTGAG CAGTCACAGCATCTCTTCCAAGCACATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTCTAGAAGAAAAT AAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ACPP_ENST00000336375_chr3_132036420_+_ARFIP1_ENST00000451320_chr4_153784758_+_3377nt TCAATCCCTTAATTAAATAGCTTCCCCTCTACAGGCTTTTGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAAC ATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCCTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTA CTAGCCAAGGAGTTGAAGTTTGTGACTTTGGATTTGAAGCATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAATTACATCTCAT GGCTTTGACAATACCAAAGAGGGTGTTATTGAAGCAGGAGCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTATGTCTCCTAGC AGGGTTGCAGCTAGTCGACTGGCTCAGCAAGGAAGTGATTTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAAGTGGACCAGTT ATTCTAGCAGATGAAATTAAAAATCCTGCAATGGAAAAGTTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGTGTACTCGACAG ATTATCTCTGAGAAGCTAGGCCGTGGCTCAAGAACTGTGGACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATAACAAGAAAAAA TATGAAAATATTTTAAAACTGGCTCAAACATTGTCGACCCAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAGATGCATTTGCT GACCTGAGTTTGAAGTCACTAGAACTTCATGAAGAATTTGGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATGGAGAGACTCTT CTTGGGGCCATTAATTTTTTCATTGCTAGTGTGAACACTTTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGAAACAGTATGAA AGTGCCAGGATTGAATATGATGCATATCGCACTGATTTGGAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGCCAAAGATTGAG CAGTCACAGCATCTCTTCCAAGCACATAAGGAAAAATATGATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTCTAGAAGAAAAT AAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACAATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACA CTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTGGATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAAAA GAAAGTCGCGTTGTTATATTTCTAAACCAACCTAACAAGAATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGATT CTTGCACAAACAGCTTTAATTTTTCCCTTTTTCATACTTTAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATAAT CTGAACACAATAATTTTCCTTTTTGAGAAATCCTTTTGTATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAGAT TTGCACTGACAAGATAAAAATTCAAGGTTTTTGGTCCTGGAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTGTA TCAACATCAGATATTTTATATGTGAATATATTAAACATCTTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCAGA GTAAAGTTATATGGTGTTCCTGCAGCGTCCACACAGAGGCAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTTTT AAAAATGAATCTGTACCACTGTAATTTTATTTAGACTTTTTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGCTT