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Fusion gene ID: 43476 |
FusionGeneSummary for ZNF587B_LHFPL4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF587B_LHFPL4 | Fusion gene ID: 43476 | Hgene | Tgene | Gene symbol | ZNF587B | LHFPL4 | Gene ID | 100293516 | 375612 |
| Gene name | zinc finger protein 587B | LHFPL tetraspan subfamily member 3 | |
| Synonyms | - | LHFPL4 | |
| Cytomap | 19q13.43 | 7q22.2-q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 587B | LHFPL tetraspan subfamily member 3 proteinLHFP-like protein 3lipoma HMGIC fusion partner-like 3 proteinlipoma HMGIC fusion partner-like 4 | |
| Modification date | 20180523 | 20180402 | |
| UniProtAcc | E7ETH6 | Q7Z7J7 | |
| Ensembl transtripts involved in fusion gene | ENST00000316462, ENST00000442832, ENST00000594901, | ENST00000287585, ENST00000495730, | |
| Fusion gene scores | * DoF score | 4 X 2 X 3=24 | 3 X 2 X 3=18 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/24*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/18*10)=1.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF587B [Title/Abstract] AND LHFPL4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-1474-01A | ZNF587B | chr19 | 58350517 | + | LHFPL4 | chr3 | 9547887 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000316462 | ENST00000287585 | ZNF587B | chr19 | 58350517 | + | LHFPL4 | chr3 | 9547887 | - |
| 5CDS-intron | ENST00000316462 | ENST00000495730 | ZNF587B | chr19 | 58350517 | + | LHFPL4 | chr3 | 9547887 | - |
| In-frame | ENST00000442832 | ENST00000287585 | ZNF587B | chr19 | 58350517 | + | LHFPL4 | chr3 | 9547887 | - |
| 5CDS-intron | ENST00000442832 | ENST00000495730 | ZNF587B | chr19 | 58350517 | + | LHFPL4 | chr3 | 9547887 | - |
| In-frame | ENST00000594901 | ENST00000287585 | ZNF587B | chr19 | 58350517 | + | LHFPL4 | chr3 | 9547887 | - |
| 5CDS-intron | ENST00000594901 | ENST00000495730 | ZNF587B | chr19 | 58350517 | + | LHFPL4 | chr3 | 9547887 | - |
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FusionProtFeatures for ZNF587B_LHFPL4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF587B | LHFPL4 |
| May be involved in transcriptional regulation.{ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >LHFPL4 | chr19:58350517 | chr3:9547887 | ENST00000287585 | - | 1 | 4 | 178_198 | 135 | 248 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ZNF587B | chr19:58350517 | chr3:9547887 | ENST00000442832 | + | 2 | 4 | 15_91 | 54 | 403 | Domain | KRAB |
| Hgene | >ZNF587B | chr19:58350517 | chr3:9547887 | ENST00000442832 | + | 2 | 4 | 120_142 | 54 | 403 | Zinc finger | C2H2-type 2%3B degenerate |
