FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 4433

FusionGeneSummary for BRF1_FOXN3

check button Fusion gene summary
Fusion gene informationFusion gene name: BRF1_FOXN3
Fusion gene ID: 4433
HgeneTgene
Gene symbol

BRF1

FOXN3

Gene ID

2972

1112

Gene nameBRF1, RNA polymerase III transcription initiation factor subunitforkhead box N3
SynonymsBRF|BRF-1|CFDS|GTF3B|HEL-S-76p|TAF3B2|TAF3C|TAFIII90|TF3B90|TFIIIB90|hBRFC14orf116|CHES1|PRO1635
Cytomap

14q32.33

14q31.3-q32.11

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor IIIB 90 kDa subunitB - related factor 1BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIBBRF1, RNA polymerase III transcription initiation factor 90 kDa subunitTATA box binding protein (TBP)-associateforkhead box protein N3checkpoint suppressor 1
Modification date2018051920180519
UniProtAcc

Q92994

O00409

Ensembl transtripts involved in fusion geneENST00000546474, ENST00000327359, 
ENST00000440513, ENST00000392557, 
ENST00000379937, ENST00000547530, 
ENST00000446501, ENST00000379932, 
ENST00000551787, ENST00000549044, 
ENST00000548421, 
ENST00000345097, 
ENST00000261302, ENST00000557258, 
ENST00000555353, ENST00000555658, 
Fusion gene scores* DoF score3 X 3 X 2=188 X 7 X 6=336
# samples 38
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRF1 [Title/Abstract] AND FOXN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFOXN3

GO:0045892

negative regulation of transcription, DNA-templated

16102918


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A08I-01ABRF1chr14

105713408

-FOXN3chr14

89878834

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000546474ENST00000345097BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000546474ENST00000261302BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000546474ENST00000557258BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000546474ENST00000555353BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-intronENST00000546474ENST00000555658BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000327359ENST00000345097BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000327359ENST00000261302BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000327359ENST00000557258BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000327359ENST00000555353BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-intronENST00000327359ENST00000555658BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000440513ENST00000345097BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000440513ENST00000261302BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000440513ENST00000557258BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000440513ENST00000555353BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-intronENST00000440513ENST00000555658BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-5UTRENST00000392557ENST00000345097BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-5UTRENST00000392557ENST00000261302BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-5UTRENST00000392557ENST00000557258BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-5UTRENST00000392557ENST00000555353BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-intronENST00000392557ENST00000555658BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000379937ENST00000345097BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000379937ENST00000261302BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000379937ENST00000557258BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000379937ENST00000555353BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-intronENST00000379937ENST00000555658BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000547530ENST00000345097BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000547530ENST00000261302BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000547530ENST00000557258BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000547530ENST00000555353BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-intronENST00000547530ENST00000555658BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000446501ENST00000345097BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000446501ENST00000261302BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000446501ENST00000557258BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000446501ENST00000555353BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-intronENST00000446501ENST00000555658BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-5UTRENST00000379932ENST00000345097BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-5UTRENST00000379932ENST00000261302BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-5UTRENST00000379932ENST00000557258BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-5UTRENST00000379932ENST00000555353BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-intronENST00000379932ENST00000555658BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-5UTRENST00000551787ENST00000345097BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-5UTRENST00000551787ENST00000261302BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-5UTRENST00000551787ENST00000557258BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-5UTRENST00000551787ENST00000555353BRF1chr14

105713408

-FOXN3chr14

89878834

-
5UTR-intronENST00000551787ENST00000555658BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000549044ENST00000345097BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000549044ENST00000261302BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000549044ENST00000557258BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000549044ENST00000555353BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-intronENST00000549044ENST00000555658BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000548421ENST00000345097BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000548421ENST00000261302BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000548421ENST00000557258BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-5UTRENST00000548421ENST00000555353BRF1chr14

105713408

-FOXN3chr14

89878834

-
intron-intronENST00000548421ENST00000555658BRF1chr14

105713408

-FOXN3chr14

89878834

-

Top

FusionProtFeatures for BRF1_FOXN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRF1

Q92994

FOXN3

O00409

Acts as a transcriptional repressor. May be involved inDNA damage-inducible cell cycle arrests (checkpoints).{ECO:0000269|PubMed:16102918}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BRF1_FOXN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BRF1_FOXN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BRF1GTF3C5, GTF3C3, RB1, CSNK2A1, CSNK2A2, TP53, TBP, RBL1, RBL2, PCBD2, DTNBP1, APP, UBC, ACSL4, TCF20, CCDC132, POLR3E, RHOUFOXN3MEN1, ELAVL1, EXOSC8, SRPK2, CHSY3, CHSY1, FOXO3B, HRNR, KBTBD7, FOXR2, RFX2, RFX3, RFX1, ZBTB34, BTRC, FBXW11, DDB2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BRF1_FOXN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for BRF1_FOXN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRF1C4015495CEREBELLOFACIODENTAL SYNDROME1ORPHANET;UNIPROT