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Fusion gene ID: 4384 |
FusionGeneSummary for BRCC3_CLIC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BRCC3_CLIC2 | Fusion gene ID: 4384 | Hgene | Tgene | Gene symbol | BRCC3 | CLIC2 | Gene ID | 79184 | 1193 |
| Gene name | BRCA1/BRCA2-containing complex subunit 3 | chloride intracellular channel 2 | |
| Synonyms | BRCC36|C6.1A|CXorf53 | CLIC2b|MRXS32|XAP121 | |
| Cytomap | Xq28 | Xq28 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lys-63-specific deubiquitinase BRCC36BRCA1-A complex subunit BRCC36BRCA1/BRCA2-containing complex subunit 36BRISC complex subunit BRCC36 | chloride intracellular channel protein 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P46736 | O15247 | |
| Ensembl transtripts involved in fusion gene | ENST00000340647, ENST00000330045, ENST00000369459, ENST00000369462, ENST00000399042, | ENST00000369449, ENST00000465553, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: BRCC3 [Title/Abstract] AND CLIC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BRCC3 | GO:0010165 | response to X-ray | 14636569 |
| Hgene | BRCC3 | GO:0070536 | protein K63-linked deubiquitination | 17525341|19214193 |
| Hgene | BRCC3 | GO:0070537 | histone H2A K63-linked deubiquitination | 19202061 |
| Tgene | CLIC2 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 15147738|15916532 |
| Tgene | CLIC2 | GO:0051099 | positive regulation of binding | 15916532 |
| Tgene | CLIC2 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 15147738|15916532 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-1487-01A | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000340647 | ENST00000369449 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| 5CDS-5UTR | ENST00000340647 | ENST00000465553 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| In-frame | ENST00000330045 | ENST00000369449 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| 5CDS-5UTR | ENST00000330045 | ENST00000465553 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| In-frame | ENST00000369459 | ENST00000369449 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| 5CDS-5UTR | ENST00000369459 | ENST00000465553 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| In-frame | ENST00000369462 | ENST00000369449 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| 5CDS-5UTR | ENST00000369462 | ENST00000465553 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| In-frame | ENST00000399042 | ENST00000369449 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| 5CDS-5UTR | ENST00000399042 | ENST00000465553 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
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FusionProtFeatures for BRCC3_CLIC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BRCC3 | CLIC2 |
| Can insert into membranes and form chloride ionchannels. Channel activity depends on the pH. Membrane insertionseems to be redox-regulated and may occur only under oxydizingconditions. Modulates the activity of RYR2 and inhibits calciuminflux. {ECO:0000269|PubMed:15147738, ECO:0000269|PubMed:15916532,ECO:0000269|PubMed:17945253}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BRCC3 | chrX:154319114 | chrX:154509357 | ENST00000330045 | + | 7 | 11 | 12_179 | 182 | 720 | Domain | MPN |
| Hgene | BRCC3 | chrX:154319114 | chrX:154509357 | ENST00000340647 | + | 7 | 11 | 12_179 | 183 | 248 | Domain | MPN |
