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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 43825

FusionGeneSummary for ZNRF3_SLC5A1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNRF3_SLC5A1
Fusion gene ID: 43825
HgeneTgene
Gene symbol

ZNRF3

SLC5A1

Gene ID

84133

6523

Gene namezinc and ring finger 3solute carrier family 5 member 1
SynonymsBK747E2.3|RNF203D22S675|NAGT|SGLT1
Cytomap

22q12.1

22q12.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase ZNRF3CTA-292E10.6RING finger protein 203RING-type E3 ubiquitin transferase ZNRF3novel C3HC4 type Zinc finger (ring finger)zinc/RING finger protein 3sodium/glucose cotransporter 1Na+/glucose cotransporter 1high affinity sodium-glucose cotransportersolute carrier family 5 (sodium/glucose cotransporter), member 1
Modification date2018052320180523
UniProtAcc

Q9ULT6

P13866

Ensembl transtripts involved in fusion geneENST00000544604, ENST00000332811, 
ENST00000402174, ENST00000406323, 
ENST00000266088, ENST00000543737, 
Fusion gene scores* DoF score14 X 4 X 12=6723 X 3 X 3=27
# samples 173
** MAII scorelog2(17/672*10)=-1.98292648664106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNRF3 [Title/Abstract] AND SLC5A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNRF3

GO:0016567

protein ubiquitination

22575959

TgeneSLC5A1

GO:1904659

glucose transmembrane transport

8836035


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-IG-A3I8-01AZNRF3chr22

29280054

+SLC5A1chr22

32445930

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000544604ENST00000266088ZNRF3chr22

29280054

+SLC5A1chr22

32445930

+
5CDS-intronENST00000544604ENST00000543737ZNRF3chr22

29280054

+SLC5A1chr22

32445930

+
5UTR-3CDSENST00000332811ENST00000266088ZNRF3chr22

29280054

+SLC5A1chr22

32445930

+
5UTR-intronENST00000332811ENST00000543737ZNRF3chr22

29280054

+SLC5A1chr22

32445930

+
intron-3CDSENST00000402174ENST00000266088ZNRF3chr22

29280054

+SLC5A1chr22

32445930

+
intron-intronENST00000402174ENST00000543737ZNRF3chr22

29280054

+SLC5A1chr22

32445930

+
intron-3CDSENST00000406323ENST00000266088ZNRF3chr22

29280054

+SLC5A1chr22

32445930

+
intron-intronENST00000406323ENST00000543737ZNRF3chr22

29280054

+SLC5A1chr22

32445930

+

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FusionProtFeatures for ZNRF3_SLC5A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNRF3

Q9ULT6

SLC5A1

P13866

E3 ubiquitin-protein ligase that acts as a negativeregulator of the Wnt signaling pathway by mediating theubiquitination and subsequent degradation of Wnt receptor complexcomponents Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in theintestinal stem cell zone by inhibiting the Wnt signaling pathway,thereby resticting the size of the intestinal stem cell zone.{ECO:0000269|PubMed:22575959}. Actively transports glucose into cells by Na(+)cotransport with a Na(+) to glucose coupling ratio of 2:1.Efficient substrate transport in mammalian kidney is provided bythe concerted action of a low affinity high capacity and a highaffinity low capacity Na(+)/glucose cotransporter arranged inseries along kidney proximal tubules.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015527_56345665IntramembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014527_563-110538IntramembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015127_14245665Topological domainCytoplasmic
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015164_17845665Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015202_20845665Topological domainCytoplasmic
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015230_27745665Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015299_31345665Topological domainCytoplasmic
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015335_38045665Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015402_42345665Topological domainCytoplasmic
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015445_45545665Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015477_48445665Topological domainCytoplasmic
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015506_52645665Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+01550_6445665Topological domainCytoplasmic
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015564_64345665Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+01586_10545665Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014127_142-110538Topological domainCytoplasmic
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014164_178-110538Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+0141_28-110538Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014202_208-110538Topological domainCytoplasmic
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014230_277-110538Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014299_313-110538Topological domainCytoplasmic
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014335_380-110538Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014402_423-110538Topological domainCytoplasmic
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014445_455-110538Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014477_484-110538Topological domainCytoplasmic
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014506_526-110538Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+01450_64-110538Topological domainCytoplasmic
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014564_643-110538Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+01486_105-110538Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015106_12645665TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015143_16345665TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015179_20145665TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015209_22945665TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015278_29845665TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015314_33445665TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015381_40145665TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015424_44445665TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015456_47645665TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015485_50545665TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+015644_66445665TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+01565_8545665TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014106_126-110538TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014143_163-110538TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014179_201-110538TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014209_229-110538TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014278_298-110538TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+01429_49-110538TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014314_334-110538TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014381_401-110538TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014424_444-110538TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014456_476-110538TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014485_505-110538TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+014644_664-110538TransmembraneHelical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000543737+01465_85-110538TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNRF3chr22:29280054chr22:32445930ENST00000332811+19241_9360837Topological domainCytoplasmic
HgeneZNRF3chr22:29280054chr22:32445930ENST00000332811+1956_2190837Topological domainExtracellular
HgeneZNRF3chr22:29280054chr22:32445930ENST00000402174+19241_936-31837Topological domainCytoplasmic
HgeneZNRF3chr22:29280054chr22:32445930ENST00000402174+1956_219-31837Topological domainExtracellular
HgeneZNRF3chr22:29280054chr22:32445930ENST00000406323+18241_936-8837Topological domainCytoplasmic
HgeneZNRF3chr22:29280054chr22:32445930ENST00000406323+1856_219-8837Topological domainExtracellular
HgeneZNRF3chr22:29280054chr22:32445930ENST00000544604+19241_936100937Topological domainCytoplasmic
HgeneZNRF3chr22:29280054chr22:32445930ENST00000544604+1956_219100937Topological domainExtracellular
HgeneZNRF3chr22:29280054chr22:32445930ENST00000332811+19220_2400837TransmembraneHelical
HgeneZNRF3chr22:29280054chr22:32445930ENST00000402174+19220_240-31837TransmembraneHelical
HgeneZNRF3chr22:29280054chr22:32445930ENST00000406323+18220_240-8837TransmembraneHelical
HgeneZNRF3chr22:29280054chr22:32445930ENST00000544604+19220_240100937TransmembraneHelical
HgeneZNRF3chr22:29280054chr22:32445930ENST00000332811+19293_3340837Zinc fingerRING-type%3B atypical
HgeneZNRF3chr22:29280054chr22:32445930ENST00000402174+19293_334-31837Zinc fingerRING-type%3B atypical
HgeneZNRF3chr22:29280054chr22:32445930ENST00000406323+18293_334-8837Zinc fingerRING-type%3B atypical
HgeneZNRF3chr22:29280054chr22:32445930ENST00000544604+19293_334100937Zinc fingerRING-type%3B atypical
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+0151_2845665Topological domainExtracellular
TgeneSLC5A1chr22:29280054chr22:32445930ENST00000266088+01529_4945665TransmembraneHelical


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FusionGeneSequence for ZNRF3_SLC5A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNRF3_ENST00000544604_chr22_29280054_+_SLC5A1_ENST00000266088_chr22_32445930_+_720aa
MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGA
TLSAEGEIVQAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGV
VTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGS
LILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAK
NMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLT
SIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGA
FWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDA
EEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFAX


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNRF3_ENST00000544604_chr22_29280054_+_SLC5A1_ENST00000266088_chr22_32445930_+_2160nt
ATGAGGCCGCGCTCGGGCGGGCGCCCAGGGGCCACGGGCCGCCGCCGCCGCCGCCTGCGCCGCCGCCCCCGCGGCCTCCGGTGCAGCCGC
CTGCCGCCGCCGCCGCCGCTGCCGCTGCTGCTCGGGCTGCTGCTGGCGGCCGCGGGGCCCGGCGCGGCGCGGGCCAAGGAGACGGCGTTC
GTGGAGGTGGTGCTGTTCGAGTCGAGCCCAAGCGGCGATTACACCACCTACACCACCGGCCTCACGGGCCGCTTCTCGCGGGCCGGGGCC
ACGCTCAGCGCCGAGGGCGAGATCGTGCAGGCTATGTTTTCCACCAATCGTGGGACTGTTGGAGGCTTCTTCCTGGCAGGCCGAAGTATG
GTGTGGTGGCCGATTGGAGCCTCCCTCTTTGCTAGTAACATTGGAAGTGGCCACTTTGTGGGGCTGGCCGGGACTGGGGCAGCTTCAGGC
ATCGCCATTGGAGGCTTTGAATGGAATGCCCTGGTTTTGGTGGTTGTGCTGGGCTGGCTGTTTGTCCCCATCTATATTAAGGCTGGGGTG
GTGACAATGCCAGAGTACCTGAGGAAGCGGTTTGGAGGCCAGCGGATCCAGGTCTACCTTTCCCTTCTGTCCCTGCTGCTCTACATTTTC
ACCAAGATCTCGGCAGACATCTTCTCGGGGGCCATATTCATCAATCTGGCCTTAGGCCTGAATCTGTATTTAGCCATCTTTCTCTTATTG
GCAATCACTGCCCTTTACACAATTACAGGGGGCCTGGCGGCGGTGATTTACACGGACACCTTGCAGACGGTGATCATGCTGGTGGGGTCT
TTAATCCTGACTGGGTTTGCTTTTCACGAAGTGGGAGGCTATGACGCCTTCATGGAAAAGTACATGAAAGCCATTCCAACCATAGTGTCT
GATGGCAACACCACCTTTCAGGAAAAATGCTACACTCCAAGGGCCGACTCCTTCCACATCTTCCGAGATCCCCTCACGGGAGACCTCCCA
TGGCCTGGGTTCATCTTTGGGATGTCCATCCTTACCTTGTGGTACTGGTGCACAGATCAGGTCATTGTGCAGCGCTGCCTCTCAGCCAAG
AATATGTCTCACGTGAAGGGTGGCTGCATCCTGTGTGGGTATCTAAAGCTGATGCCCATGTTCATCATGGTGATGCCAGGAATGATCAGC
CGCATTCTGTACACAGAAAAAATTGCCTGTGTCGTCCCTTCAGAATGTGAGAAATATTGCGGTACCAAGGTTGGCTGTACCAACATCGCC
TATCCAACCTTAGTGGTGGAGCTCATGCCCAATGGACTGCGAGGCCTGATGCTATCAGTCATGCTGGCCTCCCTCATGAGCTCCCTGACC
TCCATCTTCAACAGCGCCAGCACCCTCTTCACCATGGACATCTACGCCAAGGTCCGCAAGAGAGCATCTGAGAAAGAGCTCATGATTGCC
GGAAGGTTGTTTATCCTGGTGCTGATTGGCATCAGCATCGCCTGGGTGCCCATTGTGCAGTCAGCACAAAGTGGGCAACTCTTCGATTAC
ATCCAGTCCATCACCAGTTACTTGGGACCACCCATTGCGGCTGTCTTCCTGCTTGCTATTTTCTGGAAGAGAGTCAATGAGCCAGGAGCC
TTTTGGGGACTGATCCTAGGACTTCTGATTGGGATTTCACGTATGATTACTGAGTTTGCTTATGGAACCGGGAGCTGCATGGAGCCCAGC
AACTGTCCCACGATTATCTGTGGGGTGCACTACTTGTACTTTGCCATTATCCTCTTCGCCATTTCTTTCATCACCATCGTGGTCATCTCC
CTCCTCACCAAACCCATTCCGGATGTGCATCTCTACCGTCTGTGTTGGAGCCTGCGCAACAGCAAAGAGGAGCGTATTGACCTGGATGCG
GAAGAGGAGAACATCCAAGAAGGCCCTAAGGAGACCATTGAAATAGAAACACAAGTTCCTGAGAAGAAAAAAGGAATCTTCAGGAGAGCC
