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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4413

FusionGeneSummary for BRD7_BRD7

check button Fusion gene summary
Fusion gene informationFusion gene name: BRD7_BRD7
Fusion gene ID: 4413
HgeneTgene
Gene symbol

BRD7

BRD7

Gene ID

29117

29117

Gene namebromodomain containing 7bromodomain containing 7
SynonymsBP75|CELTIX1|NAG4BP75|CELTIX1|NAG4
Cytomap

16q12.1

16q12.1

Type of geneprotein-codingprotein-coding
Descriptionbromodomain-containing protein 775 kDa bromodomain proteinprotein CELTIX-1bromodomain-containing protein 775 kDa bromodomain proteinprotein CELTIX-1
Modification date2018051920180519
UniProtAcc

Q9NPI1

Q9NPI1

Ensembl transtripts involved in fusion geneENST00000394688, ENST00000394689, 
ENST00000401491, 
ENST00000394688, 
ENST00000394689, ENST00000401491, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: BRD7 [Title/Abstract] AND BRD7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRD7

GO:0006357

regulation of transcription by RNA polymerase II

12489984

HgeneBRD7

GO:0008285

negative regulation of cell proliferation

20228809

HgeneBRD7

GO:0035066

positive regulation of histone acetylation

20228809

HgeneBRD7

GO:0045892

negative regulation of transcription, DNA-templated

16265664

HgeneBRD7

GO:0045893

positive regulation of transcription, DNA-templated

20228809

HgeneBRD7

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

16265664

TgeneBRD7

GO:0006357

regulation of transcription by RNA polymerase II

12489984

TgeneBRD7

GO:0008285

negative regulation of cell proliferation

20228809

TgeneBRD7

GO:0035066

positive regulation of histone acetylation

20228809

TgeneBRD7

GO:0045892

negative regulation of transcription, DNA-templated

16265664

TgeneBRD7

GO:0045893

positive regulation of transcription, DNA-templated

20228809

TgeneBRD7

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

16265664


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1W26848BRD7chr16

50368762

+BRD7chr16

50402681

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000394688ENST00000394688BRD7chr16

50368762

+BRD7chr16

50402681

-
intron-3CDSENST00000394688ENST00000394689BRD7chr16

50368762

+BRD7chr16

50402681

-
intron-5UTRENST00000394688ENST00000401491BRD7chr16

50368762

+BRD7chr16

50402681

-
intron-3CDSENST00000394689ENST00000394688BRD7chr16

50368762

+BRD7chr16

50402681

-
intron-3CDSENST00000394689ENST00000394689BRD7chr16

50368762

+BRD7chr16

50402681

-
intron-5UTRENST00000394689ENST00000401491BRD7chr16

50368762

+BRD7chr16

50402681

-
intron-3CDSENST00000401491ENST00000394688BRD7chr16

50368762

+BRD7chr16

50402681

-
intron-3CDSENST00000401491ENST00000394689BRD7chr16

50368762

+BRD7chr16

50402681

-
intron-5UTRENST00000401491ENST00000401491BRD7chr16

50368762

+BRD7chr16

50402681

-

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FusionProtFeatures for BRD7_BRD7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRD7

Q9NPI1

BRD7

Q9NPI1

Acts both as coactivator and as corepressor. May play arole in chromatin remodeling. Activator of the Wnt signalingpathway in a DVL1-dependent manner by negatively regulating theGSK3B phosphotransferase activity. Induces dephosphorylation ofGSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation oftranscriptional activation by AR (By similarity). Transcriptionalcorepressor that down-regulates the expression of target genes.Binds to target promoters, leading to increased histone H3acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter.Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator forTP53-mediated activation of transcription of a set of targetgenes. Required for TP53-mediated cell-cycle arrest in response tooncogene activation. Promotes acetylation of TP53 at 'Lys-382',and thereby promotes efficient recruitment of TP53 to targetpromoters. Inhibits cell cycle progression from G1 to S phase.{ECO:0000250, ECO:0000269|PubMed:16265664,ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511,ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}. Acts both as coactivator and as corepressor. May play arole in chromatin remodeling. Activator of the Wnt signalingpathway in a DVL1-dependent manner by negatively regulating theGSK3B phosphotransferase activity. Induces dephosphorylation ofGSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation oftranscriptional activation by AR (By similarity). Transcriptionalcorepressor that down-regulates the expression of target genes.Binds to target promoters, leading to increased histone H3acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter.Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator forTP53-mediated activation of transcription of a set of targetgenes. Required for TP53-mediated cell-cycle arrest in response tooncogene activation. Promotes acetylation of TP53 at 'Lys-382',and thereby promotes efficient recruitment of TP53 to targetpromoters. Inhibits cell cycle progression from G1 to S phase.{ECO:0000250, ECO:0000269|PubMed:16265664,ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511,ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BRD7_BRD7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BRD7_BRD7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BRD7_BRD7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BRD7_BRD7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource