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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43845

FusionGeneSummary for ZSCAN23_SV2B

check button Fusion gene summary
Fusion gene informationFusion gene name: ZSCAN23_SV2B
Fusion gene ID: 43845
HgeneTgene
Gene symbol

ZSCAN23

SV2B

Gene ID

222696

9899

Gene namezinc finger and SCAN domain containing 23synaptic vesicle glycoprotein 2B
SynonymsZNF390|ZNF453|dJ29K1.3|dJ29K1.3.1HsT19680
Cytomap

6p22.1

15q26.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger and SCAN domain-containing protein 23zinc finger protein 390zinc finger protein 453synaptic vesicle glycoprotein 2Bsynaptic vesicle protein 2B homolog
Modification date2018051920180523
UniProtAcc

Q3MJ62

Q7L1I2

Ensembl transtripts involved in fusion geneENST00000289788, ENST00000486481, 
ENST00000545111, ENST00000394232, 
ENST00000557291, ENST00000330276, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 3=48
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZSCAN23 [Title/Abstract] AND SV2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA248680ZSCAN23chr6

28411174

-SV2Bchr15

91824957

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000289788ENST00000545111ZSCAN23chr6

28411174

-SV2Bchr15

91824957

+
5UTR-3CDSENST00000289788ENST00000394232ZSCAN23chr6

28411174

-SV2Bchr15

91824957

+
5UTR-intronENST00000289788ENST00000557291ZSCAN23chr6

28411174

-SV2Bchr15

91824957

+
5UTR-intronENST00000289788ENST00000330276ZSCAN23chr6

28411174

-SV2Bchr15

91824957

+
5UTR-3CDSENST00000486481ENST00000545111ZSCAN23chr6

28411174

-SV2Bchr15

91824957

+
5UTR-3CDSENST00000486481ENST00000394232ZSCAN23chr6

28411174

-SV2Bchr15

91824957

+
5UTR-intronENST00000486481ENST00000557291ZSCAN23chr6

28411174

-SV2Bchr15

91824957

+
5UTR-intronENST00000486481ENST00000330276ZSCAN23chr6

28411174

-SV2Bchr15

91824957

+

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FusionProtFeatures for ZSCAN23_SV2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZSCAN23

Q3MJ62

SV2B

Q7L1I2

May be involved in transcriptional regulation. Probably plays a role in the control of regulatedsecretion in neural and endocrine cells. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZSCAN23_SV2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZSCAN23_SV2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZSCAN23ZSCAN32, ZSCAN20SV2BSYT1, C6orf15, HSFY1, YAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZSCAN23_SV2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZSCAN23_SV2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSV2BC0022658Kidney Diseases1CTD_human