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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4488

FusionGeneSummary for BSDC1_YARS

check button Fusion gene summary
Fusion gene informationFusion gene name: BSDC1_YARS
Fusion gene ID: 4488
HgeneTgene
Gene symbol

BSDC1

YARS

Gene ID

55108

8565

Gene nameBSD domain containing 1tyrosyl-tRNA synthetase
Synonyms-CMTDIC|TYRRS|YRS|YTS
Cytomap

1p35.1

1p35.1

Type of geneprotein-codingprotein-coding
DescriptionBSD domain-containing protein 1tyrosine--tRNA ligase, cytoplasmictyrosine tRNA ligase 1, cytoplasmictyrosyl--tRNA ligasetyrosyl-tRNA synthetase, cytoplasmic
Modification date2018051920180523
UniProtAcc

Q9NW68

P54577

Ensembl transtripts involved in fusion geneENST00000455895, ENST00000413080, 
ENST00000341071, ENST00000526031, 
ENST00000419121, ENST00000446293, 
ENST00000463967, ENST00000449308, 
ENST00000469100, ENST00000373477, 
Fusion gene scores* DoF score5 X 5 X 4=1005 X 4 X 5=100
# samples 56
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BSDC1 [Title/Abstract] AND YARS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-C8-A26X-01ABSDC1chr1

32852380

-YARSchr1

33276658

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000455895ENST00000469100BSDC1chr1

32852380

-YARSchr1

33276658

-
5CDS-intronENST00000455895ENST00000373477BSDC1chr1

32852380

-YARSchr1

33276658

-
5CDS-intronENST00000413080ENST00000469100BSDC1chr1

32852380

-YARSchr1

33276658

-
5CDS-intronENST00000413080ENST00000373477BSDC1chr1

32852380

-YARSchr1

33276658

-
5CDS-intronENST00000341071ENST00000469100BSDC1chr1

32852380

-YARSchr1

33276658

-
5CDS-intronENST00000341071ENST00000373477BSDC1chr1

32852380

-YARSchr1

33276658

-
intron-intronENST00000526031ENST00000469100BSDC1chr1

32852380

-YARSchr1

33276658

-
intron-intronENST00000526031ENST00000373477BSDC1chr1

32852380

-YARSchr1

33276658

-
5CDS-intronENST00000419121ENST00000469100BSDC1chr1

32852380

-YARSchr1

33276658

-
5CDS-intronENST00000419121ENST00000373477BSDC1chr1

32852380

-YARSchr1

33276658

-
5CDS-intronENST00000446293ENST00000469100BSDC1chr1

32852380

-YARSchr1

33276658

-
5CDS-intronENST00000446293ENST00000373477BSDC1chr1

32852380

-YARSchr1

33276658

-
intron-intronENST00000463967ENST00000469100BSDC1chr1

32852380

-YARSchr1

33276658

-
intron-intronENST00000463967ENST00000373477BSDC1chr1

32852380

-YARSchr1

33276658

-
5CDS-intronENST00000449308ENST00000469100BSDC1chr1

32852380

-YARSchr1

33276658

-
5CDS-intronENST00000449308ENST00000373477BSDC1chr1

32852380

-YARSchr1

33276658

-

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FusionProtFeatures for BSDC1_YARS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BSDC1

Q9NW68

YARS

P54577

Catalyzes the attachment of tyrosine to tRNA(Tyr) in atwo-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BSDC1_YARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BSDC1_YARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BSDC1PHC2, KLC1, TMEM216, SERPINB13YARSARF6, SAP18, EIF1B, EIF6, CDK2, DYNC1H1, METTL16, XRCC5, FN1, VCAM1, ITGA4, NRD1, SARNP, HSPA8, ENO1, SHMT2, MOV10, NXF1, EGFR, ESR1, DDB1, G3BP2, HNRNPH2, NAA10, NAA15, PROSC, TATDN1, ACTB, ACTG1, AHNAK, CLUH, CPOX, EEF1A1, SNRPA, WDR48, YARS2, NTRK1, PPP2R2A, SORT1, FOXB1, FOXH1, FOXI2, FOXL1, FOXL2, FOXQ1, MCM2, TRIM5, GTF2E2, DLD, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BSDC1_YARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BSDC1_YARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneYARSC1842237Charcot-Marie-Tooth Disease, Dominant Intermediate C1CTD_human;ORPHANET;UNIPROT