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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43721

FusionGeneSummary for ZNF791_KMT2E

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF791_KMT2E
Fusion gene ID: 43721
HgeneTgene
Gene symbol

ZNF791

KMT2E

Gene ID

163049

55904

Gene namezinc finger protein 791lysine methyltransferase 2E
Synonyms-HDCMC04P|MLL5|NKp44L
Cytomap

19p13.13

7q22.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 791inactive histone-lysine N-methyltransferase 2Ehistone-lysine N-methyltransferase 2Ehistone-lysine N-methyltransferase MLL5inactive lysine N-methyltransferase 2Elysine (K)-specific methyltransferase 2Emyeloid/lymphoid or mixed-lineage leukemia 5 (trit
Modification date2018051920180519
UniProtAcc

Q3KP31

Q8IZD2

Ensembl transtripts involved in fusion geneENST00000446165, ENST00000343325, 
ENST00000458122, ENST00000540038, 
ENST00000498389, 		ENST00000311117, 
ENST00000334914, ENST00000257745, 
ENST00000334877, ENST00000476671, 
ENST00000480368, 
Fusion gene scores* DoF score6 X 3 X 5=904 X 7 X 3=84
# samples 67
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF791 [Title/Abstract] AND KMT2E [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-ER-A1A1-06AZNF791chr19

12721896

+KMT2Echr7

104714066

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000446165ENST00000311117ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5CDS-5UTRENST00000446165ENST00000334914ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5CDS-5UTRENST00000446165ENST00000257745ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5CDS-5UTRENST00000446165ENST00000334877ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5CDS-5UTRENST00000446165ENST00000476671ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5CDS-intronENST00000446165ENST00000480368ZNF791chr19

12721896

+KMT2Echr7

104714066

+
Frame-shiftENST00000343325ENST00000311117ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5CDS-5UTRENST00000343325ENST00000334914ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5CDS-5UTRENST00000343325ENST00000257745ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5CDS-5UTRENST00000343325ENST00000334877ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5CDS-5UTRENST00000343325ENST00000476671ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5CDS-intronENST00000343325ENST00000480368ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5UTR-3CDSENST00000458122ENST00000311117ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5UTR-5UTRENST00000458122ENST00000334914ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5UTR-5UTRENST00000458122ENST00000257745ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5UTR-5UTRENST00000458122ENST00000334877ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5UTR-5UTRENST00000458122ENST00000476671ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5UTR-intronENST00000458122ENST00000480368ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5UTR-3CDSENST00000540038ENST00000311117ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5UTR-5UTRENST00000540038ENST00000334914ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5UTR-5UTRENST00000540038ENST00000257745ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5UTR-5UTRENST00000540038ENST00000334877ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5UTR-5UTRENST00000540038ENST00000476671ZNF791chr19

12721896

+KMT2Echr7

104714066

+
5UTR-intronENST00000540038ENST00000480368ZNF791chr19

12721896

+KMT2Echr7

104714066

+
3UTR-3CDSENST00000498389ENST00000311117ZNF791chr19

12721896

+KMT2Echr7

104714066

+
3UTR-5UTRENST00000498389ENST00000334914ZNF791chr19

12721896

+KMT2Echr7

104714066

+
3UTR-5UTRENST00000498389ENST00000257745ZNF791chr19

12721896

+KMT2Echr7

104714066

+
3UTR-5UTRENST00000498389ENST00000334877ZNF791chr19

12721896

+KMT2Echr7

104714066

+
3UTR-5UTRENST00000498389ENST00000476671ZNF791chr19

12721896

+KMT2Echr7

104714066

+
3UTR-intronENST00000498389ENST00000480368ZNF791chr19

12721896

+KMT2Echr7

104714066

+

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FusionProtFeatures for ZNF791_KMT2E


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF791

Q3KP31

KMT2E

Q8IZD2

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF791_KMT2E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF791_KMT2E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF791HRC, EFEMP1KMT2ETP53, CDK1, ELAVL1, CUL1, KRAS, OGT, USP7, HCFC1, ILF2, RBM39, DHX30, DDX18, TRIM25, TOP2A, DDX50, ZNF768, YY1, RBBP4, MCM3, HDAC1, VPS4A, GRWD1, WDR6, DDX24, CDK11B, CDC7, SIN3A, CDK2, USP10, KPNA3, WDR12, SMYD3, SART1, RBBP6, TRAF6, ASH2L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF791_KMT2E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF791_KMT2E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKMT2EC0023418leukemia1CTD_human
TgeneKMT2EC0023470Myeloid Leukemia1CTD_human