ATGAATTTGCTTCACCCGAAGTCATTGGACAGTTACATTTGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTTTT TGACAGGTGGACGTGGGAATGGAAATTCTTAATGGTTTCTGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATTTT GATAGAAGTGAATACATAGACAGCTTTTATTGACTTCCATATGTAACAATACCGTTTAAGCCTTAAATCACAGATATGTGCCTTCTCAGA TACAGTAATTCTTGTTCAACCAATGTACAAAATCCATAAAGAAACCCCTGTTGGATAATGTTTGATGTGTCTATTCCTTCCATGGAATGG AGCACTATGTATGAATGTTGGGTTTCTTTGTACTTGTTAAGCCACATTTGAGGTTTATGGTAAAAATCATCTTTTGAGTTTGCTCTTTGG TTTTTCTTCATTCCTTTTGAGGATTGGGAAAACAGAAAGATTCTTTGATTTGGGTAATGAAGAGGTAATTTGGGACAGTGTGGTGGTACC AGGAAGAAAGAGGATTGGAAAGGCCAGTACTGTTTTAGTTGCTCGGCACTGTTGGTTTTGTTTTAATGTGGTTGCCCTGTCCACTACATG GTTCTATCAGTAGTGTAATCCATTTTCAATGTAAAGCTCTTTTAGTTTTTGTCATAGACATAAATTAATATTTTGAGAGGCATCCCTCAC CTGTTCATTTCTTCTGTGTTGAAATGAAGTACTTAAAATTACCGTTATACATGAACTTTGTGGACTGTAAGATTTGTTATATATGTTCAA ATGCCTTTTAGCTGGCTTTTTAATTAATATGCCTGTTTTGAGTGCTTAATACAATGTAATGTGATTGTAAATCATACCTATTTTAAATCA TTCCTTCCTGTATATTTGTACTCAGAGAGCCTTATTTTATTCTTCCAGCAGAATTACTACTTGTGATAGTTCATTTACATTCCCCAGAAT GTGCCTCTAGTGTGAATTTTGTATTCTTATTAAACGTGTTTGCTGCAGTAAATCGTTTCTCTGGACCTTCATAGTTTAAGAAGTAACTAT TTGGAAATTCTGAAGACACATAATTTGCGTTTTCTGAACCTTAAAAAAAAAGGTACTTCTGTCACTTATAATTGTTTTAGCTCAGTAAGC TATTTTTTTTCAATGTGAATCTCTTTTGAGAGCTGAACATGTCCATTCTTAACCACATTTCAATAACAGTTACTGTAGCTAAGGAGCTAA ATAGTTTCATGGATTAATTTTTTTCAGAATAAATTTAAAATATCCATGATTCTGATAGTGGGCACATGACCAAAAGAAAAAAGTAAATCA ATATATTTAGCCAATGGTACATTTACTTTGTTAGGAATGTAATTTATGTTCATTATAGAAAAGAATTAGAAGAAAATTTCAAGTAATAGA >In-frame_ACPP_ENST00000475741_chr3_132036420_+_ARFIP1_ENST00000451320_chr4_153784758_+_3338nt TGAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGC CTTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGATTTGAAG CATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAATTACATCTCATGGCTTTGACAATACCAAAGAGGGTGTTATTGAAGCAGGA GCATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTATGTCTCCTAGCAGGGTTGCAGCTAGTCGACTGGCTCAGCAAGGAAGTGAT TTAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAAGTGGACCAGTTATTCTAGCAGATGAAATTAAAAATCCTGCAATGGAAAAG TTAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGTGTACTCGACAGATTATCTCTGAGAAGCTAGGCCGTGGCTCAAGAACTGTG GACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATAACAAGAAAAAATATGAAAATATTTTAAAACTGGCTCAAACATTGTCGACC CAGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAGATGCATTTGCTGACCTGAGTTTGAAGTCACTAGAACTTCATGAAGAATTT GGCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATGGAGAGACTCTTCTTGGGGCCATTAATTTTTTCATTGCTAGTGTGAACACT