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Fusion gene ID: 43785 |
FusionGeneSummary for ZNF91_ASF1B |
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Fusion gene information | Fusion gene name: ZNF91_ASF1B | Fusion gene ID: 43785 | Hgene | Tgene | Gene symbol | ZNF91 | ASF1B | Gene ID | 7644 | 55723 |
Gene name | zinc finger protein 91 | anti-silencing function 1B histone chaperone | |
Synonyms | HPF7|HTF10 | CIA-II | |
Cytomap | 19p12 | 19p13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 91zinc finger protein 91 (HPF7, HTF10)zinc finger protein HPF7zinc finger protein HTF10 | histone chaperone ASF1BASF1 anti-silencing function 1 homolog BCCG1-interacting factor A-IIanti-silencing function protein 1 homolog BhAsf1hAsf1bhCIA-II | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q05481 | Q9NVP2 | |
Ensembl transtripts involved in fusion gene | ENST00000596528, ENST00000599743, ENST00000300619, ENST00000397082, | ENST00000263382, ENST00000592798, ENST00000474890, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 3 X 3 X 4=36 |
# samples | 8 | 4 | |
** MAII score | log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZNF91 [Title/Abstract] AND ASF1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZNF91 | GO:0045892 | negative regulation of transcription, DNA-templated | 25274305 |
Hgene | ZNF91 | GO:0070895 | negative regulation of transposon integration | 25274305 |
Tgene | ASF1B | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
Tgene | ASF1B | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PCPG | TCGA-S7-A7WP-01A | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000596528 | ENST00000263382 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
intron-intron | ENST00000596528 | ENST00000592798 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
intron-intron | ENST00000596528 | ENST00000474890 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
In-frame | ENST00000599743 | ENST00000263382 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
5CDS-intron | ENST00000599743 | ENST00000592798 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
5CDS-intron | ENST00000599743 | ENST00000474890 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
In-frame | ENST00000300619 | ENST00000263382 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
5CDS-intron | ENST00000300619 | ENST00000592798 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
5CDS-intron | ENST00000300619 | ENST00000474890 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
In-frame | ENST00000397082 | ENST00000263382 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
5CDS-intron | ENST00000397082 | ENST00000592798 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
5CDS-intron | ENST00000397082 | ENST00000474890 | ZNF91 | chr19 | 23578127 | - | ASF1B | chr19 | 14232520 | - |