TATGACCTATTTTGTGGGCTAGAGCAGCACGGTGCACCCAAGATGACTGAGGAAGAGGAGAAAGCCATGAAGATGAAGATGACGGACACC
TCTGAGAAGCCTTTGTGGAGGACAGTGTTGAACGTCAATGGCATCATCCTGGTGACCGTGGCTGTCTTTTGCCATGCATATTTTGCCTGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNRF3_ENST00000544604_chr22_29280054_+_SLC5A1_ENST00000266088_chr22_32445930_+_5151nt
AGATGAAAGGGCCGCGGCGCGACGGCCGGGGGAGCCGAGCTGAGCCTGCGACCCACAAAGCCGCCGCCGCCGCCGCCGTGATGGGGCTGT
GAGGCGTCCGCCCGCGTTCGGTCCTCAGCCGGCCCGCGACTATGCCCGGCCGCGCCCGCCCTCCGCGCCCTCCCGCCGCAGGACCATGAG
GCCGCGCTCGGGCGGGCGCCCAGGGGCCACGGGCCGCCGCCGCCGCCGCCTGCGCCGCCGCCCCCGCGGCCTCCGGTGCAGCCGCCTGCC
GCCGCCGCCGCCGCTGCCGCTGCTGCTCGGGCTGCTGCTGGCGGCCGCGGGGCCCGGCGCGGCGCGGGCCAAGGAGACGGCGTTCGTGGA
GGTGGTGCTGTTCGAGTCGAGCCCAAGCGGCGATTACACCACCTACACCACCGGCCTCACGGGCCGCTTCTCGCGGGCCGGGGCCACGCT
CAGCGCCGAGGGCGAGATCGTGCAGGCTATGTTTTCCACCAATCGTGGGACTGTTGGAGGCTTCTTCCTGGCAGGCCGAAGTATGGTGTG
GTGGCCGATTGGAGCCTCCCTCTTTGCTAGTAACATTGGAAGTGGCCACTTTGTGGGGCTGGCCGGGACTGGGGCAGCTTCAGGCATCGC
CATTGGAGGCTTTGAATGGAATGCCCTGGTTTTGGTGGTTGTGCTGGGCTGGCTGTTTGTCCCCATCTATATTAAGGCTGGGGTGGTGAC
AATGCCAGAGTACCTGAGGAAGCGGTTTGGAGGCCAGCGGATCCAGGTCTACCTTTCCCTTCTGTCCCTGCTGCTCTACATTTTCACCAA
GATCTCGGCAGACATCTTCTCGGGGGCCATATTCATCAATCTGGCCTTAGGCCTGAATCTGTATTTAGCCATCTTTCTCTTATTGGCAAT
CACTGCCCTTTACACAATTACAGGGGGCCTGGCGGCGGTGATTTACACGGACACCTTGCAGACGGTGATCATGCTGGTGGGGTCTTTAAT
CCTGACTGGGTTTGCTTTTCACGAAGTGGGAGGCTATGACGCCTTCATGGAAAAGTACATGAAAGCCATTCCAACCATAGTGTCTGATGG
CAACACCACCTTTCAGGAAAAATGCTACACTCCAAGGGCCGACTCCTTCCACATCTTCCGAGATCCCCTCACGGGAGACCTCCCATGGCC
TGGGTTCATCTTTGGGATGTCCATCCTTACCTTGTGGTACTGGTGCACAGATCAGGTCATTGTGCAGCGCTGCCTCTCAGCCAAGAATAT
GTCTCACGTGAAGGGTGGCTGCATCCTGTGTGGGTATCTAAAGCTGATGCCCATGTTCATCATGGTGATGCCAGGAATGATCAGCCGCAT
TCTGTACACAGAAAAAATTGCCTGTGTCGTCCCTTCAGAATGTGAGAAATATTGCGGTACCAAGGTTGGCTGTACCAACATCGCCTATCC
AACCTTAGTGGTGGAGCTCATGCCCAATGGACTGCGAGGCCTGATGCTATCAGTCATGCTGGCCTCCCTCATGAGCTCCCTGACCTCCAT
CTTCAACAGCGCCAGCACCCTCTTCACCATGGACATCTACGCCAAGGTCCGCAAGAGAGCATCTGAGAAAGAGCTCATGATTGCCGGAAG
GTTGTTTATCCTGGTGCTGATTGGCATCAGCATCGCCTGGGTGCCCATTGTGCAGTCAGCACAAAGTGGGCAACTCTTCGATTACATCCA
