FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 4438

FusionGeneSummary for BRI3BP_IL22

check button Fusion gene summary
Fusion gene informationFusion gene name: BRI3BP_IL22
Fusion gene ID: 4438
HgeneTgene
Gene symbol

BRI3BP

IL22

Gene ID

140707

50616

Gene nameBRI3 binding proteininterleukin 22
SynonymsBNAS1|HCCR-1|HCCR-2|HCCRBP-1|HCCRBP-3|KG19IL-21|IL-22|IL-D110|IL-TIF|ILTIF|TIFIL-23|TIFa|zcyto18
Cytomap

12q24.31

12q15

Type of geneprotein-codingprotein-coding
DescriptionBRI3-binding proteinI3-binding proteincervical cancer 1 proto-oncogene-binding protein KG19cervical cancer oncogene binding proteininterleukin-22IL-10-related T-cell-derived inducible factorcytokine Zcyto18
Modification date2018052320180527
UniProtAcc

Q8WY22

Q9GZX6

Ensembl transtripts involved in fusion geneENST00000341446, ENST00000538666, 
ENST00000328087, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 2=12
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BRI3BP [Title/Abstract] AND IL22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCOADTCGA-AA-3660-01ABRI3BPchr12

125478549

+IL22chr12

68647274

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000341446ENST00000538666BRI3BPchr12

125478549

+IL22chr12

68647274

-
5CDS-5UTRENST00000341446ENST00000328087BRI3BPchr12

125478549

+IL22chr12

68647274

-

Top

FusionProtFeatures for BRI3BP_IL22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRI3BP

Q8WY22

IL22

Q9GZX6

Involved in tumorigenesis and may function bystabilizing p53/TP53. {ECO:0000269|PubMed:17943721}. Cytokine that contributes to the inflammatory responsein vivo.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BRI3BP_IL22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BRI3BP_IL22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BRI3BPESR1, RNF2, AMFR, TSPAN5, GDE1, PTH1R, P2RY12, DLK1, ZACN, HTR3C, TUSC5, LCA5, TCTN2, TCTN3, TCTN1, SPPL2B, YIPF3, LPAR1, LRRC4C, TPTE, TRIM25IL22IL22RA2, IL10RB, IL22RA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BRI3BP_IL22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for BRI3BP_IL22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIL22C4277682Chemical and Drug Induced Liver Injury3CTD_human
TgeneIL22C0241910Hepatitis, Autoimmune1CTD_human
TgeneIL22C0740392Infarction, Middle Cerebral Artery1CTD_human