| Hgene | >ZNF587B | chr19:58350517 | chr3:9547887 | ENST00000442832 | + | 2 | 4 | 242_264 | 54 | 403 | Zinc finger | C2H2-type 3 |
| Hgene | >ZNF587B | chr19:58350517 | chr3:9547887 | ENST00000442832 | + | 2 | 4 | 270_292 | 54 | 403 | Zinc finger | C2H2-type 4 |
| Hgene | >ZNF587B | chr19:58350517 | chr3:9547887 | ENST00000442832 | + | 2 | 4 | 298_320 | 54 | 403 | Zinc finger | C2H2-type 5 |
| Hgene | >ZNF587B | chr19:58350517 | chr3:9547887 | ENST00000442832 | + | 2 | 4 | 326_348 | 54 | 403 | Zinc finger | C2H2-type 6 |
| Hgene | >ZNF587B | chr19:58350517 | chr3:9547887 | ENST00000442832 | + | 2 | 4 | 354_383 | 54 | 403 | Zinc finger | C2H2-type 7 |
| Hgene | >ZNF587B | chr19:58350517 | chr3:9547887 | ENST00000442832 | + | 2 | 4 | 92_114 | 54 | 403 | Zinc finger | C2H2-type 1 |
| Tgene | LHFPL4 | chr19:58350517 | chr3:9547887 | ENST00000287585 | - | 1 | 4 | 127_147 | 135 | 248 | Transmembrane | Helical |
| Tgene | LHFPL4 | chr19:58350517 | chr3:9547887 | ENST00000287585 | - | 1 | 4 | 22_42 | 135 | 248 | Transmembrane | Helical |
| Tgene | LHFPL4 | chr19:58350517 | chr3:9547887 | ENST00000287585 | - | 1 | 4 | 97_117 | 135 | 248 | Transmembrane | Helical |
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FusionGeneSequence for ZNF587B_LHFPL4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZNF587B_ENST00000316462_chr19_58350517_+_LHFPL4_ENST00000287585_chr3_9547887_-_166aa MAAAAPRRPTQGTVTFEDVAVKFTQEEWNLLSEAQRCLYRDVTLENLALMSSLALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCS >In-frame_ZNF587B_ENST00000442832_chr19_58350517_+_LHFPL4_ENST00000287585_chr3_9547887_-_167aa MAVVATLRLSAQGTVTFEDVAVKFTQEEWNLLSEAQRCLYRDVTLENLALMSSLALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDC >In-frame_ZNF587B_ENST00000594901_chr19_58350517_+_LHFPL4_ENST00000287585_chr3_9547887_-_167aa MAVVATLRLSAQGTVTFEDVAVKFTQEEWNLLSEAQRCLYRDVTLENLALMSSLALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDC |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZNF587B_ENST00000316462_chr19_58350517_+_LHFPL4_ENST00000287585_chr3_9547887_-_498nt ATGGCTGCGGCTGCGCCGAGGCGCCCTACTCAGGGCACAGTGACTTTTGAAGACGTGGCTGTGAAATTTACCCAGGAGGAATGGAATCTC CTTAGTGAGGCTCAGAGATGCCTGTACCGTGATGTGACTCTGGAGAACCTGGCACTTATGTCCTCCCTGGCTCTGTGCCTCGTCCTGGGC TGCATGATCTTTCCTGATGGCTGGGATGCCGAGACCATCCGGGACATGTGTGGGGCCAAGACGGGGAAGTACTCCCTGGGGGACTGTTCA GTGCGCTGGGCATACATCCTGGCCATCATCGGCATCCTCAACGCCCTCATCCTCTCCTTCCTCGCCTTCGTGCTGGGCAACCGGCAAACA GACCTGCTGCAGGAGGAGCTCAAGCCGGAGAACAAAGATTTTGTGGGCTCTACAGTAAGCTCCGTGTTGCGGCCCGGGGGTGATGTCTCT >In-frame_ZNF587B_ENST00000442832_chr19_58350517_+_LHFPL4_ENST00000287585_chr3_9547887_-_501nt ATGGCGGTGGTGGCCACGCTGAGGCTCTCTGCTCAGGGCACAGTGACTTTTGAAGACGTGGCTGTGAAATTTACCCAGGAGGAATGGAAT CTCCTTAGTGAGGCTCAGAGATGCCTGTACCGTGATGTGACTCTGGAGAACCTGGCACTTATGTCCTCCCTGGCTCTGTGCCTCGTCCTG GGCTGCATGATCTTTCCTGATGGCTGGGATGCCGAGACCATCCGGGACATGTGTGGGGCCAAGACGGGGAAGTACTCCCTGGGGGACTGT TCAGTGCGCTGGGCATACATCCTGGCCATCATCGGCATCCTCAACGCCCTCATCCTCTCCTTCCTCGCCTTCGTGCTGGGCAACCGGCAA ACAGACCTGCTGCAGGAGGAGCTCAAGCCGGAGAACAAAGATTTTGTGGGCTCTACAGTAAGCTCCGTGTTGCGGCCCGGGGGTGATGTC >In-frame_ZNF587B_ENST00000594901_chr19_58350517_+_LHFPL4_ENST00000287585_chr3_9547887_-_501nt ATGGCGGTGGTGGCCACGCTGAGGCTCTCTGCTCAGGGCACAGTGACTTTTGAAGACGTGGCTGTGAAATTTACCCAGGAGGAATGGAAT CTCCTTAGTGAGGCTCAGAGATGCCTGTACCGTGATGTGACTCTGGAGAACCTGGCACTTATGTCCTCCCTGGCTCTGTGCCTCGTCCTG GGCTGCATGATCTTTCCTGATGGCTGGGATGCCGAGACCATCCGGGACATGTGTGGGGCCAAGACGGGGAAGTACTCCCTGGGGGACTGT TCAGTGCGCTGGGCATACATCCTGGCCATCATCGGCATCCTCAACGCCCTCATCCTCTCCTTCCTCGCCTTCGTGCTGGGCAACCGGCAA ACAGACCTGCTGCAGGAGGAGCTCAAGCCGGAGAACAAAGATTTTGTGGGCTCTACAGTAAGCTCCGTGTTGCGGCCCGGGGGTGATGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZNF587B_ENST00000316462_chr19_58350517_+_LHFPL4_ENST00000287585_chr3_9547887_-_1094nt GTAGCGGCCACGTTGATCTGCGATACGCGTGTTTGCCCAGTGAGTGGCCCCGGACTGCTACGTGGGACTGCGGTGAATGAACCCAGAAGG TGGAGAGGAACCGTTCTCGGTGCACAGAGGCGGCTCTGCAGCCCGGTGAGGGCGCCTGCTGCTCCCGGGCAGTGCTTTCCCCAAGTAGTC CGATGGCTGCGGCTGCGCCGAGGCGCCCTACTCAGGGCACAGTGACTTTTGAAGACGTGGCTGTGAAATTTACCCAGGAGGAATGGAATC TCCTTAGTGAGGCTCAGAGATGCCTGTACCGTGATGTGACTCTGGAGAACCTGGCACTTATGTCCTCCCTGGCTCTGTGCCTCGTCCTGG GCTGCATGATCTTTCCTGATGGCTGGGATGCCGAGACCATCCGGGACATGTGTGGGGCCAAGACGGGGAAGTACTCCCTGGGGGACTGTT CAGTGCGCTGGGCATACATCCTGGCCATCATCGGCATCCTCAACGCCCTCATCCTCTCCTTCCTCGCCTTCGTGCTGGGCAACCGGCAAA CAGACCTGCTGCAGGAGGAGCTCAAGCCGGAGAACAAAGATTTTGTGGGCTCTACAGTAAGCTCCGTGTTGCGGCCCGGGGGTGATGTCT CTGGATGGGGAGTCCTTCCCTGCCCCGTGGCTCACTCACAGGGACCCTGAAAGGCCAGGATCACAGCCCAGTAATTGGCCTGACCTCAGC TTGTCCTGCCTTCTGCCCTCTCGTCACTCCATTCAAGCTCTGAGGGAAGACCCTGATCTCAGACTTACTTCTCACCGACTACCCTGCAAG CTCCAGGCTTTGAGGAGAGGAAAGCCTGGATGTGGCCTGGGGGAGAGGAGAGGCCCTCCAAACCTTGGGAGGGTCTAATTCTTGCTCCTC CCTCAATTTGACCTAAGGGAGCCTGCATCTGCGTAGGCCCTTGGGCTTCTCCTCTCCTCTCTAGACTGGCCTGGAGGTCCCTGCAGATCC CCAGGGAGAGCGGAGCTGTAGTTCCAGCTCCCCAGGCCCCCTCAGTCTGGAGGGCTGCCGCCTGGCTGTATCCGCACCTCTTCTGGTCCC >In-frame_ZNF587B_ENST00000442832_chr19_58350517_+_LHFPL4_ENST00000287585_chr3_9547887_-_1149nt TTTTGATTGGTGTTGGGTTTATTTGTCGGAGAGGCTCCTGAGCGCTAGGTCGGCACTGCGGTGACTGAACCCAGAAGGCGGAGAACAGTT GTCCTCTGCTGCACAGAGGCGACTCTGGAGCTCTGTGACGGCGCCAAGCGTGACCCACCCCTGGGCCAGGATAGGGACCGTCATGCCCAT