|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 453 |
FusionGeneSummary for ACP6_PIAS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACP6_PIAS3 | Fusion gene ID: 453 | Hgene | Tgene | Gene symbol | ACP6 | PIAS3 | Gene ID | 51205 | 10401 |
| Gene name | acid phosphatase 6, lysophosphatidic | protein inhibitor of activated STAT 3 | |
| Synonyms | ACPL1|LPAP|PACPL1 | ZMIZ5 | |
| Cytomap | 1q21.2 | 1q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysophosphatidic acid phosphatase type 6acid phosphatase-like protein 1 | E3 SUMO-protein ligase PIAS3E3 SUMO-protein transferase PIAS3protein inhibitor of activated STAT protein 3zinc finger, MIZ-type containing 5 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9NPH0 | Q9Y6X2 | |
| Ensembl transtripts involved in fusion gene | ENST00000369238, ENST00000460583, ENST00000392988, | ENST00000369299, ENST00000393045, ENST00000369298, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 2 X 3=18 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ACP6 [Title/Abstract] AND PIAS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACP6 | GO:2001311 | lysobisphosphatidic acid metabolic process | 23807634 |
| Tgene | PIAS3 | GO:0033234 | negative regulation of protein sumoylation | 24651376 |
| Tgene | PIAS3 | GO:0033235 | positive regulation of protein sumoylation | 17696781|21965678 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-AB3A-01A | ACP6 | chr1 | 147141952 | - | PIAS3 | chr1 | 145578062 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000369238 | ENST00000369299 | ACP6 | chr1 | 147141952 | - | PIAS3 | chr1 | 145578062 | + |
| 5CDS-5UTR | ENST00000369238 | ENST00000393045 | ACP6 | chr1 | 147141952 | - | PIAS3 | chr1 | 145578062 | + |
| 5CDS-5UTR | ENST00000369238 | ENST00000369298 | ACP6 | chr1 | 147141952 | - | PIAS3 | chr1 | 145578062 | + |
| intron-5UTR | ENST00000460583 | ENST00000369299 | ACP6 | chr1 | 147141952 | - | PIAS3 | chr1 | 145578062 | + |
| intron-5UTR | ENST00000460583 | ENST00000393045 | ACP6 | chr1 | 147141952 | - | PIAS3 | chr1 | 145578062 | + |
| intron-5UTR | ENST00000460583 | ENST00000369298 | ACP6 | chr1 | 147141952 | - | PIAS3 | chr1 | 145578062 | + |
| 5CDS-5UTR | ENST00000392988 | ENST00000369299 | ACP6 | chr1 | 147141952 | - | PIAS3 | chr1 | 145578062 | + |
| 5CDS-5UTR | ENST00000392988 | ENST00000393045 | ACP6 | chr1 | 147141952 | - | PIAS3 | chr1 | 145578062 | + |
| 5CDS-5UTR | ENST00000392988 | ENST00000369298 | ACP6 | chr1 | 147141952 | - | PIAS3 | chr1 | 145578062 | + |
Top |
FusionProtFeatures for ACP6_PIAS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACP6 | PIAS3 |
| Hydrolyzes lysophosphatidic acid (LPA) containing amedium length fatty acid chain to the correspondingmonoacylglycerol. Has highest activity with lysophosphatidic acidcontaining myristate (C14:0), monounsaturated oleate (C18:1) orpalmitate (C16:0), and lower activity with C18:0 and C6:0lysophosphatidic acid. {ECO:0000269|PubMed:10506173,ECO:0000269|PubMed:23807634}. | Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and thesubstrate, and as a SUMO-tethering factor. Plays a crucial role asa transcriptional coregulation in various cellular pathways,including the STAT pathway and the steroid hormone signalingpathway. Involved in regulating STAT3 signaling via inhibitingSTAT3 DNA-binding and suppressing cell growth. Enhances thesumoylation of MTA1 and may participate in its paralog-selectivesumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2which promotes its interaction with SIRT1 (PubMed:25406032).Diminishes the sumoylation of ZFHX3 by preventing thecolocalization of ZFHX3 with SUMO1 in the nucleus(PubMed:24651376). {ECO:0000269|PubMed:21965678,ECO:0000269|PubMed:24651376, ECO:0000269|PubMed:25406032,ECO:0000269|PubMed:9388184}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ACP6_PIAS3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ACP6_PIAS3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ACP6 | ILK, RGS10, RSU1, DHX36, DHCR7, LIMS1, ERH, SLC35F6, GNG7, FAM9B, ACP6, NME4, STOML2, ECH1, CYCS, NRD1, PMPCB, PMPCA, ACN9, BOLA3, C1QBP | PIAS3 | MITF, RELA, GFI1, SMAD2, SMAD3, SMAD4, EP300, CREBBP, HMGA2, STAT3, AR, TRIM32, SIAH2, SIAH1, ZMIZ2, ZMIZ1, UBE2I, SREBF2, GLUL, HABP4, TRIM27, SATB1, CARHSP1, UBA1, PSMC1, C19orf60, TRIM8, RAC1, PPP1CA, ELAVL1, ERBB4, SUMO1, SUMO2, SERBP1, HNRNPK, ZFHX3, PRPF40A, SKIL, NCOA2, CREM, SERPINA10, GEMIN4, SUMO3, CBS, TAB2, TRIM63, TRIM55, HIC1, BCL11A, SMURF2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ACP6_PIAS3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ACP6_PIAS3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PIAS3 | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|