	FusionGeneSummary
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	FusionGeneSequence
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Fusion gene ID: 4415

FusionGeneSummary for BRD8_HLA-DRA

Fusion gene summary

Fusion gene information	Fusion gene name: BRD8_HLA-DRA
	Fusion gene ID: 4415
		Hgene	Tgene
	Gene symbol	BRD8	HLA-DRA
	Gene ID	10902	3122
	Gene name	bromodomain containing 8	major histocompatibility complex, class II, DR alpha
	Synonyms	SMAP\|SMAP2\|p120	HLA-DRA1
	Cytomap	5q31.2	6p21.32
	Type of gene	protein-coding	protein-coding
	Description	bromodomain-containing protein 8skeletal muscle abundant protein 2thyroid hormone receptor coactivating protein of 120 kDatrCP120	HLA class II histocompatibility antigen, DR alpha chainMHC class II antigen DRAhistocompatibility antigen HLA-DR alpha
	Modification date	20180519	20180522
	UniProtAcc	Q9H0E9	P01903
	Ensembl transtripts involved in fusion gene	ENST00000254900, ENST00000230901, ENST00000402931, ENST00000411594, ENST00000455658, ENST00000515014,	ENST00000395388, ENST00000374982, ENST00000383127, ENST00000459705, ENST00000434866, ENST00000416883, ENST00000481943, ENST00000411505, ENST00000414698, ENST00000546379, ENST00000493431, ENST00000418111, ENST00000383259, ENST00000551750, ENST00000461633, ENST00000383258, ENST00000442960, ENST00000549531, ENST00000482781, ENST00000415767, ENST00000411524, ENST00000553193, ENST00000498597, ENST00000427753,
Fusion gene scores	* DoF score	2 X 2 X 1=4	5 X 6 X 2=60
	# samples	2	6
	** MAII score	log2(2/4*10)=2.32192809488736	log2(6/60*10)=0
Context	PubMed: BRD8 [Title/Abstract] AND HLA-DRA [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BRD8	GO:0043967	histone H4 acetylation	14966270
Hgene	BRD8	GO:0043968	histone H2A acetylation	14966270
Tgene	HLA-DRA	GO:0002503	peptide antigen assembly with MHC class II protein complex	1448172\|7606781\|22733780
Tgene	HLA-DRA	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	21502329
Tgene	HLA-DRA	GO:0002506	polysaccharide assembly with MHC class II protein complex	21502329

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AI335540	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000254900	ENST00000395388	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000374982	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000383127	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000459705	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000434866	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000416883	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000481943	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000411505	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000414698	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000546379	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000493431	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000418111	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000383259	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000551750	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000461633	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000383258	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000442960	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000549531	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-3UTR	ENST00000254900	ENST00000482781	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-3UTR	ENST00000254900	ENST00000415767	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000411524	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000553193	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000498597	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000254900	ENST00000427753	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000395388	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000374982	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000383127	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000459705	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000434866	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000416883	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000481943	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000411505	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000414698	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000546379	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000493431	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000418111	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000383259	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000551750	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000461633	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000383258	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000442960	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000549531	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-3UTR	ENST00000230901	ENST00000482781	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-3UTR	ENST00000230901	ENST00000415767	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000411524	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000553193	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000498597	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000230901	ENST00000427753	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000395388	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000374982	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000383127	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000459705	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000434866	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000416883	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000481943	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000411505	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000414698	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000546379	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000493431	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000418111	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000383259	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000551750	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000461633	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000383258	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000442960	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000549531	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-3UTR	ENST00000402931	ENST00000482781	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-3UTR	ENST00000402931	ENST00000415767	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000411524	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000553193	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000498597	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000402931	ENST00000427753	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000395388	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000374982	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000383127	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000459705	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000434866	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000416883	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000481943	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000411505	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000414698	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000546379	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000493431	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000418111	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000383259	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000551750	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000461633	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000383258	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000442960	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000549531	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-3UTR	ENST00000411594	ENST00000482781	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-3UTR	ENST00000411594	ENST00000415767	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000411524	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000553193	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000498597	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000411594	ENST00000427753	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000395388	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000374982	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000383127	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000459705	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000434866	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000416883	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000481943	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000411505	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000414698	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000546379	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000493431	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000418111	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000383259	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000551750	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000461633	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000383258	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000442960	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000549531	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-3UTR	ENST00000455658	ENST00000482781	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-3UTR	ENST00000455658	ENST00000415767	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000411524	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000553193	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000498597	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000455658	ENST00000427753	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000395388	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000374982	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000383127	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000459705	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000434866	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000416883	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000481943	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000411505	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000414698	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000546379	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000493431	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000418111	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000383259	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000551750	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000461633	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000383258	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000442960	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000549531	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-3UTR	ENST00000515014	ENST00000482781	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-3UTR	ENST00000515014	ENST00000415767	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000411524	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000553193	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000498597	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-
intron-intron	ENST00000515014	ENST00000427753	BRD8	chr5	137492769	+	HLA-DRA	chr6	3752490	-