TTGGTGAATAAAACCATTGAAGATACATTAATGACTGTGAAACAGTATGAAAGTGCCAGGATTGAATATGATGCATATCGCACTGATTTG GAAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGCCAAAGATTGAGCAGTCACAGCATCTCTTCCAAGCACATAAGGAAAAATAT GATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTCTAGAAGAAAATAAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCAC AATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACACTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTG GATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAAAAGAAAGTCGCGTTGTTATATTTCTAAACCAACCTAACAAG AATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGATTCTTGCACAAACAGCTTTAATTTTTCCCTTTTTCATACTT TAACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATAATCTGAACACAATAATTTTCCTTTTTGAGAAATCCTTTTGT ATTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAGATTTGCACTGACAAGATAAAAATTCAAGGTTTTTGGTCCTG GAAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTGTATCAACATCAGATATTTTATATGTGAATATATTAAACATC TTTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCAGAGTAAAGTTATATGGTGTTCCTGCAGCGTCCACACAGAGG CAGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTTTTAAAAATGAATCTGTACCACTGTAATTTTATTTAGACTTT TTTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGCTTATGAATTTGCTTCACCCGAAGTCATTGGACAGTTACATT TGCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTTTTTGACAGGTGGACGTGGGAATGGAAATTCTTAATGGTTTC TGGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATTTTGATAGAAGTGAATACATAGACAGCTTTTATTGACTTCCA TATGTAACAATACCGTTTAAGCCTTAAATCACAGATATGTGCCTTCTCAGATACAGTAATTCTTGTTCAACCAATGTACAAAATCCATAA AGAAACCCCTGTTGGATAATGTTTGATGTGTCTATTCCTTCCATGGAATGGAGCACTATGTATGAATGTTGGGTTTCTTTGTACTTGTTA AGCCACATTTGAGGTTTATGGTAAAAATCATCTTTTGAGTTTGCTCTTTGGTTTTTCTTCATTCCTTTTGAGGATTGGGAAAACAGAAAG ATTCTTTGATTTGGGTAATGAAGAGGTAATTTGGGACAGTGTGGTGGTACCAGGAAGAAAGAGGATTGGAAAGGCCAGTACTGTTTTAGT TGCTCGGCACTGTTGGTTTTGTTTTAATGTGGTTGCCCTGTCCACTACATGGTTCTATCAGTAGTGTAATCCATTTTCAATGTAAAGCTC TTTTAGTTTTTGTCATAGACATAAATTAATATTTTGAGAGGCATCCCTCACCTGTTCATTTCTTCTGTGTTGAAATGAAGTACTTAAAAT TACCGTTATACATGAACTTTGTGGACTGTAAGATTTGTTATATATGTTCAAATGCCTTTTAGCTGGCTTTTTAATTAATATGCCTGTTTT GAGTGCTTAATACAATGTAATGTGATTGTAAATCATACCTATTTTAAATCATTCCTTCCTGTATATTTGTACTCAGAGAGCCTTATTTTA TTCTTCCAGCAGAATTACTACTTGTGATAGTTCATTTACATTCCCCAGAATGTGCCTCTAGTGTGAATTTTGTATTCTTATTAAACGTGT TTGCTGCAGTAAATCGTTTCTCTGGACCTTCATAGTTTAAGAAGTAACTATTTGGAAATTCTGAAGACACATAATTTGCGTTTTCTGAAC CTTAAAAAAAAAGGTACTTCTGTCACTTATAATTGTTTTAGCTCAGTAAGCTATTTTTTTTCAATGTGAATCTCTTTTGAGAGCTGAACA