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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43317

FusionGeneSummary for ZNF431_SIGLEC6

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF431_SIGLEC6
Fusion gene ID: 43317
HgeneTgene
Gene symbol

ZNF431

SIGLEC6

Gene ID

170959

946

Gene namezinc finger protein 431sialic acid binding Ig like lectin 6
Synonyms-CD327|CD33L|CD33L1|CD33L2|CDW327|OBBP1
Cytomap

19p12

19q13.41

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 431sialic acid-binding Ig-like lectin 6CD33 antigen-like 1obesity-binding protein 1
Modification date2018051920180519
UniProtAcc

Q8TF32

O43699

Ensembl transtripts involved in fusion geneENST00000600692, ENST00000599296, 
ENST00000594425, ENST00000311048, 
ENST00000594821, 
ENST00000346477, 
ENST00000359982, ENST00000436458, 
ENST00000343300, ENST00000425629, 
ENST00000474054, ENST00000391797, 
Fusion gene scores* DoF score3 X 1 X 2=61 X 1 X 1=1
# samples 31
** MAII scorelog2(3/6*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ZNF431 [Title/Abstract] AND SIGLEC6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-3B-A9HX-01AZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000600692ENST00000346477ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
Frame-shiftENST00000600692ENST00000359982ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000600692ENST00000436458ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000600692ENST00000343300ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000600692ENST00000425629ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000600692ENST00000474054ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000600692ENST00000391797ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
Frame-shiftENST00000599296ENST00000346477ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
Frame-shiftENST00000599296ENST00000359982ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000599296ENST00000436458ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000599296ENST00000343300ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000599296ENST00000425629ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000599296ENST00000474054ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000599296ENST00000391797ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
Frame-shiftENST00000594425ENST00000346477ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
Frame-shiftENST00000594425ENST00000359982ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000594425ENST00000436458ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000594425ENST00000343300ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000594425ENST00000425629ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000594425ENST00000474054ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000594425ENST00000391797ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
Frame-shiftENST00000311048ENST00000346477ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
Frame-shiftENST00000311048ENST00000359982ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000311048ENST00000436458ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000311048ENST00000343300ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000311048ENST00000425629ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000311048ENST00000474054ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
5CDS-intronENST00000311048ENST00000391797ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
intron-3CDSENST00000594821ENST00000346477ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
intron-3CDSENST00000594821ENST00000359982ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
intron-intronENST00000594821ENST00000436458ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
intron-intronENST00000594821ENST00000343300ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
intron-intronENST00000594821ENST00000425629ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
intron-intronENST00000594821ENST00000474054ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-
intron-intronENST00000594821ENST00000391797ZNF431chr19

21326446

+SIGLEC6chr19

52034773

-

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FusionProtFeatures for ZNF431_SIGLEC6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF431

Q8TF32

SIGLEC6

O43699

Sequence-specific DNA binding transcriptional repressor.Represses target gene transcription by recruiting HDAC1 and HDAC2histone deacetylases. Acts as a specific transcriptional repressorfor PTCH1 during embryonic development. Required for osteoblastdifferentiation and sonic hedgehog/SHH signaling response. Bindsto the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (Bysimilarity). {ECO:0000250}. Putative adhesion molecule that mediates sialic-aciddependent binding to cells. Binds to alpha-2,6-linked sialic acid.The sialic acid recognition site may be masked by cis interactionswith sialic acids on the same cell surface.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF431_SIGLEC6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF431_SIGLEC6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF431TK1, CDKN1A, SMN1, ANXA7, TYRP1, APP, ICAM3, CDX1, ZNF512SIGLEC6FHL2, TCF4, LGALS3BP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF431_SIGLEC6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF431_SIGLEC6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSIGLEC6C0024141Lupus Erythematosus, Systemic1CTD_human