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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4409

FusionGeneSummary for BRD4_PGLYRP1

check button Fusion gene summary
Fusion gene informationFusion gene name: BRD4_PGLYRP1
Fusion gene ID: 4409
HgeneTgene
Gene symbol

BRD4

PGLYRP1

Gene ID

23476

8993

Gene namebromodomain containing 4peptidoglycan recognition protein 1
SynonymsCAP|HUNK1|HUNKI|MCAPPGLYRP|PGRP|PGRP-S|PGRPS|TAG7|TNFSF3L
Cytomap

19p13.12

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionbromodomain-containing protein 4chromosome-associated proteinpeptidoglycan recognition protein 1TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)
Modification date2018052220180523
UniProtAcc

O60885

O75594

Ensembl transtripts involved in fusion geneENST00000263377, ENST00000371835, 
ENST00000360016, ENST00000602230, 
ENST00000008938, 
Fusion gene scores* DoF score14 X 6 X 10=8401 X 1 X 1=1
# samples 191
** MAII scorelog2(19/840*10)=-2.14438990933517
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: BRD4 [Title/Abstract] AND PGLYRP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRD4

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

19103749|23086925

HgeneBRD4

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

19103749

HgeneBRD4

GO:0045944

positive regulation of transcription by RNA polymerase II

23086925|23317504

HgeneBRD4

GO:0050727

regulation of inflammatory response

19103749

HgeneBRD4

GO:1901407

regulation of phosphorylation of RNA polymerase II C-terminal domain

23086925

TgenePGLYRP1

GO:0016045

detection of bacterium

11461926

TgenePGLYRP1

GO:0031640

killing of cells of other organism

16354652

TgenePGLYRP1

GO:0050830

defense response to Gram-positive bacterium

11461926|16354652

TgenePGLYRP1

GO:0051714

positive regulation of cytolysis in other organism

16354652

TgenePGLYRP1

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

16354652


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-44-2657-01ABRD4chr19

15443101

-PGLYRP1chr19

46522905

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000263377ENST00000008938BRD4chr19

15443101

-PGLYRP1chr19

46522905

-
intron-3CDSENST00000371835ENST00000008938BRD4chr19

15443101

-PGLYRP1chr19

46522905

-
5UTR-3CDSENST00000360016ENST00000008938BRD4chr19

15443101

-PGLYRP1chr19

46522905

-
intron-3CDSENST00000602230ENST00000008938BRD4chr19

15443101

-PGLYRP1chr19

46522905

-

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FusionProtFeatures for BRD4_PGLYRP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRD4

O60885

PGLYRP1

O75594

Chromatin reader protein that recognizes and bindsacetylated histones and plays a key role in transmission ofepigenetic memory across cell divisions and transcriptionregulation. Remains associated with acetylated chromatinthroughout the entire cell cycle and provides epigenetic memoryfor postmitotic G1 gene transcription by preserving acetylatedchromatin status and maintaining high-order chromatin structure.During interphase, plays a key role in regulating thetranscription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters: BRD4 is required toform the transcriptionally active P-TEFb complex by displacingnegative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can thenphosphorylate the C-terminal domain (CTD) of RNA polymerase II.Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD)of RNA polymerase II. According to a report, directly acts as anatypical protein kinase and mediates phosphorylation of 'Ser-2' ofthe C-terminal domain (CTD) of RNA polymerase II; these datahowever need additional evidences in vivo (PubMed:22509028). Inaddition to acetylated histones, also recognizes and bindsacetylated RELA, leading to further recruitment of the P-TEFbcomplex and subsequent activation of NF-kappa-B. Also acts as aregulator of p53/TP53-mediated transcription: followingphosphorylation by CK2, recruited to p53/TP53 specific targetpromoters. {ECO:0000269|PubMed:22509028}. Isoform B: Acts as a chromatin insulator in the DNAdamage response pathway. Inhibits DNA damage response signaling byrecruiting the condensin-2 complex to acetylated histones, leadingto chromatin structure remodeling, insulating the region from DNAdamage response by limiting spreading of histone H2AFX/H2A.xphosphorylation. Pattern receptor that binds to murein peptidoglycans(PGN) of Gram-positive bacteria. Has bactericidal activity towardsGram-positive bacteria. May kill Gram-positive bacteria byinterfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.{ECO:0000269|PubMed:11461926, ECO:0000269|PubMed:16354652}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BRD4_PGLYRP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BRD4_PGLYRP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BRD4RFC1, RFC2, RFC3, RFC4, RFC5, HIST4H4, SIPA1, MED12, MED14, MED24, MED17, CCNT1, CDK9, CCNT2, HEXIM1, HIST2H3C, HIST2H4A, KDM5B, EP300, AFF1, MESDC2, C8orf33, HIST1H3A, HIST1H4A, KAT8, YWHAZ, YWHAE, MED1, CHD4, JMJD6, BAIAP2, BAIAP2L1, RBM25, BRD3, BRD2, WHSC1, GLTSCR1, ATAD5, SMARCA4, ZNF592, BRD9, WHSC1L1, SIRT1, SIRT5, AK1, PGAM2, LDHC, CKM, ELAVL1, MYC, MLLT1, RPL6, PRPF40A, RN7SK, TCERG1, STAT3, GPSM1, FAM90A1, CYP1A1, AP3M1, NUMA1, DMAP1, RTF1, ZC3H18, MMGT1, SMC1A, CDC5L, CHD8, PTAR1, BRCA1, PTEN, FGFR3, KDM5C, DHFR, RB1, MAP2K1, PIP4K2A, CAMKV, CHEK2, CHEK1, WEE1, CDC7, INO80B, TRIM25, CUL1, CUL3, SPOP, AR, ERGPGLYRP1HSPBP1, IFNA2, CNRIP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BRD4_PGLYRP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BRD4_PGLYRP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRD4C0017636Glioblastoma2CTD_human
HgeneBRD4C0002170Alopecia1CTD_human
HgeneBRD4C0009375Colonic Neoplasms1CTD_human
HgeneBRD4C0020507Hyperplasia1CTD_human
HgeneBRD4C0020542Pulmonary Hypertension1CTD_human
HgeneBRD4C0025149Medulloblastoma1CTD_human
HgeneBRD4C0029463Osteosarcoma1CTD_human
HgeneBRD4C0033578Prostatic Neoplasms1CTD_human
HgeneBRD4C0040136Thyroid Neoplasm1CTD_human
HgeneBRD4C0085413Polycystic Kidney, Autosomal Dominant1CTD_human