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Fusion gene ID: 4537 |
FusionGeneSummary for BTBD7_RGS9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BTBD7_RGS9 | Fusion gene ID: 4537 | Hgene | Tgene | Gene symbol | BTBD7 | RGS9 | Gene ID | 55727 | 8787 |
| Gene name | BTB domain containing 7 | regulator of G protein signaling 9 | |
| Synonyms | FUP1 | PERRS|RGS9L | |
| Cytomap | 14q32.12 | 17q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | BTB/POZ domain-containing protein 7BTB (POZ) domain containing 7 | regulator of G-protein signaling 9regulator of G-protein signalling 9 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9P203 | O75916 | |
| Ensembl transtripts involved in fusion gene | ENST00000334746, ENST00000554565, ENST00000393170, ENST00000298896, ENST00000555525, | ENST00000443584, ENST00000449996, ENST00000262406, ENST00000577186, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 10 X 8 X 4=320 |
| # samples | 5 | 9 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BTBD7 [Title/Abstract] AND RGS9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-1557-01A | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000334746 | ENST00000443584 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| 5UTR-3CDS | ENST00000334746 | ENST00000449996 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| 5UTR-3CDS | ENST00000334746 | ENST00000262406 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| 5UTR-3UTR | ENST00000334746 | ENST00000577186 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| In-frame | ENST00000554565 | ENST00000443584 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| In-frame | ENST00000554565 | ENST00000449996 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| In-frame | ENST00000554565 | ENST00000262406 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| 5CDS-3UTR | ENST00000554565 | ENST00000577186 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| intron-3CDS | ENST00000393170 | ENST00000443584 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| intron-3CDS | ENST00000393170 | ENST00000449996 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| intron-3CDS | ENST00000393170 | ENST00000262406 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| intron-3UTR | ENST00000393170 | ENST00000577186 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| 5UTR-3CDS | ENST00000298896 | ENST00000443584 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| 5UTR-3CDS | ENST00000298896 | ENST00000449996 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| 5UTR-3CDS | ENST00000298896 | ENST00000262406 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| 5UTR-3UTR | ENST00000298896 | ENST00000577186 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| intron-3CDS | ENST00000555525 | ENST00000443584 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| intron-3CDS | ENST00000555525 | ENST00000449996 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| intron-3CDS | ENST00000555525 | ENST00000262406 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
| intron-3UTR | ENST00000555525 | ENST00000577186 | BTBD7 | chr14 | 93799166 | - | RGS9 | chr17 | 63149540 | + |
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FusionProtFeatures for BTBD7_RGS9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BTBD7 | RGS9 |
| Acts as a mediator of epithelial dynamics and organbranching by promoting cleft progression. Induced followingaccumulation of fibronectin in forming clefts, leading to localexpression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducingcell-cell adhesion. This stimulates cell separation at the base offorming clefts by local, dynamic intercellular gap formation andpromotes cleft progression (By similarity). {ECO:0000250}. | Inhibits signal transduction by increasing the GTPaseactivity of G protein alpha subunits thereby driving them intotheir inactive GDP-bound form. Binds to GNAT1. Involved inphototransduction; key element in the recovery phase of visualtransduction (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BTBD7_RGS9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BTBD7_ENST00000554565_chr14_93799166_-_RGS9_ENST00000443584_chr17_63149540_+_646aa MAGGAGAGADGGAGGGGGGGDGSGPSGSSSGGRSLRDXSAREGHAEPRDRGPNAEPEGPGHQRSSCHDRKXCSAMDRPAALDLQSGGTEL GQLYCQVWLHLPPARPQESHSQAXWQPLQISDTVFLAHPAVASXRYRLRHLSGQAKYQKERDFGRIXKGKLQFLEPKNELXVGLCHYAGQ RAVQGWKGEEQSRQICPGLPGEGILAGAPMPSWNGQCAGLRPGPSDQSEXSQETNSRCCQKRDHVLPTGLDEVHSEVFCVPGRDCEIQXA VLIQRCHHVRLPPQQPLDHRXHPVLGLKCQIGGNPNQDASGTMGLQLQRIDPRPQRSTELPVLPQERIQWRESGILGSLRGSEVWRSVQS QGESRGDLQAVPGPGGEALDQHRWQNHGHHSEGAEAPPPLCAGRRTNPHLHAHEEGFLCSLFKISDLXGHAGQSYXTSGNHQEKLHPPFY AASPALQPKPCHPETAGRGSQGPRSSQHCGHHPAGPAHGSQPPSDRVHRDLHAPVSFXPLLLLLPLPQEAFRLTQPLHPATQHHHLPLTH QSGLGELIGLGAERGVQRVHGPPWALCHREQRGLPRHLLASQPAQGPSXGPHGSVLQQVSETRLSGLTCLCQALTQVPCCVPREGAAPGG >In-frame_BTBD7_ENST00000554565_chr14_93799166_-_RGS9_ENST00000449996_chr17_63149540_+_689aa MAGGAGAGADGGAGGGGGGGDGSGPSGSSSGGRSLRDXSAREGHAEPRDRGPNAEPEGPGHQRSSCHDRKXCSAMDRPAALDLQSGGTEL GQLYCQVWLHLPPARPQESHSQAXWQPLQISDTVFLAHPAVASXRYRLRHLSGQAKYQKERDFGRIXKGKLQFLEPKNELXVGLCHYAGQ RAVQGWKGEEQSRQICPGLPGEGILAGAPMPSWNGQCAGLRPGPSDQSEXSQETNSRCCQKRDHVLPTGLDEVHSEVFCVPGRDCEIQXA VLIQRCHHVRLPPQQPLDHRXHPVLGLKCQIGGNPNQDASGTMGLQLQRIDPRPQRSTELPVLPQERIQWRESGILGSLRGSEVWRSVQS QGESRGDLQAVPGPGGEALDQHRWQNHGHHSEGAEAPPPLCAGRRTNPHLHAHEEGFLCSLFKISDLXGHAGQSYXTSGNHQEKLHPPFY AASPALQPKPCHPETAGRGSQGPRSSQHCGHHPAGPAHGSQPPSDRVHRDLHAPVSFXPLLLLLPLPQEAFRLTQPLHPATQHHHLPLTH QSGLGELIGLGAERGVQRVHGPPWALCHREQRGLPRHLLASQPAQGPSXGPHGSVLQQVSETRLSGLTCLCQALTQVPCCVPREGAAPGG >In-frame_BTBD7_ENST00000554565_chr14_93799166_-_RGS9_ENST00000262406_chr17_63149540_+_692aa MAGGAGAGADGGAGGGGGGGDGSGPSGSSSGGRSLRDXSAREGHAEPRDRGPNAEPEGPGHQRSSCHDRKXCSAMDRPAALDLQSGGTEL GQLYCQVWLHLPPARPQESHSQAXWQPLQISDTVFLAHPAVASXRYRLRHLSGQAKYQKERDFGRIXKGKLQFLEPKNELXVGLCHYAGQ RAVQGWKGEEQSRQICPGLPGEGILAGAPMPSWNGQCAGLRPGPSDQSEXSQGKPETNSRCCQKRDHVLPTGLDEVHSEVFCVPGRDCEI QXAVLIQRCHHVRLPPQQPLDHRXHPVLGLKCQIGGNPNQDASGTMGLQLQRIDPRPQRSTELPVLPQERIQWRESGILGSLRGSEVWRS VQSQGESRGDLQAVPGPGGEALDQHRWQNHGHHSEGAEAPPPLCAGRRTNPHLHAHEEGFLCSLFKISDLXGHAGQSYXTSGNHQEKLHP PFYAASPALQPKPCHPETAGRGSQGPRSSQHCGHHPAGPAHGSQPPSDRVHRDLHAPVSFXPLLLLLPLPQEAFRLTQPLHPATQHHHLP LTHQSGLGELIGLGAERGVQRVHGPPWALCHREQRGLPRHLLASQPAQGPSXGPHGSVLQQVSETRLSGLTCLCQALTQVPCCVPREGAA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BTBD7_ENST00000554565_chr14_93799166_-_RGS9_ENST00000443584_chr17_63149540_+_1939nt ATGGCCGGGGGTGCTGGCGCCGGTGCGGACGGCGGTGCTGGTGGCGGCGGCGGCGGAGGCGACGGCAGCGGTCCCAGCGGCAGCAGCAGC GGCGGGAGGAGCCTCCGGGATTGAAGCGCTCGTGAAGGACATGCAGAACCCAGAGACAGGGGTCCGAATGCAGAACCAGAGGGTCCTGGT CACCAGCGTTCCTCATGCCATGACAGGAAGTGATGTTCTGCAATGGATCGTCCAGCGGCTTTGGATCTCCAGTCTGGAGGCACAGAACTT GGGCAACTTTATTGTCAGGTATGGCTACATTTACCCCCTGCAAGACCCCAAGAATCTCATTCTCAAGCCTGATGGCAGCCTCTACAGATT TCAGACACCGTATTTCTGGCCCACCCAGCAGTGGCCAGCTGAAGATACCGATTACGCCATCTATCTGGCCAAGCGAAATATCAAAAAGAA AGGGATTTTGGAAGAATATGAAAAGGAAAATTACAATTTCTTGAACCAAAAAATGAACTATAAGTGGGACTTTGTCATTATGCAGGCCAA AGAGCAGTACAGGGCTGGAAAGGAGAGGAACAAAGCAGACAGATATGCCCTGGACTGCCAGGAGAAGGCATACTGGCTGGTGCACCGATG CCCTCCTGGAATGGACAATGTGCTGGACTACGGCCTGGACCGAGTGACCAATCCGAATGAAGTCAAGAAACAAACAGTCGTTGCTGTCAA AAAAGAGATCATGTATTACCAACAGGCCTTGATGAGGTCCACAGTGAAGTCTTCTGTGTCCCTGGGAGGGATTGTGAAATACAGTGAGCA GTTCTCATCCAACGATGCCATCATGTCAGGCTGCCTCCCCAGCAACCCCTGGATCACCGATGACACCCAGTTCTGGGACTTAAATGCCAA ATTGGTGGAAATCCCAACCAAGATGCGAGTGGAACGATGGGCCTTCAACTTCAGCGAATTGATCCGAGACCCCAAAGGTCGACAGAGCTT CCAGTACTTCCTCAAGAAAGAATTCAGTGGAGAGAATCTGGGATTCTGGGAAGCCTGCGAGGATCTGAAGTATGGAGATCAGTCCAAAGT CAAGGAGAAAGCAGAGGAGATTTACAAGCTGTTCCTGGCCCCGGGGGCGAGGCGCTGGATCAACATAGATGGCAAAACCATGGACATCAC AGTGAAGGGGCTGAAGCACCCCCACCGCTATGTGCTGGACGCCGCACAAACCCACATTTACATGCTCATGAAGAAGGATTCTTATGCTCG