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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43325

FusionGeneSummary for ZNF438_RFTN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF438_RFTN1
Fusion gene ID: 43325
HgeneTgene
Gene symbol

ZNF438

RFTN1

Gene ID

220929

23180

Gene namezinc finger protein 438raftlin, lipid raft linker 1
SynonymsbA330O11.1MIG2|PIB10|PIG9|RAFTLIN
Cytomap

10p11.23

3p24.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 438raftlincell migration-inducing gene 2 proteinproliferation-inducing protein 10proliferation-inducing protein 9raft-linking protein
Modification date2018052320180519
UniProtAcc

Q7Z4V0

Q14699

Ensembl transtripts involved in fusion geneENST00000331737, ENST00000361310, 
ENST00000413025, ENST00000436087, 
ENST00000452305, ENST00000442986, 
ENST00000538351, ENST00000375311, 
ENST00000444692, 
ENST00000432519, 
ENST00000334133, ENST00000483671, 
Fusion gene scores* DoF score2 X 3 X 2=123 X 3 X 3=27
# samples 83
** MAII scorelog2(8/12*10)=2.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF438 [Title/Abstract] AND RFTN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-HP-A5N0-01AZNF438chr10

31273298

-RFTN1chr3

16475544

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000331737ENST00000432519ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-3CDSENST00000331737ENST00000334133ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-intronENST00000331737ENST00000483671ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-3CDSENST00000361310ENST00000432519ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-3CDSENST00000361310ENST00000334133ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-intronENST00000361310ENST00000483671ZNF438chr10

31273298

-RFTN1chr3

16475544

-
intron-3CDSENST00000413025ENST00000432519ZNF438chr10

31273298

-RFTN1chr3

16475544

-
intron-3CDSENST00000413025ENST00000334133ZNF438chr10

31273298

-RFTN1chr3

16475544

-
intron-intronENST00000413025ENST00000483671ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-3CDSENST00000436087ENST00000432519ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-3CDSENST00000436087ENST00000334133ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-intronENST00000436087ENST00000483671ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-3CDSENST00000452305ENST00000432519ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-3CDSENST00000452305ENST00000334133ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-intronENST00000452305ENST00000483671ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-3CDSENST00000442986ENST00000432519ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-3CDSENST00000442986ENST00000334133ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-intronENST00000442986ENST00000483671ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-3CDSENST00000538351ENST00000432519ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-3CDSENST00000538351ENST00000334133ZNF438chr10

31273298

-RFTN1chr3

16475544

-
5UTR-intronENST00000538351ENST00000483671ZNF438chr10

31273298

-RFTN1chr3

16475544

-
intron-3CDSENST00000375311ENST00000432519ZNF438chr10

31273298

-RFTN1chr3

16475544

-
intron-3CDSENST00000375311ENST00000334133ZNF438chr10

31273298

-RFTN1chr3

16475544

-
intron-intronENST00000375311ENST00000483671ZNF438chr10

31273298

-RFTN1chr3

16475544

-
intron-3CDSENST00000444692ENST00000432519ZNF438chr10

31273298

-RFTN1chr3

16475544

-
intron-3CDSENST00000444692ENST00000334133ZNF438chr10

31273298

-RFTN1chr3

16475544

-
intron-intronENST00000444692ENST00000483671ZNF438chr10

31273298

-RFTN1chr3

16475544

-

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FusionProtFeatures for ZNF438_RFTN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF438

Q7Z4V0

RFTN1

Q14699

Isoform 1 acts as a transcriptional repressor. Involved in protein trafficking via association withclathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Uponbacterial lipopolysaccharide stimulation, mediates internalizationof TLR4 to endosomes in dendritic cells and macrophages; andinternalization of poly(I:C) to TLR3-positive endosomes in myeloiddendritic cells and epithelial cells; resulting in activation ofTICAM1-mediated signaling and subsequent IFNB1 production(PubMed:27022195, PubMed:21266579). Involved in T-cell antigenreceptor-mediated signaling by regulating tyrosine kinase LCKlocalization, T-cell dependent antibody production and cytokinesecretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role inthe formation and/or maintenance of lipid rafts (PubMed:12805216).{ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216,ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF438_RFTN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF438_RFTN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF438RFTN1SLC25A41, UNC119, MUS81, PTEN, CTDSPL, RABGAP1L, TGM5, ATG2A, SDC1, GJB7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF438_RFTN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF438_RFTN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZNF438C0025202melanoma1CTD_human