| Hgene | BRCC3 | chrX:154319114 | chrX:154509357 | ENST00000369459 | + | 7 | 10 | 12_179 | 182 | 814 | Domain | MPN |
| Hgene | BRCC3 | chrX:154319114 | chrX:154509357 | ENST00000369462 | + | 7 | 12 | 12_179 | 182 | 885 | Domain | MPN |
| Hgene | BRCC3 | chrX:154319114 | chrX:154509357 | ENST00000330045 | + | 7 | 11 | 122_135 | 182 | 720 | Motif | JAMM motif |
| Hgene | BRCC3 | chrX:154319114 | chrX:154509357 | ENST00000340647 | + | 7 | 11 | 122_135 | 183 | 248 | Motif | JAMM motif |
| Hgene | BRCC3 | chrX:154319114 | chrX:154509357 | ENST00000369459 | + | 7 | 10 | 122_135 | 182 | 814 | Motif | JAMM motif |
| Hgene | BRCC3 | chrX:154319114 | chrX:154509357 | ENST00000369462 | + | 7 | 12 | 122_135 | 182 | 885 | Motif | JAMM motif |
| Tgene | >CLIC2 | chrX:154319114 | chrX:154509357 | ENST00000369449 | - | 2 | 6 | 99_239 | 97 | 248 | Domain | Note=GST C-terminal |
| Tgene | >CLIC2 | chrX:154319114 | chrX:154509357 | ENST00000369449 | - | 2 | 6 | 107_247 | 97 | 248 | Region | Note=C-terminal |
| Tgene | >CLIC2 | chrX:154319114 | chrX:154509357 | ENST00000369449 | - | 2 | 6 | 151_171 | 97 | 248 | Region | Note=Foot loop |
| Tgene | >CLIC2 | chrX:154319114 | chrX:154509357 | ENST00000369449 | - | 2 | 6 | 95_106 | 97 | 248 | Region | Note=Joint loop |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CLIC2 | chrX:154319114 | chrX:154509357 | ENST00000369449 | - | 2 | 6 | 1_94 | 97 | 248 | Region | Note=N-terminal |
| Tgene | CLIC2 | chrX:154319114 | chrX:154509357 | ENST00000369449 | - | 2 | 6 | 1_96 | 97 | 248 | Region | Required for insertion into the membrane |
| Tgene | CLIC2 | chrX:154319114 | chrX:154509357 | ENST00000369449 | - | 2 | 6 | 32_52 | 97 | 248 | Transmembrane | Helical%3B Note%3DAfter insertion into the membrane |
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FusionGeneSequence for BRCC3_CLIC2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BRCC3_ENST00000340647_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_334aa MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTSRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDR VEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQ KSSEYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADC >In-frame_BRCC3_ENST00000330045_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_333aa MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRV EISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK SSEYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCS >In-frame_BRCC3_ENST00000369459_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_333aa MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRV EISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK SSEYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCS >In-frame_BRCC3_ENST00000369462_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_333aa MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRV EISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK SSEYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCS >In-frame_BRCC3_ENST00000399042_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_333aa MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGEVSSPSRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRV EISPEQLSAASTETHRLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK SSEYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BRCC3_ENST00000340647_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_1002nt ATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAACCACGCTCTGAGCACAGAG AAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGTAGGAGTGACTCCAAATTTGCATATACTGGAACTGAAATG CGCACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCTGATAAGAGGAAGGACCGA GTAGAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGACAGGCCGCCCCATGAGAGTTGTGGGC TGGTATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAGATGATGGATCAAGGCTTT GTAGGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTCCAATCCATACAGGCCCAA AAGAGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCCAAGTTTTCTGCATACATT AAGAATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTGGATGACTACTTAAACACCCCACTT CTGGATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAGCTAACACTGGCTGATTGT AGCTTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGCAGAATTCTCAGGAGTCTGGCGT TATCTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACTTACGCAAATGTGGCTAAA >In-frame_BRCC3_ENST00000330045_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_999nt ATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAACCACGCTCTGAGCACAGAG AAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGGAGTGACTCCAAATTTGCATATACTGGAACTGAAATGCGC ACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCTGATAAGAGGAAGGACCGAGTA GAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGACAGGCCGCCCCATGAGAGTTGTGGGCTGG TATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAGATGATGGATCAAGGCTTTGTA GGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTCCAATCCATACAGGCCCAAAAG AGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCCAAGTTTTCTGCATACATTAAG AATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTGGATGACTACTTAAACACCCCACTTCTG GATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAGCTAACACTGGCTGATTGTAGC TTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGCAGAATTCTCAGGAGTCTGGCGTTAT CTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACTTACGCAAATGTGGCTAAACAG >In-frame_BRCC3_ENST00000369459_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_999nt ATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAACCACGCTCTGAGCACAGAG AAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGGAGTGACTCCAAATTTGCATATACTGGAACTGAAATGCGC ACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCTGATAAGAGGAAGGACCGAGTA GAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGACAGGCCGCCCCATGAGAGTTGTGGGCTGG TATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAGATGATGGATCAAGGCTTTGTA GGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTCCAATCCATACAGGCCCAAAAG AGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCCAAGTTTTCTGCATACATTAAG AATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTGGATGACTACTTAAACACCCCACTTCTG GATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAGCTAACACTGGCTGATTGTAGC TTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGCAGAATTCTCAGGAGTCTGGCGTTAT CTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACTTACGCAAATGTGGCTAAACAG >In-frame_BRCC3_ENST00000369462_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_999nt ATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAACCACGCTCTGAGCACAGAG AAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGGAGTGACTCCAAATTTGCATATACTGGAACTGAAATGCGC ACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCTGATAAGAGGAAGGACCGAGTA GAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGACAGGCCGCCCCATGAGAGTTGTGGGCTGG TATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAGATGATGGATCAAGGCTTTGTA GGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTCCAATCCATACAGGCCCAAAAG AGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCCAAGTTTTCTGCATACATTAAG AATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTGGATGACTACTTAAACACCCCACTTCTG GATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAGCTAACACTGGCTGATTGTAGC TTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGCAGAATTCTCAGGAGTCTGGCGTTAT CTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACTTACGCAAATGTGGCTAAACAG >In-frame_BRCC3_ENST00000399042_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_999nt ATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAACCACGCTCTGAGCACAGAG AAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGGTGAGTAGTCCCAGTAGGAGTGACTCCAAATTTGCATATACTGGAACTGAAATGCGC ACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCTGATAAGAGGAAGGACCGAGTA GAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGACACACAGGTTGGCTGAACTGACAGGCCGCCCCATGAGAGTTGTGGGCTGG TATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAGATGATGGATCAAGGCTTTGTA GGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTCCAATCCATACAGGCCCAAAAG AGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCCAAGTTTTCTGCATACATTAAG AATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTGGATGACTACTTAAACACCCCACTTCTG GATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAGCTAACACTGGCTGATTGTAGC TTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGCAGAATTCTCAGGAGTCTGGCGTTAT CTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACTTACGCAAATGTGGCTAAACAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BRCC3_ENST00000340647_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_2802nt AGGCCTGGGCGGAGCGCACAGCGCTGGGCGCTGGGGAGGCTGCGCCGCAGCACCCGGTTGGTCAGGACCAAGTGGGCCCGAGGCGGACGT GAGAAGGGTCGGGCCAAGATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAAC CACGCTCTGAGCACAGAGAAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGTAGGAGTGACTCCAAATTTGCA TATACTGGAACTGAAATGCGCACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCT GATAAGAGGAAGGACCGAGTAGAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGACAGGCCGC CCCATGAGAGTTGTGGGCTGGTATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAG ATGATGGATCAAGGCTTTGTAGGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTC CAATCCATACAGGCCCAAAAGAGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCC AAGTTTTCTGCATACATTAAGAATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTGGATGAC TACTTAAACACCCCACTTCTGGATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAG CTAACACTGGCTGATTGTAGCTTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGCAGAA TTCTCAGGAGTCTGGCGTTATCTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACT TACGCAAATGTGGCTAAACAGAAGAGTTAGGAGAGCTCTTACAGGAGAAAAGGCTATATTTGTGATCAGATTTTACTTATTGACATATTA GAAAGGTTTTTGCAAATAAGAATATGAAAAATACTGTTTCTTCTATCCAACTCTCTTATGAAAAGGAACTCTGTATTTTCTATTAGCCAT AAATAATCTGTCCACTGTATTTTACAGGTCTTCATACTTTTACTTAATTTTCTTTATCTGTATGGCAAACCACTGCAATCCTGAATGACA TGGAAAGCATCACAATCTTTTGCCCTTTGCTTGAATTCCTGGAATGCATACATATAAGCTAAACAGATGTCTGCAGTTATAAATGTCATA AGTAGAGGTACAATCTCACCCTGCTCCTTAGAAACATTTCCATATAAATCGCTAAAATAATTTCACATTTTTGTTAGTTTAATATATACA TGAGTTTATTTCTGATATAAATAATAAATACAGAGAGTGAGCATATCAGAGAGGCAAATTCTTAAAGAATGATTTTTAAAATCAGCTCTA