CTATTTAAAATCTCCGATCTATAAGGACATGCTGGCCAAAGCTATTGAACCTCAGGAAACCACCAAGAAAAGCTCCACCCTCCCTTTTAT GCGGCGTCACCTGCGCTCCAGCCCAAGCCCTGTCATCCTGAGACAGCTGGAAGAGGAAGCCAAGGCCCGAGAAGCAGCCAACACTGTGGA CATCACCCAGCCGGGCCAGCACATGGCTCCCAGCCCCCATCTGACCGTGTACACCGGGACCTGCATGCCCCCGTCTCCTTCTAGCCCCTT CTCCTCCTCCTGCCGCTCCCCCAGGAAGCCTTTCGCCTCACCCAGCCGCTTCATCCGGCGACCCAGCACCACCATCTGCCCCTCACCCAT CAGAGTGGCCTTGGAGAGCTCATCGGGCTTGGAGCAGAAAGGGGAGTGCAGCGGGTCCATGGCCCCCCGTGGGCCCTCTGTCACCGAGAG CAGCGAGGCCTCCCTCGACACCTCCTGGCCTCGCAGCCGGCCCAGGGCCCCTCCTAAGGCCCGCATGGCTCTGTCCTTCAGCAGGTTTCT GAGACGAGGCTGTCTGGCCTCACCTGTCTTTGCCAGGCTCTCACCCAAGTGCCCTGCTGTGTCCCACGGGAGGGTGCAGCCCCTGGGGGA >In-frame_BTBD7_ENST00000554565_chr14_93799166_-_RGS9_ENST00000449996_chr17_63149540_+_2068nt ATGGCCGGGGGTGCTGGCGCCGGTGCGGACGGCGGTGCTGGTGGCGGCGGCGGCGGAGGCGACGGCAGCGGTCCCAGCGGCAGCAGCAGC GGCGGGAGGAGCCTCCGGGATTGAAGCGCTCGTGAAGGACATGCAGAACCCAGAGACAGGGGTCCGAATGCAGAACCAGAGGGTCCTGGT CACCAGCGTTCCTCATGCCATGACAGGAAGTGATGTTCTGCAATGGATCGTCCAGCGGCTTTGGATCTCCAGTCTGGAGGCACAGAACTT GGGCAACTTTATTGTCAGGTATGGCTACATTTACCCCCTGCAAGACCCCAAGAATCTCATTCTCAAGCCTGATGGCAGCCTCTACAGATT TCAGACACCGTATTTCTGGCCCACCCAGCAGTGGCCAGCTGAAGATACCGATTACGCCATCTATCTGGCCAAGCGAAATATCAAAAAGAA AGGGATTTTGGAAGAATATGAAAAGGAAAATTACAATTTCTTGAACCAAAAAATGAACTATAAGTGGGACTTTGTCATTATGCAGGCCAA AGAGCAGTACAGGGCTGGAAAGGAGAGGAACAAAGCAGACAGATATGCCCTGGACTGCCAGGAGAAGGCATACTGGCTGGTGCACCGATG CCCTCCTGGAATGGACAATGTGCTGGACTACGGCCTGGACCGAGTGACCAATCCGAATGAAGTCAAGAAACAAACAGTCGTTGCTGTCAA AAAAGAGATCATGTATTACCAACAGGCCTTGATGAGGTCCACAGTGAAGTCTTCTGTGTCCCTGGGAGGGATTGTGAAATACAGTGAGCA GTTCTCATCCAACGATGCCATCATGTCAGGCTGCCTCCCCAGCAACCCCTGGATCACCGATGACACCCAGTTCTGGGACTTAAATGCCAA ATTGGTGGAAATCCCAACCAAGATGCGAGTGGAACGATGGGCCTTCAACTTCAGCGAATTGATCCGAGACCCCAAAGGTCGACAGAGCTT CCAGTACTTCCTCAAGAAAGAATTCAGTGGAGAGAATCTGGGATTCTGGGAAGCCTGCGAGGATCTGAAGTATGGAGATCAGTCCAAAGT CAAGGAGAAAGCAGAGGAGATTTACAAGCTGTTCCTGGCCCCGGGGGCGAGGCGCTGGATCAACATAGATGGCAAAACCATGGACATCAC AGTGAAGGGGCTGAAGCACCCCCACCGCTATGTGCTGGACGCCGCACAAACCCACATTTACATGCTCATGAAGAAGGATTCTTATGCTCG CTATTTAAAATCTCCGATCTATAAGGACATGCTGGCCAAAGCTATTGAACCTCAGGAAACCACCAAGAAAAGCTCCACCCTCCCTTTTAT GCGGCGTCACCTGCGCTCCAGCCCAAGCCCTGTCATCCTGAGACAGCTGGAAGAGGAAGCCAAGGCCCGAGAAGCAGCCAACACTGTGGA CATCACCCAGCCGGGCCAGCACATGGCTCCCAGCCCCCATCTGACCGTGTACACCGGGACCTGCATGCCCCCGTCTCCTTCTAGCCCCTT CTCCTCCTCCTGCCGCTCCCCCAGGAAGCCTTTCGCCTCACCCAGCCGCTTCATCCGGCGACCCAGCACCACCATCTGCCCCTCACCCAT CAGAGTGGCCTTGGAGAGCTCATCGGGCTTGGAGCAGAAAGGGGAGTGCAGCGGGTCCATGGCCCCCCGTGGGCCCTCTGTCACCGAGAG CAGCGAGGCCTCCCTCGACACCTCCTGGCCTCGCAGCCGGCCCAGGGCCCCTCCTAAGGCCCGCATGGCTCTGTCCTTCAGCAGGTTTCT GAGACGAGGCTGTCTGGCCTCACCTGTCTTTGCCAGGCTCTCACCCAAGTGCCCTGCTGTGTCCCACGGGAGGGTGCAGCCCCTGGGGGA