FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 4510

FusionGeneSummary for BTBD10_IPO5

check button Fusion gene summary
Fusion gene informationFusion gene name: BTBD10_IPO5
Fusion gene ID: 4510
HgeneTgene
Gene symbol

BTBD10

IPO5

Gene ID

84280

3843

Gene nameBTB domain containing 10importin 5
SynonymsGMRP-1|GMRP1IMB3|KPNB3|Pse1|RANBP5|imp5
Cytomap

11p15.3

13q32.2

Type of geneprotein-codingprotein-coding
DescriptionBTB/POZ domain-containing protein 10BTB (POZ) domain containing 10BTB (broad-complex tramtrack and bric-a-brac/pox virus and zinc finger) domain-containing protein 10K+ channel tetramerization proteinglucose metabolism-related protein 1importin-5RAN binding protein 5Ran_GTP binding protein 5importin beta-3 subunitimportin subunit beta-3karyopherin (importin) beta 3karyopherin beta-3ran-binding protein 5
Modification date2018051920180523
UniProtAcc

Q9BSF8

O00410

Ensembl transtripts involved in fusion geneENST00000278174, ENST00000530907, 
ENST00000528120, ENST00000532261, 
ENST00000261574, ENST00000490680, 
ENST00000539640, ENST00000493492, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 8 X 3=120
# samples 410
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/120*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BTBD10 [Title/Abstract] AND IPO5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIPO5

GO:0006610

ribosomal protein import into nucleus

9687515


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW606752BTBD10chr11

13441257

-IPO5chr13

98655029

-
ChiTaRS3.1AW606637BTBD10chr11

13441257

-IPO5chr13

98655029

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000278174ENST00000261574BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000278174ENST00000490680BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000278174ENST00000539640BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000278174ENST00000493492BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000530907ENST00000261574BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000530907ENST00000490680BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000530907ENST00000539640BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000530907ENST00000493492BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000528120ENST00000261574BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000528120ENST00000490680BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000528120ENST00000539640BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000528120ENST00000493492BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000532261ENST00000261574BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000532261ENST00000490680BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000532261ENST00000539640BTBD10chr11

13441257

-IPO5chr13

98655029

-
intron-intronENST00000532261ENST00000493492BTBD10chr11

13441257

-IPO5chr13

98655029

-

Top

FusionProtFeatures for BTBD10_IPO5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BTBD10

Q9BSF8

IPO5

O00410

Plays a major role as an activator of AKT family membersby inhibiting PPP2CA-mediated dephosphorylation, thereby keepingAKTs activated. Plays a role in preventing motor neuronal deathand accelerating the growth of pancreatic beta cells.{ECO:0000250|UniProtKB:Q80X66}. Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of theimportin/substrate complex to the nuclear pore complex (NPC)through binding to nucleoporin and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Mediates the nuclear import of ribosomalproteins RPL23A, RPS7 and RPL5. Binds to a beta-like importreceptor binding (BIB) domain of RPL23A. In vitro, mediatesnuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 andmediates its nuclear import following neuronal stimulation (Bysimilarity). In case of HIV-1 infection, binds and mediates thenuclear import of HIV-1 Rev. {ECO:0000250|UniProtKB:Q8BKC5,ECO:0000269|PubMed:9687515}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BTBD10_IPO5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BTBD10_IPO5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BTBD10_IPO5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for BTBD10_IPO5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIPO5C0036341Schizophrenia4PSYGENET