GGAAGAGCTCAAGATCAATTGGTCATAGAACAGCATTTGACGCCTAGAACTATGACCACCTCATGGTCAGAGATGAGAATGTAGCCTTTG TGACCAGATTATATTATTTTTAAATGAAGAAGCACTCATTAAATAAAACATAATTTTAAAAAACAATATAAGAAACAAAGTCAACTGAAT CTTTTATTCATAGAAATGAAAAGGAAAATAAAAACTGTGGCTGACCAAAAGGTCTTCTTGTTGTCCATAAAAGGATAAGGTAAACAGTCC TTAGATAATTACAAAACTTTCTACAAAAGTTAAAATGTTACATTACTATACGTATTCAGATTCACTTGTTAAAGTACTCTTAAATCATTC AAATCTGGAAACAAAAGCTGAACTTAACTCTTGCTCCCTCAAAAGAGAAACACAAGCATAAGTGCAGCTTCAAAAAAGGAAAATATTTTA GGCTTTGGTGGAAGGGTGGAGTTTAGATAAAATTTAAATGAAGTAGCGTTTTAATAGGTTCAAAGAAAAGTAAGGCAATGAGCAAACTCA AAGTACTGTCCTTGAAAACCATAGAGTCAAGATAAATGTATAGTGTATGGTTAGGTGGCAGAGAAATGCAATCATGTTGATAATCTTTGA GATACATCCTGTCATCAGTATATTTCAGAATACATGCAATGCACTAGCAAGTTACAATTGATAGAATACATTTGAAATGTTAAATGAAAT AAGCCAGGCACAGAAAGACAAACACCACATGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACTCATATGTGGAATTTTAAAA AGTTGATCTCACACAAGTAGAGGGTAGAATCGTGGTTACCAGGGGCTAGGGAGAGAAAGAAGGCAGAGGCACTGAAAGATGTTGGTCAAT GGGTATAAAGTTACACCTAGGAAGAATAAATTTTGGTATTCACCACAGTAGGGTGACTATAGCAAATAATAATGTAGCATGTATTTCAAG ATAGCTAGAAAAGCAGGTTTTTAAATGTCACCACAAAGAAATAACAAATGTTTATAGTGGTGGATATGGTAATTACGCCTATTTGATCAT TATACTGTGTGTACATGCATTGAAACACCACATTGTATCCCATATATATGTACAATTATGTGCCCATTATACATTTAAAAAATAAATTTT >In-frame_BRCC3_ENST00000330045_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_2788nt GAGCGCACAGCGCTGGGCGCTGGGGAGGCTGCGCCGCAGCACCCGGTTGGTCAGGACCAAGTGGGCCCGAGGCGGACGTGAGAAGGGTCG GGCCAAGATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAACCACGCTCTGAG CACAGAGAAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGGAGTGACTCCAAATTTGCATATACTGGAACTGA AATGCGCACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCTGATAAGAGGAAGGA CCGAGTAGAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGACAGGCCGCCCCATGAGAGTTGT GGGCTGGTATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAGATGATGGATCAAGG CTTTGTAGGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTCCAATCCATACAGGC CCAAAAGAGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCCAAGTTTTCTGCATA CATTAAGAATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTGGATGACTACTTAAACACCCC ACTTCTGGATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAGCTAACACTGGCTGA TTGTAGCTTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGCAGAATTCTCAGGAGTCTG GCGTTATCTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACTTACGCAAATGTGGC TAAACAGAAGAGTTAGGAGAGCTCTTACAGGAGAAAAGGCTATATTTGTGATCAGATTTTACTTATTGACATATTAGAAAGGTTTTTGCA AATAAGAATATGAAAAATACTGTTTCTTCTATCCAACTCTCTTATGAAAAGGAACTCTGTATTTTCTATTAGCCATAAATAATCTGTCCA CTGTATTTTACAGGTCTTCATACTTTTACTTAATTTTCTTTATCTGTATGGCAAACCACTGCAATCCTGAATGACATGGAAAGCATCACA ATCTTTTGCCCTTTGCTTGAATTCCTGGAATGCATACATATAAGCTAAACAGATGTCTGCAGTTATAAATGTCATAAGTAGAGGTACAAT CTCACCCTGCTCCTTAGAAACATTTCCATATAAATCGCTAAAATAATTTCACATTTTTGTTAGTTTAATATATACATGAGTTTATTTCTG ATATAAATAATAAATACAGAGAGTGAGCATATCAGAGAGGCAAATTCTTAAAGAATGATTTTTAAAATCAGCTCTAGGAAGAGCTCAAGA TCAATTGGTCATAGAACAGCATTTGACGCCTAGAACTATGACCACCTCATGGTCAGAGATGAGAATGTAGCCTTTGTGACCAGATTATAT TATTTTTAAATGAAGAAGCACTCATTAAATAAAACATAATTTTAAAAAACAATATAAGAAACAAAGTCAACTGAATCTTTTATTCATAGA AATGAAAAGGAAAATAAAAACTGTGGCTGACCAAAAGGTCTTCTTGTTGTCCATAAAAGGATAAGGTAAACAGTCCTTAGATAATTACAA AACTTTCTACAAAAGTTAAAATGTTACATTACTATACGTATTCAGATTCACTTGTTAAAGTACTCTTAAATCATTCAAATCTGGAAACAA AAGCTGAACTTAACTCTTGCTCCCTCAAAAGAGAAACACAAGCATAAGTGCAGCTTCAAAAAAGGAAAATATTTTAGGCTTTGGTGGAAG GGTGGAGTTTAGATAAAATTTAAATGAAGTAGCGTTTTAATAGGTTCAAAGAAAAGTAAGGCAATGAGCAAACTCAAAGTACTGTCCTTG