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FusionProtFeatures for ZNF91_ASF1B |
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Hgene | Tgene |
ZNF91 | ASF1B |
Transcription factor specifically required to repressSINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVAsequences and represses their expression by recruiting arepressive complex containing TRIM28/KAP1 (PubMed:25274305). Mayalso bind the promoter of the FCGR2B gene, leading to repress itsexpression; however, additional evidences are required to confirmthis result in vivo (PubMed:11470777).{ECO:0000269|PubMed:25274305, ECO:0000305|PubMed:11470777}. | Histone chaperone that facilitates histone depositionand histone exchange and removal during nucleosome assembly anddisassembly. Cooperates with chromatin assembly factor 1 (CAF-1)to promote replication-dependent chromatin assembly. Does notparticipate in replication-independent nucleosome deposition whichis mediated by ASF1A and HIRA. Required for spermatogenesis.{ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904,ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198,ECO:0000269|PubMed:16151251}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF91_ASF1B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ZNF91_ENST00000599743_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_138aa MPGTPGSLEMADAPNPSLIPETDAVGVTVVLITCTYHGQEFIRVGYYVNNEYLNPELRENPPMKPDFSQLQRNILASNPRVTRFHINWDN >In-frame_ZNF91_ENST00000300619_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_138aa MPGTPGSLEMADAPNPSLIPETDAVGVTVVLITCTYHGQEFIRVGYYVNNEYLNPELRENPPMKPDFSQLQRNILASNPRVTRFHINWDN >In-frame_ZNF91_ENST00000397082_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_138aa MPGTPGSLEMADAPNPSLIPETDAVGVTVVLITCTYHGQEFIRVGYYVNNEYLNPELRENPPMKPDFSQLQRNILASNPRVTRFHINWDN |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ZNF91_ENST00000599743_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_414nt ATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGACTGATGCCGTGGGTGTGACTGTGGTC CTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGTACCTCAACCCTGAGCTGCGTGAGAAC CCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGACCCGCTTCCATATCAACTGGGACAAC AACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCAACTGCACTCCTATCAAGGGCTTGGGG >In-frame_ZNF91_ENST00000300619_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_414nt ATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGACTGATGCCGTGGGTGTGACTGTGGTC CTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGTACCTCAACCCTGAGCTGCGTGAGAAC CCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGACCCGCTTCCATATCAACTGGGACAAC AACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCAACTGCACTCCTATCAAGGGCTTGGGG >In-frame_ZNF91_ENST00000397082_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_414nt ATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGACTGATGCCGTGGGTGTGACTGTGGTC CTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGTACCTCAACCCTGAGCTGCGTGAGAAC CCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGACCCGCTTCCATATCAACTGGGACAAC AACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCAACTGCACTCCTATCAAGGGCTTGGGG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ZNF91_ENST00000599743_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_1467nt CCGGAGTTTCCAGGTCTCGACTTCACTGCTCTGTGTCCTCTGCTCCAGGAGGCCCAGCCTGTGTGGCCCTGTGACCTGCAGGTATTGGAG AGCCACAGCTAAGATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGACTGATGCCGTGGG TGTGACTGTGGTCCTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGTACCTCAACCCTGA GCTGCGTGAGAACCCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGACCCGCTTCCATAT CAACTGGGACAACAACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCAACTGCACTCCTAT CAAGGGCTTGGGGCTCCCTGGCTGCATCCCTGGCCTCCTCCCTGAGAACTCCATGGACTGCATCTAACTGCAGGAACCCAGAGTGTCCCA GCACGCCGGGAGGGGCAACCAGGCCTCCCAGCGAGTCCTGCAGGGCCCATCTAGAGGACTTTGGGGGCCATCAGCTGCAATCCAGGTCTG TCAAACTCAGCCCCTAGGAAAGAACAGGCCTTGGGTCTCCCCTAGTCCTGGCCAGAAGGATGATCTCGCTTTTCCTCTACAGGCCTATAA GAAGCAGGTACTTCAGTTCTAAATTCTGACTTGTGTTCTTTTCGTCTTCATAAATTCTAACTAAGGCCACTGTGCCACTGTGCACCCTTG AGTACCATTGATCCAAAGCTTTCCCACAGACCTCCCTGGCCCACCTAGAGGCTTTCTTGGTCAGTGCCTGTCAAGGCTCCAGTCCTGCTG AGCCAAAGGCTTTGTCATTCCTTTCTCTTCCTGTACATCTGAGCAGACCCACTCCAGCTTTCTGGTGTCACAGGCGGGAATGTTAGTTAG TAGGTAGACTTAGATCCCATTTCTGTCCTGCTCCCAGGAAGATTCTTAGGTCCTCTTCAATCCAGCAGCCCCTCCCAGAGGTGTGATCAG CAGGATGCTGAGGAACCATGTTGCCTTTCCTGTCAATCACAGCCACCTTCCTGTTATCTCCTAAATGGATCTGGCTTTTCCTGGAGGCTG CCATGGTTGGAAGATGGTATCAGAGGGCCTGCCTGGGCAGTCTGTCTCCGGGCCAGGGTCAGGGACCCTCTGCCTCTGGCAGCCTTAACC TGTCCTCTGCTAGGACCAGGGTGATTTCAAGCCAGGGAAGCAACTGGGACCCTGAAAACTGTCCCTCCCCAGCCCGCTCCCCCTCTCTGT GCCCTGGTCCCCTTGCTGCCATGTGGATGCTGTTGTGATTGCTGTTTGTATATTATCAAAATGTTTTTATATTAAAAATGTTTGGTCTGA >In-frame_ZNF91_ENST00000300619_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_1570nt ATCTAATCAGGGACGCTGGGCTGGGAACTGTCCAATCAGGCACAAAGCTGGAGCGGACAGGGCGGCTTCCGGGATGTGGCTGGGCCTTTG TCTCTCGCTGCCGCCGGAGTTTCCAGGTCTCGACTTCACTGCTCTGTGTCCTCTGCTCCAGGAGGCCCAGCCTGTGTGGCCCTGTGACCT GCAGGTATTGGAGAGCCACAGCTAAGATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGA CTGATGCCGTGGGTGTGACTGTGGTCCTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGT ACCTCAACCCTGAGCTGCGTGAGAACCCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGA CCCGCTTCCATATCAACTGGGACAACAACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCA ACTGCACTCCTATCAAGGGCTTGGGGCTCCCTGGCTGCATCCCTGGCCTCCTCCCTGAGAACTCCATGGACTGCATCTAACTGCAGGAAC CCAGAGTGTCCCAGCACGCCGGGAGGGGCAACCAGGCCTCCCAGCGAGTCCTGCAGGGCCCATCTAGAGGACTTTGGGGGCCATCAGCTG CAATCCAGGTCTGTCAAACTCAGCCCCTAGGAAAGAACAGGCCTTGGGTCTCCCCTAGTCCTGGCCAGAAGGATGATCTCGCTTTTCCTC TACAGGCCTATAAGAAGCAGGTACTTCAGTTCTAAATTCTGACTTGTGTTCTTTTCGTCTTCATAAATTCTAACTAAGGCCACTGTGCCA CTGTGCACCCTTGAGTACCATTGATCCAAAGCTTTCCCACAGACCTCCCTGGCCCACCTAGAGGCTTTCTTGGTCAGTGCCTGTCAAGGC