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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4469

FusionGeneSummary for BRWD1_GSS

check button Fusion gene summary
Fusion gene informationFusion gene name: BRWD1_GSS
Fusion gene ID: 4469
HgeneTgene
Gene symbol

BRWD1

GSS

Gene ID

54014

5621

Gene namebromodomain and WD repeat domain containing 1prion protein
SynonymsC21orf107|DCAF19|N143|WDR9|WRD9ASCR|AltPrP|CD230|CJD|GSS|KURU|PRIP|PrP|PrP27-30|PrP33-35C|PrPc|p27-30
Cytomap

21q22.2

20p13

Type of geneprotein-codingprotein-coding
Descriptionbromodomain and WD repeat-containing protein 1WD repeat protein WDR9-form2WD repeat-containing protein 9transcriptional unit N143major prion proteinalternative prion proteinCD230 antigenprion-related protein
Modification date2018052320180522
UniProtAcc

Q9NSI6

P48637

Ensembl transtripts involved in fusion geneENST00000333229, ENST00000342449, 
ENST00000380800, ENST00000341322, 
ENST00000470108, 
ENST00000216951, 
ENST00000541098, ENST00000451957, 
Fusion gene scores* DoF score14 X 13 X 8=14567 X 7 X 3=147
# samples 158
** MAII scorelog2(15/1456*10)=-3.27897594970282
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRWD1 [Title/Abstract] AND GSS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGSS

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

22820466

TgeneGSS

GO:0071280

cellular response to copper ion

16254249


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW373865BRWD1chr21

40558924

-GSSchr20

33516721

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000333229ENST00000216951BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000333229ENST00000541098BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000333229ENST00000451957BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000342449ENST00000216951BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000342449ENST00000541098BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000342449ENST00000451957BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000380800ENST00000216951BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000380800ENST00000541098BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000380800ENST00000451957BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000341322ENST00000216951BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000341322ENST00000541098BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000341322ENST00000451957BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000470108ENST00000216951BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000470108ENST00000541098BRWD1chr21

40558924

-GSSchr20

33516721

-
intron-3CDSENST00000470108ENST00000451957BRWD1chr21

40558924

-GSSchr20

33516721

-

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FusionProtFeatures for BRWD1_GSS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRWD1

Q9NSI6

GSS

P48637


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BRWD1_GSS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BRWD1_GSS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BRWD1_GSS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGSSP48637DB06151AcetylcysteineGlutathione synthetasesmall moleculeapproved|investigational
TgeneGSSP48637DB00143GlutathioneGlutathione synthetasesmall moleculeapproved|investigational|nutraceutical
TgeneGSSP48637DB00145GlycineGlutathione synthetasesmall moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for BRWD1_GSS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRWD1C0028960Oligospermia1CTD_human
TgeneGSSC0011616Contact Dermatitis1CTD_human
TgeneGSSC0024667Animal Mammary Neoplasms1CTD_human
TgeneGSSC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneGSSC0026636Mouth Diseases1CTD_human
TgeneGSSC0036341Schizophrenia1PSYGENET
TgeneGSSC0398746Gluthathione synthetase deficiency1CTD_human;HPO;ORPHANET;UNIPROT