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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43341

FusionGeneSummary for ZNF460_SYT4

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF460_SYT4
Fusion gene ID: 43341
HgeneTgene
Gene symbol

ZNF460

SYT4

Gene ID

10794

6860

Gene namezinc finger protein 460synaptotagmin 4
SynonymsHZF8|ZNF272HsT1192
Cytomap

19q13.43

18q12.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 460zinc finger protein 272zinc finger protein HZF8synaptotagmin-4synaptotagmin IVsytIV
Modification date2018051920180523
UniProtAcc

Q14592

Q9H2B2

Ensembl transtripts involved in fusion geneENST00000537645, ENST00000360338, 
ENST00000255224, ENST00000586678, 
ENST00000590752, 
Fusion gene scores* DoF score4 X 3 X 3=362 X 1 X 2=4
# samples 32
** MAII scorelog2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: ZNF460 [Title/Abstract] AND SYT4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSYT4

GO:1903861

positive regulation of dendrite extension

23999003


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-E1-A7YL-01AZNF460chr19

57791492

+SYT4chr18

40854359

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000537645ENST00000255224ZNF460chr19

57791492

+SYT4chr18

40854359

-
5UTR-intronENST00000537645ENST00000586678ZNF460chr19

57791492

+SYT4chr18

40854359

-
5UTR-intronENST00000537645ENST00000590752ZNF460chr19

57791492

+SYT4chr18

40854359

-
intron-3CDSENST00000360338ENST00000255224ZNF460chr19

57791492

+SYT4chr18

40854359

-
intron-intronENST00000360338ENST00000586678ZNF460chr19

57791492

+SYT4chr18

40854359

-
intron-intronENST00000360338ENST00000590752ZNF460chr19

57791492

+SYT4chr18

40854359

-

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FusionProtFeatures for ZNF460_SYT4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF460

Q14592

SYT4

Q9H2B2

May be involved in transcriptional regulation. May be involved in Ca(2+)-dependent exocytosis ofsecretory vesicles through Ca(2+) and phospholipid binding to theC2 domain or may serve as Ca(2+) sensors in the process ofvesicular trafficking and exocytosis (By similarity). Plays a rolein dendrite formation by melanocytes (PubMed:23999003).{ECO:0000250|UniProtKB:P50232, ECO:0000269|PubMed:23999003}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF460_SYT4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF460_SYT4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF460SMARCAD1, CBX5, CDK11A, FGF12, ZNF250, CCDC67, MOV10, NXF1, PRG2, VWCE, EFEMP1, ZNF324B, ZNF550, TRIM28, GPR156, SDC2, RPF1, ZNF264, RGS3, ZNF785, ZNF408, PRICKLE3, DCAF8, TINAG, MTNR1A, TRIM25SYT4SGTA, SYNCRIP, NBR1, NTRK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF460_SYT4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF460_SYT4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSYT4C0025202melanoma1CTD_human