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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43881

FusionGeneSummary for ZYX_NUDCD3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZYX_NUDCD3
Fusion gene ID: 43881
HgeneTgene
Gene symbol

ZYX

NUDCD3

Gene ID

7791

23386

Gene namezyxinNudC domain containing 3
SynonymsESP-2|HED-2NudCL
Cytomap

7q34

7p13

Type of geneprotein-codingprotein-coding
Descriptionzyxinzyxin-2nudC domain-containing protein 3NudC-like protein
Modification date2018052220180523
UniProtAcc

Q15942

Q8IVD9

Ensembl transtripts involved in fusion geneENST00000322764, ENST00000449423, 
ENST00000392910, ENST00000477373, 
ENST00000355451, ENST00000460110, 
Fusion gene scores* DoF score5 X 6 X 1=308 X 8 X 3=192
# samples 69
** MAII scorelog2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZYX [Title/Abstract] AND NUDCD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA427508ZYXchr7

143088032

-NUDCD3chr7

44473732

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000322764ENST00000355451ZYXchr7

143088032

-NUDCD3chr7

44473732

+
3UTR-intronENST00000322764ENST00000460110ZYXchr7

143088032

-NUDCD3chr7

44473732

+
3UTR-intronENST00000449423ENST00000355451ZYXchr7

143088032

-NUDCD3chr7

44473732

+
3UTR-intronENST00000449423ENST00000460110ZYXchr7

143088032

-NUDCD3chr7

44473732

+
3UTR-intronENST00000392910ENST00000355451ZYXchr7

143088032

-NUDCD3chr7

44473732

+
3UTR-intronENST00000392910ENST00000460110ZYXchr7

143088032

-NUDCD3chr7

44473732

+
intron-intronENST00000477373ENST00000355451ZYXchr7

143088032

-NUDCD3chr7

44473732

+
intron-intronENST00000477373ENST00000460110ZYXchr7

143088032

-NUDCD3chr7

44473732

+

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FusionProtFeatures for ZYX_NUDCD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZYX

Q15942

NUDCD3

Q8IVD9

Adhesion plaque protein. Binds alpha-actinin and the CRPprotein. Important for targeting TES and ENA/VASP family membersto focal adhesions and for the formation of actin-rich structures.May be a component of a signal transduction pathway that mediatesadhesion-stimulated changes in gene expression (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZYX_NUDCD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZYX_NUDCD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZYX_NUDCD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneZYXQ15942DB11638ArtenimolZyxinsmall moleculeapproved|investigational

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RelatedDiseases for ZYX_NUDCD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUDCD3C0023903Liver neoplasms1CTD_human