GTCCATCACCAGTTACTTGGGACCACCCATTGCGGCTGTCTTCCTGCTTGCTATTTTCTGGAAGAGAGTCAATGAGCCAGGAGCCTTTTG
GGGACTGATCCTAGGACTTCTGATTGGGATTTCACGTATGATTACTGAGTTTGCTTATGGAACCGGGAGCTGCATGGAGCCCAGCAACTG
TCCCACGATTATCTGTGGGGTGCACTACTTGTACTTTGCCATTATCCTCTTCGCCATTTCTTTCATCACCATCGTGGTCATCTCCCTCCT
CACCAAACCCATTCCGGATGTGCATCTCTACCGTCTGTGTTGGAGCCTGCGCAACAGCAAAGAGGAGCGTATTGACCTGGATGCGGAAGA
GGAGAACATCCAAGAAGGCCCTAAGGAGACCATTGAAATAGAAACACAAGTTCCTGAGAAGAAAAAAGGAATCTTCAGGAGAGCCTATGA
CCTATTTTGTGGGCTAGAGCAGCACGGTGCACCCAAGATGACTGAGGAAGAGGAGAAAGCCATGAAGATGAAGATGACGGACACCTCTGA
GAAGCCTTTGTGGAGGACAGTGTTGAACGTCAATGGCATCATCCTGGTGACCGTGGCTGTCTTTTGCCATGCATATTTTGCCTGAGTCCT
ACCTTTTGCTGTAGATTTACCATGGCTGGACTCTTACTCACCTTCCTTTAGTCTCGTCCTGTGGTGTTGAAGGGAAATCAGCCAGTTGTA
AATTTTGCCCAGGTGGATAAATGTGTACATGTGTAATTATAGGCTAGCTGGAAGAAAACCATTAGTTTGCTGTTAATTTATGCATTTGAA
GCCAGTGTGATACAGCCATCTGTACCTACTGGAGCTGCAGAAGGGAAGTCCACTCAGTCACATCCAGAAAAAGGCAGACTAAGAATCAGA
AGCCATGTGATTGATGTCTGACGTGAGTCTGTCTCAGGTAGATTCCGGGTGTCAGTGTGGTTTATAATCCTTGAATATTGTTTTAGAAAC
TTTGGTCTCCCTGGTTCCTGCCACTTTTCCTGTCCGTCCTCCTCCCCATTTTTTTTTTAAAAGAAAGCTGTTTTCCCCTCATCATATCCC
TCTTGAGTTTTGCCTGGACTTTCCCTCTCAAGTGTGTCAATCAGGTAAACTGAGGAATGCATGGAAGCTGAGGATGGAGCTTGATGGGCT
CCCTGTCCTGGGTGTTTGCTCTCTGAAGTGGAGGCCTGAGGAAGGTAGTACTTCCACAAAAGGGAGGGACCCGGGCCCCAGCCTCAAGCT
AGTGGGGGAGGCAGATAGCCTGAATCCAGGGGATTTTCTGGGCTTCTTAAAATGTCCATTGTGAGTTCCCCGTGTTTGGGATTCCACTCA
TTTTGGCATTCACAGTGCCTGGAATGTCTTAGATTTTCAGCAATGCGTGTTGAATAAATGAATGACATAGGCATTTATTTTTAAATCTTT
GCTTGCTTTTTACATGAGCCTGGCCCTTAGTTAACCTTTTCTTGTGGCTACACAAAGTATGCTCACTGGTTACTAATGACTTGGGATGCA
TTTGTCAAACTGATTATATTAGTTTTCTAGGGATGCCATAACAAAGTAGCACAGACCAGATGGCTCAAGCAGCAGACATTTATTTTCTCA
CAGTTCTAGAGGCTAGAAGTTGGAGGCCAAGATGTCAGCAGGGTTGGTTTCTTCTGAGGCCTCTCTCCTTGGTTGCAGATGGTCATATCT
CACTCTGTCTTCCGTGGCCTTCCTTTTGTCTGTGTCCTAAATCTACTCTTCTGATAAGGACATCAGTCATATTGGAATAGGACCCACCCT
AATGTCTTCATTTTAATCACCTCTTTAAAGCCCCTACCTCCAAATACAGTCACACTGTGAGAAACTGAGGGTTAGGAAGTCAGCAAGTGA
GTCTTGAAGAGATACTAAACAAACCCACAACACAGATAAAGTATGCATTTTGGAGATTTCCAAGCCAGAGTCTCCCGTGAAAAAGGTAAA
CGGAAGCAGTTATTGTGCAGCAAAAGGAAAAAGAATTACAAACTGAACGTATGTAGGTGAGGCAAGGCAGGGTAGGGCAGGGCCTTTGGG
TAGGCTGATCAGAGGGTTTTTCAACAATAAATCAATGGGAATGCATTTGTTGCTCCCAGGACCCTGGCACCTTGACTCTGGTACTATAGC
ATGTCAGCAAATACAAGCAAAGCCCAACACTCTGATTTGCATTTATGCCAATCTAAACTATCCGGTGTTTAGTTTGATTTTTTGAGTGCA
GGTTCATTCAAGGACCAGGTTCCCTTGTGCTCAGGGTGAAGTAGAACCAGAAAACATCGTTATCCATTCCCAGAAGTTTTGGAAGAGCCT
TGGTAGAAAAGCAGAAGCTGCTTTGACCGTGAAAATATTTGACTCCTATCAGTTTTTGGTCAGGAGAAGATATCCACCTAGACCAACCTG
AGGAGAAGGCTCAGAGTACAGATATACCCCGAGCAACGTGATCAATGTCCTTGAACCTTCATTTTTCATCTGAAAACAGAGACATAAATG
CCTGGCTCACAGATTTAAATGTTATACATTGACAGCATTTATCAGTATAACATTTATTTAAATAAGTAGGTGCTCAATAGGTGTTGGTCT
TCTAACTTGTCTACATCCCATCCCCATTCCAGGGTCTTCAGAATTGAAGGAGAGATGTTGTATCACTGTTAGAAGGCTGCTTTGGGACAT
TCTGCAGCAGGGAGGAGGGACTGTCAACCCCTACACCATGACCACCAAGTTCCTCACCTTGGCTGAGTCCCTAAAACTCTCTGAACCTCA
GGTTCCTCCAAGCATAATGCAGACTTCACAGAGCTGTTGTAAAGATTAGGTGAGGTCAATTGATACTGCTTAAAAGGCCCGGTCCGTAGA
AAATGCCCAATAAACATTACTGCTTTCCCCCTCACCCTACTGCCTGAAAAAATATTACACCTGTGAGACTGACTTTGAGAACCAGTGTGG
GTGGGGAGTTGTGCATATAAACTATTTAATGAGTACCAAACACAAAAGTCAAGCTTGTAAAATATCAGGCCTTGCCCCAGAAAGACAAAT
ACCACATGATCTCACTGATATGTAGAATCTTAAAAAGTCAAACTCAGAAGCAGAGAGTAGAATGATGGTTATCAAGGGCTGGGGGAGGGA
GGGACTGGGGAGATGTTGGTCAAATGATACAAAGGTTTAGTTAGGTGGAATAAGTTCAGAAAATCAATTGTACAATGTATCAATTATAGT
TAATAGCAATATAACATATACTTGAAAATTGCTGAGAGTAGTGTGAGTGTTCTACCACAAAAAAATATGTGCAGTAATAGATGTTAATTA
CCTTAATTTAGTCATTTCACAATATGTACATATATAAAAATATGTTGTATGCCATGAGTATATATAATTATTATTTGTGAATTTAAAAAA


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FusionGenePPI for ZNRF3_SLC5A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNRF3UBE2N, FZD4, RSPO1, LGR4, LRP6, GFI1B, DVL2, HSPB1, RSPO2, RSPO3, LGR5, FZD7SLC5A1PAWR, HSPA1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNRF3_SLC5A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC5A1P13866DB08907CanagliflozinSodium/glucose cotransporter 1small moleculeapproved

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RelatedDiseases for ZNRF3_SLC5A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZNRF3C0030297Pancreatic Neoplasm2CTD_human
HgeneZNRF3C0206686Adrenocortical carcinoma1CTD_human
TgeneSLC5A1C0268186Congenital glucose-galactose malabsorption4CTD_human;ORPHANET;UNIPROT