TCCAGTCCTGCTGAGCCAAAGGCTTTGTCATTCCTTTCTCTTCCTGTACATCTGAGCAGACCCACTCCAGCTTTCTGGTGTCACAGGCGG GAATGTTAGTTAGTAGGTAGACTTAGATCCCATTTCTGTCCTGCTCCCAGGAAGATTCTTAGGTCCTCTTCAATCCAGCAGCCCCTCCCA GAGGTGTGATCAGCAGGATGCTGAGGAACCATGTTGCCTTTCCTGTCAATCACAGCCACCTTCCTGTTATCTCCTAAATGGATCTGGCTT TTCCTGGAGGCTGCCATGGTTGGAAGATGGTATCAGAGGGCCTGCCTGGGCAGTCTGTCTCCGGGCCAGGGTCAGGGACCCTCTGCCTCT GGCAGCCTTAACCTGTCCTCTGCTAGGACCAGGGTGATTTCAAGCCAGGGAAGCAACTGGGACCCTGAAAACTGTCCCTCCCCAGCCCGC TCCCCCTCTCTGTGCCCTGGTCCCCTTGCTGCCATGTGGATGCTGTTGTGATTGCTGTTTGTATATTATCAAAATGTTTTTATATTAAAA >In-frame_ZNF91_ENST00000397082_chr19_23578127_-_ASF1B_ENST00000263382_chr19_14232520_-_1456nt AGGTCTCGACTTCACTGCTCTGTGTCCTCTGCTCCAGGAGGCCCAGCCTGTGTGGCCCTGTGACCTGCAGGTATTGGAGAGCCACAGCTA AGATGCCAGGAACCCCTGGAAGCCTAGAAATGGCCGACGCCCCCAACCCATCCCTCATCCCAGAGACTGATGCCGTGGGTGTGACTGTGG TCCTCATCACCTGCACCTACCATGGACAGGAGTTCATCCGAGTGGGCTACTACGTCAACAACGAGTACCTCAACCCTGAGCTGCGTGAGA ACCCGCCCATGAAGCCAGATTTCTCCCAGCTCCAGCGGAACATCTTGGCCTCGAACCCCCGGGTGACCCGCTTCCATATCAACTGGGACA ACAACATGGACAGGCTGGAGGCCATAGAGACCCAGGACCCCTCCCTGGGCTGCGGCCTCCCACTCAACTGCACTCCTATCAAGGGCTTGG GGCTCCCTGGCTGCATCCCTGGCCTCCTCCCTGAGAACTCCATGGACTGCATCTAACTGCAGGAACCCAGAGTGTCCCAGCACGCCGGGA GGGGCAACCAGGCCTCCCAGCGAGTCCTGCAGGGCCCATCTAGAGGACTTTGGGGGCCATCAGCTGCAATCCAGGTCTGTCAAACTCAGC CCCTAGGAAAGAACAGGCCTTGGGTCTCCCCTAGTCCTGGCCAGAAGGATGATCTCGCTTTTCCTCTACAGGCCTATAAGAAGCAGGTAC TTCAGTTCTAAATTCTGACTTGTGTTCTTTTCGTCTTCATAAATTCTAACTAAGGCCACTGTGCCACTGTGCACCCTTGAGTACCATTGA TCCAAAGCTTTCCCACAGACCTCCCTGGCCCACCTAGAGGCTTTCTTGGTCAGTGCCTGTCAAGGCTCCAGTCCTGCTGAGCCAAAGGCT TTGTCATTCCTTTCTCTTCCTGTACATCTGAGCAGACCCACTCCAGCTTTCTGGTGTCACAGGCGGGAATGTTAGTTAGTAGGTAGACTT AGATCCCATTTCTGTCCTGCTCCCAGGAAGATTCTTAGGTCCTCTTCAATCCAGCAGCCCCTCCCAGAGGTGTGATCAGCAGGATGCTGA GGAACCATGTTGCCTTTCCTGTCAATCACAGCCACCTTCCTGTTATCTCCTAAATGGATCTGGCTTTTCCTGGAGGCTGCCATGGTTGGA AGATGGTATCAGAGGGCCTGCCTGGGCAGTCTGTCTCCGGGCCAGGGTCAGGGACCCTCTGCCTCTGGCAGCCTTAACCTGTCCTCTGCT AGGACCAGGGTGATTTCAAGCCAGGGAAGCAACTGGGACCCTGAAAACTGTCCCTCCCCAGCCCGCTCCCCCTCTCTGTGCCCTGGTCCC CTTGCTGCCATGTGGATGCTGTTGTGATTGCTGTTTGTATATTATCAAAATGTTTTTATATTAAAAATGTTTGGTCTGAAAATTAAAAGC |
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FusionGenePPI for ZNF91_ASF1B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF91 | NDEL1, ELAVL1, CHMP5, TRIM44 | ASF1B | TLK1, IPO4, CDAN1, TLK2, CHAF1B, RPS3A, DOK2, C15orf41, MMS22L, RBBP4, CHAF1A, TTN, TONSL, HIST1H3F, UBXN1, DYNLL1, PSPH, RPL31, MRPS7, HCFC1, HIRA, HIST3H3, HIST4H4, HAT1, RBBP7, HIST1H3A, H3F3A, MCM2, MCM6, HIST1H3E, ASF1A, HIST1H3C, KHSRP, IDH1, MOV10, NXF1, MCM3, MCM4, MCM5, MCM7, NASP, STAT5B, CABIN1, UBN1, UBN2, PAN3, PAN2, PPTC7, RIF1, HIST1H4A, HIST2H4A, RCVRN |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF91_ASF1B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF91_ASF1B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |