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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43520

FusionGeneSummary for ZNF613_CYP2A6

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF613_CYP2A6
Fusion gene ID: 43520
HgeneTgene
Gene symbol

ZNF613

CYP2A6

Gene ID

79898

1548

Gene namezinc finger protein 613cytochrome P450 family 2 subfamily A member 6
Synonyms-CPA6|CYP2A|CYP2A3|CYPIIA6|P450C2A|P450PB
Cytomap

19q13.41

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 613cytochrome P450 2A61,4-cineole 2-exo-monooxygenasecoumarin 7-hydroxylasecytochrome P450 IIA3cytochrome P450(I)cytochrome P450, family 2, subfamily A, polypeptide 6cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6flavoprotein-l
Modification date2018052320180523
UniProtAcc

Q6PF04

P11509

Ensembl transtripts involved in fusion geneENST00000293471, ENST00000391794, 
ENST00000601794, 
ENST00000301141, 
Fusion gene scores* DoF score3 X 1 X 3=92 X 2 X 1=4
# samples 32
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: ZNF613 [Title/Abstract] AND CYP2A6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCYP2A6

GO:0009804

coumarin metabolic process

19651758

TgeneCYP2A6

GO:0017144

drug metabolic process

19651758

TgeneCYP2A6

GO:0042738

exogenous drug catabolic process

15680923

TgeneCYP2A6

GO:0046226

coumarin catabolic process

19029318


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A0U3-01AZNF613chr19

52433149

+CYP2A6chr19

41356256

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000293471ENST00000301141ZNF613chr19

52433149

+CYP2A6chr19

41356256

-
5UTR-3CDSENST00000391794ENST00000301141ZNF613chr19

52433149

+CYP2A6chr19

41356256

-
intron-3CDSENST00000601794ENST00000301141ZNF613chr19

52433149

+CYP2A6chr19

41356256

-

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FusionProtFeatures for ZNF613_CYP2A6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF613

Q6PF04

CYP2A6

P11509

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF613_CYP2A6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF613_CYP2A6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF613CYP2A6POR, CYB5A, CYP2A7, RABAC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF613_CYP2A6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF613_CYP2A6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCYP2A6C0024121Lung Neoplasms6CTD_human
TgeneCYP2A6C0040336Tobacco Use Disorder3CTD_human
TgeneCYP2A6C0038356Stomach Neoplasms2CTD_human
TgeneCYP2A6C1861063TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)2CTD_human
TgeneCYP2A6C0001418Adenocarcinoma1CTD_human
TgeneCYP2A6C0006111Brain Diseases1CTD_human
TgeneCYP2A6C0009404Colorectal Neoplasms1CTD_human
TgeneCYP2A6C0019163Hepatitis B1CTD_human
TgeneCYP2A6C0019196Hepatitis C1CTD_human
TgeneCYP2A6C0023897Liver Diseases, Parasitic1CTD_human
TgeneCYP2A6C0024809Marijuana Abuse1PSYGENET
TgeneCYP2A6C0027439Nasopharyngeal Neoplasms1CTD_human
TgeneCYP2A6C0029106Opisthorchiasis1CTD_human
TgeneCYP2A6C0033578Prostatic Neoplasms1CTD_human
TgeneCYP2A6C0034067Pulmonary Emphysema1CTD_human
TgeneCYP2A6C0206704Carcinoma, Large Cell1CTD_human
TgeneCYP2A6C0262584Carcinoma, Small Cell1CTD_human
TgeneCYP2A6C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneCYP2A6C4277682Chemical and Drug Induced Liver Injury1CTD_human