AAAACCATAGAGTCAAGATAAATGTATAGTGTATGGTTAGGTGGCAGAGAAATGCAATCATGTTGATAATCTTTGAGATACATCCTGTCA TCAGTATATTTCAGAATACATGCAATGCACTAGCAAGTTACAATTGATAGAATACATTTGAAATGTTAAATGAAATAAGCCAGGCACAGA AAGACAAACACCACATGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACAC AAGTAGAGGGTAGAATCGTGGTTACCAGGGGCTAGGGAGAGAAAGAAGGCAGAGGCACTGAAAGATGTTGGTCAATGGGTATAAAGTTAC ACCTAGGAAGAATAAATTTTGGTATTCACCACAGTAGGGTGACTATAGCAAATAATAATGTAGCATGTATTTCAAGATAGCTAGAAAAGC AGGTTTTTAAATGTCACCACAAAGAAATAACAAATGTTTATAGTGGTGGATATGGTAATTACGCCTATTTGATCATTATACTGTGTGTAC >In-frame_BRCC3_ENST00000369459_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_2720nt GAGGCGGACGTGAGAAGGGTCGGGCCAAGATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCG TTTGTCTCAACCACGCTCTGAGCACAGAGAAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGGAGTGACTCCA AATTTGCATATACTGGAACTGAAATGCGCACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTAC GACGTTCTGATAAGAGGAAGGACCGAGTAGAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGA CAGGCCGCCCCATGAGAGTTGTGGGCTGGTATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCA TGTACCAGATGATGGATCAAGGCTTTGTAGGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACA CTTGCTTCCAATCCATACAGGCCCAAAAGAGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACC TCTTTGCCAAGTTTTCTGCATACATTAAGAATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTC TGGATGACTACTTAAACACCCCACTTCTGGATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATG GGGACCAGCTAACACTGGCTGATTGTAGCTTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTC CAGCAGAATTCTCAGGAGTCTGGCGTTATCTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTG AAAATACTTACGCAAATGTGGCTAAACAGAAGAGTTAGGAGAGCTCTTACAGGAGAAAAGGCTATATTTGTGATCAGATTTTACTTATTG ACATATTAGAAAGGTTTTTGCAAATAAGAATATGAAAAATACTGTTTCTTCTATCCAACTCTCTTATGAAAAGGAACTCTGTATTTTCTA TTAGCCATAAATAATCTGTCCACTGTATTTTACAGGTCTTCATACTTTTACTTAATTTTCTTTATCTGTATGGCAAACCACTGCAATCCT GAATGACATGGAAAGCATCACAATCTTTTGCCCTTTGCTTGAATTCCTGGAATGCATACATATAAGCTAAACAGATGTCTGCAGTTATAA ATGTCATAAGTAGAGGTACAATCTCACCCTGCTCCTTAGAAACATTTCCATATAAATCGCTAAAATAATTTCACATTTTTGTTAGTTTAA TATATACATGAGTTTATTTCTGATATAAATAATAAATACAGAGAGTGAGCATATCAGAGAGGCAAATTCTTAAAGAATGATTTTTAAAAT CAGCTCTAGGAAGAGCTCAAGATCAATTGGTCATAGAACAGCATTTGACGCCTAGAACTATGACCACCTCATGGTCAGAGATGAGAATGT AGCCTTTGTGACCAGATTATATTATTTTTAAATGAAGAAGCACTCATTAAATAAAACATAATTTTAAAAAACAATATAAGAAACAAAGTC AACTGAATCTTTTATTCATAGAAATGAAAAGGAAAATAAAAACTGTGGCTGACCAAAAGGTCTTCTTGTTGTCCATAAAAGGATAAGGTA AACAGTCCTTAGATAATTACAAAACTTTCTACAAAAGTTAAAATGTTACATTACTATACGTATTCAGATTCACTTGTTAAAGTACTCTTA AATCATTCAAATCTGGAAACAAAAGCTGAACTTAACTCTTGCTCCCTCAAAAGAGAAACACAAGCATAAGTGCAGCTTCAAAAAAGGAAA ATATTTTAGGCTTTGGTGGAAGGGTGGAGTTTAGATAAAATTTAAATGAAGTAGCGTTTTAATAGGTTCAAAGAAAAGTAAGGCAATGAG CAAACTCAAAGTACTGTCCTTGAAAACCATAGAGTCAAGATAAATGTATAGTGTATGGTTAGGTGGCAGAGAAATGCAATCATGTTGATA ATCTTTGAGATACATCCTGTCATCAGTATATTTCAGAATACATGCAATGCACTAGCAAGTTACAATTGATAGAATACATTTGAAATGTTA AATGAAATAAGCCAGGCACAGAAAGACAAACACCACATGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACTCATATGTGGAA TTTTAAAAAGTTGATCTCACACAAGTAGAGGGTAGAATCGTGGTTACCAGGGGCTAGGGAGAGAAAGAAGGCAGAGGCACTGAAAGATGT TGGTCAATGGGTATAAAGTTACACCTAGGAAGAATAAATTTTGGTATTCACCACAGTAGGGTGACTATAGCAAATAATAATGTAGCATGT ATTTCAAGATAGCTAGAAAAGCAGGTTTTTAAATGTCACCACAAAGAAATAACAAATGTTTATAGTGGTGGATATGGTAATTACGCCTAT TTGATCATTATACTGTGTGTACATGCATTGAAACACCACATTGTATCCCATATATATGTACAATTATGTGCCCATTATACATTTAAAAAA >In-frame_BRCC3_ENST00000369462_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_2716nt CGGACGTGAGAAGGGTCGGGCCAAGATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTG TCTCAACCACGCTCTGAGCACAGAGAAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGTTGAACGATGATACAAGGAGTGACTCCAAATT TGCATATACTGGAACTGAAATGCGCACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACG TTCTGATAAGAGGAAGGACCGAGTAGAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGGCAGAGAGGTTGGCTGAACTGACAGG CCGCCCCATGAGAGTTGTGGGCTGGTATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTA CCAGATGATGGATCAAGGCTTTGTAGGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTG CTTCCAATCCATACAGGCCCAAAAGAGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTT TGCCAAGTTTTCTGCATACATTAAGAATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTGGA TGACTACTTAAACACCCCACTTCTGGATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGA CCAGCTAACACTGGCTGATTGTAGCTTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGC AGAATTCTCAGGAGTCTGGCGTTATCTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAA TACTTACGCAAATGTGGCTAAACAGAAGAGTTAGGAGAGCTCTTACAGGAGAAAAGGCTATATTTGTGATCAGATTTTACTTATTGACAT ATTAGAAAGGTTTTTGCAAATAAGAATATGAAAAATACTGTTTCTTCTATCCAACTCTCTTATGAAAAGGAACTCTGTATTTTCTATTAG CCATAAATAATCTGTCCACTGTATTTTACAGGTCTTCATACTTTTACTTAATTTTCTTTATCTGTATGGCAAACCACTGCAATCCTGAAT GACATGGAAAGCATCACAATCTTTTGCCCTTTGCTTGAATTCCTGGAATGCATACATATAAGCTAAACAGATGTCTGCAGTTATAAATGT CATAAGTAGAGGTACAATCTCACCCTGCTCCTTAGAAACATTTCCATATAAATCGCTAAAATAATTTCACATTTTTGTTAGTTTAATATA TACATGAGTTTATTTCTGATATAAATAATAAATACAGAGAGTGAGCATATCAGAGAGGCAAATTCTTAAAGAATGATTTTTAAAATCAGC TCTAGGAAGAGCTCAAGATCAATTGGTCATAGAACAGCATTTGACGCCTAGAACTATGACCACCTCATGGTCAGAGATGAGAATGTAGCC TTTGTGACCAGATTATATTATTTTTAAATGAAGAAGCACTCATTAAATAAAACATAATTTTAAAAAACAATATAAGAAACAAAGTCAACT GAATCTTTTATTCATAGAAATGAAAAGGAAAATAAAAACTGTGGCTGACCAAAAGGTCTTCTTGTTGTCCATAAAAGGATAAGGTAAACA GTCCTTAGATAATTACAAAACTTTCTACAAAAGTTAAAATGTTACATTACTATACGTATTCAGATTCACTTGTTAAAGTACTCTTAAATC ATTCAAATCTGGAAACAAAAGCTGAACTTAACTCTTGCTCCCTCAAAAGAGAAACACAAGCATAAGTGCAGCTTCAAAAAAGGAAAATAT TTTAGGCTTTGGTGGAAGGGTGGAGTTTAGATAAAATTTAAATGAAGTAGCGTTTTAATAGGTTCAAAGAAAAGTAAGGCAATGAGCAAA CTCAAAGTACTGTCCTTGAAAACCATAGAGTCAAGATAAATGTATAGTGTATGGTTAGGTGGCAGAGAAATGCAATCATGTTGATAATCT TTGAGATACATCCTGTCATCAGTATATTTCAGAATACATGCAATGCACTAGCAAGTTACAATTGATAGAATACATTTGAAATGTTAAATG AAATAAGCCAGGCACAGAAAGACAAACACCACATGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACTCATATGTGGAATTTT AAAAAGTTGATCTCACACAAGTAGAGGGTAGAATCGTGGTTACCAGGGGCTAGGGAGAGAAAGAAGGCAGAGGCACTGAAAGATGTTGGT CAATGGGTATAAAGTTACACCTAGGAAGAATAAATTTTGGTATTCACCACAGTAGGGTGACTATAGCAAATAATAATGTAGCATGTATTT CAAGATAGCTAGAAAAGCAGGTTTTTAAATGTCACCACAAAGAAATAACAAATGTTTATAGTGGTGGATATGGTAATTACGCCTATTTGA TCATTATACTGTGTGTACATGCATTGAAACACCACATTGTATCCCATATATATGTACAATTATGTGCCCATTATACATTTAAAAAATAAA >In-frame_BRCC3_ENST00000399042_chrX_154319114_+_CLIC2_ENST00000369449_chrX_154509357_-_2691nt ATGGCGGTGCAGGTGGTGCAGGCGGTGCAGGCGGTTCATCTCGAGTCTGACGCTTTCCTCGTTTGTCTCAACCACGCTCTGAGCACAGAG AAGGAGGAAGTAATGGGGCTGTGCATAGGGGAGGTGAGTAGTCCCAGTAGGAGTGACTCCAAATTTGCATATACTGGAACTGAAATGCGC ACAGTTGCTGAAAAGGTTGATGCCGTCAGAATTGTTCACATTCATTCTGTCATCATCTTACGACGTTCTGATAAGAGGAAGGACCGAGTA GAAATTTCTCCAGAGCAGCTGTCTGCAGCTTCAACAGAGACACACAGGTTGGCTGAACTGACAGGCCGCCCCATGAGAGTTGTGGGCTGG TATCATTCCCATCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTCGCACACAAGCCATGTACCAGATGATGGATCAAGGCTTTGTA GGACTTATTTTTTCCTGTTTCATAGAAGATAAGAACACAAAGACTGGCCGGGTACTCTACACTTGCTTCCAATCCATACAGGCCCAAAAG AGTTCAGAGTACCCTCACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCCAAGTTTTCTGCATACATTAAG AATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTGGATGACTACTTAAACACCCCACTTCTG GATGAAATTGATCCAGACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAGCTAACACTGGCTGATTGTAGC TTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATATCGTGACTTTGACATTCCAGCAGAATTCTCAGGAGTCTGGCGTTAT CTCCACAATGCCTATGCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACTTACGCAAATGTGGCTAAACAG AAGAGTTAGGAGAGCTCTTACAGGAGAAAAGGCTATATTTGTGATCAGATTTTACTTATTGACATATTAGAAAGGTTTTTGCAAATAAGA ATATGAAAAATACTGTTTCTTCTATCCAACTCTCTTATGAAAAGGAACTCTGTATTTTCTATTAGCCATAAATAATCTGTCCACTGTATT TTACAGGTCTTCATACTTTTACTTAATTTTCTTTATCTGTATGGCAAACCACTGCAATCCTGAATGACATGGAAAGCATCACAATCTTTT GCCCTTTGCTTGAATTCCTGGAATGCATACATATAAGCTAAACAGATGTCTGCAGTTATAAATGTCATAAGTAGAGGTACAATCTCACCC TGCTCCTTAGAAACATTTCCATATAAATCGCTAAAATAATTTCACATTTTTGTTAGTTTAATATATACATGAGTTTATTTCTGATATAAA TAATAAATACAGAGAGTGAGCATATCAGAGAGGCAAATTCTTAAAGAATGATTTTTAAAATCAGCTCTAGGAAGAGCTCAAGATCAATTG GTCATAGAACAGCATTTGACGCCTAGAACTATGACCACCTCATGGTCAGAGATGAGAATGTAGCCTTTGTGACCAGATTATATTATTTTT AAATGAAGAAGCACTCATTAAATAAAACATAATTTTAAAAAACAATATAAGAAACAAAGTCAACTGAATCTTTTATTCATAGAAATGAAA AGGAAAATAAAAACTGTGGCTGACCAAAAGGTCTTCTTGTTGTCCATAAAAGGATAAGGTAAACAGTCCTTAGATAATTACAAAACTTTC TACAAAAGTTAAAATGTTACATTACTATACGTATTCAGATTCACTTGTTAAAGTACTCTTAAATCATTCAAATCTGGAAACAAAAGCTGA ACTTAACTCTTGCTCCCTCAAAAGAGAAACACAAGCATAAGTGCAGCTTCAAAAAAGGAAAATATTTTAGGCTTTGGTGGAAGGGTGGAG TTTAGATAAAATTTAAATGAAGTAGCGTTTTAATAGGTTCAAAGAAAAGTAAGGCAATGAGCAAACTCAAAGTACTGTCCTTGAAAACCA TAGAGTCAAGATAAATGTATAGTGTATGGTTAGGTGGCAGAGAAATGCAATCATGTTGATAATCTTTGAGATACATCCTGTCATCAGTAT ATTTCAGAATACATGCAATGCACTAGCAAGTTACAATTGATAGAATACATTTGAAATGTTAAATGAAATAAGCCAGGCACAGAAAGACAA ACACCACATGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACTCATATGTGGAATTTTAAAAAGTTGATCTCACACAAGTAGA GGGTAGAATCGTGGTTACCAGGGGCTAGGGAGAGAAAGAAGGCAGAGGCACTGAAAGATGTTGGTCAATGGGTATAAAGTTACACCTAGG AAGAATAAATTTTGGTATTCACCACAGTAGGGTGACTATAGCAAATAATAATGTAGCATGTATTTCAAGATAGCTAGAAAAGCAGGTTTT TAAATGTCACCACAAAGAAATAACAAATGTTTATAGTGGTGGATATGGTAATTACGCCTATTTGATCATTATACTGTGTGTACATGCATT |
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FusionGenePPI for BRCC3_CLIC2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BRCC3 | SNAPC5, BRE, BARD1, BRCA1, BRCA2, RAD51, TP53, UBE2D1, UIMC1, ATP5O, DDOST, E2F5, MCM2, NDUFA10, SHMT2, SUPT16H, FAM175B, BABAM1, CAND1, USP7, FAM175A, EXOC8, BACH1, COPS5, UBC, BRCC3, SUMO2, GRB2, MDC1, PAXIP1, CCDC6, CD2AP, GPHN, HDAC1, HNRNPR, MTA2, NR3C1, RABEP2, SF3A1, SMEK1, TRIM28, SPAG9, HUWE1, LARP7, WDHD1, FANCG, DEF6, TFDP3, SMARCD1, CENPA, MRPL1, NUMA1, WWP2, TNS1, FANCA | CLIC2 | TRAPPC2, NEDD4, NEDD4L, FN1, CLIC4, CLIC5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BRCC3_CLIC2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | BRCC3 | P46736 | DB01593 | Zinc | Lys-63-specific deubiquitinase BRCC36 | small molecule | approved|investigational |
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RelatedDiseases for BRCC3_CLIC2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CLIC2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | CLIC2 | C3550913 | MENTAL RETARDATION, X-LINKED, SYNDROMIC 32 | 1 | ORPHANET;UNIPROT |
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