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FusionProtFeatures for BRD8_HLA-DRA

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BRD8 Q9H0E9	HLA-DRA P01903
May act as a coactivator during transcriptionalactivation by hormone-activated nuclear receptors (NR). Isoform 2stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1,RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 arecomponents of the NuA4 histone acetyltransferase (HAT) complexwhich is involved in transcriptional activation of select genesprincipally by acetylation of nucleosomal histones H4 and H2A.This modification may both alter nucleosome - DNA interactions andpromote interaction of the modified histones with other proteinswhich positively regulate transcription. This complex may berequired for the activation of transcriptional programs associatedwith oncogene and proto-oncogene mediated growth induction, tumorsuppressor mediated growth arrest and replicative senescence,apoptosis, and DNA repair. NuA4 may also play a direct role in DNArepair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histoneH2A.Z/H2AFZ from the nucleosome. {ECO:0000269\|PubMed:10517671,ECO:0000269\|PubMed:14966270, ECO:0000269\|PubMed:24463511}.	Binds peptides derived from antigens that access theendocytic route of antigen presenting cells (APC) and presentsthem on the cell surface for recognition by the CD4 T-cells. Thepeptide binding cleft accommodates peptides of 10-30 residues. Thepeptides presented by MHC class II molecules are generated mostlyby degradation of proteins that access the endocytic route, wherethey are processed by lysosomal proteases and other hydrolases.Exogenous antigens that have been endocytosed by the APC are thusreadily available for presentation via MHC II molecules, and forthis reason this antigen presentation pathway is usually referredto as exogenous. As membrane proteins on their way to degradationin lysosomes as part of their normal turn-over are also containedin the endosomal/lysosomal compartments, exogenous antigens mustcompete with those derived from endogenous components. Autophagyis also a source of endogenous peptides, autophagosomesconstitutively fuse with MHC class II loading compartments. Inaddition to APCs, other cells of the gastrointestinal tract, suchas epithelial cells, express MHC class II molecules and CD74 andact as APCs, which is an unusual trait of the GI tract. To producea MHC class II molecule that presents an antigen, three MHC classII molecules (heterodimers of an alpha and a beta chain) associatewith a CD74 trimer in the ER to form a heterononamer. Soon afterthe entry of this complex into the endosomal/lysosomal systemwhere antigen processing occurs, CD74 undergoes a sequentialdegradation by various proteases, including CTSS and CTSL, leavinga small fragment termed CLIP (class-II-associated invariant chainpeptide). The removal of CLIP is facilitated by HLA-DM via directbinding to the alpha-beta-CLIP complex so that CLIP is released.HLA-DM stabilizes MHC class II molecules until primary highaffinity antigenic peptides are bound. The MHC II molecule boundto a peptide is then transported to the cell membrane surface. InB-cells, the interaction between HLA-DM and MHC class II moleculesis regulated by HLA-DO. Primary dendritic cells (DCs) also toexpress HLA-DO. Lysosomal microenvironment has been implicated inthe regulation of antigen loading into MHC II molecules, increasedacidification produces increased proteolysis and efficient peptideloading.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for BRD8_HLA-DRA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BRD8_HLA-DRA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for BRD8_HLA-DRA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for BRD8_HLA-DRA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	BRD8	C0014175	Endometriosis	1	CTD_human
Tgene	HLA-DRA	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Tgene	HLA-DRA	C0026769	Multiple Sclerosis	1	CTD_human
Tgene	HLA-DRA	C0030567	Parkinson Disease	1	CTD_human

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Fusion gene ID: 4415

FusionGeneSummary for BRD8_HLA-DRA

FusionProtFeatures for BRD8_HLA-DRA

FusionGeneSequence for BRD8_HLA-DRA

FusionGenePPI for BRD8_HLA-DRA

RelatedDrugs for BRD8_HLA-DRA

RelatedDiseases for BRD8_HLA-DRA