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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43523

FusionGeneSummary for ZNF614_FXYD5

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF614_FXYD5
Fusion gene ID: 43523
HgeneTgene
Gene symbol

ZNF614

FXYD5

Gene ID

80110

53827

Gene namezinc finger protein 614FXYD domain containing ion transport regulator 5
Synonyms-DYSAD|HSPC113|IWU1|KCT1|OIT2|PRO6241|RIC
Cytomap

19q13.41

19q13.12

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 614FXYD domain-containing ion transport regulator 5dysadherinkeratinocytes associated transmembrane protein 1
Modification date2018052320180523
UniProtAcc

Q8N883

Q96DB9

Ensembl transtripts involved in fusion geneENST00000356322, ENST00000270649, 
ENST00000543307, ENST00000392219, 
ENST00000541435, ENST00000590686, 
ENST00000342879, ENST00000588699, 
ENST00000423817, ENST00000392218, 
ENST00000591716, ENST00000392217, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF614 [Title/Abstract] AND FXYD5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A891-01AZNF614chr19

52518896

-FXYD5chr19

35660469

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000356322ENST00000543307ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-intronENST00000356322ENST00000392219ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-intronENST00000356322ENST00000541435ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-intronENST00000356322ENST00000590686ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-intronENST00000356322ENST00000342879ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-3UTRENST00000356322ENST00000588699ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-3UTRENST00000356322ENST00000423817ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-intronENST00000356322ENST00000392218ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-3UTRENST00000356322ENST00000591716ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-3UTRENST00000356322ENST00000392217ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-intronENST00000270649ENST00000543307ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-intronENST00000270649ENST00000392219ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-intronENST00000270649ENST00000541435ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-intronENST00000270649ENST00000590686ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-intronENST00000270649ENST00000342879ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-3UTRENST00000270649ENST00000588699ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-3UTRENST00000270649ENST00000423817ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-intronENST00000270649ENST00000392218ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-3UTRENST00000270649ENST00000591716ZNF614chr19

52518896

-FXYD5chr19

35660469

+
intron-3UTRENST00000270649ENST00000392217ZNF614chr19

52518896

-FXYD5chr19

35660469

+

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FusionProtFeatures for ZNF614_FXYD5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF614

Q8N883

FXYD5

Q96DB9

May be involved in transcriptional regulation. Involved in down-regulation of E-cadherin which resultsin reduced cell adhesion. Promotes metastasis.{ECO:0000269|PubMed:11756660}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF614_FXYD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF614_FXYD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF614NFIX, FAM9B, RNF2FXYD5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF614_FXYD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF614_FXYD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFXYD5C0023893Liver Cirrhosis, Experimental1CTD_human