CGTGGGCCAGCAGCTGCCACGATTGAAATCCAAGAGAGTAGCAAACTTTTTCCAGATCAAAATGGATGTGCCCACGGGGAGCGGGACCTG >In-frame_BTBD7_ENST00000554565_chr14_93799166_-_RGS9_ENST00000262406_chr17_63149540_+_2077nt ATGGCCGGGGGTGCTGGCGCCGGTGCGGACGGCGGTGCTGGTGGCGGCGGCGGCGGAGGCGACGGCAGCGGTCCCAGCGGCAGCAGCAGC GGCGGGAGGAGCCTCCGGGATTGAAGCGCTCGTGAAGGACATGCAGAACCCAGAGACAGGGGTCCGAATGCAGAACCAGAGGGTCCTGGT CACCAGCGTTCCTCATGCCATGACAGGAAGTGATGTTCTGCAATGGATCGTCCAGCGGCTTTGGATCTCCAGTCTGGAGGCACAGAACTT GGGCAACTTTATTGTCAGGTATGGCTACATTTACCCCCTGCAAGACCCCAAGAATCTCATTCTCAAGCCTGATGGCAGCCTCTACAGATT TCAGACACCGTATTTCTGGCCCACCCAGCAGTGGCCAGCTGAAGATACCGATTACGCCATCTATCTGGCCAAGCGAAATATCAAAAAGAA AGGGATTTTGGAAGAATATGAAAAGGAAAATTACAATTTCTTGAACCAAAAAATGAACTATAAGTGGGACTTTGTCATTATGCAGGCCAA AGAGCAGTACAGGGCTGGAAAGGAGAGGAACAAAGCAGACAGATATGCCCTGGACTGCCAGGAGAAGGCATACTGGCTGGTGCACCGATG CCCTCCTGGAATGGACAATGTGCTGGACTACGGCCTGGACCGAGTGACCAATCCGAATGAAGTCAAGGTAAACCAGAAACAAACAGTCGT TGCTGTCAAAAAAGAGATCATGTATTACCAACAGGCCTTGATGAGGTCCACAGTGAAGTCTTCTGTGTCCCTGGGAGGGATTGTGAAATA CAGTGAGCAGTTCTCATCCAACGATGCCATCATGTCAGGCTGCCTCCCCAGCAACCCCTGGATCACCGATGACACCCAGTTCTGGGACTT AAATGCCAAATTGGTGGAAATCCCAACCAAGATGCGAGTGGAACGATGGGCCTTCAACTTCAGCGAATTGATCCGAGACCCCAAAGGTCG ACAGAGCTTCCAGTACTTCCTCAAGAAAGAATTCAGTGGAGAGAATCTGGGATTCTGGGAAGCCTGCGAGGATCTGAAGTATGGAGATCA GTCCAAAGTCAAGGAGAAAGCAGAGGAGATTTACAAGCTGTTCCTGGCCCCGGGGGCGAGGCGCTGGATCAACATAGATGGCAAAACCAT GGACATCACAGTGAAGGGGCTGAAGCACCCCCACCGCTATGTGCTGGACGCCGCACAAACCCACATTTACATGCTCATGAAGAAGGATTC TTATGCTCGCTATTTAAAATCTCCGATCTATAAGGACATGCTGGCCAAAGCTATTGAACCTCAGGAAACCACCAAGAAAAGCTCCACCCT CCCTTTTATGCGGCGTCACCTGCGCTCCAGCCCAAGCCCTGTCATCCTGAGACAGCTGGAAGAGGAAGCCAAGGCCCGAGAAGCAGCCAA CACTGTGGACATCACCCAGCCGGGCCAGCACATGGCTCCCAGCCCCCATCTGACCGTGTACACCGGGACCTGCATGCCCCCGTCTCCTTC TAGCCCCTTCTCCTCCTCCTGCCGCTCCCCCAGGAAGCCTTTCGCCTCACCCAGCCGCTTCATCCGGCGACCCAGCACCACCATCTGCCC CTCACCCATCAGAGTGGCCTTGGAGAGCTCATCGGGCTTGGAGCAGAAAGGGGAGTGCAGCGGGTCCATGGCCCCCCGTGGGCCCTCTGT CACCGAGAGCAGCGAGGCCTCCCTCGACACCTCCTGGCCTCGCAGCCGGCCCAGGGCCCCTCCTAAGGCCCGCATGGCTCTGTCCTTCAG CAGGTTTCTGAGACGAGGCTGTCTGGCCTCACCTGTCTTTGCCAGGCTCTCACCCAAGTGCCCTGCTGTGTCCCACGGGAGGGTGCAGCC CCTGGGGGACGTGGGCCAGCAGCTGCCACGATTGAAATCCAAGAGAGTAGCAAACTTTTTCCAGATCAAAATGGATGTGCCCACGGGGAG CGGGACCTGCTTGATGGACTCGGAGGATGCTGGAACAGGAGAGTCGGGTGACCGGGCCACAGAAAAGGAGGTCATCTGCCCCTGGGAGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BTBD7_ENST00000554565_chr14_93799166_-_RGS9_ENST00000443584_chr17_63149540_+_2148nt CTCCTGCTCCGTCTAGGAGTCAAAATGGCGGCGAGGGGAACCTGGAGCAGTCCCGGAGCCTGAGCCACTGACAGGAGAGGAGAGGGCGGC GGCGGCGGCGGTGGGAGGAGGATGGCCGGGGGTGCTGGCGCCGGTGCGGACGGCGGTGCTGGTGGCGGCGGCGGCGGAGGCGACGGCAGC GGTCCCAGCGGCAGCAGCAGCGGCGGGAGGAGCCTCCGGGATTGAAGCGCTCGTGAAGGACATGCAGAACCCAGAGACAGGGGTCCGAAT GCAGAACCAGAGGGTCCTGGTCACCAGCGTTCCTCATGCCATGACAGGAAGTGATGTTCTGCAATGGATCGTCCAGCGGCTTTGGATCTC CAGTCTGGAGGCACAGAACTTGGGCAACTTTATTGTCAGGTATGGCTACATTTACCCCCTGCAAGACCCCAAGAATCTCATTCTCAAGCC TGATGGCAGCCTCTACAGATTTCAGACACCGTATTTCTGGCCCACCCAGCAGTGGCCAGCTGAAGATACCGATTACGCCATCTATCTGGC CAAGCGAAATATCAAAAAGAAAGGGATTTTGGAAGAATATGAAAAGGAAAATTACAATTTCTTGAACCAAAAAATGAACTATAAGTGGGA CTTTGTCATTATGCAGGCCAAAGAGCAGTACAGGGCTGGAAAGGAGAGGAACAAAGCAGACAGATATGCCCTGGACTGCCAGGAGAAGGC ATACTGGCTGGTGCACCGATGCCCTCCTGGAATGGACAATGTGCTGGACTACGGCCTGGACCGAGTGACCAATCCGAATGAAGTCAAGAA ACAAACAGTCGTTGCTGTCAAAAAAGAGATCATGTATTACCAACAGGCCTTGATGAGGTCCACAGTGAAGTCTTCTGTGTCCCTGGGAGG GATTGTGAAATACAGTGAGCAGTTCTCATCCAACGATGCCATCATGTCAGGCTGCCTCCCCAGCAACCCCTGGATCACCGATGACACCCA GTTCTGGGACTTAAATGCCAAATTGGTGGAAATCCCAACCAAGATGCGAGTGGAACGATGGGCCTTCAACTTCAGCGAATTGATCCGAGA CCCCAAAGGTCGACAGAGCTTCCAGTACTTCCTCAAGAAAGAATTCAGTGGAGAGAATCTGGGATTCTGGGAAGCCTGCGAGGATCTGAA GTATGGAGATCAGTCCAAAGTCAAGGAGAAAGCAGAGGAGATTTACAAGCTGTTCCTGGCCCCGGGGGCGAGGCGCTGGATCAACATAGA TGGCAAAACCATGGACATCACAGTGAAGGGGCTGAAGCACCCCCACCGCTATGTGCTGGACGCCGCACAAACCCACATTTACATGCTCAT GAAGAAGGATTCTTATGCTCGCTATTTAAAATCTCCGATCTATAAGGACATGCTGGCCAAAGCTATTGAACCTCAGGAAACCACCAAGAA AAGCTCCACCCTCCCTTTTATGCGGCGTCACCTGCGCTCCAGCCCAAGCCCTGTCATCCTGAGACAGCTGGAAGAGGAAGCCAAGGCCCG AGAAGCAGCCAACACTGTGGACATCACCCAGCCGGGCCAGCACATGGCTCCCAGCCCCCATCTGACCGTGTACACCGGGACCTGCATGCC CCCGTCTCCTTCTAGCCCCTTCTCCTCCTCCTGCCGCTCCCCCAGGAAGCCTTTCGCCTCACCCAGCCGCTTCATCCGGCGACCCAGCAC CACCATCTGCCCCTCACCCATCAGAGTGGCCTTGGAGAGCTCATCGGGCTTGGAGCAGAAAGGGGAGTGCAGCGGGTCCATGGCCCCCCG TGGGCCCTCTGTCACCGAGAGCAGCGAGGCCTCCCTCGACACCTCCTGGCCTCGCAGCCGGCCCAGGGCCCCTCCTAAGGCCCGCATGGC TCTGTCCTTCAGCAGGTTTCTGAGACGAGGCTGTCTGGCCTCACCTGTCTTTGCCAGGCTCTCACCCAAGTGCCCTGCTGTGTCCCACGG GAGGGTGCAGCCCCTGGGGGACGTGGGCCAGCAGCTGCCACGATTGAAATCCAAGAGAGTAGCAAAGTAAGAACCCGAAGGGGACGTGCC >In-frame_BTBD7_ENST00000554565_chr14_93799166_-_RGS9_ENST00000449996_chr17_63149540_+_2475nt CTCCTGCTCCGTCTAGGAGTCAAAATGGCGGCGAGGGGAACCTGGAGCAGTCCCGGAGCCTGAGCCACTGACAGGAGAGGAGAGGGCGGC GGCGGCGGCGGTGGGAGGAGGATGGCCGGGGGTGCTGGCGCCGGTGCGGACGGCGGTGCTGGTGGCGGCGGCGGCGGAGGCGACGGCAGC GGTCCCAGCGGCAGCAGCAGCGGCGGGAGGAGCCTCCGGGATTGAAGCGCTCGTGAAGGACATGCAGAACCCAGAGACAGGGGTCCGAAT GCAGAACCAGAGGGTCCTGGTCACCAGCGTTCCTCATGCCATGACAGGAAGTGATGTTCTGCAATGGATCGTCCAGCGGCTTTGGATCTC CAGTCTGGAGGCACAGAACTTGGGCAACTTTATTGTCAGGTATGGCTACATTTACCCCCTGCAAGACCCCAAGAATCTCATTCTCAAGCC TGATGGCAGCCTCTACAGATTTCAGACACCGTATTTCTGGCCCACCCAGCAGTGGCCAGCTGAAGATACCGATTACGCCATCTATCTGGC CAAGCGAAATATCAAAAAGAAAGGGATTTTGGAAGAATATGAAAAGGAAAATTACAATTTCTTGAACCAAAAAATGAACTATAAGTGGGA CTTTGTCATTATGCAGGCCAAAGAGCAGTACAGGGCTGGAAAGGAGAGGAACAAAGCAGACAGATATGCCCTGGACTGCCAGGAGAAGGC ATACTGGCTGGTGCACCGATGCCCTCCTGGAATGGACAATGTGCTGGACTACGGCCTGGACCGAGTGACCAATCCGAATGAAGTCAAGAA ACAAACAGTCGTTGCTGTCAAAAAAGAGATCATGTATTACCAACAGGCCTTGATGAGGTCCACAGTGAAGTCTTCTGTGTCCCTGGGAGG GATTGTGAAATACAGTGAGCAGTTCTCATCCAACGATGCCATCATGTCAGGCTGCCTCCCCAGCAACCCCTGGATCACCGATGACACCCA GTTCTGGGACTTAAATGCCAAATTGGTGGAAATCCCAACCAAGATGCGAGTGGAACGATGGGCCTTCAACTTCAGCGAATTGATCCGAGA CCCCAAAGGTCGACAGAGCTTCCAGTACTTCCTCAAGAAAGAATTCAGTGGAGAGAATCTGGGATTCTGGGAAGCCTGCGAGGATCTGAA GTATGGAGATCAGTCCAAAGTCAAGGAGAAAGCAGAGGAGATTTACAAGCTGTTCCTGGCCCCGGGGGCGAGGCGCTGGATCAACATAGA TGGCAAAACCATGGACATCACAGTGAAGGGGCTGAAGCACCCCCACCGCTATGTGCTGGACGCCGCACAAACCCACATTTACATGCTCAT GAAGAAGGATTCTTATGCTCGCTATTTAAAATCTCCGATCTATAAGGACATGCTGGCCAAAGCTATTGAACCTCAGGAAACCACCAAGAA AAGCTCCACCCTCCCTTTTATGCGGCGTCACCTGCGCTCCAGCCCAAGCCCTGTCATCCTGAGACAGCTGGAAGAGGAAGCCAAGGCCCG AGAAGCAGCCAACACTGTGGACATCACCCAGCCGGGCCAGCACATGGCTCCCAGCCCCCATCTGACCGTGTACACCGGGACCTGCATGCC CCCGTCTCCTTCTAGCCCCTTCTCCTCCTCCTGCCGCTCCCCCAGGAAGCCTTTCGCCTCACCCAGCCGCTTCATCCGGCGACCCAGCAC CACCATCTGCCCCTCACCCATCAGAGTGGCCTTGGAGAGCTCATCGGGCTTGGAGCAGAAAGGGGAGTGCAGCGGGTCCATGGCCCCCCG TGGGCCCTCTGTCACCGAGAGCAGCGAGGCCTCCCTCGACACCTCCTGGCCTCGCAGCCGGCCCAGGGCCCCTCCTAAGGCCCGCATGGC TCTGTCCTTCAGCAGGTTTCTGAGACGAGGCTGTCTGGCCTCACCTGTCTTTGCCAGGCTCTCACCCAAGTGCCCTGCTGTGTCCCACGG GAGGGTGCAGCCCCTGGGGGACGTGGGCCAGCAGCTGCCACGATTGAAATCCAAGAGAGTAGCAAACTTTTTCCAGATCAAAATGGATGT GCCCACGGGGAGCGGGACCTGCTTGATGGACTCGGAGGATGCTGGAACAGGAGAGTCGGGTGACCGGGCCACAGAAAAGGAGGTCATCTG CCCCTGGGAGAGCCTGTAAGGAAAGAGGCAGGCTGAGCTGGGGGCTCTGGACCAGGAAGATGCTCTGACAGATGCCATGGTATGGGCCAC AGGACACACTTGCTCGAGAACCAAAGTGCATTTGGGTGACATTTGAAGATTGGGGAGACAAGATGGGGTAGATTGTGGCAAAGAATGCTC TGGCTGGTTACCAGGGGCCAACTCCTTCTCCTCTTCCTGACCCTCCCTCCCCTGGGCAGAAGAAACGCATGTGGACCAGAAGACTTTCCC >In-frame_BTBD7_ENST00000554565_chr14_93799166_-_RGS9_ENST00000262406_chr17_63149540_+_2471nt CTCCTGCTCCGTCTAGGAGTCAAAATGGCGGCGAGGGGAACCTGGAGCAGTCCCGGAGCCTGAGCCACTGACAGGAGAGGAGAGGGCGGC GGCGGCGGCGGTGGGAGGAGGATGGCCGGGGGTGCTGGCGCCGGTGCGGACGGCGGTGCTGGTGGCGGCGGCGGCGGAGGCGACGGCAGC GGTCCCAGCGGCAGCAGCAGCGGCGGGAGGAGCCTCCGGGATTGAAGCGCTCGTGAAGGACATGCAGAACCCAGAGACAGGGGTCCGAAT GCAGAACCAGAGGGTCCTGGTCACCAGCGTTCCTCATGCCATGACAGGAAGTGATGTTCTGCAATGGATCGTCCAGCGGCTTTGGATCTC CAGTCTGGAGGCACAGAACTTGGGCAACTTTATTGTCAGGTATGGCTACATTTACCCCCTGCAAGACCCCAAGAATCTCATTCTCAAGCC TGATGGCAGCCTCTACAGATTTCAGACACCGTATTTCTGGCCCACCCAGCAGTGGCCAGCTGAAGATACCGATTACGCCATCTATCTGGC CAAGCGAAATATCAAAAAGAAAGGGATTTTGGAAGAATATGAAAAGGAAAATTACAATTTCTTGAACCAAAAAATGAACTATAAGTGGGA