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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 4442

FusionGeneSummary for BRIP1_SPAG9

check button Fusion gene summary
Fusion gene informationFusion gene name: BRIP1_SPAG9
Fusion gene ID: 4442
HgeneTgene
Gene symbol

BRIP1

SPAG9

Gene ID

83990

9043

Gene nameBRCA1 interacting protein C-terminal helicase 1sperm associated antigen 9
SynonymsBACH1|FANCJ|OFCT89|HLC-6|HLC4|HLC6|JIP-4|JIP4|JLP|PHET|PIG6
Cytomap

17q23.2

17q21.33

Type of geneprotein-codingprotein-coding
DescriptionFanconi anemia group J proteinATP-dependent RNA helicase BRIP1BRCA1-associated C-terminal helicase 1BRCA1-binding helicase-like protein BACH1BRCA1/BRCA2-associated helicase 1C-Jun-amino-terminal kinase-interacting protein 4JNK interacting proteinJNK/SAPK-associated proteinMax-binding proteinc-Jun NH2-terminal kinase-associated leucine zipper proteincancer/testis antigen 89human lung cancer oncogene 6 proteinlung cancer
Modification date2018052320180523
UniProtAcc

Q9BX63

O60271

Ensembl transtripts involved in fusion geneENST00000259008, ENST00000577598, 
ENST00000583837, 
ENST00000262013, 
ENST00000505279, ENST00000357122, 
ENST00000509724, ENST00000510283, 
Fusion gene scores* DoF score3 X 3 X 1=98 X 7 X 5=280
# samples 38
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRIP1 [Title/Abstract] AND SPAG9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRIP1

GO:0006357

regulation of transcription by RNA polymerase II

14504288

TgeneSPAG9

GO:0042147

retrograde transport, endosome to Golgi

19056739


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A0TQ-01ABRIP1chr17

59934419

-SPAG9chr17

49157065

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000259008ENST00000262013BRIP1chr17

59934419

-SPAG9chr17

49157065

-
In-frameENST00000259008ENST00000505279BRIP1chr17

59934419

-SPAG9chr17

49157065

-
In-frameENST00000259008ENST00000357122BRIP1chr17

59934419

-SPAG9chr17

49157065

-
5CDS-intronENST00000259008ENST00000509724BRIP1chr17

59934419

-SPAG9chr17

49157065

-
5CDS-intronENST00000259008ENST00000510283BRIP1chr17

59934419

-SPAG9chr17

49157065

-
Frame-shiftENST00000577598ENST00000262013BRIP1chr17

59934419

-SPAG9chr17

49157065

-
Frame-shiftENST00000577598ENST00000505279BRIP1chr17

59934419

-SPAG9chr17

49157065

-
Frame-shiftENST00000577598ENST00000357122BRIP1chr17

59934419

-SPAG9chr17

49157065

-
5CDS-intronENST00000577598ENST00000509724BRIP1chr17

59934419

-SPAG9chr17

49157065

-
5CDS-intronENST00000577598ENST00000510283BRIP1chr17

59934419

-SPAG9chr17

49157065

-
intron-3CDSENST00000583837ENST00000262013BRIP1chr17

59934419

-SPAG9chr17

49157065

-
intron-3CDSENST00000583837ENST00000505279BRIP1chr17

59934419

-SPAG9chr17

49157065

-
intron-3CDSENST00000583837ENST00000357122BRIP1chr17

59934419

-SPAG9chr17

49157065

-
intron-intronENST00000583837ENST00000509724BRIP1chr17

59934419

-SPAG9chr17

49157065

-
intron-intronENST00000583837ENST00000510283BRIP1chr17

59934419

-SPAG9chr17

49157065

-

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FusionProtFeatures for BRIP1_SPAG9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRIP1

Q9BX63

SPAG9

O60271

DNA-dependent ATPase and 5' to 3' DNA helicase requiredfor the maintenance of chromosomal stability. Acts late in theFanconi anemia pathway, after FANCD2 ubiquitination. Involved inthe repair of DNA double-strand breaks by homologous recombinationin a manner that depends on its association with BRCA1.{ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014,ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPAG9chr17:59934419chr17:49157065ENST00000262013-030408_5341011322Coiled coilOntology_term=ECO:0000269
TgeneSPAG9chr17:59934419chr17:49157065ENST00000262013-030724_7581011322Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST00000357122-029408_5341011308Coiled coilOntology_term=ECO:0000269
TgeneSPAG9chr17:59934419chr17:49157065ENST00000357122-029724_7581011308Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST00000505279-030408_5341011312Coiled coilOntology_term=ECO:0000269
TgeneSPAG9chr17:59934419chr17:49157065ENST00000505279-030724_7581011312Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST00000510283-027408_534-731178Coiled coilOntology_term=ECO:0000269
TgeneSPAG9chr17:59934419chr17:49157065ENST00000510283-02766_166-731178Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST00000510283-027724_758-731178Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST00000262013-030500_5711011322DomainRH2
TgeneSPAG9chr17:59934419chr17:49157065ENST00000357122-029500_5711011308DomainRH2
TgeneSPAG9chr17:59934419chr17:49157065ENST00000505279-030500_5711011312DomainRH2
TgeneSPAG9chr17:59934419chr17:49157065ENST00000510283-027500_571-731178DomainRH2
TgeneSPAG9chr17:59934419chr17:49157065ENST00000510283-0277_95-731178DomainRH1

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRIP1chr17:59934419chr17:49157065ENST00000259008-42011_4421261250DomainHelicase ATP-binding
HgeneBRIP1chr17:59934419chr17:49157065ENST00000259008-420158_1751261250MotifNuclear localization signal
HgeneBRIP1chr17:59934419chr17:49157065ENST00000259008-420393_3961261250MotifNote=DEAH box
HgeneBRIP1chr17:59934419chr17:49157065ENST00000259008-420185_1921261250Nucleotide bindingATP
TgeneSPAG9chr17:59934419chr17:49157065ENST00000262013-03066_1661011322Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST00000357122-02966_1661011308Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST00000505279-03066_1661011312Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST00000262013-0307_951011322DomainRH1
TgeneSPAG9chr17:59934419chr17:49157065ENST00000357122-0297_951011308DomainRH1
TgeneSPAG9chr17:59934419chr17:49157065ENST00000505279-0307_951011312DomainRH1


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FusionGeneSequence for BRIP1_SPAG9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_BRIP1_ENST00000259008_chr17_59934419_-_SPAG9_ENST00000262013_chr17_49157065_-_1347aa
MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSGKPADEGVSEKAEVQLSCCCAC
HSKDFTNNDMNQGTSRHFNYPSTPPSERNGTSSTCQEIHXIXRLSRTGKKGLTDPSGIFRISNKTTXAESEKLCXPDXQTXRKRSRTEEG
IXCITSKTHXDDPXLYGTFRKNKTSSALREXSTRIHSSXXNXKRTPYIIRNFPITCWRWIAYTXCSERRRDPWIXAMEISGIKSTTFSYQ
PEGQQXSXTSEGCRTGGXAFXCXPRRIXSYHSSINSXFRCGNNSYXYSLKGRKRRICEGYRCAKXIRDKQTHXSTGSPGNXKCIYWLCXK
XRKVRSSSNHRIYSXAGYGQRSQWIXRFKHSHQRHREQSFXSQYRISLXRTVFSWLRPNRRCGXRSRFTRNGSGSXESYIRKYTTVGNQK
CFEHSEEXFDSKSGXTDLXERCAARGIGGCEASQTETRGKEQRIGGRAXESSGRSXRCKAKSKRXRXXXYSHSPEETVYXSRNGPCSHGA
KPVXREIDGASGSCSMDRDDSGITRKSSHAGKKKVKHLAVFQPTFQLLKXHDXEAXTTCXSEVQCTHVSCYSVRQEKKQHLISAPWGXVQ
SLXFPXXRNXSXFSLTQRTKERAVSSGKSTCSEGRRXSAGFWLESASEVQTGNQWSRXKXDEKFTCACLSQTSGXKRYINEAVVCCWSQF
IWWEDQRWWFCCWSKCILQGCCWFGYRRQXTAKCLSEXFRXVRSGTXGTAEGVKKSRRIIQSSLDLYQHSFGYKSSYYXCCSTWQHPRQF
HCLQLSCSVHCKCARCTRNRLPCRRRSFRIWSGRQSIFMWKYDKQQLSRDRQPVRRHHSGWLFCRRCDGSCHFPXYKWCFSSDGXTTRNG
SRKXXGXXKCSNSRRSNXSYRRECGVSXRHSGHLPNWRLHRACLYRSFGSSDPRRPLPSVSVEQXLRCIXRSNISTAKXTRLGERRSPEN
EXSFTNYVAWSSKWLFVCPFICSPVEEMSPFHXTXRFDSQYCTREGNRVSSPGXRHPCNLSQRSGWAVGFVKLSPLRPWTASSFHPLHDC
GTXQSLVWLXEQNLCGAAKGHENREIFXCTSQEGEPSATACVGGGWRVGLHSLGFYAPSLSCTHLSTSTGCGHXALCKQNVRYWKTGLLF
CENYSSYGVLXSFVGGDRKWCHYLHPIDRNKXNLRCTRKSSWKCNPCIWXXKQXXSDSRDIYTLLFNGTCTALLPWAPGCCEILCGSPRS

>In-frame_BRIP1_ENST00000259008_chr17_59934419_-_SPAG9_ENST00000505279_chr17_49157065_-_1337aa
MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSGKPADEGVSEKAEVQLSCCCAC
HSKDFTNNDMNQGTSRHFNYPSTPPSERNGTSSTCQEIHXIXRLSRTGKKGLTDPSGIFRISNKTTXAESEKLCXPDXQTXRKRSRTEEG
IXCITSKTHXDDPXLYGTFRKNKTSSALREXSTRIHSSXXNXKRTPYIIRNFPITCWRWIAYTXCSERRRDPWIXAMEISGIKSTTFSYQ
PEGXAFXCXPRRIXSYHSSINSXFRCGNNSYXYSLKGRKRRICEGYRCAKXIRDKQTHXSTGSPGNXKCIYWLCXKXRKVRSSSNHRIYS
XAGYGQRSQWIXRFKHSHQRHREQSFXSQYRISLXRTVFSWLRPNRRCGXRSRFTRNGSGSXESYIRKYTTVGNQKCFEHSEEXFDSKSG
XTDLXERCAARGIGGCEASQTETRGKEQRIGGRAXESSGRSXRCKAKSKRXRXXXYSHSPEETVYXSRNGPCSHGAKPVXREIDGASGSC
SMDRDDSGITRKSSHAGKKKVKHLAVCANSFQPTFQLLKXHDXEAXTTCXSEVQCTHVSCYSVRQEKKQHLISAPWGXVQSLXFPXXRNX
SXFSLTQRTKERAVSSGKSTCSEGRRXSAGFWLESASEVQTGNQWSRXKXDEKFTCACLSQTSGXKRYINEAVVCCWSQFIWWEDQRWWF
CCWSKCILQGCCWFGYRRQXTAKCLSEXFRXVRSGTXGTAEGVKKSRRIIQSSLDLYQHSFGYKSSYYXCCSTWQHPRQFHCLQLSCSVH
CKCARCTRNRLPCRRRSFRIWSGRQSIFMWKYDKQQLSRDRQPVRRHHSGWLFCRRCDGSCHFPXYKWCFSSDGXTTRNGSRKXXGXXKC
SNSRRSNXSYRRECGVSXRHSGHLPNWRLHRACLYRSFGSSDPRRPLPSVSVEQXLRCIXRSNISTAKXTRLGERRSPENEXSFTNYVAW
SSKWLFVCPFICSPVEEMSPFHXTXRFDSQYCTREGNRVSSPGXRHPCNLSQRSGWAVGFVKLSPLRPWTASSFHPLHDCGTXQSLVWLX
EQNLCGAAKGHENREIFXCTSQEGEPSATACVGGGWRVGLHSLGFYAPSLSCTHLSTSTGCGHXALCKQNVRYWKTGLLFCENYSSYGVL
XSFVGGDRKWCHYLHPIDRNKXNLRCTRKSSWKCNPCIWXXKQXXSDSRDIYTLLFNGTCTALLPWAPGCCEILCGSPRSSHQPTKXQXW

>In-frame_BRIP1_ENST00000259008_chr17_59934419_-_SPAG9_ENST00000357122_chr17_49157065_-_1333aa
MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSGKPADEGVSEKAEVQLSCCCAC
HSKDFTNNDMNQGTSRHFNYPSTPPSERNGTSSTCQEIHXIXRLSRTGKKGLTDPSGIFRISNKTTXAESEKLCXPDXQTXRKRSRTEEG
IXCITSKTHXDDPXLYGTFRKNKTSSALREXSTRIHSSXXNXKRTPYIIRNFPITCWRWIAYTXCSERRRDPWIXAMEISGIKSTTFSYQ
PEGXAFXCXPRRIXSYHSSINSXFRCGNNSYXYSLKGRKRRICEGYRCAKXIRDKQTHXSTGSPGNXKCIYWLCXKXRKVRSSSNHRIYS
XAGYGQRSQWIXRFKHSHQRHREQSFXSQYRISLXRTVFSWLRPNRRCGXRSRFTRNGSGSXESYIRKYTTVGNQKCFEHSEEXFDSKSG
XTDLXERCAARGIGGCEASQTETRGKEQRIGGRAXESSGRSXRCKAKSKRXRXXXYSHSPEETVYXSRNGPCSHGAKPVXREIDGASGSC
SMDRDDSGITRKSSHAGKKKVKHLAVFQPTFQLLKXHDXEAXTTCXSEVQCTHVSCYSVRQEKKQHLISAPWGXVQSLXFPXXRNXSXFS
LTQRTKERAVSSGKSTCSEGRRXSAGFWLESASEVQTGNQWSRXKXDEKFTCACLSQTSGXKRYINEAVVCCWSQFIWWEDQRWWFCCWS
KCILQGCCWFGYRRQXTAKCLSEXFRXVRSGTXGTAEGVKKSRRIIQSSLDLYQHSFGYKSSYYXCCSTWQHPRQFHCLQLSCSVHCKCA
RCTRNRLPCRRRSFRIWSGRQSIFMWKYDKQQLSRDRQPVRRHHSGWLFCRRCDGSCHFPXYKWCFSSDGXTTRNGSRKXXGXXKCSNSR
RSNXSYRRECGVSXRHSGHLPNWRLHRACLYRSFGSSDPRRPLPSVSVEQXLRCIXRSNISTAKXTRLGERRSPENEXSFTNYVAWSSKW
LFVCPFICSPVEEMSPFHXTXRFDSQYCTREGNRVSSPGXRHPCNLSQRSGWAVGFVKLSPLRPWTASSFHPLHDCGTXQSLVWLXEQNL
CGAAKGHENREIFXCTSQEGEPSATACVGGGWRVGLHSLGFYAPSLSCTHLSTSTGCGHXALCKQNVRYWKTGLLFCENYSSYGVLXSFV
GGDRKWCHYLHPIDRNKXNLRCTRKSSWKCNPCIWXXKQXXSDSRDIYTLLFNGTCTALLPWAPGCCEILCGSPRSSHQPTKXQXWHGSD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_BRIP1_ENST00000259008_chr17_59934419_-_SPAG9_ENST00000262013_chr17_49157065_-_4042nt
ATGTCTTCAATGTGGTCTGAATATACAATTGGTGGGGTGAAGATTTACTTTCCTTATAAAGCTTACCCGTCACAGCTTGCTATGATGAAT
TCTATTCTCAGAGGATTAAACAGCAAGCAACATTGTTTGTTGGAGAGTCCCACAGGAAGTGGAAAAAGCTTAGCCTTACTTTGTTCTGCT
TTAGCATGGCAACAATCTCTTAGTGGGAAACCAGCAGATGAGGGCGTAAGTGAAAAAGCTGAAGTACAATTGTCATGTTGTTGTGCATGC
CATTCAAAGGATTTTACAAACAATGACATGAACCAAGGAACTTCACGTCATTTCAACTATCCAAGCACACCACCTTCTGAAAGAAATGGC
ACTTCATCAACTTGTCAAGAAATTCATTGAATTTGAAGACTCTCAAGAACAGGAAAAAAAGGACTTACAGACCCGAGTGGAATCTTTAGA
ATCTCAAACAAGACAACTTGAGCTGAAAGCGAAAAACTATGCTGACCAGATTAGCAGACTTGAAGAAAGAGAAGCAGAACTGAAGAAGGA
ATATAATGCATTACATCAAAGACACACTGAGATGATCCATAATTATATGGAACATTTAGAAAGAACAAAACTTCATCAGCTCTCAGGGAG
TGATCAACTAGAATCCACAGCTCATAGTAGAATTAGAAAAGAACGCCCTATATCATTAGGAATTTTCCCATTACCTGCTGGAGATGGATT
GCTTACACCTGATGCTCAGAAAGGAGGAGAGACCCCTGGATCTGAGCAATGGAAATTTCAGGAATTAAGTCAACCACGTTCTCATACCAG
CCTGAAGGTCAGCAATAGTCCTGAACCTCAGAAGGCTGTAGAACAGGAGGATGAGCTTTCTGATGTTAGCCAAGGCGGATCTAAAGCTAC
CACTCCAGCATCAACAGCTAATTCAGATGTGGCAACAATTCCTACTGATACTCCCTTAAAGGAAGAAAACGAAGGATTTGTGAAGGTTAC
AGATGCGCCAAATAAATCAGAGATAAGCAAACACATTGAAGTACAGGTAGCCCAGGAAACTAGAAATGTATCTACTGGCTCTGCTGAAAA
TGAAGAAAAGTCAGAAGTTCAAGCAATCATCGAATCTACTCCTGAGCTGGATATGGACAAAGATCTCAGTGGATATAAAGGTTCAAGCAC
TCCCACCAAAGGCATAGAGAACAAAGCTTTTGATCGCAATACAGAATCTCTCTTTGAAGAACTGTCTTCAGCTGGCTCAGGCCTAATAGG
AGATGTGGATGAAGGAGCAGATTTACTAGGAATGGGTCGGGAAGTTGAGAATCTTATATTAGAAAATACACAACTGTTGGAAACCAAAAA
TGCTTTGAACATAGTGAAGAATGATTTGATAGCAAAAGTGGATGAACTGACCTGTGAGAAAGATGTGCTGCAAGGGGAATTGGAGGCTGT
GAAGCAAGCCAAACTGAAACTAGAGGAAAAGAACAGAGAATTGGAGGAAGAGCTTAGGAAAGCTCGGGCAGAAGCTGAAGATGCAAGGCA
AAAAGCAAAAGATGACGATGATAGTGATATTCCCACAGCCCAGAGGAAACGGTTTACTAGAGTAGAAATGGCCCGTGTTCTCATGGAGCG
AAACCAGTATAAAGAGAGATTGATGGAGCTTCAGGAAGCTGTTCGATGGACAGAGATGATTCGGGCATCACGAGAAAATCCAGCCATGCA
GGAAAAAAAAAGGTCAAGCATTTGGCAGTTTTTCAGCCGACTTTTCAGCTCCTCAAGTAACACGACTAAGAAGCCTGAACCACCTGTTAA
TCTGAAGTACAATGCACCCACGTCTCATGTTACTCCGTCCGTCAAGAAAAGAAGCAGCACCTTATCTCAGCTCCCTGGGGATAAGTCCAA
AGCCTTTGATTTCCTTAGTGAAGAAACTGAAGCTAGTTTAGCCTCACGCAGAGAACAAAAGAGAGAGCAGTATCGTCAGGTAAAAGCACA
TGTTCAGAAGGAAGACGGTAGAGTGCAGGCTTTTGGCTGGAGTCTGCCTCAGAAGTACAAACAGGTAACCAATGGTCAAGGTGAAAATAA
GATGAAAAATTTACCTGTGCCTGTCTATCTCAGACCTCTGGATGAAAAAGATACATCAATGAAGCTGTGGTGTGCTGTTGGAGTCAATTT
ATCTGGTGGGAAGACCAGAGATGGTGGTTCTGTTGTTGGAGCAAGTGTATTTTACAAGGATGTTGCTGGTTTGGATACAGAAGGCAGTAA
ACAGCGAAGTGCCTCTCAGAGTAGTTTAGATAAGTTAGATCAGGAACTTAAGGAACAGCAGAAGGAGTTAAAAAATCAAGAAGAATTATC
CAGTCTAGTTTGGATCTGTACCAGCACTCATTCGGCTACAAAAGTTCTTATTATTGATGCTGTTCAACCTGGCAACATCCTAGACAGTTT
CACTGTTTGCAACTCTCATGTTCTGTGCATTGCAAGTGTGCCAGGTGCACGAGAAACAGACTACCCTGCAGGAGAAGATCTTTCAGAATC
TGGTCAGGTAGACAAAGCATCTTTATGTGGAAGTATGACAAGCAACAGCTCAGCAGAGACAGACAGCCTGTTAGGAGGCATCACAGTGGT
TGGTTGTTCTGCAGAAGGTGTGACGGGAGCTGCCACTTCCCCTAGTACAAATGGTGCTTCTCCAGTGATGGATAAACCACCAGAAATGGA
AGCAGAAAATAGTGAGGTTGATGAAAATGTTCCAACAGCAGAAGAAGCAACTGAAGCTACAGAAGGGAATGCGGGGTCAGCTGAAGACAC
AGTGGACATCTCCCAAACTGGCGTCTACACAGAGCATGTCTTTACAGATCCTTTGGGAGTTCAGATCCCAGAAGACCTCTCCCCAGTGTA
TCAGTCGAGCAATGACTCAGATGCATATAAAGATCAAATATCAGTACTGCCAAATGAACAAGACTTGGTGAGAGAAGAAGCCCAGAAAAT
GAGTAGTCTTTTACCAACTATGTGGCTTGGAGCTCAAAATGGCTGTTTGTATGTCCATTCATCTGTAGCCCAGTGGAGGAAATGTCTCCA
TTCCATTAAACTTAAAGATTCGATTCTCAGTATTGTACACGTGAAGGGAATCGTGTTAGTAGCCCTGGCTGACGGCACCCTTGCAATCTT
TCACAGAGGAGTGGATGGGCAGTGGGATTTGTCAAACTATCACCTCTTAGACCTTGGACGGCCTCATCATTCCATCCGTTGCATGACTGT
GGTACATGACAAAGTCTGGTGTGGCTATAGGAACAAAATCTATGTGGTGCAGCCAAAGGCCATGAAAATAGAGAAATCTTTTGATGCACA
TCCCAGGAAGGAGAGCCAAGTGCGACAGCTTGCGTGGGTGGGGGATGGCGTGTGGGTCTCCATTCGCTTGGATTCTACGCTCCGTCTCTA
TCATGCACACACTTATCAACATCTACAGGATGTGGACATTGAGCCTTATGTAAGCAAAATGTTAGGTACTGGAAAACTGGGCTTCTCTTT
TGTGAGAATTACAGCTCTTATGGTGTCTTGTAATCGTTTGTGGGTGGGGACAGGAAATGGTGTCATTATCTCCATCCCATTGACAGAAAC
AAATAAAACCTCAGGTGTACCAGGAAATCGTCCTGGAAGTGTAATCCGTGTATATGGTGATGAAAACAGTGATAAAGTGACTCCAGGGAC
ATTTATACCCTATTGTTCAATGGCACATGCACAGCTTTGCTTCCATGGGCACCGGGATGCTGTGAAATTCTTTGTGGCAGTCCCAGGTCA
AGTCATCAGCCCACAAAGTAGCAGTAGTGGCACGGATCTGACGGGTGACAAAGCAGGGCCATCTGCACAGGAGCCTGGTAGTCAGACGCC
CTTGAAGTCTATGCTTGTCATCAGTGGAGGAGAGGGCTACATCGACTTCCGAATGGGTGATGAAGGTGGAGAATCAGAACTTCTTGGAGA

>In-frame_BRIP1_ENST00000259008_chr17_59934419_-_SPAG9_ENST00000505279_chr17_49157065_-_4012nt
ATGTCTTCAATGTGGTCTGAATATACAATTGGTGGGGTGAAGATTTACTTTCCTTATAAAGCTTACCCGTCACAGCTTGCTATGATGAAT
TCTATTCTCAGAGGATTAAACAGCAAGCAACATTGTTTGTTGGAGAGTCCCACAGGAAGTGGAAAAAGCTTAGCCTTACTTTGTTCTGCT
TTAGCATGGCAACAATCTCTTAGTGGGAAACCAGCAGATGAGGGCGTAAGTGAAAAAGCTGAAGTACAATTGTCATGTTGTTGTGCATGC
CATTCAAAGGATTTTACAAACAATGACATGAACCAAGGAACTTCACGTCATTTCAACTATCCAAGCACACCACCTTCTGAAAGAAATGGC
ACTTCATCAACTTGTCAAGAAATTCATTGAATTTGAAGACTCTCAAGAACAGGAAAAAAAGGACTTACAGACCCGAGTGGAATCTTTAGA
ATCTCAAACAAGACAACTTGAGCTGAAAGCGAAAAACTATGCTGACCAGATTAGCAGACTTGAAGAAAGAGAAGCAGAACTGAAGAAGGA
ATATAATGCATTACATCAAAGACACACTGAGATGATCCATAATTATATGGAACATTTAGAAAGAACAAAACTTCATCAGCTCTCAGGGAG
TGATCAACTAGAATCCACAGCTCATAGTAGAATTAGAAAAGAACGCCCTATATCATTAGGAATTTTCCCATTACCTGCTGGAGATGGATT
GCTTACACCTGATGCTCAGAAAGGAGGAGAGACCCCTGGATCTGAGCAATGGAAATTTCAGGAATTAAGTCAACCACGTTCTCATACCAG
CCTGAAGGATGAGCTTTCTGATGTTAGCCAAGGCGGATCTAAAGCTACCACTCCAGCATCAACAGCTAATTCAGATGTGGCAACAATTCC
TACTGATACTCCCTTAAAGGAAGAAAACGAAGGATTTGTGAAGGTTACAGATGCGCCAAATAAATCAGAGATAAGCAAACACATTGAAGT
ACAGGTAGCCCAGGAAACTAGAAATGTATCTACTGGCTCTGCTGAAAATGAAGAAAAGTCAGAAGTTCAAGCAATCATCGAATCTACTCC
TGAGCTGGATATGGACAAAGATCTCAGTGGATATAAAGGTTCAAGCACTCCCACCAAAGGCATAGAGAACAAAGCTTTTGATCGCAATAC
AGAATCTCTCTTTGAAGAACTGTCTTCAGCTGGCTCAGGCCTAATAGGAGATGTGGATGAAGGAGCAGATTTACTAGGAATGGGTCGGGA
AGTTGAGAATCTTATATTAGAAAATACACAACTGTTGGAAACCAAAAATGCTTTGAACATAGTGAAGAATGATTTGATAGCAAAAGTGGA
TGAACTGACCTGTGAGAAAGATGTGCTGCAAGGGGAATTGGAGGCTGTGAAGCAAGCCAAACTGAAACTAGAGGAAAAGAACAGAGAATT
GGAGGAAGAGCTTAGGAAAGCTCGGGCAGAAGCTGAAGATGCAAGGCAAAAAGCAAAAGATGACGATGATAGTGATATTCCCACAGCCCA
GAGGAAACGGTTTACTAGAGTAGAAATGGCCCGTGTTCTCATGGAGCGAAACCAGTATAAAGAGAGATTGATGGAGCTTCAGGAAGCTGT
TCGATGGACAGAGATGATTCGGGCATCACGAGAAAATCCAGCCATGCAGGAAAAAAAAAGGTCAAGCATTTGGCAGTTTGTGCCAACTCG
TTTCAGCCGACTTTTCAGCTCCTCAAGTAACACGACTAAGAAGCCTGAACCACCTGTTAATCTGAAGTACAATGCACCCACGTCTCATGT
TACTCCGTCCGTCAAGAAAAGAAGCAGCACCTTATCTCAGCTCCCTGGGGATAAGTCCAAAGCCTTTGATTTCCTTAGTGAAGAAACTGA
AGCTAGTTTAGCCTCACGCAGAGAACAAAAGAGAGAGCAGTATCGTCAGGTAAAAGCACATGTTCAGAAGGAAGACGGTAGAGTGCAGGC
TTTTGGCTGGAGTCTGCCTCAGAAGTACAAACAGGTAACCAATGGTCAAGGTGAAAATAAGATGAAAAATTTACCTGTGCCTGTCTATCT
CAGACCTCTGGATGAAAAAGATACATCAATGAAGCTGTGGTGTGCTGTTGGAGTCAATTTATCTGGTGGGAAGACCAGAGATGGTGGTTC
TGTTGTTGGAGCAAGTGTATTTTACAAGGATGTTGCTGGTTTGGATACAGAAGGCAGTAAACAGCGAAGTGCCTCTCAGAGTAGTTTAGA
TAAGTTAGATCAGGAACTTAAGGAACAGCAGAAGGAGTTAAAAAATCAAGAAGAATTATCCAGTCTAGTTTGGATCTGTACCAGCACTCA
TTCGGCTACAAAAGTTCTTATTATTGATGCTGTTCAACCTGGCAACATCCTAGACAGTTTCACTGTTTGCAACTCTCATGTTCTGTGCAT
TGCAAGTGTGCCAGGTGCACGAGAAACAGACTACCCTGCAGGAGAAGATCTTTCAGAATCTGGTCAGGTAGACAAAGCATCTTTATGTGG
AAGTATGACAAGCAACAGCTCAGCAGAGACAGACAGCCTGTTAGGAGGCATCACAGTGGTTGGTTGTTCTGCAGAAGGTGTGACGGGAGC
TGCCACTTCCCCTAGTACAAATGGTGCTTCTCCAGTGATGGATAAACCACCAGAAATGGAAGCAGAAAATAGTGAGGTTGATGAAAATGT
TCCAACAGCAGAAGAAGCAACTGAAGCTACAGAAGGGAATGCGGGGTCAGCTGAAGACACAGTGGACATCTCCCAAACTGGCGTCTACAC
AGAGCATGTCTTTACAGATCCTTTGGGAGTTCAGATCCCAGAAGACCTCTCCCCAGTGTATCAGTCGAGCAATGACTCAGATGCATATAA
AGATCAAATATCAGTACTGCCAAATGAACAAGACTTGGTGAGAGAAGAAGCCCAGAAAATGAGTAGTCTTTTACCAACTATGTGGCTTGG
AGCTCAAAATGGCTGTTTGTATGTCCATTCATCTGTAGCCCAGTGGAGGAAATGTCTCCATTCCATTAAACTTAAAGATTCGATTCTCAG
TATTGTACACGTGAAGGGAATCGTGTTAGTAGCCCTGGCTGACGGCACCCTTGCAATCTTTCACAGAGGAGTGGATGGGCAGTGGGATTT
GTCAAACTATCACCTCTTAGACCTTGGACGGCCTCATCATTCCATCCGTTGCATGACTGTGGTACATGACAAAGTCTGGTGTGGCTATAG
GAACAAAATCTATGTGGTGCAGCCAAAGGCCATGAAAATAGAGAAATCTTTTGATGCACATCCCAGGAAGGAGAGCCAAGTGCGACAGCT
TGCGTGGGTGGGGGATGGCGTGTGGGTCTCCATTCGCTTGGATTCTACGCTCCGTCTCTATCATGCACACACTTATCAACATCTACAGGA
TGTGGACATTGAGCCTTATGTAAGCAAAATGTTAGGTACTGGAAAACTGGGCTTCTCTTTTGTGAGAATTACAGCTCTTATGGTGTCTTG
TAATCGTTTGTGGGTGGGGACAGGAAATGGTGTCATTATCTCCATCCCATTGACAGAAACAAATAAAACCTCAGGTGTACCAGGAAATCG
TCCTGGAAGTGTAATCCGTGTATATGGTGATGAAAACAGTGATAAAGTGACTCCAGGGACATTTATACCCTATTGTTCAATGGCACATGC
ACAGCTTTGCTTCCATGGGCACCGGGATGCTGTGAAATTCTTTGTGGCAGTCCCAGGTCAAGTCATCAGCCCACAAAGTAGCAGTAGTGG
CACGGATCTGACGGGTGACAAAGCAGGGCCATCTGCACAGGAGCCTGGTAGTCAGACGCCCTTGAAGTCTATGCTTGTCATCAGTGGAGG
AGAGGGCTACATCGACTTCCGAATGGGTGATGAAGGTGGAGAATCAGAACTTCTTGGAGAGGATCTTCCACTTGAACCTTCTGTCACCAA

>In-frame_BRIP1_ENST00000259008_chr17_59934419_-_SPAG9_ENST00000357122_chr17_49157065_-_4000nt
ATGTCTTCAATGTGGTCTGAATATACAATTGGTGGGGTGAAGATTTACTTTCCTTATAAAGCTTACCCGTCACAGCTTGCTATGATGAAT
TCTATTCTCAGAGGATTAAACAGCAAGCAACATTGTTTGTTGGAGAGTCCCACAGGAAGTGGAAAAAGCTTAGCCTTACTTTGTTCTGCT
TTAGCATGGCAACAATCTCTTAGTGGGAAACCAGCAGATGAGGGCGTAAGTGAAAAAGCTGAAGTACAATTGTCATGTTGTTGTGCATGC
CATTCAAAGGATTTTACAAACAATGACATGAACCAAGGAACTTCACGTCATTTCAACTATCCAAGCACACCACCTTCTGAAAGAAATGGC
ACTTCATCAACTTGTCAAGAAATTCATTGAATTTGAAGACTCTCAAGAACAGGAAAAAAAGGACTTACAGACCCGAGTGGAATCTTTAGA
ATCTCAAACAAGACAACTTGAGCTGAAAGCGAAAAACTATGCTGACCAGATTAGCAGACTTGAAGAAAGAGAAGCAGAACTGAAGAAGGA
ATATAATGCATTACATCAAAGACACACTGAGATGATCCATAATTATATGGAACATTTAGAAAGAACAAAACTTCATCAGCTCTCAGGGAG
TGATCAACTAGAATCCACAGCTCATAGTAGAATTAGAAAAGAACGCCCTATATCATTAGGAATTTTCCCATTACCTGCTGGAGATGGATT
GCTTACACCTGATGCTCAGAAAGGAGGAGAGACCCCTGGATCTGAGCAATGGAAATTTCAGGAATTAAGTCAACCACGTTCTCATACCAG
CCTGAAGGATGAGCTTTCTGATGTTAGCCAAGGCGGATCTAAAGCTACCACTCCAGCATCAACAGCTAATTCAGATGTGGCAACAATTCC
TACTGATACTCCCTTAAAGGAAGAAAACGAAGGATTTGTGAAGGTTACAGATGCGCCAAATAAATCAGAGATAAGCAAACACATTGAAGT
ACAGGTAGCCCAGGAAACTAGAAATGTATCTACTGGCTCTGCTGAAAATGAAGAAAAGTCAGAAGTTCAAGCAATCATCGAATCTACTCC
TGAGCTGGATATGGACAAAGATCTCAGTGGATATAAAGGTTCAAGCACTCCCACCAAAGGCATAGAGAACAAAGCTTTTGATCGCAATAC
AGAATCTCTCTTTGAAGAACTGTCTTCAGCTGGCTCAGGCCTAATAGGAGATGTGGATGAAGGAGCAGATTTACTAGGAATGGGTCGGGA
AGTTGAGAATCTTATATTAGAAAATACACAACTGTTGGAAACCAAAAATGCTTTGAACATAGTGAAGAATGATTTGATAGCAAAAGTGGA
TGAACTGACCTGTGAGAAAGATGTGCTGCAAGGGGAATTGGAGGCTGTGAAGCAAGCCAAACTGAAACTAGAGGAAAAGAACAGAGAATT
GGAGGAAGAGCTTAGGAAAGCTCGGGCAGAAGCTGAAGATGCAAGGCAAAAAGCAAAAGATGACGATGATAGTGATATTCCCACAGCCCA
GAGGAAACGGTTTACTAGAGTAGAAATGGCCCGTGTTCTCATGGAGCGAAACCAGTATAAAGAGAGATTGATGGAGCTTCAGGAAGCTGT
TCGATGGACAGAGATGATTCGGGCATCACGAGAAAATCCAGCCATGCAGGAAAAAAAAAGGTCAAGCATTTGGCAGTTTTTCAGCCGACT
TTTCAGCTCCTCAAGTAACACGACTAAGAAGCCTGAACCACCTGTTAATCTGAAGTACAATGCACCCACGTCTCATGTTACTCCGTCCGT
CAAGAAAAGAAGCAGCACCTTATCTCAGCTCCCTGGGGATAAGTCCAAAGCCTTTGATTTCCTTAGTGAAGAAACTGAAGCTAGTTTAGC
CTCACGCAGAGAACAAAAGAGAGAGCAGTATCGTCAGGTAAAAGCACATGTTCAGAAGGAAGACGGTAGAGTGCAGGCTTTTGGCTGGAG
TCTGCCTCAGAAGTACAAACAGGTAACCAATGGTCAAGGTGAAAATAAGATGAAAAATTTACCTGTGCCTGTCTATCTCAGACCTCTGGA
TGAAAAAGATACATCAATGAAGCTGTGGTGTGCTGTTGGAGTCAATTTATCTGGTGGGAAGACCAGAGATGGTGGTTCTGTTGTTGGAGC
AAGTGTATTTTACAAGGATGTTGCTGGTTTGGATACAGAAGGCAGTAAACAGCGAAGTGCCTCTCAGAGTAGTTTAGATAAGTTAGATCA
GGAACTTAAGGAACAGCAGAAGGAGTTAAAAAATCAAGAAGAATTATCCAGTCTAGTTTGGATCTGTACCAGCACTCATTCGGCTACAAA
AGTTCTTATTATTGATGCTGTTCAACCTGGCAACATCCTAGACAGTTTCACTGTTTGCAACTCTCATGTTCTGTGCATTGCAAGTGTGCC
AGGTGCACGAGAAACAGACTACCCTGCAGGAGAAGATCTTTCAGAATCTGGTCAGGTAGACAAAGCATCTTTATGTGGAAGTATGACAAG
CAACAGCTCAGCAGAGACAGACAGCCTGTTAGGAGGCATCACAGTGGTTGGTTGTTCTGCAGAAGGTGTGACGGGAGCTGCCACTTCCCC
TAGTACAAATGGTGCTTCTCCAGTGATGGATAAACCACCAGAAATGGAAGCAGAAAATAGTGAGGTTGATGAAAATGTTCCAACAGCAGA
AGAAGCAACTGAAGCTACAGAAGGGAATGCGGGGTCAGCTGAAGACACAGTGGACATCTCCCAAACTGGCGTCTACACAGAGCATGTCTT
TACAGATCCTTTGGGAGTTCAGATCCCAGAAGACCTCTCCCCAGTGTATCAGTCGAGCAATGACTCAGATGCATATAAAGATCAAATATC
AGTACTGCCAAATGAACAAGACTTGGTGAGAGAAGAAGCCCAGAAAATGAGTAGTCTTTTACCAACTATGTGGCTTGGAGCTCAAAATGG
CTGTTTGTATGTCCATTCATCTGTAGCCCAGTGGAGGAAATGTCTCCATTCCATTAAACTTAAAGATTCGATTCTCAGTATTGTACACGT
GAAGGGAATCGTGTTAGTAGCCCTGGCTGACGGCACCCTTGCAATCTTTCACAGAGGAGTGGATGGGCAGTGGGATTTGTCAAACTATCA
CCTCTTAGACCTTGGACGGCCTCATCATTCCATCCGTTGCATGACTGTGGTACATGACAAAGTCTGGTGTGGCTATAGGAACAAAATCTA
TGTGGTGCAGCCAAAGGCCATGAAAATAGAGAAATCTTTTGATGCACATCCCAGGAAGGAGAGCCAAGTGCGACAGCTTGCGTGGGTGGG
GGATGGCGTGTGGGTCTCCATTCGCTTGGATTCTACGCTCCGTCTCTATCATGCACACACTTATCAACATCTACAGGATGTGGACATTGA
GCCTTATGTAAGCAAAATGTTAGGTACTGGAAAACTGGGCTTCTCTTTTGTGAGAATTACAGCTCTTATGGTGTCTTGTAATCGTTTGTG
GGTGGGGACAGGAAATGGTGTCATTATCTCCATCCCATTGACAGAAACAAATAAAACCTCAGGTGTACCAGGAAATCGTCCTGGAAGTGT
AATCCGTGTATATGGTGATGAAAACAGTGATAAAGTGACTCCAGGGACATTTATACCCTATTGTTCAATGGCACATGCACAGCTTTGCTT
CCATGGGCACCGGGATGCTGTGAAATTCTTTGTGGCAGTCCCAGGTCAAGTCATCAGCCCACAAAGTAGCAGTAGTGGCACGGATCTGAC
GGGTGACAAAGCAGGGCCATCTGCACAGGAGCCTGGTAGTCAGACGCCCTTGAAGTCTATGCTTGTCATCAGTGGAGGAGAGGGCTACAT
CGACTTCCGAATGGGTGATGAAGGTGGAGAATCAGAACTTCTTGGAGAGGATCTTCCACTTGAACCTTCTGTCACCAAAGCAGAAAGGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_BRIP1_ENST00000259008_chr17_59934419_-_SPAG9_ENST00000262013_chr17_49157065_-_8408nt
AATTCGTCTCGGGTTGTGTGGTTGAGGGGTCTGGTGGGTCGAGGAAAGGTAACGGCGGCCCCAGTCCTGCACACAAGGCCGGGGAAGTAG
CAGCACCCCCAGGAAGAGGGAGGAGGAAGGGCTCGTGCCCTTTCTTCTCTTCCAGGGCTCCGCTTTATTTGCTCTCAGAAGTCGGTTTCC
TTTCCTTTTCTTCAGTGAATCGGAGCTCAGAGCGTTGCTTCGGTTTCCCTCCAGACAGTTAGGAATCTGAAATAAACAGGAAAGCACTAT
GTCTTCAATGTGGTCTGAATATACAATTGGTGGGGTGAAGATTTACTTTCCTTATAAAGCTTACCCGTCACAGCTTGCTATGATGAATTC
TATTCTCAGAGGATTAAACAGCAAGCAACATTGTTTGTTGGAGAGTCCCACAGGAAGTGGAAAAAGCTTAGCCTTACTTTGTTCTGCTTT
AGCATGGCAACAATCTCTTAGTGGGAAACCAGCAGATGAGGGCGTAAGTGAAAAAGCTGAAGTACAATTGTCATGTTGTTGTGCATGCCA
TTCAAAGGATTTTACAAACAATGACATGAACCAAGGAACTTCACGTCATTTCAACTATCCAAGCACACCACCTTCTGAAAGAAATGGCAC
TTCATCAACTTGTCAAGAAATTCATTGAATTTGAAGACTCTCAAGAACAGGAAAAAAAGGACTTACAGACCCGAGTGGAATCTTTAGAAT
CTCAAACAAGACAACTTGAGCTGAAAGCGAAAAACTATGCTGACCAGATTAGCAGACTTGAAGAAAGAGAAGCAGAACTGAAGAAGGAAT
ATAATGCATTACATCAAAGACACACTGAGATGATCCATAATTATATGGAACATTTAGAAAGAACAAAACTTCATCAGCTCTCAGGGAGTG
ATCAACTAGAATCCACAGCTCATAGTAGAATTAGAAAAGAACGCCCTATATCATTAGGAATTTTCCCATTACCTGCTGGAGATGGATTGC
TTACACCTGATGCTCAGAAAGGAGGAGAGACCCCTGGATCTGAGCAATGGAAATTTCAGGAATTAAGTCAACCACGTTCTCATACCAGCC
TGAAGGTCAGCAATAGTCCTGAACCTCAGAAGGCTGTAGAACAGGAGGATGAGCTTTCTGATGTTAGCCAAGGCGGATCTAAAGCTACCA
CTCCAGCATCAACAGCTAATTCAGATGTGGCAACAATTCCTACTGATACTCCCTTAAAGGAAGAAAACGAAGGATTTGTGAAGGTTACAG
ATGCGCCAAATAAATCAGAGATAAGCAAACACATTGAAGTACAGGTAGCCCAGGAAACTAGAAATGTATCTACTGGCTCTGCTGAAAATG
AAGAAAAGTCAGAAGTTCAAGCAATCATCGAATCTACTCCTGAGCTGGATATGGACAAAGATCTCAGTGGATATAAAGGTTCAAGCACTC
CCACCAAAGGCATAGAGAACAAAGCTTTTGATCGCAATACAGAATCTCTCTTTGAAGAACTGTCTTCAGCTGGCTCAGGCCTAATAGGAG
ATGTGGATGAAGGAGCAGATTTACTAGGAATGGGTCGGGAAGTTGAGAATCTTATATTAGAAAATACACAACTGTTGGAAACCAAAAATG
CTTTGAACATAGTGAAGAATGATTTGATAGCAAAAGTGGATGAACTGACCTGTGAGAAAGATGTGCTGCAAGGGGAATTGGAGGCTGTGA
AGCAAGCCAAACTGAAACTAGAGGAAAAGAACAGAGAATTGGAGGAAGAGCTTAGGAAAGCTCGGGCAGAAGCTGAAGATGCAAGGCAAA
AAGCAAAAGATGACGATGATAGTGATATTCCCACAGCCCAGAGGAAACGGTTTACTAGAGTAGAAATGGCCCGTGTTCTCATGGAGCGAA
ACCAGTATAAAGAGAGATTGATGGAGCTTCAGGAAGCTGTTCGATGGACAGAGATGATTCGGGCATCACGAGAAAATCCAGCCATGCAGG
AAAAAAAAAGGTCAAGCATTTGGCAGTTTTTCAGCCGACTTTTCAGCTCCTCAAGTAACACGACTAAGAAGCCTGAACCACCTGTTAATC
TGAAGTACAATGCACCCACGTCTCATGTTACTCCGTCCGTCAAGAAAAGAAGCAGCACCTTATCTCAGCTCCCTGGGGATAAGTCCAAAG
CCTTTGATTTCCTTAGTGAAGAAACTGAAGCTAGTTTAGCCTCACGCAGAGAACAAAAGAGAGAGCAGTATCGTCAGGTAAAAGCACATG
TTCAGAAGGAAGACGGTAGAGTGCAGGCTTTTGGCTGGAGTCTGCCTCAGAAGTACAAACAGGTAACCAATGGTCAAGGTGAAAATAAGA
TGAAAAATTTACCTGTGCCTGTCTATCTCAGACCTCTGGATGAAAAAGATACATCAATGAAGCTGTGGTGTGCTGTTGGAGTCAATTTAT
CTGGTGGGAAGACCAGAGATGGTGGTTCTGTTGTTGGAGCAAGTGTATTTTACAAGGATGTTGCTGGTTTGGATACAGAAGGCAGTAAAC
AGCGAAGTGCCTCTCAGAGTAGTTTAGATAAGTTAGATCAGGAACTTAAGGAACAGCAGAAGGAGTTAAAAAATCAAGAAGAATTATCCA
GTCTAGTTTGGATCTGTACCAGCACTCATTCGGCTACAAAAGTTCTTATTATTGATGCTGTTCAACCTGGCAACATCCTAGACAGTTTCA
CTGTTTGCAACTCTCATGTTCTGTGCATTGCAAGTGTGCCAGGTGCACGAGAAACAGACTACCCTGCAGGAGAAGATCTTTCAGAATCTG
GTCAGGTAGACAAAGCATCTTTATGTGGAAGTATGACAAGCAACAGCTCAGCAGAGACAGACAGCCTGTTAGGAGGCATCACAGTGGTTG
GTTGTTCTGCAGAAGGTGTGACGGGAGCTGCCACTTCCCCTAGTACAAATGGTGCTTCTCCAGTGATGGATAAACCACCAGAAATGGAAG
CAGAAAATAGTGAGGTTGATGAAAATGTTCCAACAGCAGAAGAAGCAACTGAAGCTACAGAAGGGAATGCGGGGTCAGCTGAAGACACAG
TGGACATCTCCCAAACTGGCGTCTACACAGAGCATGTCTTTACAGATCCTTTGGGAGTTCAGATCCCAGAAGACCTCTCCCCAGTGTATC
AGTCGAGCAATGACTCAGATGCATATAAAGATCAAATATCAGTACTGCCAAATGAACAAGACTTGGTGAGAGAAGAAGCCCAGAAAATGA
GTAGTCTTTTACCAACTATGTGGCTTGGAGCTCAAAATGGCTGTTTGTATGTCCATTCATCTGTAGCCCAGTGGAGGAAATGTCTCCATT
CCATTAAACTTAAAGATTCGATTCTCAGTATTGTACACGTGAAGGGAATCGTGTTAGTAGCCCTGGCTGACGGCACCCTTGCAATCTTTC
ACAGAGGAGTGGATGGGCAGTGGGATTTGTCAAACTATCACCTCTTAGACCTTGGACGGCCTCATCATTCCATCCGTTGCATGACTGTGG
TACATGACAAAGTCTGGTGTGGCTATAGGAACAAAATCTATGTGGTGCAGCCAAAGGCCATGAAAATAGAGAAATCTTTTGATGCACATC
CCAGGAAGGAGAGCCAAGTGCGACAGCTTGCGTGGGTGGGGGATGGCGTGTGGGTCTCCATTCGCTTGGATTCTACGCTCCGTCTCTATC
ATGCACACACTTATCAACATCTACAGGATGTGGACATTGAGCCTTATGTAAGCAAAATGTTAGGTACTGGAAAACTGGGCTTCTCTTTTG
TGAGAATTACAGCTCTTATGGTGTCTTGTAATCGTTTGTGGGTGGGGACAGGAAATGGTGTCATTATCTCCATCCCATTGACAGAAACAA
ATAAAACCTCAGGTGTACCAGGAAATCGTCCTGGAAGTGTAATCCGTGTATATGGTGATGAAAACAGTGATAAAGTGACTCCAGGGACAT
TTATACCCTATTGTTCAATGGCACATGCACAGCTTTGCTTCCATGGGCACCGGGATGCTGTGAAATTCTTTGTGGCAGTCCCAGGTCAAG
TCATCAGCCCACAAAGTAGCAGTAGTGGCACGGATCTGACGGGTGACAAAGCAGGGCCATCTGCACAGGAGCCTGGTAGTCAGACGCCCT
TGAAGTCTATGCTTGTCATCAGTGGAGGAGAGGGCTACATCGACTTCCGAATGGGTGATGAAGGTGGAGAATCAGAACTTCTTGGAGAGG
ATCTTCCACTTGAACCTTCTGTCACCAAAGCAGAAAGGAGTCACTTGATAGTGTGGCAAGTGATGTATGGCAATGAGTGAGCCCATGGGA
AACAGGTGGAGATGGGGAAGCCGTCTCTTCTGCATGGTTTATTTTCCCTCTATCCTTTTATTTAATGCTCTTTTGTGAGATAAGTTTCAC
CACATAATGTGTGAGCATTTTTTCCTGTTAACTTTATATTACAAAATCCGTTCTACCATAACAATACAGAGGAACTAGCTGTGTTACTGC
ACCAGTGTTATAGGTAACTTCAGTATATTATGAACAAATCAAAGAATGTTTACTTCCTGCAAACTGGTGAATTATAGAAAGCAATCCAGA
TGTGGTTTACTCTGCCACAGTCTAATGTCATTCACTTCATTTGATGGGGTCACTTGTTAGCTGTCACTAATAATGGAATTAATGGGAAAC
ACTTGATAAATGAAACTGTACCGTTAAATACAATAGCTGAGTTTTCCCCAGTGTATTGTAAAATTGACACACACTAATACAAGATGGATT
ATCAGGATGTATCTAAATGTCCCGAGAGGGTTAAAAGCTAACTGTAAATTACTTTAACTTTCACTTTCAAATCTGACAAATCTTGTTTAT
ATGGTATATAAAACTTTGTTTTCATCAGATTTGGGGGGGTTTTATATTAAAGAAATTAAGACTACACTATTTAAATAAACGTTTCCTGTT
TCTGACTTATTAGAGCTCTAAAGTTTATGAGGCCTACTTCTCTGAATATTCTGATGGGTTTTTTTTGAGACCAGTCTCATTTTCATACTG
ACATGTCTGAAAGATTTATTATTTATAAAGCTTAGGACATACTCTGGGAAGCTTAGAAGATACTTCAGCACTGGGAGGATTTTTTAAAGG
AAATGTGTTTTGTATTTCTTGTACCAGAGAATGGTGATGTTGATTGAGTTTTTTCCATGTAAAAAATGTACTTGTTTGCCAAATGTTCCT
AGATTGCTCTTAACCTGTTAATACAAGTAAAACTGTAGTGGGGATGGAGTCTGGCCTAAGTACAGAATGAGGGATTTAATTAGAAAAGTT
ATTTTCTTTTGTTCTGTATCAAACTGCAGAACAGCTATATACTTGGTATTTTGTACGTGAATAACGTTTTAGCTTTTGTGCCCTTTTGAG
CTTGAAGGGTTATCCTCAAAGGGGAAAACTATGAAGGGGAAGAAGACAAACCTAAGATACCATAAAGTAAAGGTTGACATTACATATTTT
CATTCACAATGCCCATTAAAAAAAAAAAATAGGTTGGGCATGGTGGCTCACGCCTGTAATCCCAACACTTTAGGAGGCTGAGGCAGATGG
ATTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACCCTGTCTCTACCAAAAAAAAAAAACAAAATAAATTAACCGG
GTGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGTGGGAGGATGACCTGGGCCCAGGAGGTGGAGGTTGCAGTGAGCC
TTGATAGCACCACTGCACTCCAGCCTGGGTGACGGAGCAAGACCCTGTCTCAAAACAGACAAACAAGCAAAAAATAGATTAAAGTCTGGA
TTTCACTGATTTTCTTGCTTAATAAGTTTTTTAAAACCACGATGCTGCAATTTTTTCCCTCTCAAGCTTCTTGAAAATGTGTGATTTACC
CTTTTTTATCTATTACTCTAGGCAAAGCTAAATATGATTTTTTTTTTTTTTTTTGAGACGGAGTCTGGCTCTGTTGCCCAGGCTGGAATG
CAGTGGTGCGATCTCAGCTCACTGCAACCTCCACCTCTCAGGTTCAAGTAGTTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGG
TGTGTGCCACCCTGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCACATTGGCCAGGCTGGTCTCAAACTCCTGACCTC
AGATGATCTACCCGCCTTGGCCTCCCGAAGTGCTTGAATTACAGGCGTGAGCCCCCGCGCCGGTCCGAAGCAAAGCTAAATGTAATTTTA
TGTACTGTTTTAACAGTATAAACCTATGGGATAAAGGCCCCCAATCATCAGAAGGACTACTGAAAAGAAAAGAAAGCAAACGTAGATGTC
AAATTGTCTAAACATTCTTAAGTACCACTGATTTTTTTTTTCTGGACTATTATACAAAGATGTCTGTAAAAAGTATACCAGTGGCTTTTA
TGCATATACACGATTAGGCTAGATTGTGAAGTACATGGGATTTCATGAGCCAGAGGAGGCATTTGGATCCATTGGGCCACATGTGACTAT
AAGCACATTGTGTACACAATAAAATTGTAGCCACTCATGTATTAAAACTGTTTTGGTAAAAGCTGTATTAAAAGAATAATTTTTTGCTTG
AGCTACTTAGTCACTTTTTTGCAGGGCACCAAAATGTAGGCTACTTTTCCATAGCTTGTTTGCTATGTTTTTATTTCATCTTAAATCTGA
GCCATTTTTGGCAATATCTTTTAAAAAATCATTATTAAACATTTATTGGAAATGTTGTATAGATTCACAAGAAAGAGACACCAAAGTGTT
TGGGAATTTTAATCCCAAGAAGTAAACATCCCAGAGTCAGATCCCATTTGCTGTTGTTCAGCCATGTTTGTATGACTGAATGTAATTTAG
GAAATCAGGAGTTAGAGATGAAAAATACAAACATGTCAAATGGTTGTAATTGCTTTTTTTGAACTTACTGGCTTTAACTTAAGTAATATA
GGTGTGTAGTTGTTTTATCTAAAGATGTCAGATTATCTGTGGCCCTGTTAATTAACTGCAGGGACCAGAGAGAGGACAAAAATGCCTGTA
TAATTTGCTTTAAAGGCTTGTCCTTATGTTTGTAATTTCAGTTAAATATTTTCTACAGATTGCTTCACTTCCCCTTTCCCCCAATAACAA
GTTCATATTCTTGTAATGTTTACTTTGGTCAACGTGGTAATTTTTGGAAGAAAATGCCAAAATGTAAGCTTCTCACAAGCAGCAAAGGAA
TGTAACTGCCTGTAGCTACCACATCAAGGGAGAGAAGAGGCTTGCGTACTTTGGGTTGATCTCACTGTACAAAAAAAGTGTACCCCTATT
GGAAGAAATAAGGAATACTTGAAGGTTTCTCCTTTTTTTACACTTGAGTCATGTGCAAGGTTGAACCATATGAAATTGCCAGTGTTCAAC
CATTGCTGATCTGCAAAAGCGACAATATCATATGCCTCAACCTAACACTTACTCTTAAATGCAGGTTAAAATCTCTGTGAGGCAAAGGGA
TAATATTCTCTAGGAACTCACTTTTGAGAGTATTTTTCTCTAACCCATGTGGATCTAAATTTTAAAAATAGGAATGAATCTCTTAATTGC
AGCTTGTGGAGAGTATAAAACATTTTGAGCACAATATGCAGCACATAACTTTTCAGATTGTGTTTGCATAGAAAAGGTTAAAATCAATTC
TTTCAGTTACTGTATTGTTCATTTCTTGTAAAGGTCTTCCTACATTTGAGACGAGACCCTTTAACATAGGCTGCCTTAGTAACAAAATAA
AACAGATGTGTCATAATATTAACTGTCCTAAAGAACATGTGTCTTGCAAATGCCATGGAACTGAATATTTATTTCCTTGTGAGTATTATG
ACCGTTACCAAAGGACTCAACCAGATTTAGGGCTCTTCTTAATTGATCATGTTCAGAAAGGGACTCATTTGGTCCCACTTTGTAACATGG
GAAGAGTAGAAGAGAAAATTAAATGTGGAAATCATAAATGCTTTTCTAACAGGGTTATGCTATTCTGTAACACTAAATGTCTGTCTTTTC
TCTTAAAAGATTAAGTTTTATTAATTTTGTCATACATTTCTCTATTTGAATATATCTTAACCATTTTATGTTCCAAATTCGTTTTTTGTC
CAAGACATTCTATCAGAATTTTACTTGCCTCTATAATCTGAAAAATGGGTTCTAGAATGTCCCACTTGCTGTCTCTTAGAGGCTGAGCTT
CATTTCTATGAGCAAAGAGCTCATTTAGCAATGTAGTTATTTCAGTATTTATTTCTATTATGGAATCCCTGGGGTTCAGAATGTAACTTT

