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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43403

FusionGeneSummary for ZNF532_DOK6

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF532_DOK6
Fusion gene ID: 43403
HgeneTgene
Gene symbol

ZNF532

DOK6

Gene ID

55205

220164

Gene namezinc finger protein 532docking protein 6
Synonyms-DOK5L|HsT3226
Cytomap

18q21.32

18q22.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 532docking protein 6downstream of tyrosine kinase 6
Modification date2018052220180519
UniProtAcc

Q9HCE3

Q6PKX4

Ensembl transtripts involved in fusion geneENST00000336078, ENST00000591083, 
ENST00000589288, ENST00000591230, 
ENST00000591808, ENST00000588956, 
ENST00000382713, ENST00000584435, 
Fusion gene scores* DoF score5 X 6 X 6=1802 X 2 X 2=8
# samples 82
** MAII scorelog2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ZNF532 [Title/Abstract] AND DOK6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-C5-A7CK-01AZNF532chr18

56532811

+DOK6chr18

67508480

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000336078ENST00000382713ZNF532chr18

56532811

+DOK6chr18

67508480

+
5UTR-intronENST00000336078ENST00000584435ZNF532chr18

56532811

+DOK6chr18

67508480

+
5UTR-3CDSENST00000591083ENST00000382713ZNF532chr18

56532811

+DOK6chr18

67508480

+
5UTR-intronENST00000591083ENST00000584435ZNF532chr18

56532811

+DOK6chr18

67508480

+
5UTR-3CDSENST00000589288ENST00000382713ZNF532chr18

56532811

+DOK6chr18

67508480

+
5UTR-intronENST00000589288ENST00000584435ZNF532chr18

56532811

+DOK6chr18

67508480

+
5UTR-3CDSENST00000591230ENST00000382713ZNF532chr18

56532811

+DOK6chr18

67508480

+
5UTR-intronENST00000591230ENST00000584435ZNF532chr18

56532811

+DOK6chr18

67508480

+
5UTR-3CDSENST00000591808ENST00000382713ZNF532chr18

56532811

+DOK6chr18

67508480

+
5UTR-intronENST00000591808ENST00000584435ZNF532chr18

56532811

+DOK6chr18

67508480

+
intron-3CDSENST00000588956ENST00000382713ZNF532chr18

56532811

+DOK6chr18

67508480

+
intron-intronENST00000588956ENST00000584435ZNF532chr18

56532811

+DOK6chr18

67508480

+

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FusionProtFeatures for ZNF532_DOK6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF532

Q9HCE3

DOK6

Q6PKX4

May be involved in transcriptional regulation. DOK proteins are enzymatically inert adaptor orscaffolding proteins. They provide a docking platform for theassembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain developmentand/or maintenance. {ECO:0000269|PubMed:15286081}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF532_DOK6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF532_DOK6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF532ELAVL1, ZMYND8, KDM5CDOK6RET, EGFR, ERBB2, RBPMS, C1orf94


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF532_DOK6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF532_DOK6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource