FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 4419

FusionGeneSummary for BRD9_CEP72

check button Fusion gene summary
Fusion gene informationFusion gene name: BRD9_CEP72
Fusion gene ID: 4419
HgeneTgene
Gene symbol

BRD9

CEP72

Gene ID

65980

55722

Gene namebromodomain containing 9centrosomal protein 72
SynonymsLAVS3040|PRO9856-
Cytomap

5p15.33

5p15.33

Type of geneprotein-codingprotein-coding
Descriptionbromodomain-containing protein 9rhabdomyosarcoma antigen MU-RMS-40.8sarcoma antigen NY-SAR-29centrosomal protein of 72 kDacentrosomal protein 72kDa
Modification date2018051920180522
UniProtAcc

Q9H8M2

Q9P209

Ensembl transtripts involved in fusion geneENST00000388890, ENST00000323510, 
ENST00000483173, ENST00000467963, 
ENST00000435709, ENST00000494422, 
ENST00000264935, ENST00000444221, 
ENST00000514507, 
Fusion gene scores* DoF score8 X 9 X 6=4321 X 2 X 1=2
# samples 101
** MAII scorelog2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/2*10)=2.32192809488736
Context

PubMed: BRD9 [Title/Abstract] AND CEP72 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-90-6837-01ABRD9chr5

891270

-CEP72chr5

647920

+
TCGALDLUSCTCGA-90-6837-01ABRD9chr5

891269

-CEP72chr5

647921

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000388890ENST00000264935BRD9chr5

891270

-CEP72chr5

647920

+
intron-3UTRENST00000388890ENST00000444221BRD9chr5

891270

-CEP72chr5

647920

+
intron-intronENST00000388890ENST00000514507BRD9chr5

891270

-CEP72chr5

647920

+
intron-3CDSENST00000323510ENST00000264935BRD9chr5

891270

-CEP72chr5

647920

+
intron-3UTRENST00000323510ENST00000444221BRD9chr5

891270

-CEP72chr5

647920

+
intron-intronENST00000323510ENST00000514507BRD9chr5

891270

-CEP72chr5

647920

+
Frame-shiftENST00000483173ENST00000264935BRD9chr5

891270

-CEP72chr5

647920

+
5CDS-3UTRENST00000483173ENST00000444221BRD9chr5

891270

-CEP72chr5

647920

+
5CDS-intronENST00000483173ENST00000514507BRD9chr5

891270

-CEP72chr5

647920

+
In-frameENST00000467963ENST00000264935BRD9chr5

891270

-CEP72chr5

647920

+
5CDS-3UTRENST00000467963ENST00000444221BRD9chr5

891270

-CEP72chr5

647920

+
5CDS-intronENST00000467963ENST00000514507BRD9chr5

891270

-CEP72chr5

647920

+
5UTR-3CDSENST00000435709ENST00000264935BRD9chr5

891270

-CEP72chr5

647920

+
5UTR-3UTRENST00000435709ENST00000444221BRD9chr5

891270

-CEP72chr5

647920

+
5UTR-intronENST00000435709ENST00000514507BRD9chr5

891270

-CEP72chr5

647920

+
intron-3CDSENST00000494422ENST00000264935BRD9chr5

891270

-CEP72chr5

647920

+
intron-3UTRENST00000494422ENST00000444221BRD9chr5

891270

-CEP72chr5

647920

+
intron-intronENST00000494422ENST00000514507BRD9chr5

891270

-CEP72chr5

647920

+
intron-3CDSENST00000388890ENST00000264935BRD9chr5

891269

-CEP72chr5

647921

+
intron-3UTRENST00000388890ENST00000444221BRD9chr5

891269

-CEP72chr5

647921

+
intron-intronENST00000388890ENST00000514507BRD9chr5

891269

-CEP72chr5

647921

+
intron-3CDSENST00000323510ENST00000264935BRD9chr5

891269

-CEP72chr5

647921

+
intron-3UTRENST00000323510ENST00000444221BRD9chr5

891269

-CEP72chr5

647921

+
intron-intronENST00000323510ENST00000514507BRD9chr5

891269

-CEP72chr5

647921

+
Frame-shiftENST00000483173ENST00000264935BRD9chr5

891269

-CEP72chr5

647921

+
5CDS-3UTRENST00000483173ENST00000444221BRD9chr5

891269

-CEP72chr5

647921

+
5CDS-intronENST00000483173ENST00000514507BRD9chr5

891269

-CEP72chr5

647921

+
In-frameENST00000467963ENST00000264935BRD9chr5

891269

-CEP72chr5

647921

+
5CDS-3UTRENST00000467963ENST00000444221BRD9chr5

891269

-CEP72chr5

647921

+
5CDS-intronENST00000467963ENST00000514507BRD9chr5

891269

-CEP72chr5

647921

+
5UTR-3CDSENST00000435709ENST00000264935BRD9chr5

891269

-CEP72chr5

647921

+
5UTR-3UTRENST00000435709ENST00000444221BRD9chr5

891269

-CEP72chr5

647921

+
5UTR-intronENST00000435709ENST00000514507BRD9chr5

891269

-CEP72chr5

647921

+
intron-3CDSENST00000494422ENST00000264935BRD9chr5

891269

-CEP72chr5

647921

+
intron-3UTRENST00000494422ENST00000444221BRD9chr5

891269

-CEP72chr5

647921

+
intron-intronENST00000494422ENST00000514507BRD9chr5

891269

-CEP72chr5

647921

+

Top

FusionProtFeatures for BRD9_CEP72


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRD9

Q9H8M2

CEP72

Q9P209

Involved in the recruitment of key centrosomal proteinsto the centrosome. Provides centrosomal microtubule-nucleationactivity on the gamma-tubulin ring complexes (gamma-TuRCs) and hascritical roles in forming a focused bipolar spindle, which isneeded for proper tension generation between sister chromatids.Required for localization of KIZ, AKAP9 and gamma-tubulin ringcomplexes (gamma-TuRCs) (PubMed:19536135). Involved in centrioleduplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63centrosomal localization and promotes the centrosomal localizationof CDK2 (PubMed:26297806). {ECO:0000269|PubMed:19536135,ECO:0000269|PubMed:26297806}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BRD9_CEP72


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_BRD9_ENST00000467963_chr5_891270_-_CEP72_ENST00000264935_chr5_647920_+_226aa
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKE
EKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPGLQTSVKRLCGEIVELKQHLEHYDKIQELTQMLQESHSSLVSTNEHL

>In-frame_BRD9_ENST00000467963_chr5_891269_-_CEP72_ENST00000264935_chr5_647921_+_226aa
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKE
EKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPGLQTSVKRLCGEIVELKQHLEHYDKIQELTQMLQESHSSLVSTNEHL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_BRD9_ENST00000467963_chr5_891270_-_CEP72_ENST00000264935_chr5_647920_+_678nt
ATGGGCAAGAAGCACAAGAAGCACAAGGCCGAGTGGCGCTCGTCCTACGAGGATTATGCCGACAAGCCCCTGGAGAAGCCTCTAAAGCTA
GTCCTGAAGGTCGGAGGAAGTGAAGTGACTGAACTCTCAGGATCCGGCCACGACTCCAGTTACTATGATGACAGGTCAGACCATGAGCGA
GAGAGGCACAAAGAAAAGAAAAAGAAGAAGAAGAAGAAGTCCGAGAAGGAGAAGCATCTGGACGATGAGGAAAGAAGGAAGCGAAAGGAA
GAGAAGAAGCGGAAGCGAGAGAGGGAGCACTGTGACACGGAGGGAGAGGCTGACGACTTTGATCCTGGGAAGAAGGTGGAGGTGGAGCCG
CCCCCAGATCGGCCAGTCCGAGCGTGCCGGACACAGCCAGGACTTCAAACAAGTGTGAAGAGGCTGTGTGGCGAGATTGTGGAACTGAAG
CAGCACCTGGAGCACTACGACAAGATCCAGGAGCTCACGCAGATGCTGCAGGAGAGCCACAGCTCCCTGGTCAGCACCAATGAACACCTG
CTGCAGGAGCTGAGCCAGGTGCGGGCGCAGCACAGAGCCGAGGTGGAGCAGATGCACTGGAGCTACCAGGAGCTCAAGAAGACCATGGCC

>In-frame_BRD9_ENST00000467963_chr5_891269_-_CEP72_ENST00000264935_chr5_647921_+_678nt
ATGGGCAAGAAGCACAAGAAGCACAAGGCCGAGTGGCGCTCGTCCTACGAGGATTATGCCGACAAGCCCCTGGAGAAGCCTCTAAAGCTA
GTCCTGAAGGTCGGAGGAAGTGAAGTGACTGAACTCTCAGGATCCGGCCACGACTCCAGTTACTATGATGACAGGTCAGACCATGAGCGA
GAGAGGCACAAAGAAAAGAAAAAGAAGAAGAAGAAGAAGTCCGAGAAGGAGAAGCATCTGGACGATGAGGAAAGAAGGAAGCGAAAGGAA
GAGAAGAAGCGGAAGCGAGAGAGGGAGCACTGTGACACGGAGGGAGAGGCTGACGACTTTGATCCTGGGAAGAAGGTGGAGGTGGAGCCG
CCCCCAGATCGGCCAGTCCGAGCGTGCCGGACACAGCCAGGACTTCAAACAAGTGTGAAGAGGCTGTGTGGCGAGATTGTGGAACTGAAG
CAGCACCTGGAGCACTACGACAAGATCCAGGAGCTCACGCAGATGCTGCAGGAGAGCCACAGCTCCCTGGTCAGCACCAATGAACACCTG
CTGCAGGAGCTGAGCCAGGTGCGGGCGCAGCACAGAGCCGAGGTGGAGCAGATGCACTGGAGCTACCAGGAGCTCAAGAAGACCATGGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_BRD9_ENST00000467963_chr5_891270_-_CEP72_ENST00000264935_chr5_647920_+_1245nt
CTGCCGCGGCCCCGCCTCGCCCCGTTTCCGGCGCGGCCCAGCGAGCTCGGCAACCTCGGCGCAGCGAGCGCGGGCGGCCAGCCAGGGCCA
GGGGGCGGTGGCGGCCAAGGTCCGACCGGGTGCCAGCTGTTCCCAGCCCCCGCCTCGGGCCCGCCGCCGGCGCCGCCATGGGCAAGAAGC
ACAAGAAGCACAAGGCCGAGTGGCGCTCGTCCTACGAGGATTATGCCGACAAGCCCCTGGAGAAGCCTCTAAAGCTAGTCCTGAAGGTCG
GAGGAAGTGAAGTGACTGAACTCTCAGGATCCGGCCACGACTCCAGTTACTATGATGACAGGTCAGACCATGAGCGAGAGAGGCACAAAG
AAAAGAAAAAGAAGAAGAAGAAGAAGTCCGAGAAGGAGAAGCATCTGGACGATGAGGAAAGAAGGAAGCGAAAGGAAGAGAAGAAGCGGA
AGCGAGAGAGGGAGCACTGTGACACGGAGGGAGAGGCTGACGACTTTGATCCTGGGAAGAAGGTGGAGGTGGAGCCGCCCCCAGATCGGC
CAGTCCGAGCGTGCCGGACACAGCCAGGACTTCAAACAAGTGTGAAGAGGCTGTGTGGCGAGATTGTGGAACTGAAGCAGCACCTGGAGC
ACTACGACAAGATCCAGGAGCTCACGCAGATGCTGCAGGAGAGCCACAGCTCCCTGGTCAGCACCAATGAACACCTGCTGCAGGAGCTGA
GCCAGGTGCGGGCGCAGCACAGAGCCGAGGTGGAGCAGATGCACTGGAGCTACCAGGAGCTCAAGAAGACCATGGCCCTGTTTCCACACA
GCAGCGCCAGCCATGGAGGCTGCCAGGCCTGCTGACTCCTGCCGAGAAGCTGGGCCACCCCTTAAGCTTCCTGGTAAAGTTACATTGTCT
GCACCTTTGTACTTCTTTATTGAGTGTACTGGCTGGCAAGAGTTCTCTCTTCTGTTGGTAATTATTTAGGATTTTTGGAATGTATTCAGG
ACCTGTAGCTTGGTTTTCTAAAGCACCTCGTAAAATGATATGATTACTCCAAGCCCTCTGCATGTTTTCAGACAGAACACATTGACATAT
TTTGAGACAAACTGACTATTAATCTTGTATCCAGTATCCTGAGATGAAGTAAATGCAGTGTTCTACTGCCTGATGTGAAAGAGAGCTATG

>In-frame_BRD9_ENST00000467963_chr5_891269_-_CEP72_ENST00000264935_chr5_647921_+_1245nt
CTGCCGCGGCCCCGCCTCGCCCCGTTTCCGGCGCGGCCCAGCGAGCTCGGCAACCTCGGCGCAGCGAGCGCGGGCGGCCAGCCAGGGCCA
GGGGGCGGTGGCGGCCAAGGTCCGACCGGGTGCCAGCTGTTCCCAGCCCCCGCCTCGGGCCCGCCGCCGGCGCCGCCATGGGCAAGAAGC
ACAAGAAGCACAAGGCCGAGTGGCGCTCGTCCTACGAGGATTATGCCGACAAGCCCCTGGAGAAGCCTCTAAAGCTAGTCCTGAAGGTCG
GAGGAAGTGAAGTGACTGAACTCTCAGGATCCGGCCACGACTCCAGTTACTATGATGACAGGTCAGACCATGAGCGAGAGAGGCACAAAG
AAAAGAAAAAGAAGAAGAAGAAGAAGTCCGAGAAGGAGAAGCATCTGGACGATGAGGAAAGAAGGAAGCGAAAGGAAGAGAAGAAGCGGA
AGCGAGAGAGGGAGCACTGTGACACGGAGGGAGAGGCTGACGACTTTGATCCTGGGAAGAAGGTGGAGGTGGAGCCGCCCCCAGATCGGC
CAGTCCGAGCGTGCCGGACACAGCCAGGACTTCAAACAAGTGTGAAGAGGCTGTGTGGCGAGATTGTGGAACTGAAGCAGCACCTGGAGC
ACTACGACAAGATCCAGGAGCTCACGCAGATGCTGCAGGAGAGCCACAGCTCCCTGGTCAGCACCAATGAACACCTGCTGCAGGAGCTGA
GCCAGGTGCGGGCGCAGCACAGAGCCGAGGTGGAGCAGATGCACTGGAGCTACCAGGAGCTCAAGAAGACCATGGCCCTGTTTCCACACA
GCAGCGCCAGCCATGGAGGCTGCCAGGCCTGCTGACTCCTGCCGAGAAGCTGGGCCACCCCTTAAGCTTCCTGGTAAAGTTACATTGTCT
GCACCTTTGTACTTCTTTATTGAGTGTACTGGCTGGCAAGAGTTCTCTCTTCTGTTGGTAATTATTTAGGATTTTTGGAATGTATTCAGG
ACCTGTAGCTTGGTTTTCTAAAGCACCTCGTAAAATGATATGATTACTCCAAGCCCTCTGCATGTTTTCAGACAGAACACATTGACATAT
TTTGAGACAAACTGACTATTAATCTTGTATCCAGTATCCTGAGATGAAGTAAATGCAGTGTTCTACTGCCTGATGTGAAAGAGAGCTATG


Top

FusionGenePPI for BRD9_CEP72


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BRD9BRD4, WHSC1L1, CATIP, SS18, SMARCD1, MUS81, NFE2L1, CXXC4, BCL7C, BCL7A, SMARCC2, TRIM25, UBE2ACEP72KIAA0408, ZBTB16, IGHM, LNX1, ZNF417, MCM10, SPATA2, PCM1, ATXN7, LATS2, SAV1, HSPA1A, DDB1, TRAP1, GPR112, PCLO, RAVER1, SLC4A10, TBC1D4, TUBA1C, PIN4, PSMA1, SRSF2, NME7, FAM90A1, STAMBPL1, SPATA24, CATIP, RASSF7, SEPT6, KIAA0753, CCDC14, MED4, CEP290, OFD1, CEP162, CEP120, SPICE1, CEP128, CEP135, CEP63, CEP89, ODF2, POC5, LCA5, CSNK1E, DSP, HSPA5, PCNT, PPP2CB, PRKAR2B, DYNLL1, FGFR1OP, MAPRE1, HAUS2, NEDD1, KIF7, PPP2R3C, GAN, TPTE2, GGA1, RGS3, AHCYL2, ZKSCAN1, HOMER1, AHCYL1, CTU2, CHAF1B, TRIM25, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BRD9_CEP72


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for BRD9_CEP72


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRD9C0036920Sezary Syndrome1CTD_human