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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4500

FusionGeneSummary for BSG_ZKSCAN1

check button Fusion gene summary
Fusion gene informationFusion gene name: BSG_ZKSCAN1
Fusion gene ID: 4500
HgeneTgene
Gene symbol

BSG

ZKSCAN1

Gene ID

682

7586

Gene namebasigin (Ok blood group)zinc finger with KRAB and SCAN domains 1
Synonyms5F7|CD147|EMMPRIN|EMPRIN|OK|TCSFKOX18|PHZ-37|ZNF139|ZNF36|ZSCAN33
Cytomap

19p13.3

7q22.1

Type of geneprotein-codingprotein-coding
DescriptionbasiginOK blood group antigencollagenase stimulatory factorextracellular matrix metalloproteinase inducerleukocyte activation antigen M6tumor cell-derived collagenase stimulatory factorzinc finger protein with KRAB and SCAN domains 1zinc finger protein 139zinc finger protein 36 (KOX 18)
Modification date2018052220180519
UniProtAcc

P35613

P17029

Ensembl transtripts involved in fusion geneENST00000346916, ENST00000545507, 
ENST00000333511, ENST00000353555, 
ENST00000574970, 
ENST00000324306, 
ENST00000426572, ENST00000535170, 
Fusion gene scores* DoF score11 X 9 X 7=6934 X 6 X 2=48
# samples 177
** MAII scorelog2(17/693*10)=-2.02732060599951
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/48*10)=0.54432051622381
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BSG [Title/Abstract] AND ZKSCAN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF819563BSGchr19

579499

-ZKSCAN1chr7

99613281

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000346916ENST00000324306BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000346916ENST00000426572BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000346916ENST00000535170BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000545507ENST00000324306BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000545507ENST00000426572BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000545507ENST00000535170BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000333511ENST00000324306BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000333511ENST00000426572BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000333511ENST00000535170BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000353555ENST00000324306BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000353555ENST00000426572BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000353555ENST00000535170BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000574970ENST00000324306BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000574970ENST00000426572BSGchr19

579499

-ZKSCAN1chr7

99613281

+
intron-5UTRENST00000574970ENST00000535170BSGchr19

579499

-ZKSCAN1chr7

99613281

+

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FusionProtFeatures for BSG_ZKSCAN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BSG

P35613

ZKSCAN1

P17029

Plays an important role in targeting the monocarboxylatetransporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 to the plasmamembrane. Plays pivotal roles in spermatogenesis, embryoimplantation, neural network formation and tumor progression.Stimulates adjacent fibroblasts to produce matrixmetalloproteinases (MMPS). Seems to be a receptor foroligomannosidic glycans. In vitro, promotes outgrowth ofastrocytic processes. {ECO:0000269|PubMed:17127621,ECO:0000269|PubMed:28666119}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BSG_ZKSCAN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BSG_ZKSCAN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BSG_ZKSCAN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BSG_ZKSCAN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBSGC0027626Neoplasm Invasiveness1CTD_human
HgeneBSGC0027627Neoplasm Metastasis1CTD_human
HgeneBSGC0027659Neoplasms, Experimental1CTD_human
HgeneBSGC0036341Schizophrenia1PSYGENET
HgeneBSGC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneBSGC2936350Plaque, Atherosclerotic1CTD_human