CTTTGTCATTATGCAGGCCAAAGAGCAGTACAGGGCTGGAAAGGAGAGGAACAAAGCAGACAGATATGCCCTGGACTGCCAGGAGAAGGC ATACTGGCTGGTGCACCGATGCCCTCCTGGAATGGACAATGTGCTGGACTACGGCCTGGACCGAGTGACCAATCCGAATGAAGTCAAGGT AAACCAGAAACAAACAGTCGTTGCTGTCAAAAAAGAGATCATGTATTACCAACAGGCCTTGATGAGGTCCACAGTGAAGTCTTCTGTGTC CCTGGGAGGGATTGTGAAATACAGTGAGCAGTTCTCATCCAACGATGCCATCATGTCAGGCTGCCTCCCCAGCAACCCCTGGATCACCGA TGACACCCAGTTCTGGGACTTAAATGCCAAATTGGTGGAAATCCCAACCAAGATGCGAGTGGAACGATGGGCCTTCAACTTCAGCGAATT GATCCGAGACCCCAAAGGTCGACAGAGCTTCCAGTACTTCCTCAAGAAAGAATTCAGTGGAGAGAATCTGGGATTCTGGGAAGCCTGCGA GGATCTGAAGTATGGAGATCAGTCCAAAGTCAAGGAGAAAGCAGAGGAGATTTACAAGCTGTTCCTGGCCCCGGGGGCGAGGCGCTGGAT CAACATAGATGGCAAAACCATGGACATCACAGTGAAGGGGCTGAAGCACCCCCACCGCTATGTGCTGGACGCCGCACAAACCCACATTTA CATGCTCATGAAGAAGGATTCTTATGCTCGCTATTTAAAATCTCCGATCTATAAGGACATGCTGGCCAAAGCTATTGAACCTCAGGAAAC CACCAAGAAAAGCTCCACCCTCCCTTTTATGCGGCGTCACCTGCGCTCCAGCCCAAGCCCTGTCATCCTGAGACAGCTGGAAGAGGAAGC CAAGGCCCGAGAAGCAGCCAACACTGTGGACATCACCCAGCCGGGCCAGCACATGGCTCCCAGCCCCCATCTGACCGTGTACACCGGGAC CTGCATGCCCCCGTCTCCTTCTAGCCCCTTCTCCTCCTCCTGCCGCTCCCCCAGGAAGCCTTTCGCCTCACCCAGCCGCTTCATCCGGCG ACCCAGCACCACCATCTGCCCCTCACCCATCAGAGTGGCCTTGGAGAGCTCATCGGGCTTGGAGCAGAAAGGGGAGTGCAGCGGGTCCAT GGCCCCCCGTGGGCCCTCTGTCACCGAGAGCAGCGAGGCCTCCCTCGACACCTCCTGGCCTCGCAGCCGGCCCAGGGCCCCTCCTAAGGC CCGCATGGCTCTGTCCTTCAGCAGGTTTCTGAGACGAGGCTGTCTGGCCTCACCTGTCTTTGCCAGGCTCTCACCCAAGTGCCCTGCTGT GTCCCACGGGAGGGTGCAGCCCCTGGGGGACGTGGGCCAGCAGCTGCCACGATTGAAATCCAAGAGAGTAGCAAACTTTTTCCAGATCAA AATGGATGTGCCCACGGGGAGCGGGACCTGCTTGATGGACTCGGAGGATGCTGGAACAGGAGAGTCGGGTGACCGGGCCACAGAAAAGGA GGTCATCTGCCCCTGGGAGAGCCTGTAAGGAAAGAGGCAGGCTGAGCTGGGGGCTCTGGACCAGGAAGATGCTCTGACAGATGCCATGGT ATGGGCCACAGGACACACTTGCTCGAGAACCAAAGTGCATTTGGGTGACATTTGAAGATTGGGGAGACAAGATGGGGTAGATTGTGGCAA AGAATGCTCTGGCTGGTTACCAGGGGCCAACTCCTTCTCCTCTTCCTGACCCTCCCTCCCCTGGGCAGAAGAAACGCATGTGGACCAGAA |
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FusionGenePPI for BTBD7_RGS9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BTBD7 | CUL3, XPO1 | RGS9 | RGS7BP, GNB5, RGS9BP, GNAO1, ADRB2, PRPF40B, RBM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BTBD7_RGS9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BTBD7_RGS9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | RGS9 | C0013386 | Dyskinesia, Drug-Induced | 2 | CTD_human |
| Tgene | RGS9 | C0033941 | Psychoses, Substance-Induced | 1 | CTD_human |
| Tgene | RGS9 | C0036341 | Schizophrenia | 1 | CTD_human |
| Tgene | RGS9 | C1842073 | Prolonged Electroretinal Response Suppression | 1 | CTD_human;HPO;ORPHANET;UNIPROT |
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