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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4397

FusionGeneSummary for BRD3_BRD3

check button Fusion gene summary
Fusion gene informationFusion gene name: BRD3_BRD3
Fusion gene ID: 4397
HgeneTgene
Gene symbol

BRD3

BRD3

Gene ID

8019

8019

Gene namebromodomain containing 3bromodomain containing 3
SynonymsORFX|RING3LORFX|RING3L
Cytomap

9q34.2

9q34.2

Type of geneprotein-codingprotein-coding
Descriptionbromodomain-containing protein 3RING3-like proteinbromodomain-containing protein 3 short isoformbromodomain-containing protein 3RING3-like proteinbromodomain-containing protein 3 short isoform
Modification date2018051920180519
UniProtAcc

Q15059

Q15059

Ensembl transtripts involved in fusion geneENST00000303407, ENST00000473349, 
ENST00000371834, ENST00000357885, 
ENST00000303407, ENST00000473349, 
ENST00000371834, ENST00000357885, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 5 X 6=90
# samples 37
** MAII scorelog2(3/8*10)=1.90689059560852log2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRD3 [Title/Abstract] AND BRD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRD3

GO:0006357

regulation of transcription by RNA polymerase II

18406326

TgeneBRD3

GO:0006357

regulation of transcription by RNA polymerase II

18406326


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1N27250BRD3chr9

136898246

-BRD3chr9

136901421

-
ChiTaRS3.1BX116849BRD3chr9

136898246

-BRD3chr9

136901421

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000303407ENST00000303407BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-5UTRENST00000303407ENST00000473349BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-3UTRENST00000303407ENST00000371834BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-intronENST00000303407ENST00000357885BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-3CDSENST00000473349ENST00000303407BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-5UTRENST00000473349ENST00000473349BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-3UTRENST00000473349ENST00000371834BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-intronENST00000473349ENST00000357885BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-3CDSENST00000371834ENST00000303407BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-5UTRENST00000371834ENST00000473349BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-3UTRENST00000371834ENST00000371834BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-intronENST00000371834ENST00000357885BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-3CDSENST00000357885ENST00000303407BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-5UTRENST00000357885ENST00000473349BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-3UTRENST00000357885ENST00000371834BRD3chr9

136898246

-BRD3chr9

136901421

-
intron-intronENST00000357885ENST00000357885BRD3chr9

136898246

-BRD3chr9

136901421

-

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FusionProtFeatures for BRD3_BRD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRD3

Q15059

BRD3

Q15059

Chromatin reader that recognizes and bindshyperacetylated chromatin and plays a role in the regulation oftranscription, probably by chromatin remodeling and interactionwith transcription factors (PubMed:18406326, PubMed:27105114).Regulates transcription by promoting the binding of thetranscription factor GATA1 to its targets (By similarity).{ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326,ECO:0000269|PubMed:27105114}. Chromatin reader that recognizes and bindshyperacetylated chromatin and plays a role in the regulation oftranscription, probably by chromatin remodeling and interactionwith transcription factors (PubMed:18406326, PubMed:27105114).Regulates transcription by promoting the binding of thetranscription factor GATA1 to its targets (By similarity).{ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326,ECO:0000269|PubMed:27105114}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BRD3_BRD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BRD3_BRD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BRD3_BRD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BRD3_BRD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRD3C0025149Medulloblastoma1CTD_human
TgeneBRD3C0025149Medulloblastoma1CTD_human