ATCTCCTGGCTGGTCACCCTCTCCTCCCAACCCTGCTTTAAACCACGTGGTTCGATGGCGGTGGTGGCCACGCTGAGGCTCTCTGCTCAG GGCACAGTGACTTTTGAAGACGTGGCTGTGAAATTTACCCAGGAGGAATGGAATCTCCTTAGTGAGGCTCAGAGATGCCTGTACCGTGAT GTGACTCTGGAGAACCTGGCACTTATGTCCTCCCTGGCTCTGTGCCTCGTCCTGGGCTGCATGATCTTTCCTGATGGCTGGGATGCCGAG ACCATCCGGGACATGTGTGGGGCCAAGACGGGGAAGTACTCCCTGGGGGACTGTTCAGTGCGCTGGGCATACATCCTGGCCATCATCGGC ATCCTCAACGCCCTCATCCTCTCCTTCCTCGCCTTCGTGCTGGGCAACCGGCAAACAGACCTGCTGCAGGAGGAGCTCAAGCCGGAGAAC AAAGATTTTGTGGGCTCTACAGTAAGCTCCGTGTTGCGGCCCGGGGGTGATGTCTCTGGATGGGGAGTCCTTCCCTGCCCCGTGGCTCAC TCACAGGGACCCTGAAAGGCCAGGATCACAGCCCAGTAATTGGCCTGACCTCAGCTTGTCCTGCCTTCTGCCCTCTCGTCACTCCATTCA AGCTCTGAGGGAAGACCCTGATCTCAGACTTACTTCTCACCGACTACCCTGCAAGCTCCAGGCTTTGAGGAGAGGAAAGCCTGGATGTGG CCTGGGGGAGAGGAGAGGCCCTCCAAACCTTGGGAGGGTCTAATTCTTGCTCCTCCCTCAATTTGACCTAAGGGAGCCTGCATCTGCGTA GGCCCTTGGGCTTCTCCTCTCCTCTCTAGACTGGCCTGGAGGTCCCTGCAGATCCCCAGGGAGAGCGGAGCTGTAGTTCCAGCTCCCCAG >In-frame_ZNF587B_ENST00000594901_chr19_58350517_+_LHFPL4_ENST00000287585_chr3_9547887_-_1131nt TTATTTGTCGGAGAGGCTCCTGAGCGCTAGGTCGGCACTGCGGTGACTGAACCCAGAAGGCGGAGAACAGTTGTCCTCTGCTGCACAGAG GCGACTCTGGAGCTCTGTGACGGCGCCAAGCGTGACCCACCCCTGGGCCAGGATAGGGACCGTCATGCCCATATCTCCTGGCTGGTCACC CTCTCCTCCCAACCCTGCTTTAAACCACGTGGTTCGATGGCGGTGGTGGCCACGCTGAGGCTCTCTGCTCAGGGCACAGTGACTTTTGAA GACGTGGCTGTGAAATTTACCCAGGAGGAATGGAATCTCCTTAGTGAGGCTCAGAGATGCCTGTACCGTGATGTGACTCTGGAGAACCTG GCACTTATGTCCTCCCTGGCTCTGTGCCTCGTCCTGGGCTGCATGATCTTTCCTGATGGCTGGGATGCCGAGACCATCCGGGACATGTGT GGGGCCAAGACGGGGAAGTACTCCCTGGGGGACTGTTCAGTGCGCTGGGCATACATCCTGGCCATCATCGGCATCCTCAACGCCCTCATC CTCTCCTTCCTCGCCTTCGTGCTGGGCAACCGGCAAACAGACCTGCTGCAGGAGGAGCTCAAGCCGGAGAACAAAGATTTTGTGGGCTCT ACAGTAAGCTCCGTGTTGCGGCCCGGGGGTGATGTCTCTGGATGGGGAGTCCTTCCCTGCCCCGTGGCTCACTCACAGGGACCCTGAAAG GCCAGGATCACAGCCCAGTAATTGGCCTGACCTCAGCTTGTCCTGCCTTCTGCCCTCTCGTCACTCCATTCAAGCTCTGAGGGAAGACCC TGATCTCAGACTTACTTCTCACCGACTACCCTGCAAGCTCCAGGCTTTGAGGAGAGGAAAGCCTGGATGTGGCCTGGGGGAGAGGAGAGG CCCTCCAAACCTTGGGAGGGTCTAATTCTTGCTCCTCCCTCAATTTGACCTAAGGGAGCCTGCATCTGCGTAGGCCCTTGGGCTTCTCCT CTCCTCTCTAGACTGGCCTGGAGGTCCCTGCAGATCCCCAGGGAGAGCGGAGCTGTAGTTCCAGCTCCCCAGGCCCCCTCAGTCTGGAGG |
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FusionGenePPI for ZNF587B_LHFPL4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF587B | SMAD9, TRIM25 | LHFPL4 | IFNA17, RABIF, ATP5B, FKRP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF587B_LHFPL4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF587B_LHFPL4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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