TGTCCATTCTTAACCACATTTCAATAACAGTTACTGTAGCTAAGGAGCTAAATAGTTTCATGGATTAATTTTTTTCAGAATAAATTTAAA ATATCCATGATTCTGATAGTGGGCACATGACCAAAAGAAAAAAGTAAATCAATATATTTAGCCAATGGTACATTTACTTTGTTAGGAATG TAATTTATGTTCATTATAGAAAAGAATTAGAAGAAAATTTCAAGTAATAGAAGATAAGTACCTTCCCAAGTGAATAAATACTGCATGGAA >In-frame_ACPP_ENST00000351273_chr3_132036420_+_ARFIP1_ENST00000451320_chr4_153784758_+_3337nt GAAGTGGTAGCAGTTCCTCCTAACTCCTGCCAGAAACAGCTCTCCTCAACATGAGAGCTGCACCCCTCCTCCTGGCCAGGGCAGCAAGCC TTAGCCTTGGCTTCTTGTTTCTGCTTTTTTTCTGGCTAGACCGAAGTGTACTAGCCAAGGAGTTGAAGTTTGTGACTTTGGATTTGAAGC ATTCATTACCATCTGGACTTGGTCTCTCAGAAACCCAAATTACATCTCATGGCTTTGACAATACCAAAGAGGGTGTTATTGAAGCAGGAG CATTTCAAGGTTCCCCAGCACCGCCACTGCCATCTGTTATGTCTCCTAGCAGGGTTGCAGCTAGTCGACTGGCTCAGCAAGGAAGTGATT TAATTGTTCCTGCAGGTGGCCAGAGAACACAGACAAAAAGTGGACCAGTTATTCTAGCAGATGAAATTAAAAATCCTGCAATGGAAAAGT TAGAACTTGTTAGAAAATGGAGTCTAAACACCTATAAGTGTACTCGACAGATTATCTCTGAGAAGCTAGGCCGTGGCTCAAGAACTGTGG ACCTTGAACTTGAAGCTCAGATTGATATATTAAGGGATAACAAGAAAAAATATGAAAATATTTTAAAACTGGCTCAAACATTGTCGACCC AGCTTTTCCAGATGGTACATACCCAAAGGCAACTTGGAGATGCATTTGCTGACCTGAGTTTGAAGTCACTAGAACTTCATGAAGAATTTG GCTATAATGCCGATACCCAGAAACTGCTGGCTAAAAATGGAGAGACTCTTCTTGGGGCCATTAATTTTTTCATTGCTAGTGTGAACACTT TGGTGAATAAAACCATTGAAGATACATTAATGACTGTGAAACAGTATGAAAGTGCCAGGATTGAATATGATGCATATCGCACTGATTTGG AAGAACTGAATCTTGGACCACGTGACGCAAACACTCTGCCAAAGATTGAGCAGTCACAGCATCTCTTCCAAGCACATAAGGAAAAATATG ATAAAATGCGCAATGATGTTTCTGTCAAATTGAAATTTCTAGAAGAAAATAAGGTTAAAGTATTGCACAATCAGCTGGTCCTTTTCCACA ATGCCATTGCCGCTTACTTTGCTGGGAATCAGAAGCAGCTTGAACAGACACTTAAACAGTTCCATATCAAATTGAAAACCCCTGGAGTGG ATGCCCCATCTTGGCTTGAAGAACAGTAAAATCACAGCGGAAAATAAAAAGAAAGTCGCGTTGTTATATTTCTAAACCAACCTAACAAGA ATTAAGCAGAGTTGGGGGAAGTGGGAGGGGTGACAAGCATTATAGTGATTCTTGCACAAACAGCTTTAATTTTTCCCTTTTTCATACTTT AACAATTGAACTGTTAAGGGTGGTTTTAATGTAAACATAGTTTCTATAATCTGAACACAATAATTTTCCTTTTTGAGAAATCCTTTTGTA TTGTGAGGGTTGATGGCTATTTCTGTAGTTTGAAAACATCTAATAGAGATTTGCACTGACAAGATAAAAATTCAAGGTTTTTGGTCCTGG AAATGAGGGCCGATTGTAACTTTTCCAAAGGGAGGTTTACATGATTTGTATCAACATCAGATATTTTATATGTGAATATATTAAACATCT TTAAGAGATTCATTTTCATGTATTAAAGAAAAAAGAAACTATTTTGCAGAGTAAAGTTATATGGTGTTCCTGCAGCGTCCACACAGAGGC AGCAGCTCTAATGAATGATTAGCTTGTGGAGTTGTGGCAAATACCTTTTTAAAAATGAATCTGTACCACTGTAATTTTATTTAGACTTTT TTTTAAAGACACAGAAATCACACTGTCATTTCTGTGAGGCTTTTAAGCTTATGAATTTGCTTCACCCGAAGTCATTGGACAGTTACATTT GCAATTTCTTTTGGTTCATAACAAAACCTGCTTAAGAGAATTTTTTTTTTTGACAGGTGGACGTGGGAATGGAAATTCTTAATGGTTTCT GGAGTAGAAATCTGTACTTAGAAAACTAGTTTTTGGGTCAGTTCCATTTTGATAGAAGTGAATACATAGACAGCTTTTATTGACTTCCAT