>In-frame_BRIP1_ENST00000259008_chr17_59934419_-_SPAG9_ENST00000505279_chr17_49157065_-_4925nt
AATTCGTCTCGGGTTGTGTGGTTGAGGGGTCTGGTGGGTCGAGGAAAGGTAACGGCGGCCCCAGTCCTGCACACAAGGCCGGGGAAGTAG
CAGCACCCCCAGGAAGAGGGAGGAGGAAGGGCTCGTGCCCTTTCTTCTCTTCCAGGGCTCCGCTTTATTTGCTCTCAGAAGTCGGTTTCC
TTTCCTTTTCTTCAGTGAATCGGAGCTCAGAGCGTTGCTTCGGTTTCCCTCCAGACAGTTAGGAATCTGAAATAAACAGGAAAGCACTAT
GTCTTCAATGTGGTCTGAATATACAATTGGTGGGGTGAAGATTTACTTTCCTTATAAAGCTTACCCGTCACAGCTTGCTATGATGAATTC
TATTCTCAGAGGATTAAACAGCAAGCAACATTGTTTGTTGGAGAGTCCCACAGGAAGTGGAAAAAGCTTAGCCTTACTTTGTTCTGCTTT
AGCATGGCAACAATCTCTTAGTGGGAAACCAGCAGATGAGGGCGTAAGTGAAAAAGCTGAAGTACAATTGTCATGTTGTTGTGCATGCCA
TTCAAAGGATTTTACAAACAATGACATGAACCAAGGAACTTCACGTCATTTCAACTATCCAAGCACACCACCTTCTGAAAGAAATGGCAC
TTCATCAACTTGTCAAGAAATTCATTGAATTTGAAGACTCTCAAGAACAGGAAAAAAAGGACTTACAGACCCGAGTGGAATCTTTAGAAT
CTCAAACAAGACAACTTGAGCTGAAAGCGAAAAACTATGCTGACCAGATTAGCAGACTTGAAGAAAGAGAAGCAGAACTGAAGAAGGAAT
ATAATGCATTACATCAAAGACACACTGAGATGATCCATAATTATATGGAACATTTAGAAAGAACAAAACTTCATCAGCTCTCAGGGAGTG
ATCAACTAGAATCCACAGCTCATAGTAGAATTAGAAAAGAACGCCCTATATCATTAGGAATTTTCCCATTACCTGCTGGAGATGGATTGC
TTACACCTGATGCTCAGAAAGGAGGAGAGACCCCTGGATCTGAGCAATGGAAATTTCAGGAATTAAGTCAACCACGTTCTCATACCAGCC
TGAAGGATGAGCTTTCTGATGTTAGCCAAGGCGGATCTAAAGCTACCACTCCAGCATCAACAGCTAATTCAGATGTGGCAACAATTCCTA
CTGATACTCCCTTAAAGGAAGAAAACGAAGGATTTGTGAAGGTTACAGATGCGCCAAATAAATCAGAGATAAGCAAACACATTGAAGTAC
AGGTAGCCCAGGAAACTAGAAATGTATCTACTGGCTCTGCTGAAAATGAAGAAAAGTCAGAAGTTCAAGCAATCATCGAATCTACTCCTG
AGCTGGATATGGACAAAGATCTCAGTGGATATAAAGGTTCAAGCACTCCCACCAAAGGCATAGAGAACAAAGCTTTTGATCGCAATACAG
AATCTCTCTTTGAAGAACTGTCTTCAGCTGGCTCAGGCCTAATAGGAGATGTGGATGAAGGAGCAGATTTACTAGGAATGGGTCGGGAAG
TTGAGAATCTTATATTAGAAAATACACAACTGTTGGAAACCAAAAATGCTTTGAACATAGTGAAGAATGATTTGATAGCAAAAGTGGATG
AACTGACCTGTGAGAAAGATGTGCTGCAAGGGGAATTGGAGGCTGTGAAGCAAGCCAAACTGAAACTAGAGGAAAAGAACAGAGAATTGG
AGGAAGAGCTTAGGAAAGCTCGGGCAGAAGCTGAAGATGCAAGGCAAAAAGCAAAAGATGACGATGATAGTGATATTCCCACAGCCCAGA
GGAAACGGTTTACTAGAGTAGAAATGGCCCGTGTTCTCATGGAGCGAAACCAGTATAAAGAGAGATTGATGGAGCTTCAGGAAGCTGTTC
GATGGACAGAGATGATTCGGGCATCACGAGAAAATCCAGCCATGCAGGAAAAAAAAAGGTCAAGCATTTGGCAGTTTGTGCCAACTCGTT
TCAGCCGACTTTTCAGCTCCTCAAGTAACACGACTAAGAAGCCTGAACCACCTGTTAATCTGAAGTACAATGCACCCACGTCTCATGTTA
CTCCGTCCGTCAAGAAAAGAAGCAGCACCTTATCTCAGCTCCCTGGGGATAAGTCCAAAGCCTTTGATTTCCTTAGTGAAGAAACTGAAG
CTAGTTTAGCCTCACGCAGAGAACAAAAGAGAGAGCAGTATCGTCAGGTAAAAGCACATGTTCAGAAGGAAGACGGTAGAGTGCAGGCTT
TTGGCTGGAGTCTGCCTCAGAAGTACAAACAGGTAACCAATGGTCAAGGTGAAAATAAGATGAAAAATTTACCTGTGCCTGTCTATCTCA
GACCTCTGGATGAAAAAGATACATCAATGAAGCTGTGGTGTGCTGTTGGAGTCAATTTATCTGGTGGGAAGACCAGAGATGGTGGTTCTG
TTGTTGGAGCAAGTGTATTTTACAAGGATGTTGCTGGTTTGGATACAGAAGGCAGTAAACAGCGAAGTGCCTCTCAGAGTAGTTTAGATA
AGTTAGATCAGGAACTTAAGGAACAGCAGAAGGAGTTAAAAAATCAAGAAGAATTATCCAGTCTAGTTTGGATCTGTACCAGCACTCATT
CGGCTACAAAAGTTCTTATTATTGATGCTGTTCAACCTGGCAACATCCTAGACAGTTTCACTGTTTGCAACTCTCATGTTCTGTGCATTG
CAAGTGTGCCAGGTGCACGAGAAACAGACTACCCTGCAGGAGAAGATCTTTCAGAATCTGGTCAGGTAGACAAAGCATCTTTATGTGGAA
GTATGACAAGCAACAGCTCAGCAGAGACAGACAGCCTGTTAGGAGGCATCACAGTGGTTGGTTGTTCTGCAGAAGGTGTGACGGGAGCTG
CCACTTCCCCTAGTACAAATGGTGCTTCTCCAGTGATGGATAAACCACCAGAAATGGAAGCAGAAAATAGTGAGGTTGATGAAAATGTTC
CAACAGCAGAAGAAGCAACTGAAGCTACAGAAGGGAATGCGGGGTCAGCTGAAGACACAGTGGACATCTCCCAAACTGGCGTCTACACAG
AGCATGTCTTTACAGATCCTTTGGGAGTTCAGATCCCAGAAGACCTCTCCCCAGTGTATCAGTCGAGCAATGACTCAGATGCATATAAAG
ATCAAATATCAGTACTGCCAAATGAACAAGACTTGGTGAGAGAAGAAGCCCAGAAAATGAGTAGTCTTTTACCAACTATGTGGCTTGGAG
CTCAAAATGGCTGTTTGTATGTCCATTCATCTGTAGCCCAGTGGAGGAAATGTCTCCATTCCATTAAACTTAAAGATTCGATTCTCAGTA
TTGTACACGTGAAGGGAATCGTGTTAGTAGCCCTGGCTGACGGCACCCTTGCAATCTTTCACAGAGGAGTGGATGGGCAGTGGGATTTGT
CAAACTATCACCTCTTAGACCTTGGACGGCCTCATCATTCCATCCGTTGCATGACTGTGGTACATGACAAAGTCTGGTGTGGCTATAGGA
ACAAAATCTATGTGGTGCAGCCAAAGGCCATGAAAATAGAGAAATCTTTTGATGCACATCCCAGGAAGGAGAGCCAAGTGCGACAGCTTG
CGTGGGTGGGGGATGGCGTGTGGGTCTCCATTCGCTTGGATTCTACGCTCCGTCTCTATCATGCACACACTTATCAACATCTACAGGATG
TGGACATTGAGCCTTATGTAAGCAAAATGTTAGGTACTGGAAAACTGGGCTTCTCTTTTGTGAGAATTACAGCTCTTATGGTGTCTTGTA
ATCGTTTGTGGGTGGGGACAGGAAATGGTGTCATTATCTCCATCCCATTGACAGAAACAAATAAAACCTCAGGTGTACCAGGAAATCGTC
CTGGAAGTGTAATCCGTGTATATGGTGATGAAAACAGTGATAAAGTGACTCCAGGGACATTTATACCCTATTGTTCAATGGCACATGCAC
AGCTTTGCTTCCATGGGCACCGGGATGCTGTGAAATTCTTTGTGGCAGTCCCAGGTCAAGTCATCAGCCCACAAAGTAGCAGTAGTGGCA
CGGATCTGACGGGTGACAAAGCAGGGCCATCTGCACAGGAGCCTGGTAGTCAGACGCCCTTGAAGTCTATGCTTGTCATCAGTGGAGGAG
AGGGCTACATCGACTTCCGAATGGGTGATGAAGGTGGAGAATCAGAACTTCTTGGAGAGGATCTTCCACTTGAACCTTCTGTCACCAAAG
CAGAAAGGAGTCACTTGATAGTGTGGCAAGTGATGTATGGCAATGAGTGAGCCCATGGGAAACAGGTGGAGATGGGGAAGCCGTCTCTTC
TGCATGGTTTATTTTCCCTCTATCCTTTTATTTAATGCTCTTTTGTGAGATAAGTTTCACCACATAATGTGTGAGCATTTTTTCCTGTTA
ACTTTATATTACAAAATCCGTTCTACCATAACAATACAGAGGAACTAGCTGTGTTACTGCACCAGTGTTATAGGTAACTTCAGTATATTA
TGAACAAATCAAAGAATGTTTACTTCCTGCAAACTGGTGAATTATAGAAAGCAATCCAGATGTGGTTTACTCTGCCACAGTCTAATGTCA
TTCACTTCATTTGATGGGGTCACTTGTTAGCTGTCACTAATAATGGAATTAATGGGAAACACTTGATAAATGAAACTGTACCGTTAAATA
CAATAGCTGAGTTTTCCCCAGTGTATTGTAAAATTGACACACACTAATACAAGATGGATTATCAGGATGTATCTAAATGTCCCGAGAGGG
TTAAAAGCTAACTGTAAATTACTTTAACTTTCACTTTCAAATCTGACAAATCTTGTTTATATGGTATATAAAACTTTGTTTTCATCAGAT

