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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43571

FusionGeneSummary for ZNF655_NUDCD3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF655_NUDCD3
Fusion gene ID: 43571
HgeneTgene
Gene symbol

ZNF655

NUDCD3

Gene ID

79027

23386

Gene namezinc finger protein 655NudC domain containing 3
SynonymsVIK|VIK-1NudCL
Cytomap

7q22.1

7p13

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 655vav-1 interacting Kruppel-like proteinnudC domain-containing protein 3NudC-like protein
Modification date2018052220180523
UniProtAcc

Q8N720

Q8IVD9

Ensembl transtripts involved in fusion geneENST00000320583, ENST00000357864, 
ENST00000252713, ENST00000454654, 
ENST00000449244, ENST00000425063, 
ENST00000493277, ENST00000424881, 
ENST00000440391, ENST00000394163, 
ENST00000419215, 
ENST00000355451, 
ENST00000460110, 
Fusion gene scores* DoF score2 X 1 X 1=28 X 8 X 3=192
# samples 39
** MAII scorelog2(3/2*10)=3.90689059560852log2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF655 [Title/Abstract] AND NUDCD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF655

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

15558030


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK127163ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
ChiTaRS3.1DA266922ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000320583ENST00000355451ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
5CDS-5UTRENST00000320583ENST00000460110ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
Frame-shiftENST00000357864ENST00000355451ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
5CDS-5UTRENST00000357864ENST00000460110ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
Frame-shiftENST00000252713ENST00000355451ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
5CDS-5UTRENST00000252713ENST00000460110ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
Frame-shiftENST00000454654ENST00000355451ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
5CDS-5UTRENST00000454654ENST00000460110ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
Frame-shiftENST00000449244ENST00000355451ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
5CDS-5UTRENST00000449244ENST00000460110ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
Frame-shiftENST00000425063ENST00000355451ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
5CDS-5UTRENST00000425063ENST00000460110ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
Frame-shiftENST00000493277ENST00000355451ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
5CDS-5UTRENST00000493277ENST00000460110ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
Frame-shiftENST00000424881ENST00000355451ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
5CDS-5UTRENST00000424881ENST00000460110ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
Frame-shiftENST00000440391ENST00000355451ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
5CDS-5UTRENST00000440391ENST00000460110ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
Frame-shiftENST00000394163ENST00000355451ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
5CDS-5UTRENST00000394163ENST00000460110ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
intron-3CDSENST00000419215ENST00000355451ZNF655chr7

99158320

+NUDCD3chr7

44444183

-
intron-5UTRENST00000419215ENST00000460110ZNF655chr7

99158320

+NUDCD3chr7

44444183

-

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FusionProtFeatures for ZNF655_NUDCD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF655

Q8N720

NUDCD3

Q8IVD9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF655_NUDCD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF655_NUDCD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF655ASUN, TRIP13, TRIM37, MTUS2, KRTAP4-12, MAGEA11, HTT, BAG3, KIFC3, TRAF2, MED21, RINT1, CARD9, KRT40, SPERT, MAGEA2B, C4BPB, TALDO1, TENC1, RIN3, BBS7NUDCD3UBE2I, KLHL13, KLHDC10, CUL3, DCUN1D1, RQCD1, SNF8, HK2, HSP90AA1, NUP205, QRICH1, RAB3GAP2, UBE4B, FKBP5, HCFC1, CARM1, PKN3, SORT1, CXorf57, PHOSPHO2-KLHL23, SSBP1, KBTBD6, SF3B3, KLHL9, FAM136A, CCNDBP1, KRTAP10-7, KRTAP10-3, KLHL20, KLHDC3, KLHL14, KLHL18, NAE1, OFD1, MKS1, CEP104, NPHP1, NPHP4, EVC2, NEK8, RPGR, PHLPP1, PTPRF, PPEF2, KLHL28, ENC1, KLHL6, KLHDC2, KLHL22, TECPR2, GAN, KBTBD4, HCFC2, KLHL29, KLHDC8A, TRIM25, PAFAH1B1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF655_NUDCD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF655_NUDCD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUDCD3C0023903Liver neoplasms1CTD_human