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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4502

FusionGeneSummary for BSN_BSN

check button Fusion gene summary
Fusion gene informationFusion gene name: BSN_BSN
Fusion gene ID: 4502
HgeneTgene
Gene symbol

BSN

BSN

Gene ID

8927

8927

Gene namebassoon presynaptic cytomatrix proteinbassoon presynaptic cytomatrix protein
SynonymsZNF231ZNF231
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionprotein bassoonneuronal double zinc finger proteinzinc finger protein 231protein bassoonneuronal double zinc finger proteinzinc finger protein 231
Modification date2018051920180519
UniProtAcc

Q9UPA5

Q9UPA5

Ensembl transtripts involved in fusion geneENST00000296452, ENST00000296452, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 1=4
# samples 33
** MAII scorelog2(3/8*10)=1.90689059560852log2(3/4*10)=2.90689059560852
Context

PubMed: BSN [Title/Abstract] AND BSN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T08000BSNchr3

49706277

-BSNchr3

49706105

+
ChiTaRS3.1T33228BSNchr3

49706277

-BSNchr3

49706105

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000296452ENST00000296452BSNchr3

49706277

-BSNchr3

49706105

+

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FusionProtFeatures for BSN_BSN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BSN

Q9UPA5

BSN

Q9UPA5

Is thought to be involved in the organization of thecytomatrix at the nerve terminals active zone (CAZ) whichregulates neurotransmitter release. Seems to act through bindingto ERC2/CAST1. Essential in regulated neurotransmitter releasefrom a subset of brain glutamatergic synapses. Involved in theformation of the retinal photoreceptor ribbon synapses (Bysimilarity). {ECO:0000250}. Is thought to be involved in the organization of thecytomatrix at the nerve terminals active zone (CAZ) whichregulates neurotransmitter release. Seems to act through bindingto ERC2/CAST1. Essential in regulated neurotransmitter releasefrom a subset of brain glutamatergic synapses. Involved in theformation of the retinal photoreceptor ribbon synapses (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BSN_BSN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BSN_BSN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BSN_BSN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BSN_BSN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBSNC0018799Heart Diseases1CTD_human
TgeneBSNC0018799Heart Diseases1CTD_human