>In-frame_BRIP1_ENST00000259008_chr17_59934419_-_SPAG9_ENST00000357122_chr17_49157065_-_4896nt
AATTCGTCTCGGGTTGTGTGGTTGAGGGGTCTGGTGGGTCGAGGAAAGGTAACGGCGGCCCCAGTCCTGCACACAAGGCCGGGGAAGTAG
CAGCACCCCCAGGAAGAGGGAGGAGGAAGGGCTCGTGCCCTTTCTTCTCTTCCAGGGCTCCGCTTTATTTGCTCTCAGAAGTCGGTTTCC
TTTCCTTTTCTTCAGTGAATCGGAGCTCAGAGCGTTGCTTCGGTTTCCCTCCAGACAGTTAGGAATCTGAAATAAACAGGAAAGCACTAT
GTCTTCAATGTGGTCTGAATATACAATTGGTGGGGTGAAGATTTACTTTCCTTATAAAGCTTACCCGTCACAGCTTGCTATGATGAATTC
TATTCTCAGAGGATTAAACAGCAAGCAACATTGTTTGTTGGAGAGTCCCACAGGAAGTGGAAAAAGCTTAGCCTTACTTTGTTCTGCTTT
AGCATGGCAACAATCTCTTAGTGGGAAACCAGCAGATGAGGGCGTAAGTGAAAAAGCTGAAGTACAATTGTCATGTTGTTGTGCATGCCA
TTCAAAGGATTTTACAAACAATGACATGAACCAAGGAACTTCACGTCATTTCAACTATCCAAGCACACCACCTTCTGAAAGAAATGGCAC
TTCATCAACTTGTCAAGAAATTCATTGAATTTGAAGACTCTCAAGAACAGGAAAAAAAGGACTTACAGACCCGAGTGGAATCTTTAGAAT
CTCAAACAAGACAACTTGAGCTGAAAGCGAAAAACTATGCTGACCAGATTAGCAGACTTGAAGAAAGAGAAGCAGAACTGAAGAAGGAAT
ATAATGCATTACATCAAAGACACACTGAGATGATCCATAATTATATGGAACATTTAGAAAGAACAAAACTTCATCAGCTCTCAGGGAGTG
ATCAACTAGAATCCACAGCTCATAGTAGAATTAGAAAAGAACGCCCTATATCATTAGGAATTTTCCCATTACCTGCTGGAGATGGATTGC
TTACACCTGATGCTCAGAAAGGAGGAGAGACCCCTGGATCTGAGCAATGGAAATTTCAGGAATTAAGTCAACCACGTTCTCATACCAGCC
TGAAGGATGAGCTTTCTGATGTTAGCCAAGGCGGATCTAAAGCTACCACTCCAGCATCAACAGCTAATTCAGATGTGGCAACAATTCCTA
CTGATACTCCCTTAAAGGAAGAAAACGAAGGATTTGTGAAGGTTACAGATGCGCCAAATAAATCAGAGATAAGCAAACACATTGAAGTAC
AGGTAGCCCAGGAAACTAGAAATGTATCTACTGGCTCTGCTGAAAATGAAGAAAAGTCAGAAGTTCAAGCAATCATCGAATCTACTCCTG
AGCTGGATATGGACAAAGATCTCAGTGGATATAAAGGTTCAAGCACTCCCACCAAAGGCATAGAGAACAAAGCTTTTGATCGCAATACAG
AATCTCTCTTTGAAGAACTGTCTTCAGCTGGCTCAGGCCTAATAGGAGATGTGGATGAAGGAGCAGATTTACTAGGAATGGGTCGGGAAG
TTGAGAATCTTATATTAGAAAATACACAACTGTTGGAAACCAAAAATGCTTTGAACATAGTGAAGAATGATTTGATAGCAAAAGTGGATG
AACTGACCTGTGAGAAAGATGTGCTGCAAGGGGAATTGGAGGCTGTGAAGCAAGCCAAACTGAAACTAGAGGAAAAGAACAGAGAATTGG
AGGAAGAGCTTAGGAAAGCTCGGGCAGAAGCTGAAGATGCAAGGCAAAAAGCAAAAGATGACGATGATAGTGATATTCCCACAGCCCAGA
GGAAACGGTTTACTAGAGTAGAAATGGCCCGTGTTCTCATGGAGCGAAACCAGTATAAAGAGAGATTGATGGAGCTTCAGGAAGCTGTTC
GATGGACAGAGATGATTCGGGCATCACGAGAAAATCCAGCCATGCAGGAAAAAAAAAGGTCAAGCATTTGGCAGTTTTTCAGCCGACTTT
TCAGCTCCTCAAGTAACACGACTAAGAAGCCTGAACCACCTGTTAATCTGAAGTACAATGCACCCACGTCTCATGTTACTCCGTCCGTCA
AGAAAAGAAGCAGCACCTTATCTCAGCTCCCTGGGGATAAGTCCAAAGCCTTTGATTTCCTTAGTGAAGAAACTGAAGCTAGTTTAGCCT
CACGCAGAGAACAAAAGAGAGAGCAGTATCGTCAGGTAAAAGCACATGTTCAGAAGGAAGACGGTAGAGTGCAGGCTTTTGGCTGGAGTC
TGCCTCAGAAGTACAAACAGGTAACCAATGGTCAAGGTGAAAATAAGATGAAAAATTTACCTGTGCCTGTCTATCTCAGACCTCTGGATG
AAAAAGATACATCAATGAAGCTGTGGTGTGCTGTTGGAGTCAATTTATCTGGTGGGAAGACCAGAGATGGTGGTTCTGTTGTTGGAGCAA
GTGTATTTTACAAGGATGTTGCTGGTTTGGATACAGAAGGCAGTAAACAGCGAAGTGCCTCTCAGAGTAGTTTAGATAAGTTAGATCAGG
AACTTAAGGAACAGCAGAAGGAGTTAAAAAATCAAGAAGAATTATCCAGTCTAGTTTGGATCTGTACCAGCACTCATTCGGCTACAAAAG
TTCTTATTATTGATGCTGTTCAACCTGGCAACATCCTAGACAGTTTCACTGTTTGCAACTCTCATGTTCTGTGCATTGCAAGTGTGCCAG
GTGCACGAGAAACAGACTACCCTGCAGGAGAAGATCTTTCAGAATCTGGTCAGGTAGACAAAGCATCTTTATGTGGAAGTATGACAAGCA
ACAGCTCAGCAGAGACAGACAGCCTGTTAGGAGGCATCACAGTGGTTGGTTGTTCTGCAGAAGGTGTGACGGGAGCTGCCACTTCCCCTA
GTACAAATGGTGCTTCTCCAGTGATGGATAAACCACCAGAAATGGAAGCAGAAAATAGTGAGGTTGATGAAAATGTTCCAACAGCAGAAG
AAGCAACTGAAGCTACAGAAGGGAATGCGGGGTCAGCTGAAGACACAGTGGACATCTCCCAAACTGGCGTCTACACAGAGCATGTCTTTA
CAGATCCTTTGGGAGTTCAGATCCCAGAAGACCTCTCCCCAGTGTATCAGTCGAGCAATGACTCAGATGCATATAAAGATCAAATATCAG
TACTGCCAAATGAACAAGACTTGGTGAGAGAAGAAGCCCAGAAAATGAGTAGTCTTTTACCAACTATGTGGCTTGGAGCTCAAAATGGCT
GTTTGTATGTCCATTCATCTGTAGCCCAGTGGAGGAAATGTCTCCATTCCATTAAACTTAAAGATTCGATTCTCAGTATTGTACACGTGA
AGGGAATCGTGTTAGTAGCCCTGGCTGACGGCACCCTTGCAATCTTTCACAGAGGAGTGGATGGGCAGTGGGATTTGTCAAACTATCACC
TCTTAGACCTTGGACGGCCTCATCATTCCATCCGTTGCATGACTGTGGTACATGACAAAGTCTGGTGTGGCTATAGGAACAAAATCTATG
TGGTGCAGCCAAAGGCCATGAAAATAGAGAAATCTTTTGATGCACATCCCAGGAAGGAGAGCCAAGTGCGACAGCTTGCGTGGGTGGGGG
ATGGCGTGTGGGTCTCCATTCGCTTGGATTCTACGCTCCGTCTCTATCATGCACACACTTATCAACATCTACAGGATGTGGACATTGAGC
CTTATGTAAGCAAAATGTTAGGTACTGGAAAACTGGGCTTCTCTTTTGTGAGAATTACAGCTCTTATGGTGTCTTGTAATCGTTTGTGGG
TGGGGACAGGAAATGGTGTCATTATCTCCATCCCATTGACAGAAACAAATAAAACCTCAGGTGTACCAGGAAATCGTCCTGGAAGTGTAA
TCCGTGTATATGGTGATGAAAACAGTGATAAAGTGACTCCAGGGACATTTATACCCTATTGTTCAATGGCACATGCACAGCTTTGCTTCC
ATGGGCACCGGGATGCTGTGAAATTCTTTGTGGCAGTCCCAGGTCAAGTCATCAGCCCACAAAGTAGCAGTAGTGGCACGGATCTGACGG
GTGACAAAGCAGGGCCATCTGCACAGGAGCCTGGTAGTCAGACGCCCTTGAAGTCTATGCTTGTCATCAGTGGAGGAGAGGGCTACATCG
ACTTCCGAATGGGTGATGAAGGTGGAGAATCAGAACTTCTTGGAGAGGATCTTCCACTTGAACCTTCTGTCACCAAAGCAGAAAGGAGTC
ACTTGATAGTGTGGCAAGTGATGTATGGCAATGAGTGAGCCCATGGGAAACAGGTGGAGATGGGGAAGCCGTCTCTTCTGCATGGTTTAT
TTTCCCTCTATCCTTTTATTTAATGCTCTTTTGTGAGATAAGTTTCACCACATAATGTGTGAGCATTTTTTCCTGTTAACTTTATATTAC
AAAATCCGTTCTACCATAACAATACAGAGGAACTAGCTGTGTTACTGCACCAGTGTTATAGGTAACTTCAGTATATTATGAACAAATCAA
AGAATGTTTACTTCCTGCAAACTGGTGAATTATAGAAAGCAATCCAGATGTGGTTTACTCTGCCACAGTCTAATGTCATTCACTTCATTT
GATGGGGTCACTTGTTAGCTGTCACTAATAATGGAATTAATGGGAAACACTTGATAAATGAAACTGTACCGTTAAATACAATAGCTGAGT
TTTCCCCAGTGTATTGTAAAATTGACACACACTAATACAAGATGGATTATCAGGATGTATCTAAATGTCCCGAGAGGGTTAAAAGCTAAC
TGTAAATTACTTTAACTTTCACTTTCAAATCTGACAAATCTTGTTTATATGGTATATAAAACTTTGTTTTCATCAGATTTGGGGGGGTTT


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FusionGenePPI for BRIP1_SPAG9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BRIP1BRCA1, MLH1, PMS1, PMS2, BLM, TOPBP1, RPA1, BARD1, MMS19, LMNA, HNRNPC, FHL3, POMK, GFOD1, C9orf41, LIPH, VAPB, USP37, CBX3, HIST1H3A, IL17RA, LYPD4, NCAPH2, TULP2, CRTAC1, PDDC1, DOCK5, AVIL, RAD51D, VWA5A, CRYL1, MSH2, FANCD2, BRIP1, MRE11A, RAD50, NBN, SPTA1, POLNSPAG9EIF4A2, NFKB1, MAX, MAPK8, MAPK14, MAP2K4, MAP3K3, PLK1, PNRC2, MAP1LC3B, SIRT7, MAP2K3, NDRG1, NENF, TP53BP1, CBX8, CD2AP, BRCC3, FAM175B, MTA2, HUWE1, LARP7, NOLC1, RABEP2, TXNDC9, ABL1, MREG, FAM219B, NTRK1, MED4, EYA1, PPEF2, PPM1D, PPM1K, TPTE, SMCO1, C16orf45, MAPK8IP3, ARFGAP1, RCCD1, COMTD1, ZBED1, SLC30A4, PODXL, SCARB2, FAM174A, ACOT12, CACNG5, TPM1, VASN, SYP, RRM2, KIF16B, TMEM44, MED9, KLHL40, ZFPL1, RRM2B, BIRC7, MND1, SPN, TPM3, USP15, MCM2, MCM4, MCM6, EPS15L1, IVNS1ABP, GTF3C4, SMC1A, GAPVD1, ANK3, SMC3, SBNO1, CDK11A, SOX4, BCR, PPP4R2, HSF1, KIAA1468, MCM7, ATG2B, SMEK1, WEE1, GTF3C2, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneBRIP1chr17:59934419chr17:49157065ENST00000259008-420888_10631261250BRCA1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BRIP1_SPAG9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BRIP1_SPAG9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRIP1C1836860FANCONI ANEMIA, COMPLEMENTATION GROUP J3CTD_human;UNIPROT
HgeneBRIP1C0006142Malignant neoplasm of breast2UNIPROT
HgeneBRIP1C0015625Fanconi Anemia1CTD_human;ORPHANET
HgeneBRIP1C0919267ovarian neoplasm1CTD_human