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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43391

FusionGeneSummary for ZNF521_RGS5

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF521_RGS5
Fusion gene ID: 43391
HgeneTgene
Gene symbol

ZNF521

RGS5

Gene ID

25925

8490

Gene namezinc finger protein 521regulator of G protein signaling 5
SynonymsEHZF|Evi3MST092|MST106|MST129|MSTP032|MSTP092|MSTP106|MSTP129
Cytomap

18q11.2

1q23.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 521LYST-interacting protein 3early hematopoietic zinc finger proteinregulator of G-protein signaling 5
Modification date2018051920180519
UniProtAcc

Q96K83

O15539

Ensembl transtripts involved in fusion geneENST00000361524, ENST00000584787, 
ENST00000538137, ENST00000579111, 
ENST00000367903, ENST00000534288, 
ENST00000313961, ENST00000530507, 
ENST00000527988, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 5 X 2=40
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF521 [Title/Abstract] AND RGS5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA659201ZNF521chr18

22825831

+RGS5chr1

163174321

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000361524ENST00000367903ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000361524ENST00000534288ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000361524ENST00000313961ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000361524ENST00000530507ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000361524ENST00000527988ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000584787ENST00000367903ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000584787ENST00000534288ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000584787ENST00000313961ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000584787ENST00000530507ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000584787ENST00000527988ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000538137ENST00000367903ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000538137ENST00000534288ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000538137ENST00000313961ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000538137ENST00000530507ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000538137ENST00000527988ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000579111ENST00000367903ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000579111ENST00000534288ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000579111ENST00000313961ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000579111ENST00000530507ZNF521chr18

22825831

+RGS5chr1

163174321

-
intron-intronENST00000579111ENST00000527988ZNF521chr18

22825831

+RGS5chr1

163174321

-

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FusionProtFeatures for ZNF521_RGS5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF521

Q96K83

RGS5

O15539

Transcription factor that can both act as an activatoror a repressor depending on the context. Involved in BMP signalingand in the regulation of the immature compartment of thehematopoietic system. Associates with SMADs in response to BMP2leading to activate transcription of BMP target genes. Acts as atranscriptional repressor via its interaction with EBF1, atranscription factor involved specification of B-cell lineage;this interaction preventing EBF1 to bind DNA and activate targetgenes. {ECO:0000269|PubMed:14630787}. Inhibits signal transduction by increasing the GTPaseactivity of G protein alpha subunits thereby driving them intotheir inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha,but not to G(s)-alpha (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF521_RGS5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF521_RGS5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF521_RGS5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF521_RGS5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRGS5C0020538Hypertensive disease1CTD_human
TgeneRGS5C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneRGS5C0036341Schizophrenia1PSYGENET