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Fusion gene ID: 43785 |
FusionGeneSummary for ZNF91_ASF1B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF91_ASF1B | Fusion gene ID: 43785 | Hgene | Tgene | Gene symbol | ZNF91 | ASF1B | Gene ID | 7644 | 55723 |
| Gene name | zinc finger protein 91 | anti-silencing function 1B histone chaperone | |
| Synonyms | HPF7|HTF10 | CIA-II | |
| Cytomap | 19p12 | 19p13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 91zinc finger protein 91 (HPF7, HTF10)zinc finger protein HPF7zinc finger protein HTF10 | histone chaperone ASF1BASF1 anti-silencing function 1 homolog BCCG1-interacting factor A-IIanti-silencing function protein 1 homolog BhAsf1hAsf1bhCIA-II | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q05481 | Q9NVP2 | |
| Ensembl transtripts involved in fusion gene | ENST00000596528, ENST00000599743, ENST00000300619, ENST00000397082, | ENST00000263382, ENST00000592798, ENST00000474890, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 3 X 3 X 4=36 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF91 [Title/Abstract] AND ASF1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZNF91 | GO:0045892 | negative regulation of transcription, DNA-templated | 25274305 |
| Hgene | ZNF91 | GO:0070895 | negative regulation of transposon integration | 25274305 |
| Tgene | ASF1B | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
| Tgene | ASF1B | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PCPG | TCGA-S7-A7WP-01A | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000596528 | ENST00000263382 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
| intron-intron | ENST00000596528 | ENST00000592798 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
| intron-intron | ENST00000596528 | ENST00000474890 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
| In-frame | ENST00000599743 | ENST00000263382 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
| 5CDS-intron | ENST00000599743 | ENST00000592798 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
| 5CDS-intron | ENST00000599743 | ENST00000474890 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
| In-frame | ENST00000300619 | ENST00000263382 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
| 5CDS-intron | ENST00000300619 | ENST00000592798 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
| 5CDS-intron | ENST00000300619 | ENST00000474890 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
| In-frame | ENST00000397082 | ENST00000263382 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
| 5CDS-intron | ENST00000397082 | ENST00000592798 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
| 5CDS-intron | ENST00000397082 | ENST00000474890 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
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FusionProtFeatures for ZNF91_ASF1B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF91 | ASF1B |
| Transcription factor specifically required to repressSINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVAsequences and represses their expression by recruiting arepressive complex containing TRIM28/KAP1 (PubMed:25274305). Mayalso bind the promoter of the FCGR2B gene, leading to repress itsexpression; however, additional evidences are required to confirmthis result in vivo (PubMed:11470777).{ECO:0000269|PubMed:25274305, ECO:0000305|PubMed:11470777}. | Histone chaperone that facilitates histone depositionand histone exchange and removal during nucleosome assembly anddisassembly. Cooperates with chromatin assembly factor 1 (CAF-1)to promote replication-dependent chromatin assembly. Does notparticipate in replication-independent nucleosome deposition whichis mediated by ASF1A and HIRA. Required for spermatogenesis.{ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904,ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198,ECO:0000269|PubMed:16151251}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF91_ASF1B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZNF91_ENST00000599743_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_138aa MPGTPGSLEMADAPNPSLIPETDAVGVTVVLITCTYHGQEFIRVGYYVNNEYLNPELRENPPMKPDFSQLQRNILASNPRVTRFHINWDN >In-frame_ZNF91_ENST00000300619_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_138aa MPGTPGSLEMADAPNPSLIPETDAVGVTVVLITCTYHGQEFIRVGYYVNNEYLNPELRENPPMKPDFSQLQRNILASNPRVTRFHINWDN >In-frame_ZNF91_ENST00000397082_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_138aa MPGTPGSLEMADAPNPSLIPETDAVGVTVVLITCTYHGQEFIRVGYYVNNEYLNPELRENPPMKPDFSQLQRNILASNPRVTRFHINWDN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZNF91_ENST00000599743_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_414nt ATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGACTGATGCCGTGGGTGTGACTGTGGTC CTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGTACCTCAACCCTGAGCTGCGTGAGAAC CCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGACCCGCTTCCATATCAACTGGGACAAC AACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCAACTGCACTCCTATCAAGGGCTTGGGG >In-frame_ZNF91_ENST00000300619_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_414nt ATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGACTGATGCCGTGGGTGTGACTGTGGTC CTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGTACCTCAACCCTGAGCTGCGTGAGAAC CCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGACCCGCTTCCATATCAACTGGGACAAC AACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCAACTGCACTCCTATCAAGGGCTTGGGG >In-frame_ZNF91_ENST00000397082_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_414nt ATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGACTGATGCCGTGGGTGTGACTGTGGTC CTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGTACCTCAACCCTGAGCTGCGTGAGAAC CCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGACCCGCTTCCATATCAACTGGGACAAC AACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCAACTGCACTCCTATCAAGGGCTTGGGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZNF91_ENST00000599743_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_1467nt CCGGAGTTTCCAGGTCTCGACTTCACTGCTCTGTGTCCTCTGCTCCAGGAGGCCCAGCCTGTGTGGCCCTGTGACCTGCAGGTATTGGAG AGCCACAGCTAAGATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGACTGATGCCGTGGG TGTGACTGTGGTCCTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGTACCTCAACCCTGA GCTGCGTGAGAACCCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGACCCGCTTCCATAT CAACTGGGACAACAACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCAACTGCACTCCTAT CAAGGGCTTGGGGCTCCCTGGCTGCATCCCTGGCCTCCTCCCTGAGAACTCCATGGACTGCATCTAACTGCAGGAACCCAGAGTGTCCCA GCACGCCGGGAGGGGCAACCAGGCCTCCCAGCGAGTCCTGCAGGGCCCATCTAGAGGACTTTGGGGGCCATCAGCTGCAATCCAGGTCTG TCAAACTCAGCCCCTAGGAAAGAACAGGCCTTGGGTCTCCCCTAGTCCTGGCCAGAAGGATGATCTCGCTTTTCCTCTACAGGCCTATAA GAAGCAGGTACTTCAGTTCTAAATTCTGACTTGTGTTCTTTTCGTCTTCATAAATTCTAACTAAGGCCACTGTGCCACTGTGCACCCTTG AGTACCATTGATCCAAAGCTTTCCCACAGACCTCCCTGGCCCACCTAGAGGCTTTCTTGGTCAGTGCCTGTCAAGGCTCCAGTCCTGCTG AGCCAAAGGCTTTGTCATTCCTTTCTCTTCCTGTACATCTGAGCAGACCCACTCCAGCTTTCTGGTGTCACAGGCGGGAATGTTAGTTAG TAGGTAGACTTAGATCCCATTTCTGTCCTGCTCCCAGGAAGATTCTTAGGTCCTCTTCAATCCAGCAGCCCCTCCCAGAGGTGTGATCAG CAGGATGCTGAGGAACCATGTTGCCTTTCCTGTCAATCACAGCCACCTTCCTGTTATCTCCTAAATGGATCTGGCTTTTCCTGGAGGCTG CCATGGTTGGAAGATGGTATCAGAGGGCCTGCCTGGGCAGTCTGTCTCCGGGCCAGGGTCAGGGACCCTCTGCCTCTGGCAGCCTTAACC TGTCCTCTGCTAGGACCAGGGTGATTTCAAGCCAGGGAAGCAACTGGGACCCTGAAAACTGTCCCTCCCCAGCCCGCTCCCCCTCTCTGT GCCCTGGTCCCCTTGCTGCCATGTGGATGCTGTTGTGATTGCTGTTTGTATATTATCAAAATGTTTTTATATTAAAAATGTTTGGTCTGA >In-frame_ZNF91_ENST00000300619_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_1570nt ATCTAATCAGGGACGCTGGGCTGGGAACTGTCCAATCAGGCACAAAGCTGGAGCGGACAGGGCGGCTTCCGGGATGTGGCTGGGCCTTTG TCTCTCGCTGCCGCCGGAGTTTCCAGGTCTCGACTTCACTGCTCTGTGTCCTCTGCTCCAGGAGGCCCAGCCTGTGTGGCCCTGTGACCT GCAGGTATTGGAGAGCCACAGCTAAGATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGA CTGATGCCGTGGGTGTGACTGTGGTCCTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGT ACCTCAACCCTGAGCTGCGTGAGAACCCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGA CCCGCTTCCATATCAACTGGGACAACAACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCA ACTGCACTCCTATCAAGGGCTTGGGGCTCCCTGGCTGCATCCCTGGCCTCCTCCCTGAGAACTCCATGGACTGCATCTAACTGCAGGAAC CCAGAGTGTCCCAGCACGCCGGGAGGGGCAACCAGGCCTCCCAGCGAGTCCTGCAGGGCCCATCTAGAGGACTTTGGGGGCCATCAGCTG CAATCCAGGTCTGTCAAACTCAGCCCCTAGGAAAGAACAGGCCTTGGGTCTCCCCTAGTCCTGGCCAGAAGGATGATCTCGCTTTTCCTC TACAGGCCTATAAGAAGCAGGTACTTCAGTTCTAAATTCTGACTTGTGTTCTTTTCGTCTTCATAAATTCTAACTAAGGCCACTGTGCCA CTGTGCACCCTTGAGTACCATTGATCCAAAGCTTTCCCACAGACCTCCCTGGCCCACCTAGAGGCTTTCTTGGTCAGTGCCTGTCAAGGC TCCAGTCCTGCTGAGCCAAAGGCTTTGTCATTCCTTTCTCTTCCTGTACATCTGAGCAGACCCACTCCAGCTTTCTGGTGTCACAGGCGG GAATGTTAGTTAGTAGGTAGACTTAGATCCCATTTCTGTCCTGCTCCCAGGAAGATTCTTAGGTCCTCTTCAATCCAGCAGCCCCTCCCA GAGGTGTGATCAGCAGGATGCTGAGGAACCATGTTGCCTTTCCTGTCAATCACAGCCACCTTCCTGTTATCTCCTAAATGGATCTGGCTT TTCCTGGAGGCTGCCATGGTTGGAAGATGGTATCAGAGGGCCTGCCTGGGCAGTCTGTCTCCGGGCCAGGGTCAGGGACCCTCTGCCTCT GGCAGCCTTAACCTGTCCTCTGCTAGGACCAGGGTGATTTCAAGCCAGGGAAGCAACTGGGACCCTGAAAACTGTCCCTCCCCAGCCCGC TCCCCCTCTCTGTGCCCTGGTCCCCTTGCTGCCATGTGGATGCTGTTGTGATTGCTGTTTGTATATTATCAAAATGTTTTTATATTAAAA >In-frame_ZNF91_ENST00000397082_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_1456nt AGGTCTCGACTTCACTGCTCTGTGTCCTCTGCTCCAGGAGGCCCAGCCTGTGTGGCCCTGTGACCTGCAGGTATTGGAGAGCCACAGCTA AGATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGACTGATGCCGTGGGTGTGACTGTGG TCCTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGTACCTCAACCCTGAGCTGCGTGAGA ACCCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGACCCGCTTCCATATCAACTGGGACA ACAACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCAACTGCACTCCTATCAAGGGCTTGG GGCTCCCTGGCTGCATCCCTGGCCTCCTCCCTGAGAACTCCATGGACTGCATCTAACTGCAGGAACCCAGAGTGTCCCAGCACGCCGGGA GGGGCAACCAGGCCTCCCAGCGAGTCCTGCAGGGCCCATCTAGAGGACTTTGGGGGCCATCAGCTGCAATCCAGGTCTGTCAAACTCAGC CCCTAGGAAAGAACAGGCCTTGGGTCTCCCCTAGTCCTGGCCAGAAGGATGATCTCGCTTTTCCTCTACAGGCCTATAAGAAGCAGGTAC TTCAGTTCTAAATTCTGACTTGTGTTCTTTTCGTCTTCATAAATTCTAACTAAGGCCACTGTGCCACTGTGCACCCTTGAGTACCATTGA TCCAAAGCTTTCCCACAGACCTCCCTGGCCCACCTAGAGGCTTTCTTGGTCAGTGCCTGTCAAGGCTCCAGTCCTGCTGAGCCAAAGGCT TTGTCATTCCTTTCTCTTCCTGTACATCTGAGCAGACCCACTCCAGCTTTCTGGTGTCACAGGCGGGAATGTTAGTTAGTAGGTAGACTT AGATCCCATTTCTGTCCTGCTCCCAGGAAGATTCTTAGGTCCTCTTCAATCCAGCAGCCCCTCCCAGAGGTGTGATCAGCAGGATGCTGA GGAACCATGTTGCCTTTCCTGTCAATCACAGCCACCTTCCTGTTATCTCCTAAATGGATCTGGCTTTTCCTGGAGGCTGCCATGGTTGGA AGATGGTATCAGAGGGCCTGCCTGGGCAGTCTGTCTCCGGGCCAGGGTCAGGGACCCTCTGCCTCTGGCAGCCTTAACCTGTCCTCTGCT AGGACCAGGGTGATTTCAAGCCAGGGAAGCAACTGGGACCCTGAAAACTGTCCCTCCCCAGCCCGCTCCCCCTCTCTGTGCCCTGGTCCC CTTGCTGCCATGTGGATGCTGTTGTGATTGCTGTTTGTATATTATCAAAATGTTTTTATATTAAAAATGTTTGGTCTGAAAATTAAAAGC |
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FusionGenePPI for ZNF91_ASF1B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF91 | NDEL1, ELAVL1, CHMP5, TRIM44 | ASF1B | TLK1, IPO4, CDAN1, TLK2, CHAF1B, RPS3A, DOK2, C15orf41, MMS22L, RBBP4, CHAF1A, TTN, TONSL, HIST1H3F, UBXN1, DYNLL1, PSPH, RPL31, MRPS7, HCFC1, HIRA, HIST3H3, HIST4H4, HAT1, RBBP7, HIST1H3A, H3F3A, MCM2, MCM6, HIST1H3E, ASF1A, HIST1H3C, KHSRP, IDH1, MOV10, NXF1, MCM3, MCM4, MCM5, MCM7, NASP, STAT5B, CABIN1, UBN1, UBN2, PAN3, PAN2, PPTC7, RIF1, HIST1H4A, HIST2H4A, RCVRN |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF91_ASF1B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF91_ASF1B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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