ATGTAACAATACCGTTTAAGCCTTAAATCACAGATATGTGCCTTCTCAGATACAGTAATTCTTGTTCAACCAATGTACAAAATCCATAAA GAAACCCCTGTTGGATAATGTTTGATGTGTCTATTCCTTCCATGGAATGGAGCACTATGTATGAATGTTGGGTTTCTTTGTACTTGTTAA GCCACATTTGAGGTTTATGGTAAAAATCATCTTTTGAGTTTGCTCTTTGGTTTTTCTTCATTCCTTTTGAGGATTGGGAAAACAGAAAGA TTCTTTGATTTGGGTAATGAAGAGGTAATTTGGGACAGTGTGGTGGTACCAGGAAGAAAGAGGATTGGAAAGGCCAGTACTGTTTTAGTT GCTCGGCACTGTTGGTTTTGTTTTAATGTGGTTGCCCTGTCCACTACATGGTTCTATCAGTAGTGTAATCCATTTTCAATGTAAAGCTCT TTTAGTTTTTGTCATAGACATAAATTAATATTTTGAGAGGCATCCCTCACCTGTTCATTTCTTCTGTGTTGAAATGAAGTACTTAAAATT ACCGTTATACATGAACTTTGTGGACTGTAAGATTTGTTATATATGTTCAAATGCCTTTTAGCTGGCTTTTTAATTAATATGCCTGTTTTG AGTGCTTAATACAATGTAATGTGATTGTAAATCATACCTATTTTAAATCATTCCTTCCTGTATATTTGTACTCAGAGAGCCTTATTTTAT TCTTCCAGCAGAATTACTACTTGTGATAGTTCATTTACATTCCCCAGAATGTGCCTCTAGTGTGAATTTTGTATTCTTATTAAACGTGTT TGCTGCAGTAAATCGTTTCTCTGGACCTTCATAGTTTAAGAAGTAACTATTTGGAAATTCTGAAGACACATAATTTGCGTTTTCTGAACC TTAAAAAAAAAGGTACTTCTGTCACTTATAATTGTTTTAGCTCAGTAAGCTATTTTTTTTCAATGTGAATCTCTTTTGAGAGCTGAACAT GTCCATTCTTAACCACATTTCAATAACAGTTACTGTAGCTAAGGAGCTAAATAGTTTCATGGATTAATTTTTTTCAGAATAAATTTAAAA TATCCATGATTCTGATAGTGGGCACATGACCAAAAGAAAAAAGTAAATCAATATATTTAGCCAATGGTACATTTACTTTGTTAGGAATGT AATTTATGTTCATTATAGAAAAGAATTAGAAGAAAATTTCAAGTAATAGAAGATAAGTACCTTCCCAAGTGAATAAATACTGCATGGAAC |
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FusionGenePPI for ACPP_ARFIP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ACPP | ACPP, UBC, SHBG, MMRN1, DDX19B, RPS6KB2, TBC1D22B, FTH1, CDK15, CCDC103, CPLX3, FBXL4, AIRE, ZIC1, DUSP21, IL31RA, FCRL5, KIF3A, NPPA, HSF2, FCF1, LACC1, L2HGDH | ARFIP1 | ARF3, ARF1, ARF5, SLC2A4, ATP6V1C1, TBC1D15, TSNAX, YAP1, DNM1L, HIST1H4A, IDE, LUC7L2, PRMT3, PSMG3, SEC24A, SHMT2, STAT3, ARFIP2, PICK1, AACS, AKR1A1, ADSS, DPYSL2, G6PD, GART, HSD17B8, MVB12A, PFKM, PFKP, PPP3CA, PROSC, SARS, SEC24D, SHMT1, TSTA3, TXNDC9, USP14, ATOX1, ECH1, FLNB, LYPLA1, PAFAH1B2, PDCD6, PGM2L1, QDPR, STIP1, TBCA, DYNLT1, TMEM17, TMEM216, CDC5L, CDH1, CLPB, HSPA8, HSPBP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACPP_ARFIP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ACPP | P15309 | DB06688 | Sipuleucel-T | Prostatic acid phosphatase | biotech | approved|investigational |
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RelatedDiseases for ACPP_ARFIP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ACPP | C3495559 | Juvenile arthritis | 1 | CTD_human |
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