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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4429

FusionGeneSummary for BRE_HADHB

check button Fusion gene summary
Fusion gene informationFusion gene name: BRE_HADHB
Fusion gene ID: 4429
HgeneTgene
Gene symbol

BRE

HADHB

Gene ID

3032

Gene namehydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
SynonymsECHB|MSTP029|MTPB|TP-BETA
Cytomap

2p23.3

Type of geneprotein-coding
Descriptiontrifunctional enzyme subunit beta, mitochondrial2-enoyl-Coenzyme A (CoA) hydratase, beta subunit3-ketoacyl-Coenzyme A (CoA) thiolase of mitochondrial trifunctional protein, beta subunitacetyl-CoA acyltransferasebeta-ketothiolasehydroxyacyl-CoA dehydr
Modification date20180523
UniProtAcc

P55084

Ensembl transtripts involved in fusion geneENST00000344773, ENST00000379624, 
ENST00000342045, ENST00000379632, 
ENST00000361704, ENST00000603461, 
ENST00000317799, ENST00000405867, 
ENST00000537713, ENST00000545822, 
ENST00000494615, 
Fusion gene scores* DoF score7 X 7 X 6=2946 X 5 X 5=150
# samples 95
** MAII scorelog2(9/294*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/150*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRE [Title/Abstract] AND HADHB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A5J0-01ABREchr2

28210954

+HADHBchr2

26477115

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000344773ENST00000317799BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000344773ENST00000405867BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000344773ENST00000537713BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000344773ENST00000545822BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-intronENST00000344773ENST00000494615BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000379624ENST00000317799BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000379624ENST00000405867BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000379624ENST00000537713BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000379624ENST00000545822BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-intronENST00000379624ENST00000494615BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000342045ENST00000317799BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000342045ENST00000405867BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000342045ENST00000537713BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000342045ENST00000545822BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-intronENST00000342045ENST00000494615BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000379632ENST00000317799BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000379632ENST00000405867BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000379632ENST00000537713BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000379632ENST00000545822BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-intronENST00000379632ENST00000494615BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000361704ENST00000317799BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000361704ENST00000405867BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000361704ENST00000537713BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-5UTRENST00000361704ENST00000545822BREchr2

28210954

+HADHBchr2

26477115

+
5CDS-intronENST00000361704ENST00000494615BREchr2

28210954

+HADHBchr2

26477115

+
3UTR-5UTRENST00000603461ENST00000317799BREchr2

28210954

+HADHBchr2

26477115

+
3UTR-5UTRENST00000603461ENST00000405867BREchr2

28210954

+HADHBchr2

26477115

+
3UTR-5UTRENST00000603461ENST00000537713BREchr2

28210954

+HADHBchr2

26477115

+
3UTR-5UTRENST00000603461ENST00000545822BREchr2

28210954

+HADHBchr2

26477115

+
3UTR-intronENST00000603461ENST00000494615BREchr2

28210954

+HADHBchr2

26477115

+

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FusionProtFeatures for BRE_HADHB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRE

HADHB

P55084

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BRE_HADHB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BRE_HADHB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BREBABAM1, BRCC3, FAM175B, BARD1, BRCA1, BRCA2, RAD51, TP53, UBE2D1, UIMC1, PHB, RPN2, SHMT2, SSR3, USP7, LRPPRC, SLC25A13, ATG2A, TTC28, FKBP8, DHRS7B, TMX3, UGGT2, MMS19, FAM175A, TNFRSF1A, FAS, COPS5, NCOA3, UBC, SUMO2, GFI1B, GRB2, MDC1, PAXIP1, AKAP2, HNRNPA2B1, OPTN, TFG, DEF6, CHI3L1, HIST1H2BG, EGFR, WWP2, FAM189B, TENC1HADHBTNNI3K, ATG101, DDA1, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, SQSTM1, UBC, MYC, PSMA3, GRB7, TK1, CDKN1A, SMN1, RCC1, ANXA7, LEO1, RTF1, CDK2, GRK5, FBXO6, HADHA, HSP90AB1, RPS8, OPA1, DES, TUBB1, ATF2, IQCB1, PAN2, ADRB2, SUOX, TIMM8B, COX17, CHCHD4, PPP6R1, PARK2, CSNK2A2, TUBG1, TP53, HUWE1, CUL7, EGFR, SYNDIG1, PEX19, LRRC46, IGSF8, SLC39A4, TMEFF1, KCNA6, ATP1A1, ATP1B1, DDOST, UQCRC2, NTRK1, HSPB2, MED4, MED23, KPNB1, NES, NAF1, SKI, MCM2, HSD17B10, ZNF746, PTPRD, GPC1, RELL2, CD44, SDC2, CDH5, CDH8, C17orf80, YBEY, POTEI, CYLD, VDAC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BRE_HADHB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BRE_HADHB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHADHBC0015695Fatty Liver1CTD_human
TgeneHADHBC0018799Heart Diseases1CTD_human
TgeneHADHBC0154251Lipid Metabolism Disorders1CTD_human
TgeneHADHBC1458155Mammary Neoplasms1CTD_human
TgeneHADHBC1969443Trifunctional Protein Deficiency With Myopathy And Neuropathy1CTD_human;ORPHANET;UNIPROT